Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | increased GAD or vGAT mRNA levels after acute SKF-81297 occurr in striatonigral neurons. Subchronic SKF-81297 induces significant increases in striatal GAD67, GAD65, preprodynorphin, and vGAT mRNA levels and decreases in nigral alpha1 mRNA levels. In the striatum contralateral to the 6-OHDA lesion, subchronic but not acute SKF-81297 induced a significant increase in GAD65 mRNA levels | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
genes GAd65 and GAD67, expression analysis in brain tissues | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | chronic systemic administration of an agonist of dopamine D1/D5-preferring receptors increases GAD mRNA levels in striatonigral neurons in intact and dopamine-depleted rats. striatal GAD67 mRNA levels were negatively correlated with nigral alpha1 mRNA levels in the dopamine-depleted but not dopamine-intact side. down-regulation of nigral GABAA receptors is linked to the increase in striatal GAD67 mRNA levels in the dopamine-depleted striatum. Different signaling pathways are involved in the modulation by dopamine D1/D5 receptors of GAD65 and GAD67 mRNA levels in striatonigral neurons, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
corpus striatum | - |
Rattus norvegicus | - |
additional information | GAD65, GAD67, PPD and vGAT mRNA levels in the striatum and GABAA receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, and striatum in rats with single or subchroninc application of unilateral 6-hydroxydopamine lesion, overview | Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
pars reticulata | - |
Rattus norvegicus | - |
substantia nigra | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | chronic systemic administration of an agonist of dopamine D1/D5-preferring receptors increases GAD mRNA levels in striatonigral neurons in intact and dopamine-depleted rats. striatal GAD67 mRNA levels were negatively correlated with nigral alpha1 mRNA levels in the dopamine-depleted but not dopamine-intact side. down-regulation of nigral GABAA receptors is linked to the increase in striatal GAD67 mRNA levels in the dopamine-depleted striatum. Different signaling pathways are involved in the modulation by dopamine D1/D5 receptors of GAD65 and GAD67 mRNA levels in striatonigral neurons, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GAD | - |
Rattus norvegicus |
GAD65 | - |
Rattus norvegicus |
GAD67 | - |
Rattus norvegicus |
Glutamic acid decarboxylase | - |
Rattus norvegicus |