Reference on EC 3.4.17.21 - Glutamate carboxypeptidase II and Organism(s) Homo sapiens and UniProt Accession Q04609
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Rawlings, N.D.; Barrett, A.J.
Structure of membrane glutamate carboxypeptidase
Biochim. Biophys. Acta
1339
247-252
1997
Homo sapiens
Gregorakis, A.K.; Holmes, E.H.; Murphy, G.P.
Prostrate-specific membrane antigen: current and future utility
Semin. Urol. Oncol.
16
2-12
1998
Homo sapiens
Maraj, B.H.; Whelan, P.; Markham, A.F.
Prostate-specific membrane antigen
Br. J. Urol.
81
523-528
1998
Homo sapiens
Fair, W.R.; Israeli, R.S.; Heston, W.D.W.
Prostrate-specific membrane antigen
Prostate
32
140-148
1997
Homo sapiens
Carter, R.E.; Feldman, A.R.; Coyle, J.T.
Prostrate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase
Proc. Natl. Acad. Sci. USA
93
749-753
1996
Homo sapiens
Pinto, J.T.; Suffoletto, B.P.; Berzin, T.M.; Qiao, C.H.; Lin, S.; Tong, W.P.; May, F.; Mukherjee, B.; Heston, W.D.W.
Prostate-specific membrane antigen: a novel folate hydrolase in human prostatic carcinoma cells
Clin. Cancer Res.
2
1445-1451
1996
Homo sapiens
Heston, W.D.W.
Characterization and glutamyl preferring carboxypeptidase function of prostrate specific membrane antigen: a novel folate hydrolase
Urology
49 (3A Suppl)
104-112
1997
Homo sapiens
Troyer, J.K.; Beckett, M.L.; Wright, G.L.
Location of prostrate-specific membrane antigen in the LNCaP prostrate carcinoma cell line
Prostate
30
232-242
1997
Homo sapiens
Rojas, C.; Frazier, S.T.; Flanary, J.; Slusher, B.S.
Kinetics and inhibition of glutamate carboxypeptidase II using a microplate assay
Anal. Biochem.
310
50-54
2002
Homo sapiens
Rodriguez, C.E.; Lu, H.; Martinez, A.R.; Hu, Y.; Brunelle, A.; Berkman, C.E.
Inhibition of glutamate carboxypeptidase II by phosphonamidothionate derivatives of glutamic acid
J. Enzyme Inhib.
16
359-365
2001
Homo sapiens
Kozikowski, A.P.; Zhang, J.; Nan, F.; Petukhov, P.A.; Grajkowska, E.; Wroblewski, J.T.; Yamamoto, T.; Bzdega, T.; Wroblewska, B.; Neale, J.H.
Synthesis of urea-based inhibitors as active site probes of glutamate carboxypeptidase II: efficacy as analgesic agents
J. Med. Chem.
47
1729-1738
2004
Homo sapiens
Meighan, M.A.; Dickerson, M.T.; Glinskii, O.; Glinsky, V.V.; Wright, G.L., Jr.; Deutscher, S.L.
Recombinant glutamate carboxypeptidase II (prostate specific membrane antigen-PSMA)-cellular localization and bioactivity analyses
J. Protein Chem.
22
317-326
2003
Homo sapiens
Thomas, A.G.; Wozniak, K.M.; Tsukamoto, T.; Calvin, D.; Wu, Y.; Rojas, C.; Vornov, J.; Slusher, B.S.
Glutamate carboxypeptidase II (NAALADase) inhibition as a novel therapeutic strategy
Adv. Exp. Med. Biol.
576
327-37
2006
Homo sapiens, Rattus norvegicus
van der Post, J.P.; de Visser, S.J.; de Kam, M.L.; Woelfler, M.; Hilt, D.C.; Vornov, J.; Burak, E.S.; Bortey, E.; Slusher, B.S.; Limsakun, T.; Cohen, A.F.; van Gerven, J.M.
The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693
Br. J. Clin. Pharmacol.
60
128-136
2005
Homo sapiens
Ghosh, A.; Wang, X.; Klein, E.; Heston, W.D.
