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(+)-(1R,3R,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-(1R,3S,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-(1S,3R,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-(1S,3S,6S)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(+)-2-carene
-
50% inhibition at 0.90 mM
(+)-3-carene
-
50% inhibition at 0.20 mM
(+)-7-deoxy-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-alpha-pinene
-
50% inhibition at 0.4 mM
(+)-benzoylbuxidienine
-
isolated from Buxus hyrcana
(+)-borneol
-
1 mM, 22.2% inhibition
(+)-buxapapillinine
-
isolated from Buxus hyrcana
(+)-buxaquamarine
-
isolated from Buxus hyrcana
(+)-Camphor
-
1 mM, 26.4% inhibition
(+)-cis-verbenol
-
1 mM, 17.7% inhibition
(+)-fenchol
-
1 mM, 37.7% inhibition
(+)-fenchone
-
1 mM, 23.3 inhibition
(+)-huperzine A
synthetic enantiomer of the anti-Alzheimer drug (-)-huperzine A and of its natural homologue (-)-huperzine B, interacts with the anionic subsite of the active site
(+)-irehine
-
isolated from Buxus hyrcana
(+)-limonene
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
(+)-O6-buxafurandiene
-
isolated from Buxus hyrcana
(+)-sabinene
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
(+)-trans-myrtanol
-
1 mM, 37.15% inhibition
(-)-(1R,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-(1R,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-(1S,3R,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-(1S,3S,6R)-9-benzyl-3-fluoro-2,4-dioxa-9-aza-3-phosphadecalin 3-oxide
-
-
(-)-10,10-dimethylhuperzine A
-
-
(-)-3-O-acetyl-spectaline
-
isolated from flowers of Senna spectabilis
(-)-3-O-acetylcassine
a semisynthetic alkaloid structure and stereochemistry by ESI-MS/MS and EI-MS
(-)-3-O-acetylspectaline
a semisynthetic alkaloid structure and stereochemistry by ESI-MS/MS and EI-MS
(-)-alpha-pinene
-
50% inhibition at 0.44 mM
(-)-beta-pinene
-
1 mM, 48.5% inhibition
(-)-borneol
-
1 mM, 22.6% inhibition
(-)-Camphor
-
1 mM, 21.2% inhibition
(-)-cassine
a piperidine alkaloid isolated from Senna spectabilis flowers, structure and stereochemistry by ESI-MS/MS and EI-MS
(-)-fenchone
-
1 mM, 28.2% inhibition
(-)-galanthamine
-
isolated from Galanthus woronowii
(-)-myrtenol
-
1 mM, 15.0% inhibition
(-)-S-3-[1-(dimethylamino)ethyl]phenol
competitive reversible inhibitor
(-)-trans-myrtanol
-
1 mM, 37.4% inhibition
(-)-verbenone
-
1 mM, 12.6% inhibition
(1alpha,3beta,22R)-stigmast-5-ene-1,3,22-triol
-
i.e. haloxysterol A, isolated from Haloxylon recurvum
(1alpha,3beta,22R)-stigmasta-4,6-diene-1,3,22-triol
-
i.e. haloxysterol B, isolated from Haloxylon recurvum
(1alpha,3beta,5alpha,6beta,22R)-stigmastane-1,3,5,6,22-pentol
-
i.e. haloxysterol D, isolated from Haloxylon recurvum
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-nitro-N'-[(R)-1-phenylethyl]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)-amino]-N'-[(R)-1-(4-fluorophenyl)ethyl]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)amino]-N-[(R)-1-phenylethyl]isophthalamide
-
shows inhibitory effects on beta amyloid production of amyloid precursor protein-transfected HEK293 cells and mild protective effect against hydrogen peroxide-induced cell injury
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-nitroisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-[methyl(methylsulfonyl)amino]isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropylisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-nitroisophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-isophthalamide
-
-
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-phenylethyl]isophthalamide
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,3,4,4a,5,6,11b-octahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(1S,2S,11bS)-4-[2-(acetyloxy)ethyl]-5-methyl-1,2,4a,5,6,11b-hexahydro[1,3]dioxolo[4,5-j]phenanthridine-1,2-diyl diacetate
-
-
(2,3-trans)-3-(3-hydroxy-5-methoxyphenyl)-N-(4-hydroxyphenethyl)-7-((E)-3-[(4-hydroxyphenethyl)amino]-3-oxoprop-1-enyl)-2,3-dihydro-benzo[b][1,4]dioxine-2-carboxamide
-
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
(2-methoxy-7-methyl-2-oxido-2,3,4,5-tetrahydro-1,2-oxaphosphepin-6-yl)methanol
-
-
(22R)-22-hydroxystigmasta-4,9(11)-dien-3-one
-
i.e. haloxysterol C, isolated from Haloxylon recurvum
(24S)-ethylcholesta-7,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
(2E)-1,3-diphenylprop-2-en-1-one
-
-
(2E)-1-(5-chloro-2-hydroxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one
-
-
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
-
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
-
(2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
a rigid DNP-like analogue compound, shows mixed-type inhibition
(2E)-2-[(1-benzylpiperidin-4-yl)methylidene]-5-methoxy-2,3-dihydro-1H-inden-1-one
a rigid DNP-like analogue compound, shows mixed-type inhibition
(2E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3,4-dimethoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(3-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-hydroxyphenyl)-1-phenylprop-2-en-1-one
-
-
(2E)-3-(4-methoxyphenyl)-1-phenylprop-2-en-1-one
-
-
(3,4-dimethoxyphenyl)(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)methanol
-
-
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone
-
-
(3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
-
-
(3,4-dimethoxyphenyl)-{4-[(ethylpropylamino)methyl]phenyl}methanone
-
-
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 10 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 760 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 94 nM
(3aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 28 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 13 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 3860 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl ethylcarbamate
-
50% inhibition at 82 nM
(3aR)-3a,8-dimethyl-3,3a,8,8a-tetrahydro-2H-furo(2,3-b)indol-5-yl methylcarbamate
-
50% inhibition at 27 nM
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4,6-trimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,6-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3,4-dimethylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (3-methylphenyl)carbamate
-
-
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (4-methylphenyl)carbamate
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-1,26-dioxo-5,6:22,26-diepoxyergost-24-en-19-oic acid
-
-
(3beta,4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,28-dihydroxy-3-methoxy-5,6:22,26-diepoxyergost-24-ene-1,26-dione
-
-
(3beta,4beta,6beta,8xi,9xi,14xi,17xi,22R)-4,6,27-trihydroxy-3-methoxy-22,26-epoxyergost-24-ene-1,26-dione
-
-
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
(3R,4aS,9bS)-9-(chloromethyl)-9b-[2-[(ethoxycarbonyl)(methyl)amino]ethyl]-6-methoxy-3,4,4a,9b-tetrahydrodibenzo[b,d]furan-3-yl ethyl carbonate
-
-
(3R,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
-
a diastereoisomeric bicyclic phosphonate analogue
(3S,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
-
a diastereoisomeric bicyclic phosphonate analogue
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-bromobenzoyl)phosphoramidic dichloride
-
-
(4-chlorobenzoyl)phosphoramidic dichloride
-
-
(4-methylbenzoyl)phosphoramidic dichloride
-
-
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
-
-
(4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
-
-
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
-
-
(4aS,6R,8aS)-3-methoxy-11-methyl-5,6,10,11,13,14-hexahydro-4aH,9H-[1]benzofuro[3a,3,2-gh][3,4]benzoxazonin-6-ol
-
-
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
-
-
(4aS,6R,8aS)-3-[[12-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)dodecyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-3-[[8-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)octyl]oxy]-6-hydroxy-11-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(10-phenyldecyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4aS,6R,8aS)-6-hydroxy-3-methyl-11-(8-phenyloctyl)-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
-
-
(4beta,5beta,6beta,8xi,9xi,14xi,17xi,22R)-4,27-dihydroxy-5,6:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
-
(5alpha,6alpha,7alpha,8xi,9xi,14xi,17xi,22R)-5-hydroxy-20-methyl-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione
-
-
(6,7-dimethoxyisoquinolin-1-yl)(2-methoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanol
-
-
(6,7-dimethoxyisoquinolin-1-yl)(3,4-dimethoxyphenyl)methanone
-
-
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate
mixed-type inhibition
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate
noncompetitive inhibition
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
mixed-type inhibition
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
mixed-type inhibition
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate
mixed-type inhibition
(7S,9R)-ar-turmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9R)-dihydro-arturmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9S)-arturmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(7S,9S)-dihydro-ar-turmerol
-
a synthetic bisabolane-type sesquiterpenoid derivative
(8Z)-5,6-dihydro-8H-isoquino[1,2b]quinazolin-8-imine
-
-
(E)-1-(2,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(2,6-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(2-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(2-chloro-6-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(2-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(2-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(2-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(2-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
-
(E)-1-(3,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(3-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(3-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
-
(E)-1-(3-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(3-methoxylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(3-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(4-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene
-
(E)-1-(4-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(4-chloromethylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(4-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(4-methoxybenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(4-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
-
-
(E)-1-(benzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
-
-
(E)-2-(4-[(diethylamino)methyl]benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one
-
i.e. BZYX, an indanone derivative, and a dual-binding-site AChE inhibitor. BZYX also shows high neuroprotection from H2O2-induced apoptosis in PC12 cells and prevents loss of membrane potential, determination with fluorescent 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazol-carbocyanine iodide, i.e. JC-1, overview
(E)-3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
-
(E)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
-
-
(R)-(+)-endo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer
(R)-(+)-exo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The R-enantiomer is potent, while the S-enantiomer is inactive
(R)-(+)-fenoxon sulfoxide
(R)-(+)-fenthion sulfoxide
(R)-bambuterol monocarbamate
inhibition kinetics of human acetylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(R)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. (R)-bambuterol, inhibition kinetics of human acetylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
(RS)-tacrine(10)-hupyridone
-
(RS)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. rac-bambuterol, inhibition kinetics of human acetylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(S)-(-)-endo-2-norbornyl-N-n-butylcarbamate
-
synthesis of enantiomers for stereoselective inhibition of AChE, overview. The S-enantiomer is more potent than the R-enantiomer
(S)-(-)-fenoxon sulfoxide
(S)-(-)-fenthion sulfoxide
(S)-ar-curcumene
-
a synthetic bisabolane-type sesquiterpenoid derivative
(S)-ar-turmerone
-
sesquiterpenoid, a competitive inhibitor
(S)-bambuterol monocarbamate
inhibition kinetics of human acetylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(S)-dihydro-ar-curcumene
-
a synthetic bisabolane-type sesquiterpenoid derivative
(S)-dihydro-ar-turmerone
-
a sesquiterpenoid, a noncompetitive inhibitor
(S)-[3-[2-(tert-butylamino)-1-hydroxyethyl]-5-(dimethylcarbamoyloxy)phenyl] N,N-dimethylcarbamate
i.e. (S)-bambuterol, inhibition kinetics of human acetylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
(S,S)-(-)-bis(10)-hupyridone
enzyme binding structure, analysis using structure PDB ID 1H22, detailed overview
(S-(2-diethylamino)isobutyl)methylphosphonothioate
-
i.e. VR, detailed analysis of inhibition kinetics
(Z)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
-
-
1,1'-(ethane-1,1-diyldifuran-5,2-diyl)bis(trifluoroethanone)
-
-
1,1'-heptane-1,7-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}
-
reversible inhibition, 0.000385 mM reduces the activity to 76%; reversible inhibition, reduces the activity to 89% and 44% at concentrations of 0.0000385 mM and 0.000385 mM, respectively
1,1'-nonane-1,9-diylbis{2-[(E)-(hydroxyimino)methyl]pyridinium}
-
reversible inhibition, enzyme activity is inhibited to 64% and 15% at 0.0000385 mM and 0.000385 mM, respectively
1,2,11,12-tetramethoxy-7-methyl-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
-
1,2,3,10,11-pentamethoxy-7-(methoxycarbonyl)-5,6-dihydro-4H,8H-pyrido[3,2,1-de]phenanthridinium
-
-
1,2,3,4,9,9a-hexahydroacridin-9-amine
-
-
1,2,3,4-tetrahydroacridin-9-amine
-
1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1,2-dihydrogalanthamine
-
from Narcissus jonquilla extract
1,3-bis(4-vinylbenzyl)benzylbenzimidazolium
-
1,3-bis(N-propylphthalimide)benzylbenzimidazolium
-
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
-
-
1,5-Bis(4-allyldimethylammonium phenyl)pentan-3-one
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
1,5-bis(allyldimethylammoniumphenyl)pentan-3-one dibromide
-
-
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
-
BW284c51, a specific inhibitor of AChE
1-(1-benzyl-7-chloro-4-methoxy-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
1-(1-benzylindol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
-
1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(2-fluorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
-
1-(2-fluorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium
-
-
1-(3,4-dimethoxybenzyl)-6,7-dimethoxyisoquinoline
-
-
1-(3-chlorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
-
1-(3-chlorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
-
1-(4,6-dimethylpyrimidin-2-yl)-3-(4-methyl-3-nitrophenyl)guanidine
-
-
1-(4-amino-3-chloro-5-iodo-phenyl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(4-amino-3-iodo-phenyl)-3-(1-benzyl-4-piperidyl)propan-1-one
-
1-(4-amino-3-iodo-phenyl)-3-(1-butyl-4-piperidyl)propan-1-one
-
1-(4-amino-3-iodo-phenyl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(4-amino-3-iodo-phenyl)-3-[1-(cyclopentylmethyl)-4-piperidyl]propan-1-one
-
1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone
1-(4-amino-5-chloro-3-iodo-2-methoxy-phenyl)-3-(1-benzyl-4-piperidyl)propan-1-one
-
1-(4-amino-5-chloro-3-iodo-2-methoxy-phenyl)-3-[1-(cyclohexylmethyl)-4-piperidyl] propan-1-one
-
1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
1-(4-cyclopentyl-6-methylpyrimidin-2-yl)-3-(2,4-dimethylphenyl)guanidine
-
-
1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane
-
1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane
-
1-(4-vinylbenzyl)-3-(2,3,5,6-tetramethylbenzyl)-imidazolidinium
-
1-(4-vinylbenzyl)-3-(2,4,6-trimethylbenzyl)-imidazolidinium
-
1-(4-vinylbenzyl)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
-
1-(4-vinylbenzyl)-3-(2-methylbenzyl)-imidazolidinium
-
1-(4-vinylbenzyl)-3-(2-methylbenzyl)benzimidazolium
-
1-(4-vinylbenzyl)-3-(3-methylbenzyl)-imidazolidinium
-
1-(4-vinylbenzyl)-3-(4-methylbenzyl)-imidazolidinium
-
1-(4-vinylbenzyl)-3-(4-methylbenzyl)benzimidazolium
-
1-(4-vinylbenzyl)-3-benzylbenzimidazolium
-
1-(4-vinylbenzyl)-3-benzylimidazolidinium
-
1-(4-vinylbenzyl)-3-methylbenzimidazolium
-
1-(4-vinylbenzyl)benzimidazole
-
1-(7-chloro-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
1-(7-chloro-4-methoxy-1-methyl-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
1-(7-chloro-4-methoxy-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
1-(hydroxymethyl)-5-methyloctahydro-2H-quinolizinium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-(N-propylphthalimide)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
-
1-(N-propylphthalimide)-3-(3-methylbenzyl)benzimidazolium
-
1-(N-propylphthalimide)-3-(4-methylbenzyl)benzimidazolium
-
1-(N-propylphthalimide)-3-naphthalenemethylbenzimidazolium
-
1-(N-propylphthalimide)benzoimidazole
-
1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
-
1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-chloro-3-(2,3-dihydro-benzo[1,4]-dioxin-2-ylmethyl)imidazolidine
-
1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
-
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-6-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
1-benzyl-3-[4-(4-benzylpiperazin-1-yl)butyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
1-benzyl-N-[3-(2,3-dihydro-1H-indol-1-yl)propyl]piperidin-4-amine
-
1-benzyl-N-[5-(2,3-dihydro-1H-indol-1-yl)pentyl]piperidin-4-amine
-
1-benzyl-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
-
1-benzyl-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
-
1-butanoyl-3-(2,6-dimethylphenyl)thiourea
-
1-butanoyl-3-(3-methoxyphenyl)thiourea
-
1-butanoyl-3-(4-chlorophenyl)thiourea
-
1-butanoyl-3-benzylthiourea
-
1-dodecyl-1H-pyrrole-2,5-dione
-
-
1-epideacetylbowdensine
-
-
1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one
-
1-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]quinolinium
-
-
1-ethyl-2-[(Z)-(1-ethyl[1]benzothieno[3,2-d][1,3]thiazol-2(1H)-ylidene)methyl]quinolinium
-
-
1-ethyl-6-methyl-2-[(1-methyl-1,2-dihydro[1]benzofuro[3,2-d][1,3]thiazol-2-yl)methyl]quinolinium
-
-
1-methyl-1-[2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propyl]pyrrolidinium
-
-
1-methyl-1-[3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butyl]pyrrolidinium
-
-
1-methyl-1-[4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentyl]pyrrolidinium
-
-
1-methyl-3-(3-(methylamino)cyclohexyl)pyridinium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
1-methyl-3-(methylcarbamoyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
1-methyl-3-(morpholin-4-ylcarbonyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
1-methyl-4,5-dihydro[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridin-6-ium-2-olate
-
-
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 56 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 4300 nM
1-methyl-8,10-dioxatricyclo(7.2.1.0 2,7)dodeca-2,4,6-trien-5-yl ethylcarbamate
-
50% inhibition at 830 nM
1-naphthyl phenothiazine carbamate
-
-
1-[1-(benzenesulfonyl)-7-chloro-4-methoxy-indol-5-yl]-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
1-[3-(4-benzylpiperazin-1-yl)propyl]-3-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
1-[5-(5-nitro-1H-indazol-3-yl)thiophen-3-yl]ethanone
-
1-[5-[(1E)-1-hydrazinylideneethyl]-2-methoxybenzyl]piperidine
-
-
1-[5-[(1H-benzimidazol-2-ylsulfanyl)methyl]furan-2-yl]-2,2,2-trifluoroethanone
-
-
1-[7-chloro-2-(trimethylsilyl)-1H-inden-5-yl]-3-[1-(cyclohexylmethyl)piperidin-4-yl]propan-1-one
-
1-[7-chloro-4-methoxy-2-(trimethylsilyl)-1H-inden-5-yl]-3-[1-(cyclohexylmethyl)piperidin-4-yl]propan-1-one
-
1-[[(3-acetylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-butanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-decanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-heptanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
1-[[(3-hexanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
-
-
10-(2,2-dimethylpropanoyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 4.7
10-(chloroacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 7.3
10-(cyclobutylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 11.6
10-(cyclopropylcarbonyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.9
10-(methoxyacetyl)-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 0.8
10-acetyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.1
10-butyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.9
10-hydroxy-infractopicrin
-
isolated from Cortinarius infractus, inhibits acetylcholinesterase, but does not inhibit butyrylcholinesterase
10-isobutyryl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 2.7
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
-
-
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
-
-
10-O-methylhostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
10-propionyl-10H-phenothiazine
-
relative potency EC 3.1.1.8 to EC3.1.1.7 is 1.8
11-hydroxygalantamine
-
-
12-n-butoxy-demethoxykesselringine
-
-
13-methyl-5,8-dihydro-6H isoquino[1,2b]quinazolin-13-ium chloride
-
-
13-methyl-5,8-dihydro-6H-isoquino[1,2b]quinazolin-13-ium chloride
-
-
14-ethoxy-14-oxogalanthamine
-
-
19,20-dihydroervahanin A
-
-
19,20-dihydrotabernamine
-
-
1alpha,2alpha,6beta, 8alpha,15-pentaacetoxy-9beta-benzoyloxy-beta-agarofuran
-
-
1alpha,2alpha,6beta,8alpha-tetraacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
-
-
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
-
-
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-8alpha,15-dihydroxy-beta-agarofuran
-
-
1alpha,6beta,8alpha-triacetoxy-9beta-furoyloxy-beta-agarofuran
-
IC50 is 0.0029 mg/ml
1alpha-acetoxy-6beta,9beta-difuroyloxy-4beta-hydroxy-beta-agarofuran
-
-
2'-ethylphenylgeneserine N-oxide
-
50% inhibition at 125 nM
2,2'-[[(E)-1,2-diphenylethene-1,2-diyl]bis(benzene-4,1-diyloxy)]diethanesulfonate
-
-
2,2-dichlorovinyl dimethyl phosphate
2,3,4-trimethylpyrimido[2,1-a]isoquinolin-5-ium
-
-
2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
2,3-dihydroquinazolin-4(1H)-one
-
2,3-dimethoxy-6-methyl-9H-xanthen-9-one
-
-
2,3-dimethylmaleic anhydride
2,6-dichlorophenolindophenol
causes substrate inhibition at concentrations above 0.25 mM
2-((Z)-(hydroxyimino)methyl)-1-methylpyridinium chloride
-
i.e. 2-PAM, reversible, detailed kinetic analysis
2-(1-piperidinyl)ethyl phenothiazine carbamate
-
-
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate
-
-
2-(2-methyl-1H-imidazol-1-yl)-1-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]ethanone
-
-
2-(2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl)phenol
-
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(3-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(3-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(3-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(3-methylphenyl)-4H-chromen-4-one
-
-
2-(3-[2-bromo-3-(2,3,5,6-tetramethylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
-
2-(3-[2-bromo-3-(2,4,6-trimethylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
-
2-(3-[2-bromo-3-(2-methylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
-
2-(3-[2-bromo-3-(3-methylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
-
2-(3-[2-bromo-3-(4-methylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
-
2-(3-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(3-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(3-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(3-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
-
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
-
-
2-(4-(2-(diethylamino)acetyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(2-(ethyl(methyl)amino)acetyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
displays neuroprotective effect against H2O2-induced cell death
2-(4-(3-(diethylamino)propyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(3-(ethyl(methyl)amino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(4-(diethylamino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-(4-(diethylamino)butyl)phenoxy)-5,6-dimethoxyindan-1-one
-
-
2-(4-(4-(ethyl(methyl)amino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
-
-
2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
-
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
neuroprotective effect of K3-2 against H2O2-induced toxicity
2-(4-hydroxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
2-(4-hydroxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
-
2-(4-hydroxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
-
2-(4-methylphenyl)-4H-chromen-4-one
-
-
