Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment with the NSAID FR122047 promotes apoptosis and caspase activation in MCF-7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of caspase-9 expression by specific siRNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Z-LEHD-fluoromethylketone | a caspase-9 inhibitor | Homo sapiens | |
Z-VAD-fluoromethylketone | a pan-caspase inhibitor | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
poly (ADP-ribose) polymerase + H2O | Homo sapiens | i.e. PARP | ? | - |
? | |
procaspase-7 + H2O | Homo sapiens | - |
caspase-7 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | - |
Homo sapiens | - |
MCF-7 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
LEDH-4-nitroanilide + H2O | - |
Homo sapiens | LEDH + 4-nitroaniline | - |
? | |
poly (ADP-ribose) polymerase + H2O | i.e. PARP | Homo sapiens | ? | - |
? | |
procaspase-7 + H2O | - |
Homo sapiens | caspase-7 + ? | - |
? |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | inhibition of caspase-9 activity results in unexpected, marked enhancement of cell death, inhibition of caspase-9 blocks the autophagic process by modulating lysosomal pH and acid-dependent cathepsin activities and augments cell death due to blockage of cytoprotective autophagy. Knockdown of caspase-9 expression by specific siRNA causes increased susceptibility to NSAID FR122047-induced cell death | Homo sapiens |
additional information | treatment with the NSAID FR122047 promotes apoptosis and caspase activation in MCF-7 cells | Homo sapiens |
physiological function | involvement of caspase-9 in autophagy-mediated cell survival pathway | Homo sapiens |