Novel role of prostate-specific membrane antigen in suppressing prostate cancer invasiveness
Cancer Res.
65
727-731
2005
Homo sapiens
Mesters, J.R.; Barinka, C.; Li, W.; Tsukamoto, T.; Majer, P.; Slusher, B.S.; Konvalinka, J.; Hilgenfeld, R.
Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer
EMBO J.
25
1375-1384
2006
Homo sapiens (Q04609)
Yamamoto, T.; Hirasawa, S.; Wroblewska, B.; Grajkowska, E.; Zhou, J.; Kozikowski, A.; Wroblewski, J.; Neale, J.H.
Antinociceptive effects of N-acetylaspartylglutamate (NAAG) peptidase inhibitors ZJ-11, ZJ-17 and ZJ-43 in the rat formalin test and in the rat neuropathic pain model
Eur. J. Neurosci.
20
483-494
2004
Homo sapiens, Rattus norvegicus
Marchal, C.; Redondo, M.; Padilla, M.; Caballero, J.; Rodrigo, I.; Garcia, J.; Quian, J.; Boswick, D.G.
Expression of prostate specific membrane antigen (PSMA) in prostatic adenocarcinoma and prostatic intraepithelial neoplasia
Histol. Histopathol.
19
715-718
2004
Homo sapiens
Castelletti, D.; Fracasso, G.; Alfalah, M.; Cingarlini, S.; Colombatti, M.; Naim, H.Y.
Apical transport and folding of prostate-specific membrane antigen occurs independent of glycan processing
J. Biol. Chem.
281
3505-3512
2006
Homo sapiens
Ghosh, A.; Heston, W.D.
Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer
J. Cell. Biochem.
91
528-539
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Tsukamoto, T.; Majer, P.; Vitharana, D.; Ni, C.; Hin, B.; Lu, X.C.; Thomas, A.G.; Wozniak, K.M.; Calvin, D.C.; Wu, Y.; Slusher, B.S.; Scarpetti, D.; Bonneville, G.W.
Enantiospecificity of glutamate carboxypeptidase II inhibition
J. Med. Chem.
48
2319-2324
2005
Homo sapiens, Rattus norvegicus
Majer, P.; Hin, B.; Stoermer, D.; Adams, J.; Xu, W.; Duvall, B.R.; Delahanty, G.; Liu, Q.; Stathis, M.J.; Wozniak, K.M.; Slusher, B.S.; Tsukamoto, T.
Structural optimization of thiol-based inhibitors of glutamate carboxypeptidase II by modification of the P1 side chain
J. Med. Chem.
49
2876-2885
2006
Homo sapiens
Christiansen, J.J.; Rajasekaran, S.A.; Inge, L.; Cheng, L.; Anilkumar, G.; Bander, N.H.; Rajasekaran, A.K.
N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy
Mol. Cancer Ther.
4
704-714
2005
Homo sapiens
Zhou, J.; Neale, J.H.; Pomper, M.G.; Kozikowski, A.P.
NAAG peptidase inhibitors and their potential for diagnosis and therapy
Nat. Rev. Drug Discov.
4
1015-1026
2005
Homo sapiens, Rattus norvegicus
Ghose, S.; Weickert, C.S.; Colvin, S.M.; Coyle, J.T.; Herman, M.M.; Hyde, T.M.; Kleinman, J.E.
Glutamate carboxypeptidase II gene expression in the human frontal and temporal lobe in schizophrenia
Neuropsychopharmacology
29
117-125
2004
Homo sapiens
Davis, M.I.; Bennett, M.J.; Thomas, L.M.; Bjorkman, P.J.
Crystal structure of prostate-specific membrane antigen, a tumor marker and peptidase
Proc. Natl. Acad. Sci. USA
102
5981-5986
2005
Homo sapiens (Q04609)
Aggarwal, S.; Ricklis, R.M.; Williams, S.A.; Denmeade, S.R.
Comparative study of PSMA expression in the prostate of mouse, dog, monkey, and human
Prostate
66
903-910
2006
Canis lupus familiaris, Macaca fascicularis, Homo sapiens, Macaca mulatta, Mus musculus
Liu, T.; Toriyabe, Y.; Berkman, C.E.