2-(4-morpholino)ethyl phenothiazine carbamate
-
-
2-(6-oxo-7,11-diazatricyclo(7.3.1.0 2,7)tridec-11-yl)ethyl acetate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
2-(6-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(6-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(6-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(6-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
-
2-(8-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
-
2-(8-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
-
2-(8-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
-
2-(8-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
-
2-(dimethylamino)-7-ethyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.011 mM
2-(dimethylamino)-7-isobutyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00036 mM
2-(dimethylamino)-7-methyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.039 mM
2-(N,N-diethylamino)ethyl phenothiazine carbamate
-
-
2-(N,N-dimethylamino)ethyl phenothiazine carbamate
-
-
2-(trifluoromethyl)phenyl butylcarbamate
-
-
2-acetamido-N,N,N-trimethylethen-1-aminium
2-amino-3-((1R)-1-cyclohexyl-2-[(cyclohexylcarbonyl)amino]ethyl)-6-phenoxyquinazolin-3-ium
-
2-amino-3-[2-oxo-2-[phenyl(propan-2-yl)amino]ethyl]-1,3-thiazol-3-ium
-
-
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.0059 mM
2-amino-7-benzyl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.0012 mM
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(2,3,5,6-tetramethylbenzyl)imidazolidine
-
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(2,4,6-trimethylbenzyl)imidazolidine
-
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(2-methylbenzyl)imidazolidine
-
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(3-methylbenzyl)imidazolidine
-
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(4-methylbenzyl)imidazolidine
-
2-chloro-5-methyl-1,3,2-benzodioxaphosphole 2-oxide
-
50% inhibition at 0.48 mM, detailed kinetic analysis
2-chloro-5-methyl-2,3-dihydro-1H-1,3,2-benzodiazaphosphole 2-oxide
-
50% inhibition at 1.54 mM, detailed kinetic analysis
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
2-chlorophenyl 1-methylhydrazinecarboxylate
2-chlorophenyl butylcarbamate
-
-
2-chlorophenyl phenothiazine carbamate
-
-
2-ethylphenyl butylcarbamate
-
-
2-methoxyphenyl butylcarbamate
-
-
2-methoxyphenyl phenothiazine carbamate
-
-
2-methylphenyl butylcarbamate
-
-
2-methylphenyl phenothiazine carbamate
-
-
2-naphthyl phenothiazine carbamate
-
-
2-nitrophenyl butylcarbamate
-
-
2-oxo-N-[2-(piperidin-1-yl)ethyl]-2H-chromene-3-carboxamide
-
2-t-butylphenyl phenothiazine carbamate
-
-
2-tert-butoxyphenyl butylcarbamate
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
2-[(1-[2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(1-[3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]propyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione
-
-
2-[(5-acetyl-6-methyl-4-phenyl-1,4-dihydropyrimidin-2-yl)sulfanyl]-N-phenylacetamide
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-nonanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-octanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-pentanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-propanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[(E)-(hydroxyimino)methyl]-1-[[(3-undecanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
-
-
2-[2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
-
2-[2-(4-methylphenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
-
2-[3-(3-benzyl-2-bromo-imidazolidin-1-yl)-propyl]isoindole-1,3-dione
-
2-[3-[(1-benzylpiperidin-4-yl)amino]propyl]-1H-isoindole-1,3(2H)-dione
-
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-N-[3-nitro-5-(pyridin-3-yloxy)phenyl]acetamide
-
-
2-[5-[(1-benzylpiperidin-4-yl)amino]pentyl]-1H-isoindole-1,3(2H)-dione
-
2-[6-[(1-benzylpiperidin-4-yl)amino]hexyl]-1H-isoindole-1,3(2H)-dione
-
2-[8-[(1-benzylpiperidin-4-yl)amino]octyl]-1H-isoindole-1,3(2H)-dione
-
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium
2-[[(4S)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl]methyl]-1H-isoindole-1,3(2H)-dione
-
-
2-[[2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
2-[[2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl](methyl)amino]butanoic acid
-
-
2-[[5-acetyl-6-methyl-4-(4-phenoxyphenyl)-1,4-dihydropyrimidin-2-yl]sulfanyl]-N-phenylacetamide
-
24-ethyl-cholest-7-ene-3,5,6-triol
-
isolated from Haloxylon recurvum
24-ethylcholest-6-ene-3,5-diol
-
isolated from Haloxylon recurvum
2alpha,11alpha-dihydroxyfawcettiine
-
-
2beta-hydroxyepipachysamine D
-
-
3,3'-((1,5-dioxopentane-1,5-diyl)bis(iminocyclohexane-3,1-diyl))bis(1-methylpyridinium)
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3,3'-demethyl-grossamide
87.37% inhibition at 0.1 mg/ml
3,3'-demethyl-heliotropamide
62.84% inhibition at 0.1 mg/ml
3,3'-[nonane-1,9-diylbis[(3S)-3-ethylazepane-1,3-diyl]]diphenol
binding by a bis-(-)-nor-meptazinol derivative disrupts the catalytic triad, structure analysis and molecular docking, overview
3,3-dimethylbutyl methylphosphonyl thiocholine
-
3,5,7,3',4'-pentamethoxyflavone
-
3-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
-
3-(1-benzyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-1H-indol-5-yl)propan-1-one
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-2-trimethylsilyl-1H-indol-5-yl)propan-1-one
3-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
-
3-(1-butyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
3-(1-butylpiperidin-4-yl)-1-[2-(trimethylsilyl)-1H-inden-5-yl]propan-1-one
-
3-(1-phenoxypiperidin-4-yl)-1-[2-(trimethylsilyl)-1H-inden-5-yl]propan-1-one
-
3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(3-methylphenyl)-2H-chromen-2-one
-
-
3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
-
-
3-(4-methylphenyl)-2H-chromen-2-one
-
-
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-(6-oxo-6-(8-oxooctahydro-2H-2,6-methanopyrido(1,2-a)(1,5)diazocin-3(4H)-yl)hexanoyl)decahydro-8H-1,5-methanopyrido(1,2-a)(1,5)diazocin-8-one
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
3-(9-hydroxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(9-methoxy-5,6-dimethyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-yl)propane-1,2-diol
-
-
3-(dimethylcarbamoyl)-1-methyl-1,4-dihydroquinolin-5-yl dimethylcarbamate
-
-
3-(dimethylcarbamoyl)-5-[(dimethylcarbamoyl)oxy]-1-methylquinolinium
-
-
3-(N,N-diethylamino)propyl phenothiazine carbamate
-
-
3-(N,N-dimethylamino) phenyl phenothiazine carbamate
-
binding by residues F329 and Y332, structure, overview
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one
-
-
3-benzyl-1-[3-(4-benzylpiperazin-1-yl)propyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
-
3-carene
-
50% inhibition at 2 mM
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
3-chlorophenyl 1-methylhydrazinecarboxylate
3-chlorophenyl phenothiazine carbamate
-
-
3-ethyl-2-[(1E)-2-(phenylamino)but-1-en-1-yl]naphtho[2,3-d][1,3]oxazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethyl-6-methoxyquinolin-2(1H)-ylidene)methyl]-5-methoxy-1,3-benzothiazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethyl-6-methylquinolin-2(1H)-ylidene)methyl]-5-hydroxy-1,3-benzothiazol-3-ium
-
-
3-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]-5-iodo-1,3-benzothiazol-3-ium
-
-
3-hydroxy-2,2,6-trimethyl-3,4,5,6-tetrahydro-2H-pyrano[3,2c] quinoline 5-one
-
isolated from Skimmia laureola
3-methoxy-6-methyl-9H-xanthen-9-one
-
-
3-methoxyphenyl phenothiazine carbamate
-
-
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one
-
-
3-methylphenyl phenothiazine carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
3-oxo-N-[(1,2,3,4-tetrahydroacridin-9-ylamino)methyl]butanamide
-
3-oxo-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]butanamide
-
3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
-
3-oxo-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]butanamide
-
3-[(1S)-1-(dimethylamino)ethyl]phenyl ethyl(methyl)carbamate
-
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(4-methoxy-1Hindol-5-yl)propan-1-one
3-[1-(cyclohexylmethyl)piperidin-4-yl]-1-[2-(trimethylsilyl)-1H-inden-5-yl]propan-1-one
-
3-[1-(cyclopentylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
3-[1-(cyclopentylmethyl)piperidin-4-yl]-1-[2-(trimethylsilyl)-1H-inden-5-yl]propan-1-one
-
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
-
-
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
-
-
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
-
-
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
-
-
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
-
-
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
-
-
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[4-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]butyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]propanamide
-
-
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]propanamide
-
-
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
-
-
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
-
-
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
-
-
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
-
-
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
-
-
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
-
-
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
-
-
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
-
-
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
-
-
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
-
-
3-[omega-(benzylmethylamino)alkoxy]xanthen-9-ones
-
structure-activity relationships, overview
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (2-methylphenyl)carbamate
-
50% inhibition at 23 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl (4-isopropylphenyl)carbamate
-
50% inhibition at 2650 nM
3a-methyl-2,3,3a,8a-tetrahydrofuro(2,3-b)(1)benzofuran-5-yl ethylcarbamate
-
50% inhibition at 360 nM
4,4'-(3-oxo-1,5-pentanediyl)bis(N-allyl-N,N-dimethylanilinium) dibromide
-
BW284c51
4,4-difluoro-8-(propan-2-yl)-N-(2,3,4-trifluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
4,4-difluoro-8-(propan-2-yl)-N-propyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
4,4-difluoro-N,8-di(propan-2-yl)-1,3,4,5-tetrahydro-2Hpyrido[4,3-b]indole-2-carboxamide
-
-
4,4-difluoro-N-(2-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
4,4-difluoro-N-(3-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
4,4-difluoro-N-(4-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
4,5-diethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
-
-
4-(1-benzylpiperidin-4-yloxy)benzaldehyde
-
-
4-(1H-benzimidazol-2-yl)phenol
4-(5-chloro-1H-benzimidazol-2-yl)phenol
4-(5-methyl-1H-benzimidazol-2-yl)phenol
4-(aminocarbonyl)-1-(((2-((Z)-(hydroxyimino)methyl)pyridinium-1-yl)methoxy)methyl)pyridinium dichloride
-
i.e. HI-6, reversible, detailed kinetic analysis
4-acetyl-1,1-dimethylpiperazin-1-ium
4-amino-3-chloro-5-iodobenzoic acid
-
4-amino-3-iodobenzoic acid
-
4-amino-5-chloro-3-iodo-2-methoxybenzoic acid
-
4-biphenyl phenothiazine carbamate
-
-
4-bromo-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
4-carbamoyl-1-(3-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium
-
4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)butyl)pyridinium
-
4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium
-
4-carbamoyl-1-(4-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)butyl)pyridinium
-
4-carbamoyl-1-[(2E)-4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)but-2-en-1-yl]pyridinium
-
4-carbamoyl-1-[(2E)-4-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)but-2-en-1-yl]pyridinium
-
4-chloro-N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
4-chlorophenyl 1-methylhydrazinecarboxylate
4-chlorophenyl phenothiazine carbamate
-
-
4-cymene
-
isolated from Melaleuca atlernifolia
4-ethenyl-5-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethenyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-hexyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine hydrobromide
-
-
4-ethyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-pentyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-5-propyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
4-ethyl-N-methyl-dihydrophenanthridine
-
-
4-ketoamyl trimethyl ammonium iodide
-
nonhydrolysable substrate analogue, mechanism of substrate inhibition
4-ketoamyltrimethylammonium
binding structure analysis
4-methoxy-1H-indole-5-carboxylic acid
-
4-methoxyphenyl phenothiazine carbamate
-
-
4-methylphenyl phenothiazine carbamate
-
-
4-nitrophenyl allylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl benzylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl butylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl hexylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl octylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl phenylcarbamate
-
detailed kinetic analysis and mechanism
4-nitrophenyl tert-butylcarbamate
-
detailed kinetic analysis and mechanism
4-O-methylhonokiol
-
isolated from ethanol extract of Magnolia officinalis. 4-O-methylhonokiol also dose-dependently attenuates the scopolamine-induced increase of AChE activity in the cortex and hippocampus of mice
4-oxo-N,N,N-trimethylpentanaminium iodide
i.e. OTMA, a hydrolysable substrate analogue, binding structure analysis
4-t-butylphenyl phenothiazine carbamate
-
-
4-[(4-[[6-(1H-indol-1-yl)hexyl]amino]piperidin-1-yl)methyl]phenol
-
4-[(4-[[8-(1H-indol-1-yl)octyl]amino]piperidin-1-yl)methyl]phenol
-
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[2,3-e]pyrazin-5(4H)-one
-
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[3,2-e]pyrazin-5(4H)-one
-
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
5,5'-dithiobis(2-nitrobenzoic acid)
inactivation, the peripheral site ligand propidium accelerates inactivation in the wild type ChE2, but retards inactivation in the F312I mutant
5,6-dimethoxy-2-(3-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(3-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(3-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)acetyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)acetyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(piperidin-1-yl)butanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butanoyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butyl)phenoxy)-indan-1-one
-
-
5,6-dimethoxy-2-([1-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
-
-
5,6-dimethoxy-2-([1-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
-
-
5,6-dimethoxy-9-prop-2-en-1-yl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-ol
-
-
5,7,8,13-tetrahydroindolo [2',3':3,4]pyrido[2,1-b]quinazoline
-
-
5,8-dihydro-6H isoquino[1,2b]quinazoline
-
-
5-(4-chlorophenyl)-N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
-
5-butyl-4-ethenyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-butyl-4-ethyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
-
-
5-hydroxy-5,6-seco-dihydrolycorine
-
-
5-hydroxy-5,6-secolycorine
-
-
5-[(1-benzylpiperidin-4-yl)methoxy]-1-methylpyrrolo[1,2-a]thieno[2,3-e]pyrazine
-
5-[(1-benzylpiperidin-4-yl)methoxy]pyrrolo[1,2-a]thieno[3,2-e]pyrazine
-
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(methylcarbamoyl)quinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(morpholin-4-ylcarbonyl)quinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
-
5-[(dimethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
-
5-[(E)-(dimethylhydrazinylidene)methyl]-1-(4-methoxy-3-nitrobenzyl)-1H-imidazole
-
-
5-[(ethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
-
-
5-[4-(4-benzylpiperazin-1-yl)butyl]-7-phenyl-1,5-dihydro-4H-furo[2,3-b]pyrrolo[2,3-d]pyridin-4-one
-
5alpha,8alpha-epidioxy-(24S)-ethylcholesta-6,9(11),22(E)-triene-3beta-ol
-
isolated from Haloxylon recurvum
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6,8-dibromo-2-(4-chlorophenyl)-2-methyl-2,3-dihydroquinazolin-4(1H)-one
-
6-chloro-N-(2-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]ethyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
6-chloro-N-(3-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]propyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
6-formyl umbelliferone
isolated from Angelica decursiva, noncompetitive inhibition
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
6-methoxytacrine
-
mixed competitive-uncompetitive inhibition
6-O-demethylgalanthamine
-
-
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
-
-
6beta,8alpha-diacetoxy-9beta-furoyloxy-1alpha-hydroxy-beta-agarofuran
-
-
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
-
-
7-benzoyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.036 mM
7-benzyl-2-((3,4-dimethoxybenzyl)(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00033 mM
7-benzyl-2-(4-benzylpiperazin-1-yl)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00132 mM
7-benzyl-2-(benzyl(methyl)amino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00084 mM
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00286 mM
7-benzyl-2-(benzylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.0052 mM
7-benzyl-2-(cyclohexylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00282 mM
7-benzyl-2-(diethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00208 mM
7-benzyl-2-(dimethylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00089 mM
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00074 mM
7-benzyl-2-(isopropylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00058 mM
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00094 mM
7-benzyl-2-(phenylamino)-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)thiazin-4-one
-
50% inhibition at 0.00103 mM
7-benzyl-2-(propan-2-ylamino)-1,2,5,6,7,8-hexahydro-4H-pyrido[4',3':4,5]thieno[2,3-d][1,3]thiazin-4-one
-
the substance acts as a hyperbolic mixed-type inhibitor
7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-4H-pyrido(4',3':4,5)thieno(2,3-d)(1,3)oxazin-4-one
-
50% inhibition at 0.00077 mM
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
-
-
7-deoxy-trans-dihydronarciclasine
-
-
7-hydroxy-3-(piperidin-1-ylcarbonyl)-2H-chromen-2-one
-
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
-
-
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
-
-
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
-
-
7-methyloctahydro-2H-quinolizin-1-yl (7-methyloctahydro-2H-quinolizin-1-yl)methyl butanedioate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
7-O-galloyl-D-sedoheptulose
a mixed-type inhibitor, enzyme interacting residues, overview
7-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
-
-
8-alpha-ethoxyprecriwelline
-
-
8-demethoxy-10-O-methylhostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
8-demethoxyhostasine
-
benzylphenethylamine alkaloid from Hosta plantaginea
8-formyl umbelliferone
noncompetitive inhibition, forms a hydrogen bond with the Glu199 residue. In addition, residues Trp84, Gly117, Gly118, Phe330, His440, and Gly441 are involved in hydrophobic interactions with the coumarin
8-methoxyflindersine
-
an alkaloid isolated from Waltheria brachypetala
9,10-dimethoxy-1,2,3,12,15,16-hexadehydrogalanthan
-
-
9-(2-oxo-3-pyrrolidin-1-ylpropyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-4-pyrrolidin-1-ylbutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(2-oxo-5-pyrrolidin-1-ylpentyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-(3-bromo-5-ethoxy-4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
-
-
9-(4-[[2-(dimethylamino)ethyl]amino]-2-oxobutyl)-7H-dibenzo[de,h]quinolin-7-one
-
-
9-amino-1,2,3,4-tetrahydroacridin-1-ol
9-O-demethyl-7-O-methyllycorenine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide
-
-
9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide
-
-
9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide
-
-
9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide
-
-
9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide
-
-
9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide
-
-
9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide
-
most potent berberine derivative inhibitor, mixed type inhibition
9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide
-
-
9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide
-
-
9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide
-
-
9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide
-
-
9-[3-(dimethylamino)-2-oxopropyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(diethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-(dimethylamino)-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[4-[(2-hydroxyethyl)amino]-2-oxobutyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
9-[5-(dimethylamino)-2-oxopentyl]-7H-dibenzo[de,h]quinolin-7-one
-
-
acetamiprid
-
complete inhibition
acetonitrile
-
a competitive pseudo-inhibition is observed for 6% acetonitrile
acetyl-[beta-methyl]thiocholine
-
-
acetylcholine iodide
-
substrate inhibition above 4 mM
acrifoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
aflatoxin B1
-
50% inhibition at 0.031 mM by increase of Km-value and decrease of vmax-value. Partial recativation by 2-aldoxime, i.e. 2-PAM, pyridin-2-aldoxime 1-methoiodide
alpha-amyrin
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin
alpha-pinene
-
IC50 is 0.022 mg/ml
alpha-terpinen
-
isolated from Melaleuca atlernifolia
alpha-terpineol
-
IC50 is 1.3 mg/ml
amberboin
a sesquiterpene lactone from extract of Volutaria abyssinica, inhibition mechanism
anhydrolycodoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotine N-oxide
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
annotinine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
Aspartame
-
and its metabolites, inhibitory above 2.8 mg per kg body weight
benzoyl phosphoramidic dichloride
-
-
benzoylphosphoramidic dichloride
-
-
beta-amyrin
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves as a mixture of alpha- and beta amyrin
biphenyl-2-yl butylcarbamate
-
-
bis-N,N-dimethylfulleropyrrolidinium salts
-
inhibitory activity and mechanism of cationic fulleropyrrolidinium regioisomers, AChE docking parameters, molecular modleing, overview
-
bulbocapnine
-
isolated from Corydalis cava
butylsarin
-
detailed analysis of inhibition kinetics
butyrylthiocholine iodide
-
buxabenzacinine
-
isolated from Buxus hyrcana
buxamine-B
-
50% inhibition at 0.074 mM, noncompetitive
buxamine-C
-
50% inhibition at 0.0075 mM, noncompetitive
buxandrine
-
isolated from Buxus hyrcana
buxidin
-
isolated from Buxus hyrcana
buxippine-K
-
isolated from Buxus hyrcana
buxoviricine
-
isolated from Buxus hyrcana
BW 284C51
-
50% inhibition at 0.0063 mM
BW284C5
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide, complete inhibition at 1 mM
calenduladiol
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves. 31.2% inhibition at 0.5 mM
cannabisin A
47.13% inhibition at 0.1 mg/ml
cannabisin C
42.89% inhibition at 0.1 mg/ml
cannabisin D
13.97% inhibition at 0.1 mg/ml
cannabisin E
11.17% inhibition at 0.1 mg/ml
cannabisin F
47.16% inhibition at 0.1 mg/ml
cannabisin N
51.99% inhibition at 0.1 mg/ml
chitooligosaccharides
-
90-COSs and 50-COSs are prepared from 90% and 50% deacetylated chitosan, cellular AChE activity is decreased with increasing concentration of 90-MMWCOS chitooligosaccharides in PC12 cell lines, the 90-COSs exhibit more potent AChE inhibitory activities compared to 50-COSs, while 90-MMWCOS, 1-5 kDa, in the 90COSs show the highest activity, overview
Chloroquine
-
mixed type, 33% inhibition at 0.022 mM, 67% inhibition at 0.193 mM
chlorpyrifos-oxon
-
complete inhibition of wild-type enzyme
cis-rosmarinic acid
-
from extracts of Melissa officinalis leaves
conarrhimin
-
strong inhibition, 94% inhibition at 0.1 mg/ml
conessimin
-
strong, reversible and noncompetitive inhibition, 98% inhibition at 0.1 mg/ml
conessine
-
strong inhibition, 95% inhibition at 0.1 mg/ml
conimin
-
strong inhibition, 96% inhibition at 0.1 mg/ml
coumarin 106
-
exhibits mixed-type AChE inhibition, targets a primary binding site at the active gorge and a secondary peripheral anionic binding site. Analysis of inhibitor binding, overview
cryptotanshinone
mixed non-competitive inhibitor
cycloheptyl methylphosphonyl thiocholine
SP and RP enantiomers
cyclopentyl phenothiazine carbamate
-
-
dec-N-dimethylregeline
-
-
decursidin
mixed-type inhibition
dehydroevodiamine hydrochloride
-
isolated from Evodia rutaecarpa
demeton
-
complete inhibition of wild-type enzyme
diazinon oxon
-
high inhibition, irreversible inhibitor
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanedioate
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)succinate
