Any feedback?
Literature summary for 3.4.22.62 extracted from
- Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK (2003), Nat. Cell Biol., 5, 647-654.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | caspase-9 is phosphorylated on Thr125 in a MEK172-dependent manner in vivo, efficiently phosphorylated on Thr125 by ERK in vitro. Phosphorylation of Thr125 on caspase-9 may be an important mechanism through which growth factor and survival signals that activate the ERK MAPK pathway can inhibit apoptosis | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-DEVD-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | acetyl-DEVD + 7-amino-4-methylcoumarin | - |
? |  |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
