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Literature summary for 4.1.1.15 extracted from

  • Obata, K.; Hirono, M.; Kume, N.; Kawaguchi, Y.; Itohara, S.; Yanagawa, Y.
    GABA and synaptic inhibition of mouse cerebellum lacking glutamate decarboxylase 67 (2008), Biochem. Biophys. Res. Commun., 370, 429-433.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
additional information construction of cerebellum-selective GAD67-knockout mice, selective GAD67 deletion in the cerebellum iss achieved using a Cre-loxP strategy. GABA level is reduced to 16-44% in the cerebellum but not in the cerebrum, inhibitory synaptic transmission to Purkinje cells is seriously impaired, however, the morphology of Purkinje cells and the density of synaptic terminals in the cerebellar cortex appears unaffected, phenotype, overview Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutamate Mus musculus
-
4-aminobutanoate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Mus musculus
-
cerebellum Purkinje cells and cerebellar cortex Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
Mus musculus 4-aminobutanoate + CO2
-
?

Synonyms

Synonyms Comment Organism
GAD67
-
Mus musculus
glutamate decarboxylase 67
-
Mus musculus