diethylfluorophosphate
-
-
diethyltabun
-
detailed analysis of inhibition kinetics
dihydrotanshinone
mixed non-competitive inhibitor
diisopropyl fluorophosphate
diisopropyl phosphofluoridate
-
complete inhibition of wild-type enzyme, not of mutant G122H/Y124Q/S125T
diisopropyl phosphorofluoridate
diisopropylfluorophosphate
dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
-
-
dimethyl [(10R)-10-(4-methoxyphenyl)-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]propanedioate
-
-
dimethyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]propanedioate
-
-
dimethyl [(4R)-4,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]propanedioate
-
-
dimethyl [(4S)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]propanedioate
-
-
dimethyl [(9R)-9-phenyl-6-oxa-7-azaspiro[3.5]non-7-en-8-yl]propanedioate
-
-
dimethyl [2-acetyl-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-3-yl]propanedioate
-
-
dipropan-2-yl phosphorofluoridate
disodium calenduladiol disulfate
-
a semisynthetic derivative of calenduladiol, elicits higher AChE inhibition than this with 94.1% inhibition at 0.5 mM
DL-homocysteine
inhibits the enzyme in cardiac tissue of male rats
DL-homocysteine thiolactone
inhibits the enzyme in cardiac tissue of male rats
epinorgalanthamine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
ethyl ((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)acetate
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-3-phenylpropanoate
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)hexanoate
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)propanoate
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
ethyl (2S)-4-(methylthio)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
ethyl (2S)-4-amino-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-4-oxobutanoate
ethyl (2S)-4-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
ethyl 2-oxo-7-[2-(piperidin-1-yl)ethoxy]-2H-chromene-3-carboxylate
-
ethyl 3-(4-amino-3-chloro-5-iodo-phenyl)-3-oxo-propanoate
-
ethyl 3-(4-amino-3-iodo-phenyl)-3-oxo-propanoate
-
ethyl 3-(4-amino-5-chloro-3-iodo-2-methoxy-phenyl)-3-oxo-propanoate
-
ethyl 3-(4-methoxy-1H-indol-5-yl)-3-oxo-propanoate
-
ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
-
ethyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
ethyl 7-hydroxy-8-(3-methoxyphenyl)-2-oxo-2H-chromene-3-carboxylate
-
ethyl 7-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
ethyl N,N-di-isopropylphosphorofluoridate
-
-
ethyl N,N-di-n-propylphosphoamidocyanidate
-
-
ethyl N,N-diethylphosphorofluoridate
-
-
ethyl N-ethylphosphorofluoridate
-
-
ethyl N-methylphosphorofluoridate
-
-
ethyl N-n-propylphosphorofluoridate
-
-
ethyl [2-[(5aS,7R,9aS)-1-formyl-7-hydroxy-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethyl [2-[(5aS,7R,9aS)-7-hydroxy-1-(hydroxymethyl)-4-methoxy-6,7-dihydrodibenzo[b,d]furan-9a(5aH)-yl]ethyl]methylcarbamate
-
-
ethyl((2-[bis(propan-2-yl)amino]ethyl)sulfanyl)-(methyl)phosphinate
VX, stereospecific inhibition of the enzyme by VX and subsequent reactivation by HI-6, structural analysis, overview
eugenol
-
IC50 is 0.48 mg/ml
faradiol
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves
fasciculin-2
-
potent inhibitor
-
FP-biotin
-
i.e. 10-(fluoroethoxyphosphinyl)-N-(biotinamidopentyl)decanamide, second order rate constant for inhibition is 18000000 per M and min
gamma-terpinen
-
isolated from Melaleuca atlernifolia
giganteone C
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
gnidioidine
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
grossamide
22.42% inhibition at 0.1 mg/ml
heliantriol B2
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves
hostasine
-
a benzylphenethylamine alkaloid from Hosta plantaginea
hyrcamine
-
isolated from Buxus hyrcana
hyrcanone
-
isolated from Buxus hyrcana
hyrcatrienine
-
isolated from Buxus hyrcana
infractopicrin
-
isolated from Cortinarius infractus, inhibits acetylcholinesterase, but does not inhibit butyrylcholinesterase
Insulin
-
AChE activity in detergent soluble fraction of scopolamine amnesic mice is inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in salt soluble fraction is not much affected, overview
-
interferon-beta
-
mechanisms of action of IFN-b is through the inhibition of AChE activity, overview
-
iolantamine iodomethylate
-
-
iso-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
isoconessimine
-
55% inhibition at 0.1 mg/ml
isolariin A
-
isolated from Linaria reflexa
isolariin B
-
isolated from Linaria reflexa
isopropyl methylphosphonyl thiocholine
SP and RP enantiomers
isoquinolin-1-yl(2-methoxyphenyl)methanol
-
-
isosorbide di-(2-chlorobenzoate)
-
-
isosorbide di-(3-chlorobenzoate)
-
-
isosorbide di-(4-bromobenzoate)
-
-
isosorbide di-(4-chlorobenzoate)
-
-
K+
-
AChEA and AChEB lose 80% actiivty at 1 mM of K+
kesselridine iodomethylate
-
-
L-aspartate
-
inhibitory above 2.8 mM
L-phenylalanine
-
inhibitory above 0.14 mM
lannotinidine D
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
lawsaritol
-
isolated from Haloxylon recurvum
leufolin A
-
isolated from Leucas urticifolia
leufolin B
-
isolated from Leucas urticifolia
lipidiol
a sesquiterpene lactone from extract of Volutaria abyssinica, inhibition mechanism
loganin
a mixed-type inhibitor, enzyme interacting residues, overview
lupeol
-
a pentacyclic triterpene, isolated the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves
luteidine iodomethylate
-
-
lycodoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
lycofoline
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
lycoparin C
-
an alkaloid from Lycopodium casuarinoides, NMR structure determination and analysis, overview
lycoposerramine M
-
isolated from ethanolic extracts of Lycopodium annotinum ssp. alpestre
m-(N,N,N-trimethylammonio)-trifluoroacetophenone
binding structure analysis
mahanimbine
-
i.e. 3, 5-dimethyl-3-(4-methylpent-3-enyl)-11H-pyrano [5,6-a] carbazole, IC50 is 0.03 g/ml, isolated from the petroleum ether extract of the leaves of Murraya koenigii, an Indian medical plant
maingayone B
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
maingayone C
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
malabaricone A
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
malabaricone B
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
malabaricone C
-
isolated from ethyl acetate and methanol extracts from the leaves and the fruits of Myristica crassa, structure analysis by mass spectrometry
Melatonin
-
AChE activity in detergent soluble fraction of scopolamine amnesic mice is inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in salt soluble fraction is not much affected, overview
Melissa officinalis leaf extract
-
most of the fractions show inhibitory activity and are more potent than the extract due to antagonistic and synergistic effects between various constituents within the plant extract, mass spectrometric analysis of the inhibitory extract fractions, overview
-
metamidophos
-
easy reactivation by oximes
methanol
-
inhibitory above 0.14 mM
methyl (2R,5R)-5-[(benzyloxy)methyl]-2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
-
-
methyl (2S,5R)-5-[(benzyloxy)methyl]-2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
-
-
methyl (3-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
methyl (3-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
methyl (4-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
methyl (4-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
methyl 1-methoxy-5-methyl-1,2,3,6-tetrahydrophosphinine-4-carboxylate 1-oxide
-
-
methyl 2-acetyl-4-(dimethoxyphosphoryl)butanoate
-
-
methyl 2-acetyl-5-(dimethoxyphosphoryl)pent-4-enoate
-
-
methyl 2-acetyl-5-(dimethoxyphosphoryl)pentanoate
-
-
methyl 2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
-
-
methyl 4-amino-5-chloro-3-iodo-2-methoxybenzoate
-
methyl 4-methoxy-1H-indole-5-carboxylate
-
methyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
methyl 5-[(ethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
-
-
methyl 7-chloro-4-methoxy-1H-indole-5-carboxylate
-
methyl paraoxon
-
reversible binding to a site on acetylcholinesterase distinct from the active site reduces their subsequent capacity to phosphorylate the active site, probably by steric hindrance or allosteric modification of the active site
methyl [(10R)-10-phenyl-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]acetate
-
-
methyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]acetate
-
-
methyl [(4S)-4-(4-methoxyphenyl)-6,6-dimethyl-5,6-dihydro-4H-1,2-oxazin-3-yl]acetate
-
-
methyl [3-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
methyl [3-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
methyl [4-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
methyl [4-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
methyl {3-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propyl}phosphonofluoridate
methyl {4-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]butyl}phosphonofluoridate
methylorganophosphonates
-
the Sp-enantiomer is more reactive
-
methylsulfomethylate-O-ethyl-S-2-ethylmercaptoethyl methylthiophosphanate
-
Gd-42, selective inhibitor for acetylcholine esterase
Mn2+
-
about 20% inhibition at 1 mM
morroniside
a noncompetitive inhibitor, enzyme interacting residues, overview
muscarine
-
treatment with 0.01 mM muscarine leads to a 20% decrease in enzyme activity in SN-56 cells
N'-[(1E)-1-(4-hydroxyphenyl)ethylidene]-2-(2-nitrophenoxy)acetohydrazide
-
-
N,N'-bis(3-pyridin-3-ylcyclohexyl)pentanediamide
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
N,N,N,N',N',N'-hexamethylbutane-1,4-diaminium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N,N-triethylethanaminium
N,N,N-trimethyl-10-(methylsulfonylthio)decan-1-aminium bromide
N,N,N-trimethyl-11-(methylsulfonylthio)undecan-1-aminium bromide
N,N,N-trimethyl-12-(methylsulfonylthio)dodecan-1-aminium bromide
N,N,N-trimethyl-13-(methylsulfonylthio)tridecan-1-aminium bromide
N,N,N-trimethyl-14-(methylsulfonylthio)tetradecan-1-aminium bromide
N,N,N-trimethyl-15-(methylsulfonylthio)pentadecan-1-aminium bromide
N,N,N-trimethyl-16-(methylsulfonylthio)hexadecan-1-aminium bromide
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
N,N,N-trimethyl-19-(methylsulfonylthio)nonadecan-1-aminium bromide
-
i.e. AMTS19, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-2-oxo-3-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)propan-1-aminium
-
-
N,N,N-trimethyl-20-(methylsulfonylthio)eicosan-1-aminiumbromi de
-
i.e. AMTS20, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-3-oxo-4-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)butan-1-aminium
-
-
N,N,N-trimethyl-4-oxo-5-(7-oxo-7H-dibenzo[de,h]quinolin-9-yl)pentan-1-aminium
-
-
N,N,N-trimethyl-7-(methylsulfonylthio)heptan-1-aminium bromide
N,N,N-trimethyl-8-(methylsulfonylthio)octan-1-aminium bromide
N,N,N-trimethyl-9-(methylsulfonylthio)nonan-1-aminium bromide
N,N,N-trimethylmethanaminium
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
N,N-Diisopropylphosphorodiamidic anhydride
-
weak
N,N-dimethyl phosphoramidic acid bis-(4-chlorophenyl) ester
-
binding activity and lipophilicity, overview
N,N-dimethyl phosphoramidic acid bis-(4-methylphenyl) ester
-
binding activity and lipophilicity, overview
N,N-dimethyl phosphoramidic acid bis-phenyl ester
-
binding activity and lipophilicity, overview
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]carbamoyl-5-hydroxy-2-methyloct-4-yl)-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenyl ethyl]isophthalamide
-
48.7% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]carbamoyl-5-hydroxy-2-methyloct-4-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
-
47.5% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-5-hydroxy-2-methyloctan-4-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
-
23.8% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(1-benzylpiperidin-4-yl)]methylcarbamoyl-5-hydroxy-2-methyloct-4-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]isophthalamide
-
45.9% inhibition at 0.025 mM
N-((4S,5S,7R)-2-[7-(4-benzylpiperazin-1-yl)]carbamoyl-5-hydroxy-2-methyloct-4-yl)-5-[methyl(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
-
5.2% inhibition at 0.025 mM
N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
-
N-(14-methylallyl)norgalanthamine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy
N-(2,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2,5-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2,6-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2-cyanophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(2-phenylethyl)-N-[(12Z)-7,8,9,10-tetrahydroazepino [2,1b]quinazolin-12(6H)-ylidene]amine
-
-
N-(2-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]ethyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
N-(3,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(3,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(3,5-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(3-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(3-ethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(3-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(3-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]propyl)-1,2,3,4-tetrahydroacridin-9-amine
-
-
N-(4-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-(4-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethyl-carbamoyl-3-hydroxy-1-phenylbut-2-yl)-5-[methyl-(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
-
-
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-3-hydroxy-1-phenylbut-2-yl)-N',N'-dipropyl-5-nitroisophthalamide
-
-
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-3-hydroxy-1-phenylbut-2-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]iso phthalamide
-
-
N-allylnorgalanthamine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves, structure determination by NMR spectroscopy
N-benzoyl N',N'-(tert-butybenzyl) phosphoramidic chloride
-
26% reactivation of enzyme activity by pralidoxime, 4% by obidoxime
N-benzoyl N',N'-(tert-butybenzyl) thiophosphoramidic chloride
-
22% reactivation of enzyme activity by pralidoxime, 3% by obidoxime
n-butanol
-
inhibits below 100 mM and activates above 100 mM
N-cyclopentyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-desmethyl-8alpha-ethoxypretazzettine
-
-
N-desmethyl-8beta-ethoxypretazzettine
-
-
N-ethyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
-
-
N-ethylmaleimide
inactivation
N-methyl,N-alkyl carbamates
-
AChE inhibition is mainly determined by the size of the N-alkyl substituent and to a lesser extent by the nature of the leaving group, Ki was highest when the alkyl is methyl, hexyl, cyclohexyl, or an aromatic substituent and lowest when it is ethyl, ki depends on a delicate balance between the length of the residue and its degree of freedom of rotation, overview
-
N-methyl-3-pyridin-3-ylcyclohexanamine
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N-methyl-N-(3-carbamoyloxyphenyl)methyl-amino inhibitor
-
-
N-methylwaltherione
-
an alkaloid isolated from Waltheria brachypetala
N-trans-caffeoyltyramine
83.28% inhibition at 0.1 mg/ml
N-trans-feruloyltyramine
13.25% inhibition at 0.1 mg/ml
N-[(2,3-dichlorophenyl)carbamothioyl]butanamide
-
N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
-
N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
-
N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
-
N-[(2-methoxyphenyl)carbamothioyl]butanamide
-
N-[(3-nitrophenyl)carbamothioyl]butanamide
-
N-[(4-methoxyphenyl)carbamothioyl]butanamide
-
N-[(4-methylphenyl)carbamothioyl]butanamide
-
N-[(4-nitrophenyl)carbamothioyl]butanamide
-
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
N-[4-[4-(1,3-benzothiazol-2-yl)phenoxy]butyl]-6-chloro-1,2,3,4-tetrahydroacridin-9-amine
-
N-[6-(1H-indol-1-yl)hexyl]-1-(4-methoxybenzyl)piperidin-4-amine
-
N-[8-(1H-indol-1-yl)octyl]-1-(4-methoxybenzyl)piperidin-4-amine
-
N-[di(morpholin-4-yl)phosphoryl]-4-methylbenzamide
-
-
N-[di(morpholin-4-yl)phosphoryl]benzamide
-
-
N3-demethylsaracodine
-
-
narwedine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
Nb-dimethylcycloxobuxoviricine
-
isolated from Buxus hyrcana
neostigmine methyl sulfate
-
neostigmine methylsulfate
-
painkiller
Ni2+
-
AChEA and AChEB are completely inhibited by 1 mM of Ni2+
O,O-diethyl S-hexyl phosphorothioate
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
O-ethyl S-(2-(diisopropylamino)ethyl) methylphosphonothioate
-
i.e. VX, detailed analysis of inhibition kinetics
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate
O-ethyl S-heptyl methylphosphonothioate
O-ethyl S-hexyl methylphosphonothioate
O-ethyl S-neopentyl methylphosphonothioate
O-ethyl S-pentyl methylphosphonothioate
O-ethyl S-[2-(diisopropylamino)ethyl]methylphosphonothioate
VX
O-ethyl-O-(4-nitrophenyl)-phenylphosphonothioate
-
-
O-ethyl-S-pentyl methylthiophosphonate
-
LG-64
O-ethyl-S-[2-(diisopropylamino)-ethyl]-methylphosphonothioate
O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate
O-isopropyl methylphosphonofluoridate
-
i.e. sarin, a nerve agent, leads to irrversible inhibition of AChE
O-isopropylmethylphosphonofluoridate
-
-
O-O-dimethyl-O-(2,2-dichlorovinyl)phosphate
-
phosphorylates the active site serine
O-pinacolyl methyl phophonofluoridate
-
-
O-pinacolyl methylphosphonofluoridate
octahydro-2H-quinolizin-1-yl octahydro-2H-quinolizin-1-ylmethyl butanedioate
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
octahydro-2H-quinolizin-1-ylmethanol
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
organophosphorus compounds
-
determination of reactivation efficiency with oxims, e.g. obixime, 2-PAM, HI 6, HLö 7, and MMB-4, reactivation kinetics, overview, structure-activity relationship for inhibition and spontaneous reactivation, overview
-
oxamyl
-
complete inhibition
oxazaphenalene lactone
-
-
p-Carboxyphenyltrimethylammonium iodide
-
p-quat
paracetamol/caffeine
-
painkiller preparation
paracetamol/propifenazone/caffeine
-
painkiller preparation
paraoxonethyl
diethyl-O-4-nitrophenylphosphate, paraoxon, PXE
phenyl 1,2-dimethylhydrazinecarboxylate
phenyl 1-methylhydrazinecarboxylate
phenyl butylcarbamate
-
-
phenyl phenothiazine carbamate
-
-
phenylethylcymserine
-
50% inhibition at 0.03 mM
phenylmethylsulfonyl fluoride
-
about 60% inhibition at 0.5 mM
Phenylmethylsulfonylfluoride
pilocarpine
-
pilocarpine induction of status epilepticus leads to enzyme inhibition during seizures in the rat brain, overview
polyamidoamine dendrimer PAMAM G3.5
-
0.1 mM, 75% residual activity due to changes in enzyme conformation
-
polyamidoamine dendrimer PAMAM G4
-
0.1 mM, 40% residual activity due to changes in enzyme conformation
-
polyamidoamine dendrimer PAMAM-OH G4
-
0.1 mM, 85% residual activity due to changes in enzyme conformation
-
primaquine
-
mixed type, 33% inhibition at 0.038 mM, 67% inhibition at 0.247 mM
procaine hydrochloride
-
-
propionylthioacetylcholine
-
-
propyl phenothiazine carbamate
-
-
pyridine-2-aldoxime methochloride
-
inhibition mechanism
Quinine
-
mixed type, 33% inhibition at 3.2 mM, 67% inhibition at 7.5 mM
quinuclidinyl benzilate
-
-
rac-bambuterol monocarbamate
inhibition kinetics of human acetylcholinesterase by bambuterol and bambuterol monocarbamate enantiomers
regeline iodomethylate
-
-
rosmarinic acid derivative
-
from extracts of Melissa officinalis leaves
-
RP cycloheptyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-3,3-dimethylbutyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can only poorly be reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
RP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate
-
i.e. VX, a nerve agent, leads to irrversible inhibition of AChE
salignarine-C
-
isolated from Sarcococca saligna
SDZ 212-712
-
optical isomer of rivastigmine
slavin A
-
isolated from Salvia santolinifolia
slavin B
-
isolated from Salvia santolinifolia
sodium 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
-
sodium dodecylsulfate
-
inhibition is partially prevented by addition of ethanol
Sodium fluoride
-
about 60% inhibition at 0.5 mM
SP-3,3-dimethylbutyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-cycloheptyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
SP-isopropyl methylphosphonyl thiocholine
-
phosphonylates the enzyme, wild-type enzyme and mutant enzymes can be partially reactivated by 1-(2'-hydroxyiminomethyl-1'-pyridinium)-3-(4''-carbamoyl-1''-pyridinium)-2-oxapropane dichloride or 2-(hydroxyiminomethyl)-1-methylpyridinium iodide
succinyldicholine
substrate inhibition, binding structure analysis
t-butyl phenothiazine carbamate
-
-
tacrine-caffeic acid hybrid
-
taspine
-
isolated from Thymus vulgaris essential oil
tea polyphenol
-
up to 60% inhibition of enzyme
tert-butyl 4-[3-(4-amino-3-chloro-5-iodo-phenyl)-3-oxopropyl]piperidine-1-carboxylate
-
tert-butyl 4-[3-(4-amino-3-iodo-phenyl)-3-oxo-propyl]piperidine-1-carboxylate
-
tert-butyl 4-[3-(4-amino-5-chloro-3-iodo-2-methoxyphenyl)-3-oxo-propyl]piperidine-1-carboxylate
-
tert-butyl 4-[3-(4-methoxy-1H-indol-5-yl)-3-oxo-propyl]piperidine-1-carboxylate
-
tetra(monoisopropyl)diphosphortetramide
irreversible
tetra(monoisopropyl)diphosphotetramide
-
isoOMPA
tetracaine hydrochloride
-
-
tetraisopropyl diphosphoramide
-
-
tetra[monoisopropyl]pyrophosphortetramide
-
-
TFK+
analysis of the inhibition mechanism by ab initio quantum mechanical/molecular mechanical approach and classical molecular dynamics simulations, overview
TFK0
analysis of the inhibition mechanism by ab initio quantum mechanical/molecular mechanical approach and classical molecular dynamics simulations, overview
thyme essential oil
-
-
-
trans-anethole
-
isolated from the ethanolic extract from the fruits of Pimpinella anisoides
trans-rosmarinic acid
-
from extracts of Melissa officinalis leaves
trifluoroacetophenone
-
inhibits Y124C mutant slower than the wild-type enzyme
Trimethyl(p-aminophenyl)ammonium chloride hydrochloride
-
-
Triton X-100
-
uncompetitive inhibition at 0.01%, below the critical micelle concentration, and above at concentration higher than 0.013%
True cholinesterase inhibitor
-
-
-
tubocurarine
-
a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge
umbelliferone
isolated from Angelica decursiva, forms three hydrogen bonds with the interacting residues Tyr121, Phe288, and Arg289. Residues Phe288 and Arg289 are involved in strong hydrogen bonding interactions with the hydroxyl group at position C-7, and Tyr121 is also involved in hydrogen bonding interactions with the ketone group at position C-2. In particular, important peripheral anionic site (PAS) residues, Trp279 and Tyr334, are involved in hydrogen bonding interactions with umbelliferone
Urea
-
the stability of the immobilized recombinant enzyme is 2.7fold increased compared to the soluble recombinant enzyme
waltherine
-
an alkaloid isolated from Waltheria brachypetala, 51.4% inhibition at 0.1 mg/ml
waltherione-A
-
an alkaloid isolated from Waltheria brachypetala, Waltheria douradinha, Melochia chamaedrys, and Melochia odorata leaves
waltherione-B
-
an alkaloid isolated from Waltheria brachypetala
[1-(2-nitrophenyl)-2,2,2-trifluoroethyl]-arsenocholine iodide
caged compound, binding structure and mechanism with AChE, binding within the active-site gorge, overview
[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone
-
-
(+)-tabun
-
-
(-)-huperzine A
-
(-)-huperzine A
anti-Alzheimer drug
(-)-spectaline
-
isolated from flowers of Senna spectabilis
(-)-spectaline
a piperidine alkaloid isolated from Senna spectabilis flowers, structure and stereochemistry by ESI-MS/MS and EI-MS
(-)-tabun
-
-
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
-
-
(2-((ethoxy(hydroxy)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium methanesulfonate
-
-
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
-
-
(2-((ethoxy(methyl)phosphoryl)thio)ethyl)(ethyl)(methyl)sulfonium
-
-
(7R,11R)-huprine 19
huprines are a family of nano- to femtomolar inhibitors of AChE with specificity for the A-site interaction. The main feature is the remarkable embedding of the chloroquinolinium moiety into an aromatic stacking pile involving Trp86/HuprineW/Tyr337/Phe338/Phe295/Trp236
(7R,11R)-huprine 19
huprines are a family of nano- to femtomolar inhibitors of AChE with specificity for the A-site interaction. The main feature is the remarkable embedding of the chloroquinolinium moiety into an aromatic stacking pile involving Trp86/HuprineW/Tyr337/Phe338/Phe295/Trp236
(7S,11S)-huprine W
