Application | Comment | Organism |
---|---|---|
diagnostics | PSMA is a well-known imaging biomarker for staging and monitoring therapy, assessment of an 18F-labeled phosphoramidate peptidomimetic as a PSMA-targeted imaging agent for prostate cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibitor in vivo distribution studies in mice bearing either PSMA-positive LNCaP or PSMA-negative PC-3 tumors, overview | Homo sapiens | |
S-2-((2-(S-4-(4-18F-fluorobenzamido)-4-carboxybutanamido)-S-2-carboxyethoxy)hydroxyphosphorylamino)-pentanedioic acid | - |
Homo sapiens | |
S-2-((2-(S-4-amino-4-carboxybutanamido)-S-2-carboxyethoxy)-hydroxyphosphorylamino)-pentanedioic acid | phosphoramidate | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer | Homo sapiens | 9986 | - |
membrane | PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
LNCaP cell | - |
Homo sapiens | - |
additional information | no activity in PC-3 cells | Homo sapiens | - |
prostate | - |
Homo sapiens | - |
prostate cancer cell | PSMA is a transmembrane protein commonly found on the surface of late-stage and metastatic prostate cancer | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Prostate-specific membrane antigen | - |
Homo sapiens |
PSMA | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000068 | - |
- |
Homo sapiens | S-2-((2-(S-4-amino-4-carboxybutanamido)-S-2-carboxyethoxy)-hydroxyphosphorylamino)-pentanedioic acid | |
0.000014 | - |
- |
Homo sapiens | S-2-((2-(S-4-(4-18F-fluorobenzamido)-4-carboxybutanamido)-S-2-carboxyethoxy)hydroxyphosphorylamino)-pentanedioic acid |