Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | treatment of HL-60 cells with 1 microM benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) elicits induction of caspase-9 activity | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cadmium | anti-apoptotic cell survival function of cadmium, cadmium inhibits apoptosis induced by benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) at non-cytotoxic concentrations, 40% and 52% inhibition at 10 and 20 microM cadmium chloride, respectively | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cd2+ | anti-apoptotic cell survival function of cadmium, cadmium inhibits apoptosis induced by benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) at non-cytotoxic concentrations, cadmium chloride pre-treatment of cells significantly inhibits caspase-9 activation in a dose dependent manner, 40% and 52% inhibition at 10 and 20 microM cadmium chloride, respectively | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P55211 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cortical collecting duct cell | - |
Homo sapiens | - |
fibroblast cell line | human fibroblast GM03349 | Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
protective effects of cadmium on apoptosis induced by benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), inhibition of BPDE-induced apoptosis by cadmium is associated with downregulation of caspase-9 activation, cadmium-induced inhibition of apoptosis associated with downregulation of caspase-9 activation, 40% and 52% inhibition of apoptosis after pre-treatment of cells with 10 and 20 microM cadmium chloride, respectively | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-Leu-Glu-His-Asp-p-nitroanilide + H2O | i.e. LEHD-pNA, caspase-9 activity determined, anti-apoptotic cell survival function of cadmium | Homo sapiens | acetyl-Leu-Glu-His-Asp + p-nitroaniline | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
caspase-9 activity determined at | Homo sapiens |