Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.17.21 extracted from

  • Liu, C.; Hasegawa, K.; Russell, S.J.; Sadelain, M.; Peng, K.W.
    Prostate-specific membrane antigen retargeted measles virotherapy for the treatment of prostate cancer (2009), Prostate, 69, 1128-1141.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.17.21

Application

Application Comment Organism
pharmacology usage of the ectodomain of PSMA as target for a retargeted measles virus, that harbors a single-chain antibody specific for the extracellular domain of PSMA (J591) inserted as a C-terminal extension on its viral attachment protein. Live attenuated vaccine strain of measles virus has promising antitumor activity. Fully retargeted MV that infects cells exclusively through the PSMA receptor, which is overexpressed on prostate cancer cells and tumor neovasculature, method, overview. The construct leads to tumor regression Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information usage of the ectodomain of PSMA as target for a retargeted measles virus, that harbors a single-chain antibody specific for the extracellular domain of PSMA (J591) inserted as a C-terminal extension on its viral attachment protein. Live attenuated vaccine strain of measles virus has promising antitumor activity. Fully retargetedMVthat infects cells exclusively through the PSMA receptor, which is overexpressed on prostate cancer cells and tumor neovasculature, method, overview. Stable transfection of LNCaP cells. The construct leads to tumor regression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Prostate-specific membrane antigen
-
 Homo sapiens
PSMA
-
 Homo sapiens