Application | Comment | Organism |
---|---|---|
diagnostics | the enzyme, prostate-specific membrane antigen, is a good marker for prostate cancer | Homo sapiens |
pharmacology | enzyme inhibitors are used in therapy of neruological disorders, overview | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
prostate-specific membrane antigen crystal structure analysis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S)-2-[3-((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)ureido]pentanedioic acid | i.e. inhibitor ZJ17 | Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-2-(4-hydroxyphenyl)ethyl)ureido]pentanedioic acid | i.e. inhibitor ZJ17 | Rattus norvegicus | |
(S)-2-[3-((S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid | i.e. inhibitor ZJ38 | Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-3-(1H-tetrazol-5-yl)propyl)ureido]pentanedioic acid | i.e. inhibitor ZJ38 | Rattus norvegicus | |
(S)-2-[3-((S)-1-carboxy-3-(methylsulfanyl)propyl)ureido]pentanedioic acid | i.e. inhibitor ZJ11 | Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-3-(methylsulfanyl)propyl)ureido]pentanedioic acid | i.e. inhibitor ZJ11 | Rattus norvegicus | |
(S)-2-[3-((S)-1-carboxy-3-methylbutyl)ureido]pentanedioic acid | i.e. inhibitor ZJ43 | Homo sapiens | |
(S)-2-[3-((S)-1-carboxy-3-methylbutyl)ureido]pentanedioic acid | i.e. inhibitor ZJ43 | Rattus norvegicus | |
(S)-2-[3-(S)-(1,3-dicarboxypropyl)ureido]pentanedioinc acid | - |
Homo sapiens | |
(S)-2-[3-(S)-(1,3-dicarboxypropyl)ureido]pentanedioinc acid | - |
Rattus norvegicus | |
2-(3-mercaptopropyl)-pentanedioic acid | i.e. 2-MPPA or GPI5693 | Homo sapiens | |
2-(3-mercaptopropyl)-pentanedioic acid | i.e. 2-MPPA or GPI5693 | Rattus norvegicus | |
2-(phosphonomethyl)-pentanedioic acid | i.e. 2-PMPA | Homo sapiens | |
2-(phosphonomethyl)-pentanedioic acid | i.e. 2-PMPA | Rattus norvegicus | |
4,4'-phosphinicobis(butane-1,3-dicarboxylic acid) | i.e. PBDA, effects of stereoisomers, overview | Homo sapiens | |
4,4'-phosphinicobis(butane-1,3-dicarboxylic acid) | i.e. PBDA | Rattus norvegicus | |
diazabicycloalkane | cis- and trans-isomers, dipeptide mimetic | Homo sapiens | |
diazabicycloalkane | cis- and trans-isomers, dipeptide mimetic | Rattus norvegicus | |
GPI5232 | i.e. 2-([((hydroxypentyfluorophenyl)methyl)phosphinoyl]methyl)pentanedioic acid | Homo sapiens | |
GPI5232 | i.e. 2-([((hydroxypentyfluorophenyl)methyl)phosphinoyl]methyl)pentanedioic acid | Rattus norvegicus | |
additional information | design of urea-based NAAG peptidase-specific inhibitors, IC50 values of the stereoisomers, inhibition strategies, overview, inhibitors are used in therapy of neurological disorders, overview, construction of a human traumatic brain injury, TBI, to test inhibitor effects, overview | Homo sapiens | |
additional information | design of urea-based NAAG peptidase-specific inhibitors, inhibition strategies, overview, construction of a stroke rat model and traumatic brain injury, TBI, to test inhibitor effects, overview | Rattus norvegicus | |
VA-033 | i.e. 2-([(benzyloxy)phosphonyl]methyl)pentanedioic acid | Homo sapiens | |
VA-033 | i.e. 2-([(benzyloxy)phosphonyl]methyl)pentanedioic acid | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | type II membrane glycoprotein | Homo sapiens | 16020 | - |
membrane | type II membrane glycoprotein | Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc-metallopeptidase | Homo sapiens | |
Zn2+ | zinc-metallopeptidase | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Rattus norvegicus | supply of the primary excitatory neurotransmitter glutamate | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | Homo sapiens | supply of the primary excitatory neurotransmitter glutamate, the enzyme is involved in neurological disorders, and neuropathic and inflammatory pain | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | type II membrane glycoprotein | Homo sapiens |
glycoprotein | type II membrane glycoprotein | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Homo sapiens | - |
brain | - |
Homo sapiens | - |
brain | - |
Rattus norvegicus | - |
central nervous system | - |
Homo sapiens | - |
central nervous system | - |
Rattus norvegicus | - |
glial cell | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
neuron | - |
Homo sapiens | - |
neuron | - |
Rattus norvegicus | - |
peripheral nervous system | - |
Homo sapiens | - |
peripheral nervous system | - |
Rattus norvegicus | - |
prostate cancer cell | prostate-specific membrane antigen, PSMA | Homo sapiens | - |
prostate gland | prostate-specific membrane antigen, PSMA | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | supply of the primary excitatory neurotransmitter glutamate | Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | supply of the primary excitatory neurotransmitter glutamate, the enzyme is involved in neurological disorders, and neuropathic and inflammatory pain | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG | Homo sapiens | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? | |
N-acetyl-alpha-L-aspartyl-L-glutamate + H2O | i.e. NAAG | Rattus norvegicus | N-acetyl-alpha-L-aspartate + L-glutamate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GCPII | - |
Homo sapiens |
GCPII | - |
Rattus norvegicus |
GCPIII | - |
Homo sapiens |
GCPIII | - |
Rattus norvegicus |
NAAG peptidase | - |
Homo sapiens |
NAAG peptidase | - |
Rattus norvegicus |
Prostate-specific membrane antigen | - |
Homo sapiens |
PSMA | - |
Homo sapiens |