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Literature summary for 3.4.22.62 extracted from

  • Conte da Frota, M.L.; Braganhol, E.; Delgado Canedo, A.; Klamt, F.; Apel, M.A.; Mothes, B.; Lerner, C.; Oliveira Battastini, A.M.; Henriques, A.T.; Fonseca Moreira, J.C.
    Extracts of marine sponge Polymastia janeirensis induce oxidative cell death through a caspase-9 apoptotic pathway in human U138MG glioma cell line (2008), Invest. New Drugs, 27, 440-446.
    View publication on PubMed
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Application

Application Comment Organism
pharmacology drug development, studies on mechanisms of apoptosis activated in response to marine sponge extracts of Polymastia janeirensis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
benzyloxycarbonyl-Leu-Glu-His-Asp-fluoromethylketone i.e. z-LEHD-FMK, inhibitor concentration 100 microM Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pro-caspase-3 + H2O Homo sapiens induction of oxidative cell death by marine sponge extracts of Polymastia janeirensis mediated through caspase-9 apoptotic pathway caspase-3 + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P55211
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-

Source Tissue

Source Tissue Comment Organism Textmining
U-138MG cell treated with different concentrations of marine sponge extracts of Polymastia janeirensis Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
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 mechanisms of apoptosis induced in response to marine sponge extracts of Polymastia janeirensis, flow cytometry analysis, assessment of glioma cell viability, dose-dependent increase in ROS production, inhibitor studies to determine whether the extracts activate the extrinsic or intrinsic pathways of apoptosis, marine sponge extracts of Polymastia janeirensis induce oxidative cell death mediated through the caspase-9 pathway Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-caspase-3 + H2O induction of oxidative cell death by marine sponge extracts of Polymastia janeirensis mediated through caspase-9 apoptotic pathway Homo sapiens caspase-3 + ?
-
 ?