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Literature summary for 3.4.17.21 extracted from

  • Youn, S.; Kim, K.; Ptacek, J.; Ok, K.; Novakova, Z.; Kim, Y.; Koo, J.; Barinka, C.; Byun, Y.
    Carborane-containing urea-based inhibitors of glutamate carboxypeptidase II Synthesis and structural characterization (2015), Bioorg. Med. Chem. Lett., 25, 5232-5236 .
    View publication on PubMed
Search for more literature for 3.4.17.21

Crystallization (Commentary)

Crystallization (Comment) Organism
X-ray crystal structure of glutamate carboxypeptidase II in complex with (S)-2-(3-((S)-1-carboxy-5-(1,2-dicarba-closo-dodecarboranylamido) pentyl)ureido)pentanedioic acid at 1.79 A resolution. The X-ray analysis reveals that the bulky closo-carborane cluster is located in the spacious entrance funnel region of the enzyme, indicating that the carborane cluster can be further structurally modified to identify promising lead structures of novel glutamate carboxypeptidase II inhibitors Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S)-2-(3-((S)-1-carboxy-5-(1,2-dicarba-closo-dodecarboranylamido) pentyl)ureido)pentanedioic acid
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloprotease Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q04609
-
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-L-aspartyl-L-glutamate + H2O
-
 Homo sapiens N-acetyl-L-Asp + L-Glu
-
 ?

Synonyms

Synonyms Comment Organism
GCPII
-
 Homo sapiens
glutamate carboxypeptidase II
-
 Homo sapiens