huprines are a family of nano- to femtomolar inhibitors of AChE with specificity for the A-site interaction. The main feature is the remarkable embedding of the chloroquinolinium moiety into an aromatic stacking pile involving Trp86/HuprineW/Tyr337/Phe338/Phe295/Trp236
(7S,11S)-huprine W
huprines are a family of nano- to femtomolar inhibitors of AChE with specificity for the A-site interaction. The main feature is the remarkable embedding of the chloroquinolinium moiety into an aromatic stacking pile involving Trp86/HuprineW/Tyr337/Phe338/Phe295/Trp236
(R)-(+)-fenoxon sulfoxide
-
-
(R)-(+)-fenoxon sulfoxide
-
-
(R)-(+)-fenthion sulfoxide
-
-
(R)-(+)-fenthion sulfoxide
-
-
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, inhibition kinetics
(R,S)-1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride
-
E2020, acetylcholinesterase inhibitor used in treatment of Alzheimer's diaease, interacts with the active site and the peripheral anionic site of the enzyme
(rac) fenoxon sulfoxide
-
-
(rac) fenoxon sulfoxide
-
-
(rac) fenthion sulfoxide
-
-
(rac) fenthion sulfoxide
-
-
(S)-(-)-fenoxon sulfoxide
-
-
(S)-(-)-fenoxon sulfoxide
-
-
(S)-(-)-fenthion sulfoxide
-
-
(S)-(-)-fenthion sulfoxide
-
-
1,5-Bis(4-allyldimethylammonium phenyl)pentan-3-one
-
-
1,5-Bis(4-allyldimethylammonium phenyl)pentan-3-one
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
-
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, inhibits to a lesser extent than the vertebrate enzyme
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, complete inhibition of SS ChE at 0.1 mM, complete inhibition of DS ChE at 0.1-0.01 mM
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, complete inhibition
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, 98% inhibition at 0.01 mM
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
-
i.e. BW284c51, shows inhibition at high substrate concentrations
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
-
BW284c51
1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
i.e. BW284c51
1,8-cineole
-
isolated from Melaleuca atlernifolia
1,8-cineole
-
IC50 is 0.015 mg/ml
1-(1-benzyl-7-chloro-4-methoxy-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(1-benzyl-7-chloro-4-methoxy-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(1-benzylindol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(1-benzylindol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone
i.e. RS67333
1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone
i.e. RS67333
1-(7-chloro-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(7-chloro-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(7-chloro-4-methoxy-1-methyl-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(7-chloro-4-methoxy-1-methyl-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(7-chloro-4-methoxy-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-(7-chloro-4-methoxy-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-[1-(benzenesulfonyl)-7-chloro-4-methoxy-indol-5-yl]-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
1-[1-(benzenesulfonyl)-7-chloro-4-methoxy-indol-5-yl]-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
-
2,2-dichlorovinyl dimethyl phosphate
-
-
2,2-dichlorovinyl dimethyl phosphate
-
i.e. DDVP, reversible, detailed kinetic analysis
2,3-dimethylmaleic anhydride
biochemical efficacy, molecular docking and inhibitory effect on insect acetylcholinesterase. The knockdown activity of 2,3-dimethylmaleic anhydride is associated with in vivo inhibition of AChE, at KD99 dosage, it shows more than 90% inhibition of AChE activity in insects. 2,3-Dimethylmaleic anhydride elicits toxicity in Periplaneta americana primarily by AChE inhibition along with oxidative stress. The compound interacts with 9 amino acids forming hydrogen bonds with Cys198 and Glu199. Residues Glu191, and Phe202 are contributors of polar or electrostatic interaction, whereas the Phe241, Phe200, and Tyr244 are involved in van der Waals interactions
2,3-dimethylmaleic anhydride
-
biochemical efficacy, molecular docking and inhibitory effect on insect acetylcholinesterase. The knockdown activity of 2,3-dimethylmaleic anhydride is associated with in vivo inhibition of AChE, at KD99 dosage, it shows more than 90% inhibition of AChE activity in insects. 2,3-Dimethylmaleic anhydride elicits toxicity in Sitophilus oryzae primarily by AChE inhibition along with oxidative stress
2-acetamido-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
2-acetamido-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
2-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
2-chlorophenyl 1-methylhydrazinecarboxylate
-
-
2-chlorophenyl 1-methylhydrazinecarboxylate
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
-
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
-
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
-
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
-
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
-
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
-
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
-
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
-
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
-
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
-
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
-
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
-
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
-
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
-
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
2-[acetyl(methyl)amino]-N,N,N-trimethylethen-1-aminium
-
reversible inhibitor
3-(1-benzyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
-
3-(1-benzyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
-
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-1H-indol-5-yl)propan-1-one
-
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-1H-indol-5-yl)propan-1-one
-
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-2-trimethylsilyl-1H-indol-5-yl)propan-1-one
-
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-2-trimethylsilyl-1H-indol-5-yl)propan-1-one
-
3-(1-butyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
-
3-(1-butyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
-
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
3-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
3-chlorophenyl 1-methylhydrazinecarboxylate
-
-
3-chlorophenyl 1-methylhydrazinecarboxylate
-
-
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates
-
inhibit quickly by carbamoylation
3-N,N-diethylaminophenyl-N'-(1-alkyl) carbamates
-
inhibit quickly by carbamoylation
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-butyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-ethyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-hexyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-octyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
-
3-N,N-diethylaminophenyl-N'-(1-propyl) carbamate
-
-
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
-
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
-
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(4-methoxy-1Hindol-5-yl)propan-1-one
-
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(4-methoxy-1Hindol-5-yl)propan-1-one
-
3-[1-(cyclopentylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
-
3-[1-(cyclopentylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
-
4-(1H-benzimidazol-2-yl)phenol
-
-
4-(1H-benzimidazol-2-yl)phenol
-
-
4-(5-chloro-1H-benzimidazol-2-yl)phenol
-
-
4-(5-chloro-1H-benzimidazol-2-yl)phenol
-
-
4-(5-methyl-1H-benzimidazol-2-yl)phenol
-
-
4-(5-methyl-1H-benzimidazol-2-yl)phenol
-
-
4-acetyl-1,1-dimethylpiperazin-1-ium
-
reversible inhibitor
4-acetyl-1,1-dimethylpiperazin-1-ium
-
reversible inhibitor
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
4-chlorophenyl 1,2-dimethylhydrazinecarboxylate
-
-
4-chlorophenyl 1-methylhydrazinecarboxylate
-
-
4-chlorophenyl 1-methylhydrazinecarboxylate
-
-
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
-
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
-
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
-
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
-
9-amino-1,2,3,4-tetrahydroacridin-1-ol
-
-
9-amino-1,2,3,4-tetrahydroacridin-1-ol
-
9-aminoacridine
-
-
Acetylcholine
-
substrate inhibition above 1 mM
Acetylcholine
-
mechanism of substrate inhibition
Acetylcholine
substrate inhibition
Acetylcholine
-
above 2.5 mM
Acetylcholine
-
substrate inhibition above 1 mM, less pronounced than in Pseudorasbora parva or Carassius auratus auratus
Acetylcholine
-
substrate inhibition above 1 mM
Acetylcholine
substrate inhibition due to choline exit being hindered by a substrate molecule bound at the peripheral site
acetylthiocholine
-
substrate inhibition
acetylthiocholine
the enzyme AChE is inhibited by high concentrations of substrate
acetylthiocholine
the recombinant carp AChE shows substrate inhibition at high substrate concentrations of acetyl- and propionylthiocholine
acetylthiocholine
-
substrate inhibition above 2.56 mM
acetylthiocholine
-
bothe isozymes show substrate inhibition at 10 mM acetylthiocholine
acetylthiocholine
-
substrate inhibition above 1 mM
acetylthiocholine
substrate inhibition at high concentrations
acetylthiocholine
-
substrate inhibition
acetylthiocholine
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
acetylthiocholine
-
substrate activitation at low concentrations, substrate inhibition at high concentrations
acetylthiocholine
interaction with Glu199 of ATCh, substrate inhibition due to choline exit being hindered by a substrate molecule bound at the peripheral site
acetylthiocholine iodide
-
acetylthiocholine iodide
-
above 5 mM
acetylthiocholine iodide
-
above 5 mM
AH233683
-
-
Aldicarb
-
aldicarb-sulfone
-
-
aldicarb-sulfoxide
-
-
aminocarb
-
-
amlodipine besylate
-
reversible mixed-type inhibition
As3+
-
-
azamethiphos
-
-
azamethiphos
-
50% inhibition at 0.1 mM, 80% inhibition after 60 min at 0.003 mM
bambuterol
-
50% inhibition at 0.03 mM
bambuterol
a specific and stereoselective inhibitor of butyrylcholinesterase, which is about 8000times faster inhibited than acetylcholinesterase. AChE wild-type enzyme, and mutants F297I/Y337A and F295L/F297I/Y337A show a deviation from linearity, either enzymes are inhibited by racemate or enantiomers, indicating the presence of reversible enzyme-inhibitor complex, overview
bendiocarb
-
-
Berberine
-
-
Berberine
-
competitive inhibition
bisnorcymserine
-
-
bisnorcymserine
-
50% inhibition at mM
bromchlophos
-
-
butocarboxim
-
-
butoxycarboxim
-
-
butyrylthiocholine
-
butyrylthiocholine
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
BW284c51
-
-
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
BW284c51
-
0.01 mM, more than 97% inhibition
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
BW284c51
-
complete inhibition at 0.1 mM
BW284c51
-
reversible inhibitor
BW284c51
-
specific inhibition of acetylthiocholinesterase activity
BW284c51
-
selective inhibitor
BW284c51
-
isozyme AChE1A, complete competitive inhibition at 0.016 mM
BW284c51
-
specific and competitive inhibitor, time course of inhibition for the isozymes AChEA and AChEB, inactivation of both within 30 min at 0.6 mM BW284C51
BW284c51
-
specific inhibitor of AChE
BW284c51
-
0.001 mM, almost complete inhibition
BW284c51
-
50% inhibition at 0.000021 mM
BW284c51
-
i.e. 1,5-bis(4-allyldimethyl-ammoniumphenyl)pentane-3-one dibromide, specific inhibition of AChE
BW284c51
-
a specific inhibitor of AChE, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
BW284c51
1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide; 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide; 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide; 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide; 1,5-bis(4-allyldimethylammoniumphenyl)-pentan-3-one dibromide
BW284c51
-
a specific inhibitor of AChE, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM
BW284c51
-
a specific inhibitor of AChE, moderately inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM
BW284c51
-
i.e. 1,5-bis(4-allyldimethylammoniumphenyl)pentan-3-one dibromide
BW284c51
-
highly sensitive to inhibition by BW284C51
BW284c51
50% inhibition at 0.0025 mM
BW284c51
50% inhibition at 0.002 mM
BW284c51
50% inhibition at 0.0022 mM
BW284c51
-
highly sensitive to inhibition by BW284C51
BW284c51
-
a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge
BW4c51
-
-
carbanolate
-
-
Carbaryl
-
-
Carbaryl
i.e. N-methyl-1-naphthylcarbamate, complete inhibition at concentrations exceeding 100 nM; i.e. N-methyl-1-naphthylcarbamate, complete inhibition at concentrations exceeding 100 nM
Carbaryl
-
low inhibition, irreversible inhibitor
Carbaryl
-
i.e. Ziofil 5, a pesticide, in vivo and in vitro inhibition, 85% inhibition at 0.001 mM, clearing within 5 days, overview
carbofuran
-
carbofuran
-
complete inhibition
carbosulfan
-
50% inhibition at 0.717 nM
carbosulfan
-
50% inhibition at 0.836 nM
carvacrol
-
in vitro inhibition, compound of the essential oil of Thymus vulgaris
carvacrol
-
isolated from Thymus vulgaris essential oil
Cd2+
-
-
Cd2+
-
25% inhibition at 1 mM
chlordiazepoxide HCl
-
reversible mixed-type inhibition
chlorfenvinphos
-
-
chlorpyrifos
an anti-cholinesterase organophosphate insecticide used in the production of food derived from animal, fruit and horticultural origin. The therapeutic treatment of castrated male bovines treated with chlorpyrifos, applied by pour-on according to the manufacturer's instructions, does not cause changes in the variables evaluated, i.e. total proteins, liver enzymes, urea, and creatinine
chlorpyrifos
-
a widely used organophosphorous pesticide, complete inhibition at 0.1 mM
chlorpyrifos
-
strong inhibition, used for active site titration
chlorpyrifos oxon
-
-
chlorpyrifos oxon
-
irreversible inhibitor
chlorpyrifos oxon
-
i.e. (O,O-diethyl O-(3,5,6-trichloro-2-pyridyl)) phosphate, an organophosphate
chlorpyrifos oxon
-
enzyme from Huanghua population is 62fold less sensitive than from Pingshan population
choline
-
product inhibition
choline
product inhibition, binding structure analysis
choline
-
the activity decreases to 40% at 200 mM
compound C547
a very potent and selective reversible inhibitor of AChE, shows a high level of pharmacological selectivity in inhibiting acetylcholinesterase as compared to butyrylcholinesterase (EC 3.1.1.8)
compound C547
a fast-binding inhibitor of mixed-type and a very potent and selective reversible inhibitor of AChE, shows a high level of pharmacological selectivity in inhibiting acetylcholinesterase as compared to butyrylcholinesterase (EC 3.1.1.8)
coumaphos-oxon
-
-
Crotoxyphos
-
-
Cu2+
-
-
Cu2+
-
slight inhibition of ChE activity at 0.0125-0.4 mM
Cu2+
-
53% inhibition at 1 mM
Cu2+
-
slight inhibition of ChE activity at 0.0125-0.4 mM
cyclophostin
-
a natural AChE inhibitor
cyclosarin
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
cyclosarin
-
detailed analysis of inhibition kinetics
cyclosarin
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
cyclosarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
cyclosarin
superposition of model complexes between cyclosarin-AChE conjugate (from PDB ID 5FPP) and oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane dibromide, 4-carbamoyl-1-(3-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium dibromide, and 4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium dibromide
cyclosarin
cyclohexylmethylphosphonofluoridate, GF
cyclosarin
-
a nerve agent
cymserine
-
-
cymserine
-
inhibition in the nanomolar range
decamethonium
decamethonium is a prototypical dual binding site ligand of AChE that spans the active site gorge from the P-site to the choline binding pocket in the A-site
decamethonium
-
a reversible elongated gorge-spanning inhibitor, which bridges the two sites, the anionic subsite at the bottom of the active-site gorge and the peripheral anionic site at the entrance to the gorge
decamethonium
decamethonium is a prototypical dual binding site ligand of AChE that spans the active site gorge from the P-site to the choline binding pocket in the A-site, where it is stabilized by the cation-Pi interactions illustrated in its complex with Torpedo californica AChE (TcAChE), binding structure, overview
demeton-S-methyl
-
-
demeton-S-methyl
-
enzyme from Huanghua population is 2fold less sensitive than from Pingshan population
diazepam
-
reversible mixed-type inhibition
diazinon
-
-
diazoxon
-
second order rate constant for inhibition is 420000 per M and min
dichlorvos
-
-
dichlorvos
-
irreversible inhibitor
dichlorvos
-
irreversible inhibition
dichlorvos
-
in vivo inhibition in the brain, overview
dichlorvos
50% inhibition at 0.00059 mM
dichlorvos
50% inhibition at 0.00058 mM
dichlorvos
50% inhibition at 0.00056 mM
dicrotophos
-
-
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanedioate
-
50% inhibition at 0.454 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanedioate
-
50% inhibition at 1.226 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)succinate
-
50% inhibition at 0.651 mM
diethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)succinate
-
50% inhibition at 0.577 mM
diisopropyl fluorophosphate
inhibition, aging, and reactivation kinetics
diisopropyl fluorophosphate
nerve agent, binding structure, overview
diisopropyl phosphorofluoridate
-
synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase, overview. 1,3-Dimethoxymethyl benzene bis-[4,40-(hydroxyiminomethyl) pyridinium] dichloride and 1,4-dimethoxy but-2-ene bis-[4,40-(hydroxyiminomethyl) pyridinium] dichloride show high efficacy
diisopropyl phosphorofluoridate
-
-
diisopropylfluorophosphate
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
detailed analysis of inhibition kinetics
diisopropylfluorophosphate
-
-
diisopropylfluorophosphate
-
-
Dimethoate
-
-
Dimethoate
-
affects the Km of the enzyme
dioxacarb
-
-
dipropan-2-yl phosphorofluoridate
-
-
dipropan-2-yl phosphorofluoridate
-
-
donecopride
synthesized from donepezil and RS67333, shows a double mechanism of action and good bioavailability, docking into the active-site gorge of hAChE. Replacement of the benzene ring of the compound by an indole residue should increase the interaction of the ligand with the peripheral anionic site (PAS), thus resulting in increased inhibition of beta-amyloid aggregation
donecopride
synthesized from donepezil and RS67333, shows a double mechanism of action and good bioavailability. Replacement of the benzene ring of the compound by an indole residue should increase the interaction of the ligand with the peripheral anionic site (PAS), thus resulting in increased inhibition of beta-amyloid aggregation
donepezil
-
reversible inhibitor
donepezil
-
inhibition in the nanomolar range
donepezil
-
50% inhibition at 22 nM
donepezil
-
7.9% inhibition at 0.025 mM
donepezil
-
besides inhibiting the acetylcholinesterase donepezil can act as a therapeutic tool to accelerate angiogenesis in cardiovascular disease patients, overview
donepezil
-
AChE activity in detergent soluble fraction of scopolamine amnesic mice is inhibited by donepezil, insulin and melatonin with varying extent in different brain regions, whereas AChE activity in salt soluble fraction is not much affected, overview
donepezil
-
donepezil concomitantly elevates VEGF expression in intracardiac endothelial cells of wild-type and alpha7 KO mice and further increases choline acetyltransferase protein expression, which is critical for acetylcholine synthesis in endothelial cells
donepezil
enzyme binding structure, analysis using structure PDB ID 1EVE, detailed overview
Echothiophate
-
complete inhibition of wild-type enzyme, not of mutant G122H/Y124Q/S125T
Echothiophate
-
99% inhibition of detergent-soluble enzyme activity at 0.001 mM, does not inhibit the soluble enzyme
edrophonium
-
-
edrophonium
-
reversible inhibitor
edrophonium
-
33.7% inhibition at 0.1 mM, competitive inhibition
edrophonium
-
the inhibitor binds specifically to the A-site of the enzyme
edrophonium
-
a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge
eptastigmine
-
inhibition in the nanomolar range
eptastigmine
-
50% inhibition at 22 nM
eserine
-
-
eserine
-
0.01 mM, more than 97% inhibition
eserine
-
strongest inhibition
eserine
-
less than 10% residual activity ar 10 mM
eserine
-
20.1% inhibition at 0.1 mM
eserine
-
almost complete inhibition
eserine
-
isozyme AChE1A, complete competitive inhibition at 0.016 mM
eserine
-
nonspecific and competitive inhibitor, time course of inhibition for the isozymes AChEA and AChEB, 10% and 30% activity remain after 60 min at 1.0 mM eserine, respectively
eserine
-
0.001 mM, almost complete inhibition
eserine
-
90% inhibition of the gill microsomal enzyme after 30 min at 0.005 mM
eserine
-
slight inhibition
eserine
-
a nonspecific inhibitor of ChEs, strongly inhibits the ChE activity at all concentrations tested, 0.00625-0.2 mM
eserine
-
a nonspecific inhibitor of ChEs, strongly inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM
eserine
-
a nonspecific inhibitor of ChEs, moderately inhibits ChE activity at all concentrations tested, 0.00625-0.2 mM
eserine
-
highly sensitive to inhibition by eserine (20% residual activity at 0.01 mM)
eserine
50% inhibition at 0.00054 mM
eserine
50% inhibition at 0.0006 mM
eserine
50% inhibition at 0.0005 mM
eserine
-
98% inhibition at 0.01 mM
eserine
-
highly sensitive to inhibition by eserine (10% residual activity at 0.01 mM)
eserine
i.e. physostigamine
eserine sulfate
-
selective inhibitor
Ethidium bromide
-
uncompetitive inhibition at concentrations of 0.00625-0.1 mM in all brain regions except for the cerebellum where the inhibition is of a mixed-type
ethiofencarb
-
-
ethopropazine
-
-
ethopropazine
-
0.01 mM, about 57% inhibition
ethopropazine
low inhibition
ethopropazine
-
reversible inhibitor
ethopropazine
-
50% inhibition at 0.26 mM
ethopropazine
ethopropazine is a substituted phenothiazine with a marked specificity for BChE. The 9000fold difference in Ki between hAChE and hBChE (EC 3.1.1.8) reflects this specificity
ethopropazine
-
about 5% inhibition at 0.001 mM
ethopropazine
-
partially
ethopropazine
-
7% inhibition at 0.01 mM
ethyl ((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)acetate
-
50% inhibition at 0.626 mM
ethyl ((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)acetate
-
50% inhibition at 0.460 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-3-phenylpropanoate
-
50% inhibition at 0.332 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-3-phenylpropanoate
-
50% inhibition at 0.406 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)hexanoate
-
50% inhibition at 0.321 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)hexanoate
-
50% inhibition at 0.506 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)propanoate
-
50% inhibition at 0.615 mM
ethyl (2S)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)propanoate
-
50% inhibition at 0.537 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.454 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.394 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.345 mM
ethyl (2S)-3-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.387 mM
ethyl (2S)-4-(methylthio)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.386 mM
ethyl (2S)-4-(methylthio)-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)butanoate
-
50% inhibition at 0.551 mM
ethyl (2S)-4-amino-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-4-oxobutanoate
-
50% inhibition at 0.420 mM
ethyl (2S)-4-amino-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)-4-oxobutanoate
-
50% inhibition at 0.385 mM
ethyl (2S)-4-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.196 mM
ethyl (2S)-4-methyl-2-((2-oxido-1,3,2-benzodioxaphosphol-2-yl)amino)pentanoate
-
50% inhibition at 0.427 mM
ethylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
F-
-
-
famphur-O
-
-
fasciculin
-
-
-
fasciculin
-
inhibits catalysis peripherally by sealing the mouth of the active center gorge
-
fasciculin
binds at the mouth of the gorge, decreases the mobility of reporter groups attached to L76C and Y124C, increases the mobility of reporter groups attached to E81C and E84C
-
fenamiphos
-
detailed analysis of inhibition kinetics
fenamiphos
-
a phosphoramidate, no reactivation by oximes
fenamiphos
an organophosphorous-based insecticide, binding structure, overview
fenamiphos
an organophosphorus compound and insecticide
fenitrothion
-
i.e. O,O-dimethyl-O-(3-methyl-4-nitrophenyl) phosphorothioate, 50% inhibition at 394 mM
fenitrothion
-
i.e. O,O-dimethyl-O-(3-methyl-4-nitrophenyl) phosphorothioate, 50% inhibition at 366 mM