Purification of prostate-specific membrane antigen using conformational epitope-specific antibody-affinity chromatography
Protein Expr. Purif.
49
251-255
2006
Homo sapiens
Barinka, C.; Sacha, P.; Sklenar, J.; Man, P.; Bezouska, K.; Slusher, B.S.; Konvalinka, J.
Identification of the N-glycosylation sites on glutamate carboxypeptidase II necessary for proteolytic activity
Protein Sci.
13
1627-1635
2004
Homo sapiens
Ding, P.; Helquist, P.; Miller, M.J.
Design, synthesis and pharmacological activity of novel enantiomerically pure phosphonic acid-based NAALADase inhibitors
Org. Biomol. Chem.
5
826-831
2007
Homo sapiens
Klusak, V.; Barinka, C.; Plechanovova, A.; Mlcochova, P.; Konvalinka, J.; Rulisek, L.; Lubkowski, J.
Reaction mechanism of glutamate carboxypeptidase II revealed by mutagenesis, X-ray crystallography, and computational methods
Biochemistry
48
4126-4138
2009
Homo sapiens (Q04609), Homo sapiens
Lopreato, F.R.; Stabler, S.P.; Carvalho, F.R.; Hirata, R.D.; Hirata, M.H.; Robi, D.L.; Sampaio-Neto, L.F.; Allen, R.H.; Guerra-Shinohara, E.M.
Relationships between gene polymorphisms of folate-related proteins and vitamins and metabolites in pregnant women and neonates
Clin. Chim. Acta
398
134-139
2008
Homo sapiens
Barinka, C.; Byun, Y.; Dusich, C.L.; Banerjee, S.R.; Chen, Y.; Castanares, M.; Kozikowski, A.P.; Mease, R.C.; Pomper, M.G.; Lubkowski, J.
Interactions between human glutamate carboxypeptidase II and urea-based inhibitors: structural characterization
J. Med. Chem.
51
7737-7743
2008
Homo sapiens (Q04609), Homo sapiens
Guilarte, T.R.; Hammoud, D.A.; McGlothan, J.L.; Caffo, B.S.; Foss, C.A.; Kozikowski, A.P.; Pomper, M.G.
Dysregulation of glutamate carboxypeptidase II in psychiatric disease
Schizophr. Res.
99
324-332
2008
Homo sapiens
Thomas, A.G.; Rojas, C.J.; Hill, J.R.; Shaw, M.; Slusher, B.S.
Bioanalysis of N-acetyl-aspartyl-glutamate as a marker of glutamate carboxypeptidase II inhibition
Anal. Biochem.
404
94-96
2010
Homo sapiens
Liu, T.; Wu, L.Y.; Berkman, C.E.
Prostate-specific membrane antigen-targeted photodynamic therapy induces rapid cytoskeletal disruption
Cancer Lett.
296
106-112
2010
Homo sapiens
Hillier, S.M.; Maresca, K.P.; Femia, F.J.; Marquis, J.C.; Foss, C.A.; Nguyen, N.; Zimmerman, C.N.; Barrett, J.A.; Eckelman, W.C.; Pomper, M.G.; Joyal, J.L.; Babich, J.W.
Preclinical evaluation of novel glutamate-urea-lysine analogues that target prostate-specific membrane antigen as molecular imaging pharmaceuticals for prostate cancer
Cancer Res.
69
6932-6940
2009
Homo sapiens
Regino, C.A.; Wong, K.J.; Milenic, D.E.; Holmes, E.H.; Garmestani, K.; Choyke, P.L.; Brechbiel, M.W.
Preclinical evaluation of a monoclonal antibody (3C6) specific for prostate-specific membrane antigen
Curr. Radiopharm.
2
9-17
2009
Homo sapiens
Dharmasiri, U.; Balamurugan, S.; Adams, A.A.; Okagbare, P.I.; Obubuafo, A.; Soper, S.A.
