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Literature summary for 4.1.1.15 extracted from

  • Yamamoto, N.; Soghomonian, J.J.
    Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats (2009), Neuroscience, 163, 1171-1180.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
striatal neuron
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 Rattus norvegicus
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striatonigral neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-glutamate
-
 Rattus norvegicus 4-aminobutanoate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
GAD65
-
 Rattus norvegicus
GAD67
-
 Rattus norvegicus
Glutamic acid decarboxylase
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus subchronic L-DOPA administration (6 mg/kg) is paralleled by a significant increase in mRNA levels of the two isoforms of glutamic acid decarboxylase (GAD67 and GAD65), 1 mg/kg 2-methyl-6-(phenylethynyl)-pyridine completely reverses the effects of L-DOPA on GAD67 and GAD65 and reduces the increases in mRNA levels up