fenobucarb
-
-
fenoxon
-
-
fenthion
-
-
fospirate
-
-
fuel oil
-
considering the complex composition of fuel oil, it is difficult to attribute the effects to specific substances
-
fuel oil
-
considering the complex composition of fuel oil, it is difficult to attribute the effects to specific substances
-
fuel oil
-
considering the complex composition of fuel oil, it is difficult to attribute the effects to specific substances
-
galantamine
galantamine competes with the substrate for binding to the active site of enzyme AChE in a reversible manner, inhibitory mechanism, overview
galantamine
-
inhibition in the nanomolar range
galantamine
89.26% inhibition at 0.1 mg/ml, docking study using the enzyme's crystal structure, PBD ID 1DX6
galanthamine
-
-
galanthamine
-
a naturally occurring alkaloid and a drug for the treatment of mild to moderate Alzheimer's disease
galanthamine
-
50% inhibition at 800 nM
galanthamine
-
inhibits also butyrylcholinesterase
galanthamine
-
a competitive and reversible, specific inhibitor, crosses the blood brain barrier, significantly increases brain cholinergic network activity
galanthamine
-
mixed type inhibition
galanthamine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
gallamine
-
inhibition by gallamine follows the steric blockade hypothesis, i.e. only substrate association to as well as substrate-product dissociation from the active site were reduced in the presence of the inhibitor
H2O2
-
1 mM significantly inhibits, 0.001 mM increases activity 2fold
H2O2
-
soluble isoform, 0.006 mM, 2.5fold increase in Km-value, at 0.6 mM, complete inhibition. Membrane isoform, activation at small concentrations, inhibition at higher concentrations, but also depending on substrate concentration
heptenophos
-
-
heptylene-bis-tacrine
-
-
Hg2+
-
-
Hg2+
-
AChEA and AChEB are completely inhibited by 1 mM of Hg2+
Hg2+
-
complete inhibition at 1 mM
HI-6
-
-
HI-6
-
more than 95% inhibition at 20 nM
huperzine
-
inhibition in the nanomolar range
huperzine
binds at the base of the active site gorge, has no effect on the mobility of reporter groups attached to L76C and Y124C, increases the mobility of reporter groups attached to E81C and E84C
huperzine A
-
-
huperzine A
-
linear mixed inhibition of AChE
huperzine A
-
a reversible AChE inhibitor
huperzine A
-
50% inhibition above 47 nM
huperzine A
-
reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
huperzine A
-
reversible inhibition
hydralazine HCl
-
reversible mixed-type inhibition
iso-ompa
-
50% inhibition at 0.034 mM
iso-ompa
-
very poor inhibitor
iso-ompa
tetraisopropyl diphosphoramide, inhibition of activity with butyrylthiocholine
isoprocarb
-
leptophos
-
linalool
-
weak in vitro inhibition
linalool
-
isolated from Thymus vulgaris essential oil
lovastatin
-
reversible mixed-type inhibition
lycorine
-
-
lycorine
-
isolated from mother liquors/waste material obtained after industrial production of galanthamine hydrobromide from Leucojum aestivum leaves
malaoxon
-
-
malaoxon
-
low inhibition, irreversible inhibitor
malathion
-
malathion
-
non-competitive inhibition
methamidophos
-
-
methamidophos
-
detailed analysis of inhibition kinetics
methamidophos
an organophosphorous-based insecticide, binding structure, overview
methiocarb
-
-
methomyl
-
-
methomyl
-
complete inhibition
methyl (3-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
-
-
methyl (3-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
-
-
methyl (3-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
-
-
methyl (3-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}propyl)phosphonofluoridate
-
-
methyl (4-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
-
-
methyl (4-{4-[({[5-(dimethylamino)naphthalen-1-yl]sulfonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
-
-
methyl (4-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
-
-
methyl (4-{4-[({[6-(diethylamino)-2-oxo-2H-chromen-3-yl]carbonyl}amino)methyl]-1H-1,2,3-triazol-1-yl}butyl)phosphonofluoridate
-
-
methyl [3-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
-
-
methyl [3-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
-
-
methyl [3-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
-
-
methyl [3-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)propyl]phosphonofluoridate
-
-
methyl [4-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
-
-
methyl [4-(4-{[(4-{(E)-[4-(dimethylamino)phenyl]diazenyl}benzoyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
-
-
methyl [4-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
-
-
methyl [4-(4-{[(pyren-2-ylsulfonyl)amino]methyl}-1H-1,2,3-triazol-1-yl)butyl]phosphonofluoridate
-
-
methyl {3-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propyl}phosphonofluoridate
-
-
methyl {3-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propyl}phosphonofluoridate
-
-
methyl {4-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]butyl}phosphonofluoridate
-
-
methyl {4-[4-({[(6-methoxy-2-oxo-2H-chromen-3-yl)carbonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]butyl}phosphonofluoridate
-
-
methylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
metrifonate
-
inhibition in the nanomolar range
mevinphos
-
-
mexacarbate
-
-
MMB-4
-
-
Monocrotophos
-
-
Monocrotophos
-
N-methyl carbamate-resistant strain is 65fold more sensitive than susceptible strain
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5,7,7,9,9-decamethylpentasiloxane-1,9-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5,7,7-octamethyltetrasiloxane-1,7-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3,5,5-hexamethyltrisiloxane-1,5-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N'-[(1,1,3,3-tetramethyldisiloxane-1,3-diyl)bis(methylene)]bis(N,N-dimethylmethanaminium)
-
reversible inhibitor
N,N,N-triethylethanaminium
-
reversible inhibitor
N,N,N-triethylethanaminium
-
reversible inhibitor
N,N,N-trimethyl-10-(methylsulfonylthio)decan-1-aminium bromide
-
i.e. AMTS10, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-10-(methylsulfonylthio)decan-1-aminium bromide
-
i.e. AMTS10, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-11-(methylsulfonylthio)undecan-1-aminium bromide
-
i.e. AMTS11, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-11-(methylsulfonylthio)undecan-1-aminium bromide
-
i.e. AMTS11, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-12-(methylsulfonylthio)dodecan-1-aminium bromide
-
i.e. AMTS12, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-12-(methylsulfonylthio)dodecan-1-aminium bromide
-
i.e. AMTS12, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-13-(methylsulfonylthio)tridecan-1-aminium bromide
-
i.e. AMTS13, causes a degree of apparently irreversible of the AChE activity in erythrocytes. AMTS13 at 0.006 mM leads to 43% inhibition after 1 h, 70% after 6 h, and 78% after 16 h
N,N,N-trimethyl-13-(methylsulfonylthio)tridecan-1-aminium bromide
-
i.e. AMTS13, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-14-(methylsulfonylthio)tetradecan-1-aminium bromide
-
i.e. AMTS14, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-14-(methylsulfonylthio)tetradecan-1-aminium bromide
-
i.e. AMTS14, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-15-(methylsulfonylthio)pentadecan-1-aminium bromide
-
i.e. AMTS15, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-15-(methylsulfonylthio)pentadecan-1-aminium bromide
-
i.e. AMTS15, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-16-(methylsulfonylthio)hexadecan-1-aminium bromide
-
i.e. AMTS16, causes a degree of apparently irreversible of the AChE activity in erythrocytes
N,N,N-trimethyl-16-(methylsulfonylthio)hexadecan-1-aminium bromide
-
i.e. AMTS16, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes 95% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
-
i.e. AMTS17, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes 95% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes over 80% irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, irreversibly inhibits 99% of the AChE activity in greenbug extracts, AChE species-selectivity
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
-
i.e. AMTS18, a Cys-targeting methanethiosulfonate molecule, causes irreversible inhibition, under conditions that spare the human enzyme
N,N,N-trimethyl-7-(methylsulfonylthio)heptan-1-aminium bromide
-
i.e. AMTS7, causes weak and purely reversible inhibition of AChE activity in erythrocytes
N,N,N-trimethyl-7-(methylsulfonylthio)heptan-1-aminium bromide
-
i.e. AMTS7, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-8-(methylsulfonylthio)octan-1-aminium bromide
-
i.e. AMTS8, causes weak and purely reversible inhibition of AChE activity in erythrocytes
N,N,N-trimethyl-8-(methylsulfonylthio)octan-1-aminium bromide
-
i.e. AMTS8, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethyl-9-(methylsulfonylthio)nonan-1-aminium bromide
-
i.e. AMTS9, causes weak and purely reversible inhibition of AChE activity in erythrocytes
N,N,N-trimethyl-9-(methylsulfonylthio)nonan-1-aminium bromide
-
i.e. AMTS9, irreversibly inhibits over 87% of the AChE activity in greenbug extracts
N,N,N-trimethylmethanaminium
-
reversible inhibitor
N,N,N-trimethylmethanaminium
-
pKi-values and comparison with inhibitory effect on horse and Berrytheutis magister butyrylcholinesterase EC 3.1.1.8
N,N,N-trimethylmethanaminium
-
reversible inhibitor
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
-
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
-
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
-
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
-
n-butylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
n-propylsarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
-
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
-
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
-
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
-
neostigmine
-
almost complete inhibition at 0.1 mM
neostigmine
-
high inhibition, irreversible inhibitor
neostigmine
-
31.1% inhibition at 0.1 mM
neostigmine
-
about 60% inhibition at 0.02 mM
neostigmine
-
as bromide or metasulfate, a non-specific cholinesterase inhibitor, used to inhibit hemolysate AChE activity in order to understand the specificity of 1-naphthyl acetate or acetylthiocholine for AChE
neostigmine
-
covalent, slow, and reversible inhibition
neostigmine
-
50% inhibition at 0.56 nM
neostigmine bromide
-
-
neostigmine bromide
-
competitive
neostigmine bromide
-
weak inhibition
neostigmine bromide
-
competitive
nifedipine
-
reversible mixed-type inhibition
O,O-diethyl S-hexyl phosphorothioate
-
-
O,O-diethyl S-hexyl phosphorothioate
-
-
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-butyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-ethyl S-(2-(ethylthio)ethyl) methylphosphonothioate
-
-
O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
O-ethyl S-heptyl methylphosphonothioate
-
-
O-ethyl S-heptyl methylphosphonothioate
-
-
O-ethyl S-hexyl methylphosphonothioate
-
-
O-ethyl S-hexyl methylphosphonothioate
-
-
O-ethyl S-neopentyl methylphosphonothioate
-
-
O-ethyl S-neopentyl methylphosphonothioate
-
-
O-ethyl S-pentyl methylphosphonothioate
-
-
O-ethyl S-pentyl methylphosphonothioate
-
-
O-ethyl-S-[2-(diisopropylamino)-ethyl]-methylphosphonothioate
nerve agent VX
O-ethyl-S-[2-(diisopropylamino)-ethyl]-methylphosphonothioate
nerve agent VX
O-ethyl-S-[2-(diisopropylamino)-ethyl]-methylphosphonothioate
VX
O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
O-pinacolyl methylphosphonofluoridate
-
i.e. soman, a nerve agent, leads to irrversible inhibition of AChE
O-pinacolyl methylphosphonofluoridate
i.e. soman
obidoxime
-
-
omethoate
-
oxidized malathion
-
50% inhibition at 0.216 mM
oxidized malathion
-
50% inhibition at 0.203 mM
oxidized malathion
-
50% inhibition at 0.248 mM
oxidized triazophos
-
50% inhibition at 0.043 mM
oxidized triazophos
-
50% inhibition at 0.036 mM
oxidized triazophos
-
50% inhibition at 0.043 mM
oxydemeton methyl
-
-
palmatine
-
-
paraoxon
-
-
paraoxon
-
complete inhibition of wild-type enzyme, not of mutant G122H/Y124Q/S125T
paraoxon
-
more than 95% inhibition at 0.001 mM
paraoxon
-
irreversible inhibitor
paraoxon
-
an organophosphate compound, a quasi-irreversible AChE inhibitor
paraoxon
-
irreversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
paraoxon
-
oxime-induced reactivation of the enzyme following inhibition by sarin or paraoxon, overview
paraoxon
-
irreversible inhibition
paraoxon
-
activity of cholinesterase reactivators pralidoxime, obidoxime, trimedoxime, methoxime and H-oxime HI-6, i.e. 1-(4-hydroxyiminomethylpyridinium)-3-(4-carbamoylpyridinium)-2-oxapropane dichloride, in reactivation of plasma AChE inhibited by pesticide paraoxon, efficacies, none of tested oximes surpassed 25% of AChE reactivation, overview
paraoxon
-
the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview
paraoxon
-
i.e. O,O-diethyl-O-4-nitrophenyl phosphate, the paraoxon-inhibited enzyme is reactivated by several compounds, kinetics, overview. Best reactivating compounds are obidoxime, K027, and trimedoxie
paraoxon
-
more than 95% inhibition at 0.001 mM
paraoxon
-
50% inhibition at 212.5 nM
paraoxon
-
50% inhibition at 357 nM
paraoxon
-
enzyme from Huanghua population is 1.6fold less sensitive than from Pingshan population
paraoxon
-
irreversible inhibition
paraoxon
-
26% inhibition at 0.0000001 mM, reversible binding to a site on acetylcholinesterase distinct from the active site reduces their subsequent capacity to phosphorylate the active site
paraoxon
-
does not inhibit SS ChE, completely inhibits DS ChE at 1 mM
paraoxon
-
more than 95% inhibition at 0.001 mM
paraoxon-ethyl
-
paraoxon-ethyl
-
detailed analysis of inhibition kinetics
paraoxon-methyl
-
inhibition mechanism and reactivation of paraoxon-methyl-inhibited AChE by pyridine-2-aldoxime methochloride, overview
paraoxon-methyl
-
detailed analysis of inhibition kinetics
parathion
-
-
Pb2+
-
-
phenserine
-
inhibition in the nanomolar range
phenserine
-
50% inhibition at 22 nM
phenyl 1,2-dimethylhydrazinecarboxylate
-
-
phenyl 1,2-dimethylhydrazinecarboxylate
-
-
phenyl 1-methylhydrazinecarboxylate
-
-
phenyl 1-methylhydrazinecarboxylate
-
-
Phenylmethylsulfonylfluoride
-
Phenylmethylsulfonylfluoride
-
-
Phosphamidon
-
-
physostigmine
-
-
physostigmine
-
irreversible inhibitor
physostigmine
-
mechanism of inhibition
physostigmine
-
92.5% inhibition, IC50 is 0.0028 mg/ml
physostigmine
-
about 50% inhibition at 0.02 mM
physostigmine
-
inhibition in the nanomolar range
physostigmine
-
reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
physostigmine
-
reversible inhibition
physostigmine
-
71.2% inhibition at 0.1 mg/ml
physostigmine
-
83-85% inhibition at 250 nM of erythrocyte and muscle enzymes, pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE
physostigmine
-
inhibits also butyrylcholinesterase
physostigmine
-
covalent, slow, and reversible inhibition
pirimicarb
-
-
pralidoxime
-
-
procainamide
low inhibition
profenofos
-
-
promecarb
-
-
propidium
-
-
propidium
-
reversible inhibitor
propidium
-
the inhibitor binds specifically to the P-site of the enzyme
propidium
50% inhibition at 0.196 mM
propidium
50% inhibition at 0.114 mM
propidium
50% inhibition at 0.155 mM
propidium
-
a reversible peripheral anionic site inhibitor, which interacts with a site at the entrance to the gorge
propidium
structure of the complex is solved at 3.0 A resolution, absence involving Trp279 in TcAChE at the gorge
propidium iodide
-
-
propionylthiocholine
the recombinant carp AChE shows substrate inhibition at high substrate concentrations of acetyl- and propionylthiocholine
propionylthiocholine
-
substrate inhibition
propionylthiocholine
-
N-methyl carbamate-resistant strain, no substrate inhibition up to 0.01 mM
propoxur
-
propoxur
i.e. 2-isopropoxyphenyl-N-methylcarbamate, complete inhibition at concentrations exceeding 100 nM; i.e. 2-isopropoxyphenyl-N-methylcarbamate, complete inhibition at concentrations exceeding 100 nM
propoxur
-
N-methyl carbamate-resistant strain is 53fold less sensitive than susceptible strain
pyridostigmine
-
irreversible inhibitor
pyridostigmine
-
6.1% inhibition at 0.1 mM
pyridostigmine
-
reversible inhibition, effects of pre-inhibition by physostigmine, pyridostigmine and huperzine A on inhibition by paraoxon, overview
pyridostigmine
-
reversible inhibition
pyridostigmine
-
pre-inhibition of AChE with pyridostigmine or physostigmine results in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between erythrocyte and muscle AChE
pyridostigmine
a non-selective inhibitor of cholinesterases (ChEs)
pyridostigmine
a non-selective inhibitor of cholinesterases (ChEs)
R-DEPP
O,S-diethylphenylphosphonothioate, both S- and R-DEPP are poor inhibitors of eel AChE, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative. Kinetic analysis of S-DEPP with cholinesterases
R-DEPP
O,S-diethylphenylphosphonothioate, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative O,S-diethylphenylphosphonothioate. Chemical modification by DEPP, a measurable amount of the enzyme-phosphonate adduct does not undergo aging
rivastigmin
-
-
rivastigmine
-
trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneous at a slow rate
rivastigmine
-
trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneously at a slow rate
rivastigmine
-
50% inhibition at 0.048 mM
rivastigmine
-
50% inhibition at 4150 nM
rivastigmine
trade name: Exelon, carbamylates the enzyme, 10% spontaneous reactivation after 48 h
russian VX
-
-
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
-
-
S-(3,3-dimethylbutyl) O,O-diethyl phosphorothioate
-
-
S-DEPP
O,S-diethylphenylphosphonothioate, both S- and R-DEPP are poor inhibitors of eel AChE, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative
S-DEPP
O,S-diethylphenylphosphonothioate, stereospecific inhibition kinetics and stereospecificity of the chiral nerve agent derivative O,S-diethylphenylphosphonothioate. Chemical modification by DEPP, a measurable amount of the enzyme-phosphonate adduct does not undergo aging. Pralidoxime, a common rescue agent, affects a modest recovery of eqBChE from treatment with S-DEPP. S-DEPP inhibition is practically irreversible. Kinetic analysis of S-DEPP with cholinesterases
sarcovagenine-C
-
isolated from Sarcococca saligna
sarin
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
sarin
-
more than 95% inhibition at 50 nM
sarin
-
detailed analysis of inhibition kinetics
sarin
-
oxime-induced reactivation of the enzyme following inhibition by sarin or paraoxon, overview
sarin
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
sarin
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
sarin
-
more than 95% inhibition at 30 nM
sarin
isopropylmethylphosphonofluoridate, GB
sarin
nerve agent, binding structure, overview
sarin
-
more than 95% inhibition at 50 nM
serine
-
-
serpentine
-
isolated from aqueous extracts of Catharanthus roseus roots
serpentine
-
isolated from aqueous extracts of Catharanthus roseus roots, competitive blockade of muscarinic receptors with high efficiency
sevin
-
-
simvastatin
-
reversible mixed-type inhibition
soman
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
soman
-
pyridostigmine or physostigmine pre-treatment protects a critical level of muscle AChE from inhibition by soman
soman
-
detailed analysis of inhibition kinetics
soman
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
soman
-
a methylfluorophosphonate, enzyme reactivation by oximes, overview
soman
-
inhibition with rapid aging of the inhibited enzyme, partial protection of the enzyme by reversible inhibition in case of soman exposure or of paraoxon inhibition, overview
soman
-
the inhibition gets irreversible due to aging, but is reversible before by oximes, pre-treatment with carbamates improves antidotal treatment substantially, high reversibility effects by pyridostigmine or physostigmine, overview
soman
-
pyridostigmine or physostigmine pre-treatment protects a critical level of muscle AChE from inhibition by soman
soman
-
pyridostigmine or physostigmine pre-treatment protects a critical level of muscle AChE from inhibition by soman
soman
-
pyridostigmine or physostigmine pre-treatment protects a critical level of muscle AChE from inhibition by soman
Tabun
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
Tabun
-
detailed analysis of inhibition kinetics
Tabun
-
a phosphoramidate, 16 derivatives, overview, no reactivation by oximes
Tabun
-
reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview
Tabun
i.e. N,N-dimethylamido-O-ethyl cyanophosphate, superposition of model complexes between tabun-AChE conjugate (from PDB IDs 2JEZ, 3DL4, and 2JF0) and oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane dibromide, 4-carbamoyl-1-(3-(3-chloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium dibromide, and 4-carbamoyl-1-(4-(3,5-dichloro-4-[(hydroxyimino)methyl]-pyridinium-1-yl)propyl)pyridinium dibromide
Tabun
-
an organophosphorous inhibitor
tacrine
-
tacrine
-
reversible inhibitor
tacrine
-
a mixed-type inhibitor with a strong noncompetitive component, completely blocks deacylation of the acyl-enzyme
tacrine
-
i.e. 9-amino-1,2,3,4-tetrahydroacridine hydrochloride, 54.2% inhibition at 0.1 mM, mixed-type inhibition
tacrine
-
inhibition in the nanomolar range
tacrine
-
50% inhibition at 190 nM
tacrine
-
inhibits also butyrylcholinesterase
tacrine
-
i.e. 9-amino-1,2,3,4-tetrahydroacridine, mixed competitive-uncompetitive inhibition
tacrine
-
a reversible active-site directed inhibitor, which interacts with the catalytic anionic subsite, at the bottom of the active-site gorge
temephos
-
-
terpinen-4-ol
-
isolated from Melaleuca atlernifolia
terpinen-4-ol
-
IC50 is 3.2 mg/ml
tetrachlorvinphos
-
-
tetraethyl diphosphate
-
-
tetraethyl diphosphate
-
-
tetraethylpyrophosphate
-
-
tetraethylpyrophosphate
-
thiodicarb
-
-
thioflavin T
-
the P-site-specific ligand inhibits the hydrolysis of the rapidly hydrolyzed substrate acetylthiocholine but fails to show any inhibition of the slowly hydrolyzed substrates 3-(acetamido)-N,N,N-trimethylanilinium and carbachol
thioflavin T
ThT, is not sufficiently long to span the P-site and the choline binding site pocket of enzyme TcAChE. The benzothiazole and dimethylaminophenyl rings, and the dimethylamino group of this ligand are coplanar and lay parallel to Trp279 and Tyr334 and Phe330, respectively. The dimethylamino group is at 3.3 A from the aromatic ring of Phe330 but remains far from the gorge bottom, at a distance of 8.5 A from the carboxylate oxygens of Glu199. This position at the P-site allows concomitant binding of A-site ligands like edrophonium or m-(N,N,N-trimethylammonio)trifluoroacetophenone (TMTFA) through an adjustment of the orientation of Phe330
thiomethylcyclosarin
-
thiomethylsarin
-
thiomethylsoman
-
thymohydroquinone
-
high in vitro inhibition, compound of the essential oil of Thymus vulgaris
thymohydroquinone
-
isolated from Thymus vulgaris essential oil
Thymol
-
in vitro inhibition, compound of the essential oil of Thymus vulgaris
Thymol
-
isolated from Thymus vulgaris essential oil
thymoquinone
-
in vitro inhibition, compound of the essential oil of Thymus vulgaris
thymoquinone
-
isolated from Thymus vulgaris essential oil
VX (nerve agent)
-
-
VX (nerve agent)
-
i.e. S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothionate, a nerve agent
VX (nerve agent)
-
pseudo-irreversible inhibition
VX (nerve agent)
i.e. O-ethyl S-2-isopropylaminoethyl methylphosphonothiolate, nerve agent, binding structure, overview
VX (nerve agent)
-
a nerve agent
xanthostigmine
-
-
xanthostigmine
-
three-dimensional model of the quaternary complex between AChE and xanthostigmine
Zn2+
-
-
Zn2+
-
17% inhibition at 1 mM
additional information
greater sensitivity of recombinant isozyme TcAChE1 to the 10 tested insecticides compared to isozyme TcAChE2; greater sensitivity of recombinant isozyme TcAChE1 to the 10 tested insecticides compared to isozyme TcAChE2
-
additional information
greater sensitivity of recombinant isozyme TcAChE1 to the 10 tested insecticides compared to isozyme TcAChE2; greater sensitivity of recombinant isozyme TcAChE1 to the 10 tested insecticides compared to isozyme TcAChE2
-
additional information
-
greater sensitivity of recombinant isozyme TcAChE1 to the 10 tested insecticides compared to isozyme TcAChE2; greater sensitivity of recombinant isozyme TcAChE1 to the 10 tested insecticides compared to isozyme TcAChE2
-
additional information
-
not inhibited by Iso-OMPAand aldicarb
-
additional information
-