Highly efficient capture and enumeration of low abundance prostate cancer cells using prostate-specific membrane antigen aptamers immobilized to a polymeric microfluidic device
Electrophoresis
30
3289-3300
2009
Homo sapiens
Hlouchova, K.; Barinka, C.; Konvalinka, J.; Lubkowski, J.
Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III
FEBS J.
276
4448-4462
2009
Homo sapiens
Haffner, M.C.; Kronberger, I.E.; Ross, J.S.; Sheehan, C.E.; Zitt, M.; Muehlmann, G.; Ofner, D.; Zelger, B.; Ensinger, C.; Yang, X.J.; Geley, S.; Margreiter, R.; Bander, N.H.
Prostate-specific membrane antigen expression in the neovasculature of gastric and colorectal cancers
Hum. Pathol.
40
1754-1761
2009
Homo sapiens
Maresca, K.; Hillier, S.; Femia, F.; Keith, D.; Barone, C.; Joyal, J.; Zimmerman, C.; Kozikowski, A.; Barrett, J.; Eckelman, W.; Babich, J.
A series of halogenated heterodimeric inhibitors of prostate specific membrane antigen (PSMA) as radiolabeled probes for targeting prostate cancer
J. Med. Chem.
52
347-357
2009
Homo sapiens
Lapi, S.E.; Wahnishe, H.; Pham, D.; Wu, L.Y.; Nedrow-Byers, J.R.; Liu, T.; Vejdani, K.; VanBrocklin, H.F.; Berkman, C.E.; Jones, E.F.
Assessment of an 18F-labeled phosphoramidate peptidomimetic as a new prostate-specific membrane antigen-targeted imaging agent for prostate cancer
J. Nucl. Med.
50
2042-2048
2009
Homo sapiens
Elsaesser-Beile, U.; Reischl, G.; Wiehr, S.; Buehler, P.; Wolf, P.; Alt, K.; Shively, J.; Judenhofer, M.S.; Machulla, H.J.; Pichler, B.J.
PET imaging of prostate cancer xenografts with a highly specific antibody against the prostate-specific membrane antigen
J. Nucl. Med.
50
606-611
2009
Homo sapiens
Rubenstein, M.; Hollowell, C.M.; Guinan, P.
Increased prostate-specific membrane antigen expression in LNCaP cells following treatment with bispecific antisense oligonucleotides directed against bcl-2 and EGFR
Med. Oncol.
27
1212-1218
2009
Homo sapiens
Guo, Z.; Huang, H.; Zeng, L.; Du, T.; Xu, K.; Lin,T.; Jiang, C.; Dong, W.; Cao, Y.; Chen, J.; Zhong, W.; Huang, J.
Lentivirus-mediated RNAi knockdown of prostate-specific membrane antigen suppresses growth, reduces migration ability and the invasiveness of prostate cancer cells
Med. Oncol.
28
878-887
2011
Homo sapiens (Q04609)
Kularatne, S.A.; Wang, K.; Santhapuram, H.K.; Low, P.S.
Prostate-specific membrane antigen targeted imaging and therapy of prostate cancer using a PSMA inhibitor as a homing ligand
Mol. Pharm.
6
780-789
2009
Homo sapiens (Q04609), Homo sapiens
Kularatne, S.A.; Zhou, Z.; Yang, J.; Post, C.B.; Low, P.S.
Design, synthesis, and preclinical evaluation of prostate-specific membrane antigen targeted (99m)Tc-radioimaging agents
Mol. Pharm.
6
790-800
2009
Homo sapiens
Mannweiler, S.; Amersdorfer, P.; Trajanoski, S.; Terrett, J.; King, D.; Mehes, G.
Heterogeneity of prostate-specific membrane antigen (PSMA) expression in prostate carcinoma with distant metastasis
Pathol. Oncol. Res.
15
167-172
2009
Homo sapiens
Colombatti, M.; Grasso, S.; Porzia, A.; Fracasso, G.; Scupoli, M.T.; Cingarlini, S.; Poffe, O.; Naim, H.Y.; Heine, M.; Tridente, G.; Mainiero, F.; Ramarli, D.
