Literature summary for 3.4.22.62 extracted from

Seol, D.W.; Billiar, T.R.
A caspase-9 variant missing the catalytic site is an endogenous inhibitor of apoptosis (1999), J. Biol. Chem., 274, 2072-2076.

Search for more literature for 3.4.22.62

Cloned(Commentary)

Cloned (Comment)	Organism
naturally occuring variant caspase-9S, that is missing most of the large subunit of caspase-9	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	caspase-9S is a naturally occuring variant of caspase-9 that is missing most of the large subunit of caspase-9, including the catalytic site, but has the intact prodomain and small subunit. Caspase-9S does not show apoptotic activity in transfection analysis. Overexpression of caspase 9S inhibits apoptosis induced by caspase-9. Caspase-9S inhibits apoptosis induced by tumor necrosis factor alpha, TNF factor-related apoptosis-inducing ligand, Bax, or fas-associated death domain-containing protein as well as the combination of Apaf-1 and caspase-9	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
30000	-	x * 30000, caspase 9S, SDS-PAGE	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P55211	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Subunits

Subunits	Comment	Organism
?	x * 30000, caspase 9S, SDS-PAGE	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)