Reference on EC 3.4.22.62 - caspase-9 and Organism(s) Homo sapiens and UniProt Accession P55211
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Duan H.; Orth K.; Chinnaiyan A.M.; Poirier G.G.; Froelich C.J.; He W.W.; Dixit V.M.
ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B
J. Biol. Chem.
271
16720-16724
1996
Homo sapiens (P55211)
Srinivasula, S.M.; Fernandes-Alnemri, T.; Zangrilli, J.; Robertson, N.; Armstrong, R.C.; Wang, L.; Trapani, J.A.; Tomaselli, K.J.; Litwack, G.; Alnemri E.S.
The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32
J. Biol. Chem.
271
27099-27106
1996
Homo sapiens (P55211)
Seol, D.W.; Billiar, T.R.
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis
J. Biol. Chem.
274
2072-2076
1999
Homo sapiens (P55211), Homo sapiens
Allan, L.A.; Morrice, N.; Brady, S.; Magee, G.; Pathak, S.; Clarke, P.R.
Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
Nat. Cell Biol.
5
647-654
2003
Homo sapiens
Chou, K.C.; Tomasselli, A.G.; Heinrikson, R.L.
Prediction of the tertiary structure of a caspase-9/inhibitor complex
FEBS Lett.
470
249-256
2000
Homo sapiens
Rodriguez, J.; Lazebnik, Y.
Caspase-9 and APAF-1 form an active holoenzyme
Genes Dev.
13
3179-3184
1999
Homo sapiens
Zhivotovsky, B.; Samali, A.; Gahm, A.; Orrenius, S.
Caspases: their intracellular localization and translocation during apoptosis
Cell Death Differ.
6
644-651
1999
Homo sapiens
Pan, G.; O'Rourke, K.; Dixit, V.M.
Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex
J. Biol. Chem.
273
5841-5845
1998
Homo sapiens
Garcia-Calvo, M.; Peterson, E.P.; Leiting, B.; Ruel, R.; Nicholson, D.W.; Thornberry, N.A.
Inhibition of human caspases by peptide-based and macromolecular inhibitors
J. Biol. Chem.
273
32608-32613
1998
Homo sapiens
Garcia-Calvo, M.; Peterson, E.P.; Rasper, D.M.; Vaillancourt, J.P.; Zamboni, R.; Nicholson, D.W.; Thornberry, N.A.
Purification and catalytic properties of human caspase family members
Cell Death Differ.
6
362-369
1999
Homo sapiens
Li, P.; Nijhawan, D.; Budihardjo, I.; Srinivasula, S.M.; Ahman, M.; Alnemric, E.S.; Wang, X.
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
Cell
91
479-489
1997
Homo sapiens
Srinivasula, S.M.; Ahmad, M.; Fernandes-Alnemric, T.; Alnemri, E.S.
Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization
Mol. Cell
1
949-957
1998
Homo sapiens
Cardone, M.H.; Roy, N.; Stennicke, H.R.; Salvesen, G.S.; Franke, T.F.; Stanbridge, E.; Frisch, S.; Reed, J.C.
Regulation of cell death protease caspase-9 by phosphorylation
Science
282
1318-1321
1998
Homo sapiens
Chang, H.Y.; Yang, X.
Proteases from cell suicide: functions and regulation of caspases
Microbiol. Mol. Biol. Rev.
64
821-846
2000
Homo sapiens
Thornberry, N.A.; Rano, T.A.; Peterson, E.P.; et al.
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis
J. Biol. Chem.
272
17907-17911
1997
Homo sapiens
Soung, Y.H.; Lee, J.W.; Kim, S.Y.; Park, W.S.; Nam, S.W.; Lee, J.Y.; Yoo, N.J.; Lee, S.H.
Mutational analysis of proapoptotic caspase-9 gene in common human carcinomas
APMIS
114
292-297
2006
Homo sapiens
Johnson, C.R.; Jarvis, W.D.
