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BRENDA support

Literature summary for 3.4.22.62 extracted from

  • Cardone, M.H.; Roy, N.; Stennicke, H.R.; Salvesen, G.S.; Franke, T.F.; Stanbridge, E.; Frisch, S.; Reed, J.C.
    Regulation of cell death protease caspase-9 by phosphorylation (1998), Science, 282, 1318-1321.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein kinase Akt and p21-Ras, an Akt activator, induce phosphorylation of pro-caspase-9 in cells. Akt phosphorylates recombinant caspase-9 in vitro on Ser196 and inhibits its protease activity. Mutant pro-caspase9(Ser196Ala) is resistant to Akt-mediated phosphorylation Homo sapiens