The prostate specific membrane antigen regulates the expression of IL-6 and CCL5 in prostate tumour cells by activating the MAPK pathways
PLoS ONE
4
e4608
2009
Homo sapiens
Ananias, H.J.; van den Heuvel, M.C.; Helfrich, W.; de Jong, I.J.
Expression of the gastrin-releasing peptide receptor, the prostate stem cell antigen and the prostate-specific membrane antigen in lymph node and bone metastases of prostate cancer
Prostate
69
1101-1108
2009
Homo sapiens
Liu, C.; Hasegawa, K.; Russell, S.J.; Sadelain, M.; Peng, K.W.
Prostate-specific membrane antigen retargeted measles virotherapy for the treatment of prostate cancer
Prostate
69
1128-1141
2009
Homo sapiens
Kuroda, K.; Liu, H.; Kim, S.; Guo, M.; Navarro, V.; Bander, N.H.
Docetaxel down-regulates the expression of androgen receptor and prostate-specific antigen but not prostate-specific membrane antigen in prostate cancer cell lines: implications for PSA surrogacy
Prostate
69
1579-1585
2009
Homo sapiens
Liu, T.; Wu, L.Y.; Choi, J.K.; Berkman, C.E.
In vitro targeted photodynamic therapy with a pyropheophorbide - a conjugated inhibitor of prostate-specific membrane antigen
Prostate
69
585-594
2009
Homo sapiens
Kuang, Y.; Zhu, H.; Weng, X.; Liu, X.; Chen, Z.; Chen, H.; Jiang, B.; Zheng, Y.
Antitumor immune response induced by DNA vaccine encoding human prostate-specific membrane antigen and mouse 4-1BBL
Urology
76
510e1-510e6
2010
Homo sapiens
Lee, S.; Kim, H.; Cheong, Y.; Kim, M.; Jo, S.; Youn, H.; Park, S.
S1 pocket of glutamate carboxypeptidase II: A new binding site for amyloid-beta degradation
Biochem. Biophys. Res. Commun.
438
765-771
2013
Homo sapiens (Q04609)
Choi, J.; Kim, J.; Jo, S.
Acetylation regulates the stability of glutamate carboxypeptidase II protein in human astrocytes
Biochem. Biophys. Res. Commun.
450
372-377
2014
Homo sapiens (Q04609), Homo sapiens
Pavlicek, J.; Ptacek, J.; Cerny, J.; Byun, Y.; Skultetyova, L.; Pomper, M.G.; Lubkowski, J.; Barinka, C.
Structural characterization of P1-diversified urea-based inhibitors of glutamate carboxypeptidase II
Bioorg. Med. Chem. Lett.
24
2340-2345
2014
Homo sapiens (Q04609), Homo sapiens
Alt, J.; Stathis, M.; Rojas, C.; Slusher, B.
Glutamate carboxypeptidase II is not an amyloid peptide-degrading enzyme
FASEB J.
27
2620-2625
2013
Homo sapiens (Q04609), Homo sapiens
Navratil, M.; Ptacek, J.; Sacha, P.; Starkova, J.; Lubkowski, J.; Bakinka, C.; Konvalinka, J.
Structural and biochemical characterization of the folyl-poly-gamma-L-glutamate hydrolyzing activity of human glutamate carboxypeptidase II
FEBS J.
281
3228-3242
2014
Homo sapiens (Q04609), Homo sapiens
Knedlik, T.; Navratil, V.; Vik, V.; Pacik, D.; Sacha, P.; Konvalinka, J.
Detection and quantitation of glutamate carboxypeptidase II in human blood
Prostate
74
768-780
2014
Homo sapiens (Q04609), Homo sapiens
Lee, S.K.; Kim, H.; Cheong, Y.H.; Kim, M.J.; Jo, S.A.; Youn, H.S.; Park, S.I.
S1 pocket of glutamate carboxypeptidase II a new binding site for amyloid-beta degradation
Biochem. Biophys. Res. Commun.
438
765-771
2013
Homo sapiens (Q04609)
Choi, J.-Y.; Kim, J.-H.; Jo, S.A.