Caspase-9 regulation: an update
Apoptosis
9
423-427
2004
Homo sapiens
Cheung, H.H.; Lynn Kelly, N.; Liston, P.; Korneluk, R.G.
Involvement of caspase-2 and caspase-9 in endoplasmic reticulum stress-induced apoptosis: a role for the IAPs
Exp. Cell Res.
312
2347-2357
2006
Homo sapiens
Martelli, A.M.; Cappellini, A.; Tazzari, P.L.; Billi, A.M.; Tassi, C.; Ricci, F.; Fala, F.; Conte, R.
Caspase-9 is the upstream caspase activated by 8-methoxypsoralen and ultraviolet-A radiation treatment of Jurkat T leukemia cells and normal T lymphocytes
Haematologica
89
471-479
2004
Homo sapiens
Kasili, P.M.; Song, J.M.; Vo-Dinh, T.
Optical sensor for the detection of caspase-9 activity in a single cell
J. Am. Chem. Soc.
126
2799-2806
2004
Homo sapiens
Akasaki, Y.; Liu, G.; Matunda, H.H.; Ng, H.; Yuan, X.; Zeng, Z.; Black, K.L.; Yu, J.S.
A peroxisome proliferator-activated receptor-gamma agonist, troglitazone, facilitates caspase-8 and -9 activities by increasing the enzymatic activity of protein-tyrosine phosphatase-1B on human glioma cells
J. Biol. Chem.
281
6165-6174
2006
Homo sapiens
Wang, P.; Shi, T.; Ma, D.
Cloning of a novel human caspase-9 splice variant containing only the CARD domain
Life Sci.
79
934-940
2006
Homo sapiens (P55211), Homo sapiens
Maglione, V.; Cannella, M.; Gradini, R.; Cislaghi, G.; Squitieri, F.
Huntingtin fragmentation and increased caspase 3, 8, and 9 activities in lymphoblasts with heterozygous and homozygous Huntington's disease mutation
Mech. Ageing Dev.
127
213-216
2006
Homo sapiens
Yin, Q.; Park, H.H.; Chung, J.Y.; Lin, S.C.; Lo, Y.C.; da Graca, L.S.; Jiang, X.; Wu, H.
Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine
Mol. Cell
22
259-268
2006
Homo sapiens (P55211)
Pop, C.; Timmer, J.; Sperandio, S.; Salvesen, G.S.
The apoptosome activates caspase-9 by dimerization
Mol. Cell
22
269-275
2006
Homo sapiens
Sadhukhan, R.; Leone, J.W.; Lull, J.; Wang, Z.; Kletzien, R.F.; Heinrikson, R.L.; Tomasselli, A.G.
An efficient method to express and refold a truncated human procaspase-9: a caspase with activity toward Glu-X bonds
Protein Expr. Purif.
46
299-308
2006
Homo sapiens
Samraj, A.K.; Keil, E.; Ueffing, N.; Schulze-Osthoff, K.; Schmitz, I.
Loss of caspase-9 provides genetic evidence for the type I/II concept of CD95-mediated apoptosis
J. Biol. Chem.
281
29652-29659
2006
Homo sapiens
Chen, M.; Guerrero, A.D.; Huang, L.; Shabier, Z.; Pan, M.; Tan, T.H.; Wang, J.
Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members
J. Biol. Chem.
282
33888-33895
2007
Homo sapiens
Martin, M.C.; Allan, L.A.; Mancini, E.J.; Clarke, P.R.
The docking interaction of caspase-9 with ERK2 provides a mechanism for the selective inhibitory phosphorylation of caspase-9 at threonine 125
J. Biol. Chem.
283
3854-3865
2008
Homo sapiens
Samraj, A.K.; Sohn, D.; Schulze-Osthoff, K.; Schmitz, I.
Loss of caspase-9 reveals its essential role for caspase-2 activation and mitochondrial membrane depolarization
Mol. Biol. Cell
18
84-93
2007
Homo sapiens
Allan, L.A.; Clarke, P.R.
Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis
Mol. Cell
26
301-310
2007
Homo sapiens
Eeva, J.; Nuutinen, U.; Ropponen, A.; Maettoe, M.; Eray, M.; Pellinen, R.; Wahlfors, J.; Pelkonen, J.
The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells
Apoptosis
14
687-698
2009
Homo sapiens (P55211)
Day, T.W.; Huang, S.; Safa, A.R.
c-FLIP knockdown induces ligand-independent DR5-, FADD-, caspase-8-, and caspase-9-dependent apoptosis in breast cancer cells
Biochem. Pharmacol.
76
1694-1704
2008
Homo sapiens (P55211)
Yamakawa, N.; Takahashi, A.; Mori, E.; Imai, Y.; Furusawa, Y.; Ohnishi, K.; Kirita, T.; Ohnishi, T.
High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase-9 activation
Cancer Sci.
99
1455-1460
2008
Homo sapiens (P55211), Homo sapiens
Zuo, Y.; Xiang, B.; Yang, J.; Sun, X.; Wang, Y.; Cang, H.; Yi, J.
Oxidative modification of caspase-9 facilitates its activation via disulfide-mediated interaction with APAF-1
Cell Res.
19
449-457
2009
Homo sapiens (P55211)
Seifert, A.; Allan, L.A.; Clarke, P.R.
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine
FEBS J.
275
6268-6280
2008
Homo sapiens (P55211), Homo sapiens
Yiang, G.T.; Yu, Y.L.; Hu, S.C.; Chen, M.H.; Wang, J.J.; Wei, C.W.
PKC and MEK pathways inhibit caspase-9/-3-mediated cytotoxicity in differentiated cells
FEBS Lett.
582
881-885
2008
Homo sapiens (P55211)
Tichy, A.; Zaskodova, D.; Pejchal, J.; Rezacova, M.; Osterreicher, J.; Vavrova, J.; Cerman, J.
Gamma irradiation of human leukaemic cells HL-60 and MOLT-4 induces decrease in Mcl-1 and Bid, release of cytochrome c, and activation of caspase-8 and caspase-9
Int. J. Radiat. Biol.
84
523-530
2008
Homo sapiens (P55211), Homo sapiens
Conte da Frota, M.L.; Braganhol, E.; Delgado Canedo, A.; Klamt, F.; Apel, M.A.; Mothes, B.; Lerner, C.; Oliveira Battastini, A.M.; Henriques, A.T.; Fonseca Moreira, J.C.
Extracts of marine sponge Polymastia janeirensis induce oxidative cell death through a caspase-9 apoptotic pathway in human U138MG glioma cell line
Invest. New Drugs
27
440-446
2008
Homo sapiens (P55211), Homo sapiens
Yasuda, Y.; Saito, M.; Yamamura, T.; Yaguchi, T.; Nishizaki, T.
Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors
J. Gastroenterol.
44
56-65
2009
Homo sapiens (P55211), Homo sapiens
Mondragon, L.; Orzaez, M.; Sanclimens, G.; Moure, A.; Arminan, A.; Sepulveda, P.; Messeguer, A.; Vicent, M.J.; Perez-Paya, E.
Modulation of cellular apoptosis with apoptotic protease-activating factor 1 (Apaf-1) inhibitors
J. Med. Chem.
51
521-529
2008
Rattus norvegicus, Homo sapiens (P55211)
Andreoli, V.; Trecroci, F.; La Russa, A.; Valentino, P.; Condino, F.; Latorre, V.; Nistico, R.; Pirritano, D.; Del Giudice, F.; Canino, M.; Cittadella, R.; Quattrone, A.
CASP-9: A susceptibility locus for multiple sclerosis in Italy
J. Neuroimmunol.
210
100-103
2009
Homo sapiens (P55211), Homo sapiens
Checinska, A.; Giaccone, G.; Rodriguez, J.A.; Kruyt, F.A.; Jimenez, C.R.
Comparative proteomics analysis of caspase-9-protein complexes in untreated and cytochrome c/dATP stimulated lysates of NSCLC cells
J. Proteomics
72
575-585
2009
Homo sapiens (P55211)
Zhao, J.F.; Sun, A.H.; Ruan, P.; Zhao, X.H.; Lu, M.Q.; Yan, J.
