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Literature summary for 3.4.17.21 extracted from
- Design, synthesis, and preclinical evaluation of prostate-specific membrane antigen targeted (99m)Tc-radioimaging agents (2009), Mol. Pharm., 6, 790-800.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | synthesis of a series of PSMA-targeted 99mTc-chelate complexes for imaging PSMA-expressing human prostate cancer cells, in silico docking studies using the crystal structure of PSMA, overview. Synthesis of core ligand 2-[3-(3-benzyloxycarbonyl-1-tert-butoxycarbonyl-propyl)-ureido]pentanedioic acid di-tert-butyl ester and deprotected core ligand 2-[3-(1,3-bis-tert-butoxycarbonyl-propyl)-ureido]pentanedioic acid 1-tert-butyl ester | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DUPA | enzyme active site binding structure, docking and modelling, detailed overview | Homo sapiens |  |
| GPI-18431 | enzyme active site binding structure, docking and modelling, detailed overview | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Homo sapiens | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-aspartyl-L-glutamate + H2O | Homo sapiens | - |
L-glutamate + N-acetyl-L-aspartate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| LNCaP cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-acetyl-L-aspartyl-L-glutamate + H2O | - |
Homo sapiens | L-glutamate + N-acetyl-L-aspartate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NAALADase | - |
Homo sapiens |
| Prostate-specific membrane antigen | - |
Homo sapiens |
| PSMA | - |
Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000008 | - |
DUPA | - |
Homo sapiens | |
| 0.00003 | - |
GPI-18431 | - |
Homo sapiens | |
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