Cloned (Comment) | Organism |
---|---|
expression of wild-type and mutant enzymes in PC3 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
H380G | site-directed mutagenesis, active site mutant, inactive mutant | Homo sapiens |
L4A/L5A | site-directed mutagenesis, internalization motif mutant, active mutant, no endocytic internalization | Homo sapiens |
N336A | site-directed mutagenesis, glycosylation site E mutant, inactive mutant, no endocytic internalization | Homo sapiens |
N459A | site-directed mutagenesis, glycosylation site E mutant, inactive mutant, no endocytic internalization | Homo sapiens |
N476A | site-directed mutagenesis, glycosylation site E mutant, inactive mutant, no iendocytic nternalization | Homo sapiens |
N638A | site-directed mutagenesis, glycosylation site F mutant, inactive mutant | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
plasma membrane | type II transmembrane glycoprotein | Homo sapiens | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Homo sapiens | the enzyme is involved in suppressing prostate cancer invasiveness | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | type II transmembrane glycoprotein | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
CWR22Rv1 cell | - |
Homo sapiens | - |
epithelium | - |
Homo sapiens | - |
LNCaP cell | originating from a prostate cancer lymph node metastasis | Homo sapiens | - |
prostate cancer cell | overexpression of the enzyme in prostate cancer | Homo sapiens | - |
prostate gland | epithelial cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | - |
Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | the enzyme is involved in suppressing prostate cancer invasiveness | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PMSA | - |
Homo sapiens |
Prostate-specific membrane antigen | - |
Homo sapiens |