Vibrio vulnificus cytolysin induces apoptosis in HUVEC, SGC-7901 and SMMC-7721 cells via caspase-9/3-dependent pathway
Microb. Pathog.
46
194-200
2009
Homo sapiens (P55211), Homo sapiens
Mukherjee, J.J.; Gupta, S.K.; Kumar, S.
Inhibition of benzopyrene-diol-epoxide (BPDE)-induced bax and caspase-9 by cadmium: role of mitogen activated protein kinase
Mutat. Res.
661
41-46
2009
Homo sapiens (P55211), Homo sapiens
Darwish, R.S.; Amiridze, N.S.
Detectable levels of cytochrome C and activated caspase-9 in cerebrospinal fluid after human traumatic brain injury
Neurocrit. Care
12
337-341
2010
Homo sapiens
Jeong, H.S.; Choi, H.Y.; Lee, E.R.; Kim, J.H.; Jeon, K.; Lee, H.J.; Cho, S.G.
Involvement of caspase-9 in autophagy-mediated cell survival pathway
Biochim. Biophys. Acta
1813
80-90
2011
Homo sapiens
Abou-Kandil, A.; Chamias, R.; Huleihel, M.; Godbey, W.T.; Aboud, M.
Role of caspase 9 in activation of HTLV-1 LTR expression by DNA damaging agents
Cell Cycle
10
3337-3345
2011
Homo sapiens
Wu, Y.; Wang, D.; Wang, X.; Wang, Y.; Ren, F.; Chang, D.; Chang, Z.; Jia, B.
Caspase 3 is activated through caspase 8 instead of caspase 9 during H2O2-induced apoptosis in HeLa cells
Cell. Physiol. Biochem.
27
539-546
2011
Homo sapiens
Li, T.; Cui, Z.B.; Ke, X.X.; Tan, J.; Li, F.F.; Li, T.; Wang, X.W.; Cui, H.J.
Essential role for p53 and caspase-9 in DNA damaging drug-induced apoptosis in neuroblastoma IMR32 cells
DNA Cell Biol.
30
1045-1050
2011
Homo sapiens
Du, R.H.; Cui, J.T.; Wang, T.; Zhang, A.H.; Tan, R.X.
Trichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway
Toxicon
59
143-150
2012
Homo sapiens
Bourguet, C.B.; Boulay, P.L.; Claing, A.; Lubell, W.D.
Design and synthesis of novel azapeptide activators of apoptosis mediated by caspase-9 in cancer cells
Bioorg. Med. Chem. Lett.
24
3361-3365
2014
Homo sapiens
Huber, K.L.; Ghosh, S.; Hardy, J.A.
Inhibition of caspase-9 by stabilized peptides targeting the dimerization interface
Biopolymers
98
451-465
2012
Homo sapiens
Nie, C.; Luo, Y.; Zhao, X.; Luo, N.; Tong, A.; Liu, X.; Yuan, Z.; Wang, C.; Wei, Y.
Caspase-9 mediates Puma activation in UCN-01-induced apoptosis
Cell Death Dis.
5
e1495
2014
Homo sapiens
Wuerstle, M.L.; Laussmann, M.A.; Rehm, M.
The central role of initiator caspase-9 in apoptosis signal transduction and the regulation of its activation and activity on the apoptosome
Exp. Cell Res.
318
1213-1220
2012
Homo sapiens
Huber, K.L.; Hardy, J.A.
Mechanism of zinc-mediated inhibition of caspase-9
Protein Sci.
21
1056-1065
2012
Homo sapiens
Wei, X.; Li, Q.; Han, Z.; Lin, D.; Yu, P.
Differences in caspase-8 and -9 activity and sperm motility in infertile males of Li nationality in China
Int. J. Clin. Exp. Med.
8
4721-4726
2015
Homo sapiens (P55211), Homo sapiens
