Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
striatal neuron | - |
Rattus norvegicus | - |
striatonigral neuron | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutamate | - |
Rattus norvegicus | 4-aminobutanoate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAD65 | - |
Rattus norvegicus |
GAD67 | - |
Rattus norvegicus |
Glutamic acid decarboxylase | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | subchronic L-DOPA administration (6 mg/kg) is paralleled by a significant increase in mRNA levels of the two isoforms of glutamic acid decarboxylase (GAD67 and GAD65), 1 mg/kg 2-methyl-6-(phenylethynyl)-pyridine completely reverses the effects of L-DOPA on GAD67 and GAD65 and reduces the increases in mRNA levels | up |