no substrate inhibition by acetylthiocholine
-
additional information
-
organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from erythrocytes, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship
-
additional information
-
not inhibited by iso-OMPA
-
additional information
-
some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin
-
additional information
-
lycoparin A and lycoparin B, alkaloids from Lycopodium casuarinoides, are not inhibitory, NMR structure determination and analysis, overview
-
additional information
-
inhibitory potency of Trigonella foenum graecum crude seed extract, the ethylacetate fractions gives strong AChE inhibition with IC50 of 0.053 mg/ml, and the total alkaloid fraction inhibits with IC50 of 0.0092 mg/ml, overview
-
additional information
-
inhibitory potency of sesquiterpenoids with dihydroagarofuran skeleton, isolated from methanolic extracts of stems, leaves, and seeds of Maytenus disticha, collected in Chillan, Chile, NMR structure determination, overview
-
additional information
-
inhibition mechanism, overview
-
additional information
-
the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, determination of the aging rate constants of nerve agent-inhibited AChE, overview
-
additional information
-
acute toxicity of the nerve agents in guinea pigs is age- and sex-dependent and cannot be fully accounted for by the irreversible inhibition of AChE
-
additional information
-
no inhibitory effect by EDTA and tetraisopropyl diphosphoramide
-
additional information
-
diazinon and temephos do not inhibit the enzyme
-
additional information
-
tetraisopropyl diphosphoramide does not reach 50% inhibition in the concentration range of the assays (0.001-10 mM)
-
additional information
-
no inhibition by Cd2+ and Zn2+ up to 1 mM of the brain enzyme
-
additional information
ethanol does not inhibit the enzyme activity, but decreases enzyme expression by over 80% at 1%, no inhibition by acetate
-
additional information
-
ethanol does not inhibit the enzyme activity, but decreases enzyme expression by over 80% at 1%, no inhibition by acetate
-
additional information
the interaction between AChE and silver nanoparticles (AgNPs) leads not only to a decrease in AChE activity, but also to a reduction in the crystallinity and stability of AgNPs. The circular dichroism demonstrates that the secondary structure of AChE also declines after 30 min of incubation with AgNPs at 37°C. Smaller AgNPs result in size increments after interaction with enzymes, while the larger ones show size decrements
-
additional information
-
the quaternary pyridinium aldoximes, pralidoxime (2-PAM) and a lead zwitterionic oxime (RS194B), are both able to reactivate DjChE ATCh hydrolyzing activity at concentrations of 4 mM. Also NaF can reactivate DjChE activity, and the rate of reactivation shows a linear dependence on fluoride concentration. Reactivation of DjChE is significantly more rapid with 10 mM NaF than with 4 mM 2-PAM
-
additional information
-
inhibition of DjChE activity by exposing animals to either an organophosphorus pesticides (e.g. diazinon) or carbamates (e.g. physostigmine). At high doses, organophosphorus pesticides are lethal to both insects and humans due to inhibition of AChE and subsequent cholinergic toxicity
-
additional information
-
no inhibition by iso-OMPA
-
additional information
-
inhibition of enzyme activity after exposure to cellular phone irradiation for more than 10 min. Irradiation induces formation of a enzyme hydrogel from the assembly of highly hydrated protein molecules
-
additional information
-
proposed mechanism for enzyme inhibition by N-butylcarbamates and detailed kinetics of inhibition
-
additional information
-
the enzyme is not affected by ethanol concentrations up to 500 mM
-
additional information
-
some inhibitors fullfill the competitive inhibition model with irreversible reaction between enzyme and inhibitor, but e.g. not galantamin
-
additional information
-
selectivity and inhibitory potency of isaindigotone derivatives for inhibition of AChE
-
additional information
-
binding structures and inhibitory potencies of isosorbide di-esters, that are mixed inhibitors of the enzyme forming a ternary enzyme-inhibitor-substrate complex, molecular modelling, overview. The di-esters dock within the butyrylcholinesterase gorge in a very different manner, with the ester side chain at the 5-position occupying the acyl pocket at residues Leu286 and Val288, and the 2-ester binding to Trp82. The carbonyl group of the 2-ester is susceptible to nucleophilic attack by Ser198 of the catalytic triad. The larger residues of the acyl pocket in acetylcholinesterase prevent binding in this manner
-
additional information
-
potency and mechanism of diverse enzyme inhibitors, corydaline and ribalinine, isolated from Skimmia laureola, are specific for acetylcholinesterase, overview
-
additional information
-
inhibitor screening by solid-phase extraction-liquid chromatography/electrospray ionisation-octopole-orthogonal acceleration time-of-flight-mass spectrometry and novel thin-layer chromatography-based bioautography, overview
-
additional information
-
ethanolic extract from the fruits of Pimpinella anisoides, an aromatic plant and a spice, exhibits activity against AChE with an IC50 value of 0.2275 mg/ml, chemical composition of the extract, GC analysis, overview
-
additional information
-
chromophore-linked fluorophosphonate inhibitors show bimolecular inhibition constants ranging from 0.3 * 105 M/min to 10.4 * 105 M/min
-
additional information
-
synthesis and biological evaluation of berberine derivatives as potent acetylcholinesterase inhibitors, kinetic and molecular modeling studies, overview
-
additional information
-
synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of acetylcholinesterase, mechanism of inhibition, overview
-
additional information
-
comparison of bisquaternary pyridinium oximes in in vitro reactivation paraoxon-inhibited and tabun-inhibited acetylcholinesterase from Electrophorus electricus and Homo sapiens, overview. Effects on reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers, kinetics, overview
-
additional information
-
synthesis and inhibitory potencies of 2(2-alkoxyphenyl)-1H-imidazoles and benzyl[1-(1H-imidazol-4(5)-yl)ethyl]carbamate compounds, inhibition mechanism, overview
-
additional information
-
acetylcholinesterase inhibition induced by endogenous neurotoxin with an enzyme-semiconductor photoelectrochemical system, method development and evaluation, overview
-
additional information
-
adsorption and inhibition of AChE by eight nanoparticles, SiO2, TiO2, Al2O3, Al, Cu, Cu-C (carbon-coated copper), multiwalled carbon nanotubes (MWCNT) and single-walled carbon nanotubes (SWCNT), adsorption and inhibition rates of AChE by different nanoparticles, overview
-
additional information
-
no inhibition by (S)-(-)-exo-2-norbornyl-N-n-butylcarbamate at 0.01 mM. Optically pure2-norbornyl-N-n-butylcarbamate enantiomers are synthesized from condensations of optically pure (R)-(1)-exo-, (S)-(2)-exo-, (R)-(1)-endo-, and (S)-(2)-endo-2-norborneols with n-butyl isocyanate, respectively. Molecular modeling, overview
-
additional information
-
inhibitor analysis using capillary electrophoresis with contactless conductivity detection, method development, overview
-
additional information
-
inhibitor design and evaluation using cardanol derivatives and the B3LYP method, structures with substitution by N,N-dimethycarbamoyl, N,N-dimethylamine, and pyrrolidine groups are better correlated to rivastigmine, and represent possible AChE inhibitors against Alzheimer's disease, overview. Cardanol is a non-isoprenoid phenolic lipid of cashew Anacardium occidentale nut-shell liquid
-
additional information
-
interaction of acetylcholinesterase with acetonitrile and tacrine or gallamine results in a 7-10fold increase in the KI values, whereas the principal mode of inhibition is not affected by the organic solvent
-
additional information
-
commercially available essential oils extracted from Artemisia dracunculus L., Inula graveolens L., Lavandula officinalis Chaix, and Ocimum sanctum L. show inhibitory activity on the enzyme, with highest inhibitory activity of Artemisia dracunculus oil with an IC50 of 0.058 mg/ml, overview
-
additional information
-
descending order of inhibitory potency is tacrine, edrophonium, neostigmine, eserine, pyridostigmine
-
additional information
-
isolation of acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp. alpestre, NMR structure determination, and molecular modelling of interactions of the alkaloids with the enzyme, overview
-
additional information
-
extracts of Achyrocline tomentosa, Eupatorium viscidum, Ruprechtia apetala, Trichocline reptans, and Zanthoxylum coco present strong inhibition of AChE, higher than 80% at 1 mg/mL. The extracts from Ruprechtia apetala and Trichocline reptans are the most potent, showing complete inhibition of the enzyme with IC50 values 0.0779 and 0.1118 mg/mL, respectively, overview. Acetylcholinesterase inhibitory activity of organic and aqueous fractions obtained from extracts of diverse other plants of central Argentina, overview. IC50 value of Achyrocline tomentosa extract is 0.485 mg/ml, of Eupatorium viscidum is 0.479 mg/ml, and 0.158 mg/ml for extract of Zanthoxylum coco
-
additional information
-
Mg2+ ameliorates inhibitory effects of AChE inhibitors
-
additional information
-
total alkaloidal extract from the seeds of Holarrhen antidysenterica strongly inhibit the enzyme with an IC50 value of 0.0061 mg/ml
-
additional information
thiols block the enzymatic etching of gold nanorods(thiocholine on the rate of horseradish peroxidase-catalyzed AuNR etching), application to colorimetric detection of acetylcholinesterase activity and its inhibitors, method, detailed overview
-
additional information
evaluation of the potential of six dihydroxanthyletin-type coumarins, isolated from Angelica decursiva, to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (BChE, EC 3.1.1.8), and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1, EC 3.4.23.46). AChE protein-ligand docking studies, overview
-
additional information
synthesis, crystal structure determination, biological screening, and docking studies of N1-substituted derivatives of 2,3-dihydroquinazolin-4(1H)-one as inhibitors of cholinesterases, structure-activity relationships, overview
-
additional information
evaluation of a combination of both anticholinesterase and beta-amyloid anti-aggregation activities in one molecule, and therapeutic potential in vivo. Design and synthesis of 28 compounds as derivatives of donepezil that contain the N-benzylpiperidine moiety combined with the phthalimide or indole moieties. No or poor inhibition by 23, 27, 28, 30, 38, 39, 40, and 41
-
additional information
design, synthesis, and biological evaluation of multifunctional tacrine-curcumin hybrids as cholinesterase inhibitors with metal ions-chelating and neuroprotective properties, overview. The hybrid compounds show good cholinesterase inhibitory activity, some of the compounds exhibited different selectivity on acetylcholinesterase or butyrylcholinesterase due to the structural difference. Structure-activity relationships, molecular modelling, overview
-
additional information
designed and molecular recognition studies of coumarin-based inhibitors towards acetylcholinesterase (AChE), molecular docking simulations, dissociation constant and bound conformations of these inhibitors within the inhibitor-AChE complex, overview. The docking simulations mimic NMR results
-
additional information
molecular docking, modelling, overview
-
additional information
mass spectrometric analysis and inhibitory potency of homologous piperidine alkaloids as acetylcholinesterase inhibitors, overview. Besides other aspects, the 2-methyl-3-hydroxypiperidine moiety is an important interaction site for the observed activity
-
additional information
-
no substrate inhibition up to 17 mM acetylcholine iodide
-
additional information
-
-
-
additional information
-
no inhibition by iso-OMPA, lethal effects due to enzyme inhibition in vivo appear at inhibition levels over 50%
-
additional information
-
no inhibition by iso-OMPA
-
additional information
-
both isoenzymes are not affected by tetra(monoinopropyl)diphosphotetramide (isoOMPA) at high concentrations up to 50 mM
-
additional information
-
AChE isoenzymes, AChEAII and AChEBI isolated from Heterorhabditid bacteriophora EM2 strain, show insensitivity to inhibition by insecticides in a descending order: methomyl, carbofuran, acetamiprid, oxamyl, malathion. The two AChE isoforms are several folds less sensitive to inhibition by methomyl and carbofuran compared to those previously reported for other insect species. Except for malathion, all the insecticides competitively inhibit Heterorhabditid bacteriophora AChEs with Ki values ranging from 0.10 to 15 mM
-
additional information
-
comparison of reaction rates with human acetylcholinesterase EC 3.1.1.7 and butyrylcholinesterase EC 3.1.1.8 for several organophosphate inhibitors
-
additional information
-
comparison of 50% inhibitory concentration for EC 3.1.1.7 and EC 3.1.1.8
-
additional information
-
structure-function relationship of inhibition, overview
-
additional information
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the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, determination of the aging rate constants of nerve agent-inhibited AChE, overview
-
additional information
-
no inhibition by albomaculine, 7-deoxy-trans-dihydronarciclasine, and haemanthidine
-
additional information
-
influence of pre-inhibition with reversible inhibitors on irreversible inhibition by other compounds, overview
-
additional information
-
inhibitor structure-activity relationships, simulation of pseudo-irreversible AChE covalent inhibitors, overview
-
additional information
-
design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview
-
additional information
-
quantitative structure-activity relationships, overview
-
additional information
-
inhibitor molecular mechanics calculations, general mechanism of pseudoirreversible cholinesterase inhibition by carbamates. Enzyme deactivation is initiated by nucleophilic attack of the catalytic triad serine oxygen on the carbonyl group of the carbamate, structure-activity relationships, overview
-
additional information
-
design and study of two classes of noncompetitive acetylcholinesterase inhibitors, which also function as non-steroidal anti-inflammatory drug prodrugs. The most potent AChEIs disclosed contain an aromatic alkyl-aryl linker between an non-steroidal anti-inflammatory drug and a lipophilic choline mimic, and they inhibit AChE in the submicromolar range, overview
-
additional information
-
inhibitors docking studies, enzyme binding structure and molecular modeling, overview
-
additional information
-
comparison of bisquaternary pyridinium oximes in in vitro reactivation paraoxon-inhibited and tabun-inhibited acetylcholinesterase from Electrophorus electricus and Homo sapiens, overview. Effects on reactivation potency of compounds bearing aliphatic linkers and heteroaromatic linkers, kinetics, detailed overview
-
additional information
-
inhibitory potencies of sarin and tabun derivatives, overview
-
additional information
-
the enzyme inhibited by organophosphorous compounds can not or poorly be reactivated by pyridinium oximes, 1-phenacyl-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide, 1-(4'-chlorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide, 1-(4'-fluorophenacyl)-3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methylpyridinium bromide, 3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methyl-1-(4'-methylphenacyl)pyridinium bromide, and 3-hydroxy-4-hydroxyiminomethyl-5-hydroxymethyl-2-methyl-1-(4'-methoxyphenacyl)pyridinium bromide, overview
-
additional information
-
development and synthesis of two families of dual binding site acetylcholinesterase inhibitors consisting of a tacrine or 6-chlorotacrine unit as the active site interacting moiety, either the 5,6-dimethoxy-2-[(4-piperidinyl)methyl]-1-indanone fragment of donepezil (or the indane derivative thereof) or a 5-phenylpyrano[3,2-c]quinoline system, reminiscent to the tryciclic core of propidium, as the peripheral site interacting unit, and a linker of suitable length as to allow the simultaneous binding at both sites. These hybrid compounds are all potent and selective inhibitors of human AChE, and are able to interfere in vitro both formation and aggregation of the beta-amyloid peptide, the latter effects endowing these compounds with the potential to modify Alzheimers disease progression. No inhibition by propidium iodide. In hibitor molecular dynamics simulations, overview
-
additional information
-
chemical compositions and acetylcholinesterase inhibitory activitiy of the volatile oil from the bark of Peltophorum dasyrachis, yellow batai, IC50 value is 0.083 mg/ml, overview. The order of AChE inhibitory potency by bisabolane-type sesquiterpenoids is: ketones > alcohols > hydrocarbons, Structure-activity relationships of inhibitors, overview
-
additional information
-
pesticide and organophosphate analysis in different soil samples using the enzyme in a photometric assay, overview
-
additional information
-
carbacylamidophosphate derivatives, inhibitor synthesis and evaluation in inhibition of acetylcholinesterase and butyrylcholinesterase, EC 3.1.1.8, kinetics and comparisons, overview
-
additional information
-
synthesis of a set of 1,4-dihydroquinolines and their corresponding quinolinium salts as potential enzyme inhibitors, overview. All reduced forms are unable to exhibit any anticholinesterase activity, while most of the quinolinium salts display high AChE inhibitory activity with IC50 values ranging from 0.006 mM to 7 nM. Design of a bio-oxidisable prodrug for central selective AChE inhibitory activity
-
additional information
-
the ensemble of compounds 1 and 2 can be used for the AChE activity assay and the inhibitor-screening by making use of the aggregation-induced emission feature of tetraphenyl ethylene compounds, method development, overview
-
additional information
-
no inhibition by pseudotaraxasterol and taraxasterol from the ethanolic extract of Chuquiraga erinacea D. Don. subsp. erinacea leaves
-
additional information
-
poor inhibition of 0-2% by N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide, i.e. AMTS17, N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide, i.e. AMTS18, N,N,N-trimethyl-19-(methylsulfonylthio)nonadecan-1-aminium bromide, i.e. AMTS19, and N,N,N-trimethyl-20-(methylsulfonylthio)eicosan-1-aminiumbromide, i.e. i.e. AMTS20
-
additional information
-
pentylsarin derivative inhibitors, structure-activity relationship and inhibition kinetics, overview
-
additional information
-
semi-preparative isolation of the tabun enantiomers, and analysis of inhibitory potential and kinetics, overview. Reactivation kinetics of tabun-inhibited AChE with obidoxime, overview. Aging of tabun-inhibited human AChE, kinetics are similar for the tabun enantiomers, overview
-
additional information
determination and analysis of the crystal structures of enzyme-bound ligands
-
additional information
recombinant HuAChE shows substrate inhibition
-
additional information
synthesis of three series of imidazolidinium ligands (NHC precursors) substituted with 4-vinylbenzyl, 2-methyl-1,4-benzodioxane, and N-propylphthalimide, and evaluation of the inhibitory potency against enzyme AChE
-
additional information
-
synthesis of three series of imidazolidinium ligands (NHC precursors) substituted with 4-vinylbenzyl, 2-methyl-1,4-benzodioxane, and N-propylphthalimide, and evaluation of the inhibitory potency against enzyme AChE
-
additional information
organophosphates covalently modify acetylcholinesterase catalytic serine leading to inhibition and in most cases can result in additional processes that age the enzyme
-
additional information
-
organophosphates covalently modify acetylcholinesterase catalytic serine leading to inhibition and in most cases can result in additional processes that age the enzyme
-
additional information
development, synthesis, and evaluation of a series of indole derivatives possessing in vitro inhibitory activities against AChE, structure-function analysis, overview
-
additional information
structure-activity relationships, kinetics and molecular docking studies of 1-butanoyl-3-arylthiourea derivatives, overview
-
additional information
development and synthesis of N-propylphthalimide- and 4-vinylbenzyl-substituted benzimidazole salts as inhibitors of acetylcholinesterase, structure-activity relationships, overview. Determination of Fe2+ chelating capacities of the compounds
-
additional information
pyridinium oximes with ortho-positioned chlorine moiety provide efficient reactivation of human acetylcholinesterase inhibited by several nerve agents, overview. The most potent is the dichlorinated analogue of oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane dibromide with significantly improved ability to reactivate the conjugated enzyme due to improved binding affinity and molecular recognition. Among the standard oximes, trimedoxime (TMB-4) is the superior reactivator of tabun-inhibited AChE, but it is also the most toxic, which prevents its use in therapy, while asoxime (HI-6) has no reactivation potency (below 20%). Reversible inhibition of recombinant human AChE and purified human plasma butyrylcholinesterase (BChE, EC 3.1.1.8) with oximes. The parent compounds and the commercial standards pralidoxime and asoxime are predicted to have minimal CNS penetrability. 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane dibromide, 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide, and (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene dibromide oximes show low cytotoxic potential in different cell lines, fibroblasts and hepatic, kidney, blood, and ovary cells
-
additional information
-
pyridinium oximes with ortho-positioned chlorine moiety provide efficient reactivation of human acetylcholinesterase inhibited by several nerve agents, overview. The most potent is the dichlorinated analogue of oxime 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane dibromide with significantly improved ability to reactivate the conjugated enzyme due to improved binding affinity and molecular recognition. Among the standard oximes, trimedoxime (TMB-4) is the superior reactivator of tabun-inhibited AChE, but it is also the most toxic, which prevents its use in therapy, while asoxime (HI-6) has no reactivation potency (below 20%). Reversible inhibition of recombinant human AChE and purified human plasma butyrylcholinesterase (BChE, EC 3.1.1.8) with oximes. The parent compounds and the commercial standards pralidoxime and asoxime are predicted to have minimal CNS penetrability. 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)propane dibromide, 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane dibromide, and (E)-1-(4-carbamoylpyridinium)-4-(4-hydroxyiminomethylpyridinium)but-2-ene dibromide oximes show low cytotoxic potential in different cell lines, fibroblasts and hepatic, kidney, blood, and ovary cells
-
additional information
the inhibition of cholinesterases (ChEs) by carbamates includes a carbamylation (inhibition) step, in which the drug transfers its carbamate moiety to the active site of the enzyme and a decarbamylation (activity recovery) step, in which the carbamyl group is hydrolyzed from the enzyme. The carbamylation and decarbamylation kinetics decide the extent and the duration of the inhibition, thus the full characterization of candidate carbamate inhibitors requires the measurement of the kinetic constants describing both steps. By the analysis of the area under the inhibition-time curve of cholinesterases inhibited by carbamates it is possible to calculate the decarbamylation rate constant from the same data traditionally used to characterize only the carbamylation kinetics, therefore it is possible to obtain a full characterization of the inhibition with a single set of experiments, method validation, a simple and useful approach to reduce the time required for the characterization of carbamate inhibitors, overview
-
additional information