Acetylation regulates the stability of glutamate carboxypeptidase II protein in human astrocytes
Biochem. Biophys. Res. Commun.
450
372-377
2014
Homo sapiens (Q04609), Homo sapiens
Choi, J.Y.; Ko, J.H.; Jo, S.A.
HDAC1 regulates the stability of glutamate carboxypeptidase II protein by modulating acetylation status of lysine 479 residue
Biochem. Biophys. Res. Commun.
497
416-423
2018
Homo sapiens (Q04609), Homo sapiens
Youn, S.; Kim, K.; Ptacek, J.; Ok, K.; Novakova, Z.; Kim, Y.; Koo, J.; Barinka, C.; Byun, Y.
Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II Synthesis and structural characterization
Bioorg. Med. Chem. Lett.
25
5232-5236
2015
Homo sapiens (Q04609)
Novakova, Z.; Cerny, J.; Choy, C.J.; Nedrow, J.R.; Choi, J.K.; Lubkowski, J.; Berkman, C.E.; Barinka, C.
Design of composite inhibitors targeting glutamate carboxypeptidase II the importance of effector functionalities
FEBS J.
283
130-143
2016
Homo sapiens (Q04609), Homo sapiens
Navratil, M.; Tykvart, J.; Schimer, J.; Pachl, P.; Navratil, V.; Rokob, T.; Hlouchova, K.; Rulisek, L.; Konvalinka, J.
Comparison of human glutamate carboxypeptidases II and III reveals their divergent substrate specificities
FEBS J.
283
2528-2545
2016
Homo sapiens (Q04609), Homo sapiens
Knedlik, T.; Vorlova, B.; Navratil, V.; Tykvart, J.; Sedlak, F.; Vaculin, S.; Franek, M.; Sacha, P.; Konvalinka, J.
Mouse glutamate carboxypeptidase II (GCPII) has a similar enzyme activity and inhibition profile but a different tissue distribution to human GCPII
FEBS Open Bio
7
1362-1378
2017
Mus musculus (O35409), Mus musculus, Homo sapiens (Q04609), Homo sapiens
Tykvart, J.; Schimer, J.; Jankarik, A.; Barinkova, J.; Navratil, V.; Starkova, J.; Sramkova, K.; Konvalinka, J.; Majer, P.; Sacha, P.
Design of highly potent urea-based, exosite-binding inhibitors selective for glutamate carboxypeptidase II
J. Med. Chem.
58
4357-4363
2015
Homo sapiens (Q04609), Homo sapiens
Novakova, Z.; Wozniak, K.; Jancarik, A.; Rais, R.; Wu, Y.; Pavlicek, J.; Ferraris, D.; Havlinova, B.; Ptacek, J.; Vavra, J.; Hin, N.; Rojas, C.; Majer, P.; Slusher, B.S.; Tsukamoto, T.; Barinka, C.
Unprecedented binding mode of hydroxamate-based inhibitors of glutamate carboxypeptidase II structural characterization and biological activity
J. Med. Chem.
59
4539-4550
2016
Homo sapiens (Q04609), Homo sapiens
Naushad, S.M.; Janaki Ramaiah, M.; Stanley, B.A.; Prasanna Lakshmi, S.; Vishnu Priya, J.; Hussain, T.; Alrokayan, S.A.; Kutala, V.K.
In silico approaches to identify the potential inhibitors of glutamate carboxypeptidase II (GCPII) for neuroprotection
J. Theor. Biol.
406
137-142
2016
Homo sapiens (Q04609)
Knedlik, T.; Nayvratil, V.; Vik, V.; Pacik, D.; Sacha, P.; Konvalinka, J.
Detection and quantitation of glutamate carboxypeptidase II in human blood
Prostate
74
768-780
2014
Homo sapiens (Q04609), Homo sapiens
Ptacek, J.; Nedvedova, J.; Navratil, M.; Havlinova, B.; Konvalinka, J.; Barinka, C.
The calcium-binding site of human glutamate carboxypeptidase II is critical for dimerization, thermal stability, and enzymatic activity
Protein Sci.
27
1575-1584
2018
Homo sapiens (Q04609), Homo sapiens
