Application | Comment | Organism |
---|---|---|
diagnostics | PSMA is a biomarker for prostate cancer | Homo sapiens |
pharmacology | PSMA is a target for imaging and therapeutic applications for prostate cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | phosphoramidate peptidomimetic PSMA inhibitors are capable of both cell-surface labeling of prostate cancer cells and intracellular delivery. Use of a PSMA inhibitor-conjugate of pyropheophorbide-a, i.e. Ppa-conjugate 2, for targeted photodynamic therapy to achieve apoptosis in PSMA and LNCaP cells, overview | Homo sapiens | |
pyropheophorbide-a conjugate | i.e. Ppa-2 conjugate, non-specificity of unconjugated Ppa, conjugation of a peptidomimetic inhibitor of PSMA to the porphyrinic PS, pyropheophorbide-a gives | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | - |
Homo sapiens | - |
additional information | PC-3 cells are PSMA-negative | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-[4-(phenylazo)-benzoyl]-L-glutamyl-gamma-L-glutamic acid + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Prostate-specific membrane antigen | - |
Homo sapiens |
PSMA | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000102 | - |
pH 7.4, 37°C | Homo sapiens | pyropheophorbide-a conjugate |