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the inhibition of cholinesterases (ChEs) by carbamates includes a carbamylation (inhibition) step, in which the drug transfers its carbamate moiety to the active site of the enzyme and a decarbamylation (activity recovery) step, in which the carbamyl group is hydrolyzed from the enzyme. The carbamylation and decarbamylation kinetics decide the extent and the duration of the inhibition, thus the full characterization of candidate carbamate inhibitors requires the measurement of the kinetic constants describing both steps. By the analysis of the area under the inhibition-time curve of cholinesterases inhibited by carbamates it is possible to calculate the decarbamylation rate constant from the same data traditionally used to characterize only the carbamylation kinetics, therefore it is possible to obtain a full characterization of the inhibition with a single set of experiments, method validation, a simple and useful approach to reduce the time required for the characterization of carbamate inhibitors, overview
-
additional information
enzyme-inhibitor binding structure from the crystal structure analysis, molecular docking and modelling, overview
-
additional information
no inhibition by bambuterol
-
additional information
-
no inhibition by bambuterol
-
additional information
interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators, analysis of reactivation and inhibition kinetics in vitro, overview. A combination of 4-amino-2-[[ethyl(methyl)amino]methyl]phenol and the bispyridinium oxime HI-6 is tested to reactivate OP-inhibited AChE, the superior reactivator of the respective OP-AChE combination dominates the reactivation process and a synergistic effect cannot be observed
-
additional information
-
interactions between acetylcholinesterase, toxic organophosphorus compounds and a short series of structurally related non-oxime reactivators, analysis of reactivation and inhibition kinetics in vitro, overview. A combination of 4-amino-2-[[ethyl(methyl)amino]methyl]phenol and the bispyridinium oxime HI-6 is tested to reactivate OP-inhibited AChE, the superior reactivator of the respective OP-AChE combination dominates the reactivation process and a synergistic effect cannot be observed
-
additional information
resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis; resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis
-
additional information
resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis; resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis
-
additional information
-
resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis; resistance towards organophosphates is widespread in the marine arthropod Lepeophtheirus salmonis
-
additional information
-
organophosphate inhibitor binding and active site gorge structure, oveview, nucleophilic oximes, i.e. bis-quarternary oximes, aldoximes, and hydroxamates, act as reactivators of the inhibited enzyme and are of therapeutic use, overview
-
additional information
-
blueberry polyphenols, as gallic acid equivalents, directly inhibit AChE to 64-66% reduced activity of the detergent soluble and the salt soluble enzyme, respectively
-
additional information
oxime-based reactivators, such as [(E)-[1-[(4-carbamoylpyridin-1-ium-1-yl)methoxymethyl]pyridin-2-ylidene]methyl]-oxoazanium dichloride, i.e. HI-6, and 1,7-heptylene-bis-N,N0-2-pyridiniumaldoxime dichloride, i.e. Ortho-7, restore the organophosphate-inhibited enzymatic activity by cleaving the phosphorous conjugate, overview. Flipping of the His447 imidazole ring allows the formation of a hydrogen bonding network among the Glu334-His447-Ortho-7 triad, which presumably deprotonates the Ortho-7 oxime hydroxyl group, increases the nucleophilicity of the oxime group, and leads to cleavage of the phosphorous conjugate. Binding structure determination and analysis, higher reactivation rate of HI-6 than Ortho-7, overview
-
additional information
-
oxime-based reactivators, such as [(E)-[1-[(4-carbamoylpyridin-1-ium-1-yl)methoxymethyl]pyridin-2-ylidene]methyl]-oxoazanium dichloride, i.e. HI-6, and 1,7-heptylene-bis-N,N0-2-pyridiniumaldoxime dichloride, i.e. Ortho-7, restore the organophosphate-inhibited enzymatic activity by cleaving the phosphorous conjugate, overview. Flipping of the His447 imidazole ring allows the formation of a hydrogen bonding network among the Glu334-His447-Ortho-7 triad, which presumably deprotonates the Ortho-7 oxime hydroxyl group, increases the nucleophilicity of the oxime group, and leads to cleavage of the phosphorous conjugate. Binding structure determination and analysis, higher reactivation rate of HI-6 than Ortho-7, overview
-
additional information
-
chromophore-linked fluorophosphonate inhibitors show bimolecular inhibition constants ranging from 0.3 * 105 M/min to 10.4 * 105 M/min
-
additional information
-
oximes poorly reactivate tabun-inhibited AChE. In silico pharmacophore model for binding affinity of tabun-inhibited AChE from a set of 11 oximes, 9 of which show binding to the inhibited enzyme, overview. Stereoelectronic profiles and three-dimensional quantitative structure-activity relationship pharmacophores using ab initio quantum chemical and pharmacophore generation methods, detailed overview
-
additional information
-
inhibitory effect on AChE of the ethanol extract of Magnolia officinalis, overview
-
additional information
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not inhibited by GM6001
-
additional information
-
proposed inhibition mechanism for 1,3,2-benzodioxaphopholenes
-
additional information
-
for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview
-
additional information
-
tetraisopropyl diphosphoramide does not reach 50% inhibition in the concentration range of the assays (0.001-10 mM)
-
additional information
-
proposed inhibition mechanism for 1,3,2-benzodioxaphopholenes
-
additional information
-
bimolecular rate konstant values for several inhibitors
-
additional information
no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide)
-
additional information
no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide)
-
additional information
no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide)
-
additional information
no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide)
-
additional information
no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide); no inhibition of activity with butyrylthiocholine by ISO-OMPA (tetraisopropyl diphosphoramide)
-
additional information
-
for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cu2+ is a poor inhibitor of ChE activity at 0.0125-0.4 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview
-
additional information
-
no substrate inhibition
-
additional information
the recombinant enzyme is sensitive to inhibition by methamidophos and pirimicarb, the calculated IC50 values of the two pesticides are 0.357 and 0.888 mg/l, respectively, and the calculated IC70 values are 0.521 and 0.839 mg/l, respectively
-
additional information
-
for tetra(monoisopropyl)diphosphortetramide (iso-OMPA), a specific inhibitor for BuChE, no inhibition of ChE activity is observed at any concentration tested, 0.25-8.0 mM. Cyanobacterial extracts with AChE inhibition and induction potential, overview
-
additional information
-
tetraisopropyl diphosphoramide does not reach 50% inhibition in the concentration range of the assays (0.001-10 mM)
-
additional information
-
no inhibition by oxotremorine, effects of inhibitors on muscarinic acetylcholine receptors, overview
-
additional information
-
design, synthesis and evaluation of galanthamine derivatives as acetylcholinesterase inhibitors, overview
-
additional information
-
acetylcholinesterase activity remains unaffected by the two drugs simvastatin and atorvastatin, that reduce brain lathosterol and cholesterol synthesis rate but do not reduce cholesterol levels, overview
-
additional information
-
molecular modelling and inhibitor docking, overview. No inhibition by 3-(1-benzylpiperidin-4-yloxy)benzaldehyde, 3-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde, 4-(1-benzylpiperidin-4-yloxy)benzaldehyde, {(E)-3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one, and (E)-3-(3-((1-benzylpiperidin-4-yl)nethoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
-
additional information
-
no inhibition and blockade of muscarinic receptors by serpentine precursor ajmaline at 0.08 mM, weak by catharanthine at over 0.01 mM, but both compounds inhibit nicotinic receptors in a reversible but non-competitive manner, a more potent nicotinic antagonist is tubocurarine
-
additional information
DL-homocysteine and DL-homocysteine thiolactone inhibit the activity of enzyme AChE in rat cardiac tissue, but increase the activity of antioxidant enzymes, overview
-
additional information
-
synthesis of difluoropyrido[4,3-b]indoles and evaluation as acetylcholinesterase inhibitors, anti-amnesic effect of synthesized compounds against scopolamine-induced memory loss, overview
-
additional information
no inhibition by bambuterol
-
additional information
-
in vitro sensitivity of cholinesterases from gilthead seabream (Sparus aurata) to organophosphate pesticides (OPs), overview. The inhibitory potency of OPs on brain and muscle AChEs based on bimolecular inhibition constants (ki) is in ascending order: omethoate, dichlorvos, azinphosmethyl-oxon
-
additional information
-
reactivation of organophosphorous compound/nerve agent-inhibited AChE by antimuscarinic drug oximes obidoxime, pralidoxime and HI 6, overview, aging and spontaneous reactivation of inhibited AChE
-
additional information
-
semi-preparative isolation of the tabun enantiomers, and analysis of inhibitory potential and kinetics, overview. Reactivation kinetics of tabun-inhibited AChE with obidoxime, overview
-
additional information
binding structure of sulfhydryl reagents to AChE, overview
-
additional information
-
inhibitor structural screening by GC-MS, binding structure, overview
-
additional information
three-dimensional structure and molecular docking to AChE of benzodiazepine inhibitors, amino acid residues involved in docking, overview
-
additional information
inhibitor binding, molecular modelling, overview
-
additional information
inhibitor identification by docking and pharmacophore virtual screenings, overview
-
additional information
determination and analysis of the crystal structures of enzyme-bound ligands
-
additional information
kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Cornus officinalis fruits (Corni fructus) as cholinesterase and beta-secretase 1 inhibitors, overview
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additional information
development, synthesis, and evaluation of a series of indole derivatives possessing in vitro inhibitory activities against AChE, structure-function analysis, overview. Crystal structures of complexes of the most promising compounds with Torpedo californica AChE are solved in order to further understand their mode of inhibition
-
additional information
-
development, synthesis, and evaluation of a series of indole derivatives possessing in vitro inhibitory activities against AChE, structure-function analysis, overview. Crystal structures of complexes of the most promising compounds with Torpedo californica AChE are solved in order to further understand their mode of inhibition
-
additional information
acetylcholinesterase inhibitory activities of lignanamides from hemp, Cannabis sativa, seeds, NMR compound structure analysis and structure comparisons, molecular modeling studies on AChE, overview
-
additional information
the DNP rigidification results in a likely entropy-enthalpy compensation with solvation effects contributing primarily to AChE binding affinity. Detailed kinetic study and inhibition mechanism of 1 and 2 with Torpedo californica AChE (TcAChE), enzyme-ligands crystal structure (PDB ID 5E4T) analysis, molecular docking study, overview
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additional information
-
the DNP rigidification results in a likely entropy-enthalpy compensation with solvation effects contributing primarily to AChE binding affinity. Detailed kinetic study and inhibition mechanism of 1 and 2 with Torpedo californica AChE (TcAChE), enzyme-ligands crystal structure (PDB ID 5E4T) analysis, molecular docking study, overview
-
additional information
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organophosphoric enzyme inhibitors and inhibition potencies, comparison to the human enzyme from erythrocytes, overview. The sensitivity of ChE to the siloxane reversible inhibitors is lower in Todarodes pacificus and much lower in commander squid Berryteuthis magister compared to mammals. Substrate-inhibitor binding analysis of homogeneity of visual ganglion activity in individuals, reversible onium ChE inhibitors reveal an inverse relationship
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0.452
(+)-haemanthamine
Homo sapiens
-
-
0.226
(+)-limonene
Electrophorus electricus
-
-
0.177
(+)-sabinene
Electrophorus electricus
-
-
0.00035
(-)-galanthamine
Electrophorus electricus
-
-
0.00253
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-nitro-N'-[(R)-1-phenylethyl]isophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00135
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)-amino]-N'-[(R)-1-(4-fluorophenyl)ethyl]isophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00183 - 0.0987
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)amino]-N-[(R)-1-phenylethyl]isophthalamide
0.00127
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-nitroisophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00105
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropyl-5-[methyl(methylsulfonyl)amino]isophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00228
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N',N'-dipropylisophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00209
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-nitroisophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.0117
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-isophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00306
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-N'-[(R)-1-phenylethyl]isophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.6
(2-methoxy-7-methyl-2-oxido-2,3,4,5-tetrahydro-1,2-oxaphosphepin-6-yl)methanol
Electrophorus electricus
-
pH 7.5, 25°C
0.00126
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.0021
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00029
(2E)-2-(4-hydroxy-3-methoxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00964
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.0038
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00295
(2E)-2-(4-hydroxybenzylidene)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.0024
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone
Homo sapiens
-
pH 8.0, 37°C
0.0037
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone
Homo sapiens
-
pH 8.0, 37°C
0.0017
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0043
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.345
(3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0368
(3,4-dimethoxyphenyl)-(4-[(ethylpropylamino)methyl]phenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0272
(3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.000023
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,3-dimethylphenyl)carbamate
Electrophorus electricus
-
-
0.000014
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,4-dimethylphenyl)carbamate
Electrophorus electricus
-
-
0.000026
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2,5-dimethylphenyl)carbamate
Electrophorus electricus
-
-
0.00001
(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indol-5-yl (2-ethylphenyl)carbamate
Electrophorus electricus
-
-
0.48
(3E)-3-([4-[2-(diethylamino)ethoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
2.41
(3E)-3-([4-[3-(diethylamino)propoxy]phenyl]methylidene)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
0.16
(3E)-3-[(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
0.72
(3E)-3-[(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]phenyl)methylidene]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
0.003
(3R,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
Electrophorus electricus
-
pH 7.5, 25°C
0.0003
(3S,5aR)-3-methoxy-1-methyl-4,5,5a,6-tetrahydro-3H,8H-furo[3,4-e][1,2]oxaphosphepin-8-one 3-oxide
Electrophorus electricus
-
pH 7.5, 25°C
0.0086
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0014
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.385
(4-bromobenzoyl)phosphoramidic dichloride
Homo sapiens
-
pH 7.4, 37°C
0.087
(4-chlorobenzoyl)phosphoramidic dichloride
Homo sapiens
-
pH 7.4, 37°C
4.15
(4-methylbenzoyl)phosphoramidic dichloride
Homo sapiens
-
pH 7.4, 37°C
0.0006
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.00046
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0016
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0018
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.0196
(4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone
Homo sapiens
-
pH 8.0, 37°C
0.0021
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
0.00023
(4aS,6R,8aS)-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10,11,12-hexahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-6-ol
Electrophorus electricus
-
-
0.000016
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[10-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]decyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
Electrophorus electricus
-
-
0.000022
(4aS,6R,8aS)-6-hydroxy-3-methoxy-11-[8-[(4aS,6R,8aS)-3-methoxy-6-methyl-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11(12H)-yl]octyl]-5,6,9,10-tetrahydro-4aH-[1]benzofuro[3a,3,2-ef][2]benzazepin-11-ium
Electrophorus electricus
-
-
0.00371
(6R,7S)-6-(acetyloxy)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2Z)-2-methylbut-2-enoate
Electrophorus electricus
pH 8.0, 22°C
0.00109
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl (2E)-2-methylbut-2-enoate
Electrophorus electricus
pH 8.0, 22°C
0.00184
(6R,7S)-6-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
Electrophorus electricus
pH 8.0, 22°C
0.0029
(6R,7S)-6-methoxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl 3-methylbut-2-enoate
Electrophorus electricus
pH 8.0, 22°C
0.00401
(6R,7S)-7-hydroxy-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-benzo[1,2-b:5,4-b']dipyran-6-yl 4-methylpent-3-enoate
Electrophorus electricus
pH 8.0, 22°C
0.0002576
(E)-1-(2,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.000017
(E)-1-(2,6-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.00000146
(E)-1-(2-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000041
(E)-1-(2-chloro-6-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.00000044
(E)-1-(2-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.00000125
(E)-1-(2-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000153
(E)-1-(2-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.000214
(E)-1-(2-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000294
(E)-1-(3,4-dichlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000103
(E)-1-(3-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000049
(E)-1-(3-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000128
(E)-1-(3-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000066
(E)-1-(3-methoxylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000052
(E)-1-(3-methylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0006534
(E)-1-(4-bromobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.00059
(E)-1-(4-chlorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0001034
(E)-1-(4-chloromethylbenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.000677
(E)-1-(4-fluorobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.000677
(E)-1-(4-methoxybenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.000744
(E)-1-(4-nitrobenzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium chloride
Electrophorus electricus
-
at pH 8.0 and 25°C
0.0000471
(E)-1-(benzyl)-4-((2-oxoindolin-3-ylidene)methyl)pyridinium bromide
Electrophorus electricus
-
at pH 8.0 and 25°C
0.000058
(E)-2-(4-[(diethylamino)methyl]benzylidene)-5,6-dimethoxy-2,3-dihydroinden-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0242
(E)-3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0204
(E)-3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-1-(2-hydroxy-4,5-dimethoxyphenyl)prop-2-en-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.07
(E)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
Electrophorus electricus
-
pH 7.5, 25°C
0.00008
(R)-(+)-endo-2-norbornyl-N-n-butylcarbamate
Electrophorus electricus
-
pH 7.0, 25°C
0.000056
(R)-(+)-exo-2-norbornyl-N-n-butylcarbamate
Electrophorus electricus
-
pH 7.0, 25°C
0.0065 - 0.0069
(R)-(+)-fenoxon sulfoxide
1
(R)-(+)-fenthion sulfoxide
0.0087 - 0.023
(rac) fenoxon sulfoxide
1
(rac) fenthion sulfoxide
1
(S)-(+)-fenthion sulfoxide
0.00002
(S)-(-)-endo-2-norbornyl-N-n-butylcarbamate
Electrophorus electricus
-
pH 7.0, 25°C
0.111 - 0.23
(S)-(-)-fenoxon sulfoxide
0.1911
(S)-ar-turmerone
Homo sapiens
-
-
0.0815
(S)-dihydro-ar-turmerone
Homo sapiens
-
-
1
(Z)-dimethyl 1-(2-oxodihydrofuran-3(2H)-ylidene)ethyl phosphate
Electrophorus electricus
-
above, pH 7.5, 25°C
0.000219
1,1'-(ethane-1,1-diyldifuran-5,2-diyl)bis(trifluoroethanone)
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0391
1,2,2-triethyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0217
1,2-diethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0000604
1,3-bis(4-vinylbenzyl)benzylbenzimidazolium
Homo sapiens
pH 8.0, 37°C
0.0000348
1,3-bis(N-propylphthalimide)benzylbenzimidazolium
Homo sapiens
pH 8.0, 37°C
0.105
1,5,6-trimethyl-9-oxo-7H,9H-pyrano[3,4,5-ij]isoquinolin-1-ium
Electrophorus electricus
-
-
0.00005 - 0.00006
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
0.0002606
1-(1-benzyl-7-chloro-4-methoxy-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
0.000133
1-(1-benzylindol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
0.0038
1-(2-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0132
1-(2-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0132
1-(2-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1Hquinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0193
1-(2-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.013
1-(2-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0229
1-(2-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0218
1-(2-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.001
1-(2-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.05322
1-(2-fluorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
Electrophorus electricus
pH 8.0, 25°C
0.02168
1-(2-fluorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
Electrophorus electricus
pH 8.0, 25°C
0.04741
1-(3-chlorobenzyl)-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
Electrophorus electricus
pH 8.0, 25°C
0.0261
1-(3-chlorobenzyl)-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
Electrophorus electricus
pH 8.0, 25°C
0.01
1-(4,6-dimethylpyrimidin-2-yl)-3-(4-methyl-3-nitrophenyl)guanidine
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0041
1-(4-chloro-benzyl)-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.6
1-(4-chloro-benzyl)-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0012
1-(4-chloro-benzyl)-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0073
1-(4-chloro-benzyl)-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0092
1-(4-chloro-benzyl)-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0194
1-(4-chloro-benzyl)-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0024
1-(4-chloro-benzyl)-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.01
1-(4-cyclopentyl-6-methylpyrimidin-2-yl)-3-(2,4-dimethylphenyl)guanidine
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00004422
1-(4-vinylbenzyl)-3-(2,3,5,6-tetramethylbenzyl)-imidazolidinium
Homo sapiens
pH and temperature not specified in the publication
0.00004046
1-(4-vinylbenzyl)-3-(2,4,6-trimethylbenzyl)-imidazolidinium
Homo sapiens
pH and temperature not specified in the publication
0.0000755
1-(4-vinylbenzyl)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
Homo sapiens
pH 8.0, 37°C
0.00004629
1-(4-vinylbenzyl)-3-(2-methylbenzyl)-imidazolidinium
Homo sapiens
pH and temperature not specified in the publication
0.0000832
1-(4-vinylbenzyl)-3-(2-methylbenzyl)benzimidazolium
Homo sapiens
pH 8.0, 37°C
0.00004565
1-(4-vinylbenzyl)-3-(3-methylbenzyl)-imidazolidinium
Homo sapiens
pH and temperature not specified in the publication
0.00004249
1-(4-vinylbenzyl)-3-(4-methylbenzyl)-imidazolidinium
Homo sapiens
pH and temperature not specified in the publication
0.0000739
1-(4-vinylbenzyl)-3-(4-methylbenzyl)benzimidazolium
Homo sapiens
pH 8.0, 37°C
0.0000739
1-(4-vinylbenzyl)-3-benzylbenzimidazolium
Homo sapiens
pH 8.0, 37°C
0.00005593
1-(4-vinylbenzyl)-3-benzylimidazolidinium
Homo sapiens
pH and temperature not specified in the publication
0.0000454
1-(4-vinylbenzyl)-3-methylbenzimidazolium
Homo sapiens
pH 8.0, 37°C
0.0001178
1-(4-vinylbenzyl)benzimidazole
Homo sapiens
pH 8.0, 37°C
0.0000288
1-(7-chloro-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
0.0000844
1-(7-chloro-4-methoxy-1-methyl-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
0.0000914
1-(7-chloro-4-methoxy-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
0.0000621
1-(N-propylphthalimide)-3-(2,4,6-trimethylbenzyl)benzylbenzimidazolium
Homo sapiens
pH 8.0, 37°C
0.0000318
1-(N-propylphthalimide)-3-(3-methylbenzyl)benzimidazolium
Homo sapiens
pH 8.0, 37°C
0.0000688
1-(N-propylphthalimide)-3-(4-methylbenzyl)benzimidazolium
Homo sapiens
pH 8.0, 37°C
0.0000561
1-(N-propylphthalimide)-3-naphthalenemethylbenzimidazolium
Homo sapiens
pH 8.0, 37°C
0.0000883
1-(N-propylphthalimide)benzoimidazole
Homo sapiens
pH 8.0, 37°C
0.0024
1--(4-chloro-benzyl)-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0018
1-benzyl-2,2-diethyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0008
1-benzyl-2,2-diisobutyl-2,3-dihydro-1Hquinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0064
1-benzyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0094
1-benzyl-2-(4-chloro-phenyl)-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.00004753
1-benzyl-2-chloro-3-(2,3-dihydro-benzo[1,4]-dioxin-2-ylmethyl)imidazolidine
Homo sapiens
pH and temperature not specified in the publication
0.0118
1-benzyl-2-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0017
1-benzyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0167
1-benzyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0053
1-benzyl-2-methyl-2-propyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.000045
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
Tetronarce californica
-
0.000553
1-benzyl-3-[(2E)-4-(4-benzylpiperazin-1-yl)but-2-en-1-yl]-6-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
Tetronarce californica
-
0.000298
1-benzyl-3-[4-(4-benzylpiperazin-1-yl)butyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
Tetronarce californica
-
0.07011
1-benzyl-N-[5-(2,3-dihydro-1H-indol-1-yl)pentyl]piperidin-4-amine
Electrophorus electricus
pH 8.0, 25°C
0.042
1-benzyl-N-[6-(1H-indol-1-yl)hexyl]piperidin-4-amine
Electrophorus electricus
pH 8.0, 25°C
0.02961
1-benzyl-N-[8-(1H-indol-1-yl)octyl]piperidin-4-amine
Electrophorus electricus
pH 8.0, 25°C
0.00892
1-butanoyl-3-(2,6-dimethylphenyl)thiourea
Homo sapiens
pH 7.7, 37°C
0.0343
1-butanoyl-3-(3-methoxyphenyl)thiourea
Homo sapiens
pH 7.7, 37°C
0.0117
1-butanoyl-3-(4-chlorophenyl)thiourea
Homo sapiens
pH 7.7, 37°C
0.1325
1-butanoyl-3-benzylthiourea
Homo sapiens
pH 7.7, 37°C
0.0161
1-ethyl-2,2-diisobutyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0338
1-ethyl-2,2-dimethyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0432
1-ethyl-2-isobutyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0186
1-ethyl-2-methyl-2-phenyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.0323
1-ethyl-2-methyl-2-propyl -2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.007716
1-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]quinolinium
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.002924
1-ethyl-2-[(Z)-(1-ethyl[1]benzothieno[3,2-d][1,3]thiazol-2(1H)-ylidene)methyl]quinolinium
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000897
1-ethyl-6-methyl-2-[(1-methyl-1,2-dihydro[1]benzofuro[3,2-d][1,3]thiazol-2-yl)methyl]quinolinium
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
1
1-methyl-3-(methylcarbamoyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
Homo sapiens
-
above
1
1-methyl-3-(morpholin-4-ylcarbonyl)-1,4-dihydroquinolin-5-yl dimethylcarbamate
Homo sapiens
-
above
0.00096
1-O-acetyllycorine
Homo sapiens
-
-
0.000559
1-[1-(benzenesulfonyl)-7-chloro-4-methoxy-indol-5-yl]-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
0.00039
1-[3-(4-benzylpiperazin-1-yl)propyl]-3-methyl-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
Tetronarce californica
-
0.00054
1-[5-(5-nitro-1H-indazol-3-yl)thiophen-3-yl]ethanone
Tetronarce californica
-
0.01
1-[5-[(1E)-1-hydrazinylideneethyl]-2-methoxybenzyl]piperidine
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000115
1-[5-[(1H-benzimidazol-2-ylsulfanyl)methyl]furan-2-yl]-2,2,2-trifluoroethanone
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.2206
1-[[(3-acetylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.1649
1-[[(3-butanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.0087
1-[[(3-decanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.0555
1-[[(3-heptanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.0828
1-[[(3-hexanoylpyridinium-1-yl)methoxy]methyl]-2-[(E)-(hydroxyimino)methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.0127
10-hydroxy-infractopicrin
Homo sapiens
-
-
0.0000612
10-N-demethyl-10-N-(10-(4-(piperidin-1-ylmethyl)-phenoxy)decan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000581
10-N-demethyl-10-N-(12-(4-(piperidin-1-ylmethyl)-phenoxy)dodecan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000245
10-N-demethyl-10-N-(2-(4-(piperidin-1-ylmethyl)phenoxy)ethan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000018
10-N-demethyl-10-N-(3-(4-(piperidin-1-ylmethyl)phenoxy)propan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000306
10-N-demethyl-10-N-(4-(1-benzylpiperidin-4-yloxy)-butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000941
10-N-demethyl-10-N-(4-(3-(1-morpholinoethyl)phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000146
10-N-demethyl-10-N-(4-(4-((diethylamino)methyl)-phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000991
10-N-demethyl-10-N-(4-(4-(morpholinomethyl)phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000124
10-N-demethyl-10-N-(4-(4-(piperidin-1-ylmethyl)phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000538
10-N-demethyl-10-N-(4-(4-(pyrrolidine-1-carbonyl)-phenoxy)butan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000065
10-N-demethyl-10-N-(5-(4-(piperidin-1-ylmethyl)phenoxy)pentan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000222
10-N-demethyl-10-N-(6-(1-benzylpiperidin-4-yloxy)-hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000154
10-N-demethyl-10-N-(6-(3-(1-morpholinoethyl)phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000089
10-N-demethyl-10-N-(6-(4-((diethylamino)methyl)-phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000113
10-N-demethyl-10-N-(6-(4-(morpholinomethyl)phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000056
10-N-demethyl-10-N-(6-(4-(piperidin-1-ylmethyl)phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.000122
10-N-demethyl-10-N-(6-(4-(pyrrolidine-1-carbonyl)-phenoxy)hexan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000347
10-N-demethyl-10-N-(8-(4-(piperidin-1-ylmethyl)phenoxy)octan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0000881
10-N-demethyl-10-N-(9-(4-(piperidin-1-ylmethyl)phenoxy)nonan-1-yl)-galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.00161
11-hydroxygalantamine
Homo sapiens
-
-
0.000071
19,20-dihydroervahanine
Electrophorus electricus
-
-
0.000227
19,20-dihydrotabernamine
Electrophorus electricus
-
-
0.33
1alpha,2alpha,6beta, 8alpha,15-pentaacetoxy-9beta-benzoyloxy-beta-agarofuran
Bos taurus
-
pH 7.6, 22°C
0.12
1alpha,2alpha,6beta,8alpha-tetraacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
Bos taurus
-
pH 7.6, 22°C
0.26
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-15-hydroxy-beta-agarofuran
Bos taurus
-
pH 7.6, 22°C
0.4
1alpha,2alpha,6beta-triacetoxy-9beta-benzoyloxy-8alpha,15-dihydroxy-beta-agarofuran
Bos taurus
-
pH 7.6, 22°C
0.74
1alpha-acetoxy-6beta,9beta-difuroyloxy-4beta-hydroxy-beta-agarofuran
Bos taurus
-
pH 7.6, 22°C
0.00335 - 0.0861
2,2-dichlorovinyl dimethyl phosphate
0.01
2,3,4-trimethylpyrimido[2,1-a]isoquinolin-5-ium
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00000156
2,3-dimethoxy-6-methyl-9H-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.01
2-(2-methyl-1H-imidazol-1-yl)-1-[2-(trifluoromethyl)-4a,10a-dihydro-10H-phenothiazin-10-yl]ethanone
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0008
2-(2-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl)phenol
Tetronarce californica
pH 8.0, 25°C
0.0086
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0304
2-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0066
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0127
2-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00209
2-(3-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00071
2-(3-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00237
2-(3-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00000052
2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.00002898
2-(3-[2-bromo-3-(2,3,5,6-tetramethylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
Homo sapiens
pH and temperature not specified in the publication
0.00003116
2-(3-[2-bromo-3-(2,4,6-trimethylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
Homo sapiens
pH and temperature not specified in the publication
0.00004394
2-(3-[2-bromo-3-(2-methylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
Homo sapiens
pH and temperature not specified in the publication
0.00004378
2-(3-[2-bromo-3-(3-methylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
Homo sapiens
pH and temperature not specified in the publication
0.00004081
2-(3-[2-bromo-3-(4-methylbenzyl)imidazolidin-1-yl]-propyl)-isoindole-1,3-dione
Homo sapiens
pH and temperature not specified in the publication
0.02308
2-(3-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.06833
2-(3-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.00452
2-(3-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]propyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.00028
2-(4(2-(diethylamino)acetyl)phenoxy)-5,6-dimethoxyindan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0137
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.011
2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxychroman-4-one
Rattus norvegicus
-
-
0.0041
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0076
2-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxychroman-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0000421
2-(4-(2-(diethylamino)ethyl)phenoxy)-5,6-dimethoxyindan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0000316
2-(4-(2-(ethyl(methyl)amino)acetyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00000516
2-(4-(2-(ethyl(methyl)amino)ethyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00000078
2-(4-(3-(diethylamino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000277
2-(4-(3-(diethylamino)propyl)phenoxy)-5,6-dimethoxyindan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00000185
2-(4-(3-(ethyl(methyl)amino)propanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0000406
2-(4-(4-(diethylamino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000481
2-(4-(4-(diethylamino)butyl)phenoxy)-5,6-dimethoxyindan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0000376
2-(4-(4-(ethyl(methyl)amino)butanoyl)phenoxy)-5,6-dimethoxy-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0232
2-(4-chloro-phenyl)-1-ethyl-2-methyl-2,3-dihydro-1H-quinazolin-4-one
Electrophorus electricus
pH and temperature not specified in the publication
0.00571
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00368
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00008
2-(4-hydroxy-3-methoxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00876
2-(4-hydroxybenzyl)-3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00199
2-(4-hydroxybenzyl)-3-oxo-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino)butyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00013
2-(4-hydroxybenzyl)-3-oxo-N-[6-(1,2,3,4-tetrahydroacridin-9-ylamino)hexyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00000073
2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.0853
2-(6-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.05441
2-(6-[[1-(3-chlorobenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.02977
2-(6-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]hexyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.04339
2-(8-[[1-(2-fluorobenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.02354
2-(8-[[1-(4-hydroxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
43.34
2-(8-[[1-(4-methoxybenzyl)piperidin-4-yl]amino]octyl)-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.01
2-amino-3-[2-oxo-2-[phenyl(propan-2-yl)amino]ethyl]-1,3-thiazol-3-ium
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00003451
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(2,3,5,6-tetramethylbenzyl)imidazolidine
Homo sapiens
pH and temperature not specified in the publication
0.0000428
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(2,4,6-trimethylbenzyl)imidazolidine
Homo sapiens
pH and temperature not specified in the publication
0.00003885
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(2-methylbenzyl)imidazolidine
Homo sapiens
pH and temperature not specified in the publication
0.00004901
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(3-methylbenzyl)imidazolidine
Homo sapiens
pH and temperature not specified in the publication
0.00005047
2-chloro-1-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-3-(4-methylbenzyl)imidazolidine
Homo sapiens
pH and temperature not specified in the publication
0.00000067
2-[(1-[2-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]ethyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Homo sapiens
-
-
0.00000027
2-[(1-[3-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]propyl]piperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
Homo sapiens
-
-
0.0025
2-[(2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)methyl]-1H-isoindole-1,3(2H)-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.0174
2-[(E)-(hydroxyimino)methyl]-1-[[(3-nonanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.0275
2-[(E)-(hydroxyimino)methyl]-1-[[(3-octanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.1486
2-[(E)-(hydroxyimino)methyl]-1-[[(3-pentanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.2406
2-[(E)-(hydroxyimino)methyl]-1-[[(3-propanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.0124
2-[(E)-(hydroxyimino)methyl]-1-[[(3-undecanoylpyridinium-1-yl)methoxy]methyl]pyridinium diiodide
Homo sapiens
-
at pH 7.4 and 37°C
0.0011
2-[2-(4-fluorophenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
Tetronarce californica
pH 8.0, 25°C
0.0015
2-[2-(4-methylphenyl)-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-yl]phenol
Tetronarce californica
pH 8.0, 25°C
0.00004031
2-[3-(3-benzyl-2-bromo-imidazolidin-1-yl)-propyl]isoindole-1,3-dione
Homo sapiens
pH and temperature not specified in the publication
0.00811
2-[3-[(1-benzylpiperidin-4-yl)amino]propyl]-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.01564 - 0.1
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
0.01068 - 0.01312
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
0.0035 - 0.00875
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
0.00268 - 0.00802
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
0.00103 - 0.00108
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
0.00213 - 0.00305
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
0.01
2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-N-[3-nitro-5-(pyridin-3-yloxy)phenyl]acetamide
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.06903
2-[5-[(1-benzylpiperidin-4-yl)amino]pentyl]-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.04536
2-[6-[(1-benzylpiperidin-4-yl)amino]hexyl]-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.01767
2-[8-[(1-benzylpiperidin-4-yl)amino]octyl]-1H-isoindole-1,3(2H)-dione
Electrophorus electricus
pH 8.0, 25°C
0.06532
2-[[(4S)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl]methyl]-1H-isoindole-1,3(2H)-dione
Homo sapiens
-
pH and temperature not specified in the publication
0.0279
2alpha,11alpha-dihydroxyfawcettiine
Electrophorus electricus
-
-
0.0387
3,3'-demethyl-grossamide
Tetronarce californica
pH 7.8, 25°C
0.0462
3,3'-demethyl-heliotropamide
Tetronarce californica
pH 7.8, 25°C
0.0000133
3-(1-benzyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
0.0000204
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-1H-indol-5-yl)propan-1-one
0.000275
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-2-trimethylsilyl-1H-indol-5-yl)propan-1-one
0.000716
3-(1-butyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
0.00163
3-(3-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00129
3-(3-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0000036
3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.00072
3-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000093
3-(4-(1-benzylpiperidin-4-yloxy)phenyl)-6,7-dimethoxy-4H-chromen-4-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0000012
3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
1.62
3-(4-propoxybenzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
0.75
3-(4-[2-[diethenyl(methylidene)-l5-azanyl]ethoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
5.58
3-(4-[3-[diethenyl(methylidene)-l5-azanyl]propoxy]benzyl)-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
1
3-(dimethylcarbamoyl)-1-methyl-1,4-dihydroquinolin-5-yl dimethylcarbamate
Homo sapiens
-
above
0.000015
3-(dimethylcarbamoyl)-5-[(dimethylcarbamoyl)oxy]-1-methylquinolinium
Homo sapiens
-
-
0.00000032
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.001374
3-benzyl-1-[3-(4-benzylpiperazin-1-yl)propyl]-1,3-dihydro-2H-thieno[2,3-d]imidazol-2-one
Tetronarce californica
-
0.01
3-ethyl-2-[(1E)-2-(phenylamino)but-1-en-1-yl]naphtho[2,3-d][1,3]oxazol-3-ium
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001076
3-ethyl-2-[(E)-(1-ethyl-6-methoxyquinolin-2(1H)-ylidene)methyl]-5-methoxy-1,3-benzothiazol-3-ium
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001252
3-ethyl-2-[(E)-(1-ethyl-6-methylquinolin-2(1H)-ylidene)methyl]-5-hydroxy-1,3-benzothiazol-3-ium
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001391
3-ethyl-2-[(E)-(1-ethylquinolin-2(1H)-ylidene)methyl]-5-iodo-1,3-benzothiazol-3-ium
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00000085
3-methoxy-6-methyl-9H-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00000176
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.00046
3-oxo-N-[(1,2,3,4-tetrahydroacridin-9-ylamino)methyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00024
3-oxo-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00009
3-oxo-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.00057
3-oxo-N-[5-(1,2,3,4-tetrahydroacridin-9-ylamino)pentyl]butanamide
Electrophorus electricus
pH 8.0, 37°C
0.000051
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
0.00004
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(4-methoxy-1Hindol-5-yl)propan-1-one
0.000094
3-[1-(cyclopentylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
0.388
3-[10-(benzylmethylamino)decyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.626
3-[11-(benzylmethylamino)undecyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.908
3-[12-(benzylmethylamino)dodecyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00268
3-[3-(benzylmethylamino)propoxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.0034
3-[3-[(2-methoxybenzyl)methylamino]propoxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00625
3-[4-(benzylmethylamino)butoxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
8.95
3-[4-[3-(diethylamino)propoxy]benzyl]-2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-one
Electrophorus electricus
-
-
0.0000166
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[4-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]butyl]propanamide
Homo sapiens
-
-
0.0000096
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[5-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]pentyl]propanamide
Homo sapiens
-
-
0.0000111
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]propanamide
Homo sapiens
-
-
0.0000144
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]propanamide
Homo sapiens
-
-
0.000014
3-[5-(4-chlorophenyl)-3,4-dihydro-2H-pyrano[3,2-c]quinolin-9-yl]-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]propanamide
Homo sapiens
-
-
0.00778
3-[5-(benzylmethylamino)pentyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00289
3-[6-(benzylmethylamino)hexyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00282
3-[7-(benzylmethylamino)-heptyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00784
3-[7-(benzylmethylamino)heptyloxy]-6-methoxyxanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.138
3-[7-[(2,3-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.127
3-[7-[(2,5-dimethoxybenzyl)methylamino]heptyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.433
3-[7-[(2-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00218
3-[7-[(2-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.594
3-[7-[(3-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.04
3-[7-[(3-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
1.05
3-[7-[(4-chlorobenzyl)methylamino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.36
3-[7-[(4-methoxybenzyl)methylamino]heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.00315
3-[7-[ethyl-(2-methoxybenzyl)amino]heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.155
3-[7-[methyl-(2,3,4-trimethoxybenzyl)amino]-heptyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.565
3-[7-[methyl-(2-methylbenzyl)amino]-heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.413
3-[7-[methyl-(2-nitrobenzyl)amino]heptyloxy]-xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.0103
3-[8-(benzylmethylamino)octyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.152
3-[9-(benzylmethylamino)nonyloxy]xanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.0000476
4,4-difluoro-8-(propan-2-yl)-N-(2,3,4-trifluorophenyl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000967
4,4-difluoro-8-(propan-2-yl)-N-propyl-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001052
4,4-difluoro-N,8-di(propan-2-yl)-1,3,4,5-tetrahydro-2Hpyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000563
4,4-difluoro-N-(2-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000527
4,4-difluoro-N-(3-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000515
4,4-difluoro-N-(4-fluorophenyl)-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0566
4-((1-benzylpiperidin-4-yl)methoxy)benzaldehyde
Rattus norvegicus
-
pH 7.4, 37°C
0.01733 - 0.1
4-(1H-benzimidazol-2-yl)phenol
0.01459 - 0.1
4-(5-chloro-1H-benzimidazol-2-yl)phenol
0.01593 - 0.1
4-(5-methyl-1H-benzimidazol-2-yl)phenol
0.26
4-bromo-N-[di(morpholin-4-yl)phosphoryl]benzamide
Homo sapiens
-
pH 7.4, 37°C
0.057
4-chloro-N-[di(morpholin-4-yl)phosphoryl]benzamide
Homo sapiens
-
pH 7.4, 37°C
0.00000289
4-ethenyl-5-methyl-5,6-dihydro[1,3]dioxolo[4,5-j]phenanthridine
Electrophorus electricus
-
-
0.000012
4-O-methylhonokiol
Mus musculus
-
pH 7.4, 25°C
0.01879 - 0.1
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.00973 - 0.01105
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.01292 - 0.1
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.001283
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[2,3-e]pyrazin-5(4H)-one
Tetronarce californica
-
0.000514
4-[4-(4-benzylpiperazin-1-yl)butyl]pyrrolo[1,2-a]thieno[3,2-e]pyrazin-5(4H)-one
Tetronarce californica
-
0.00013 - 0.00061
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.0014 - 0.00324
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.00039 - 0.00084
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.0004 - 0.00134
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.00155
5,6-dimethoxy-2-(3-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00177
5,6-dimethoxy-2-(3-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000832
5,6-dimethoxy-2-(3-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000364
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)acetyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00000502
5,6-dimethoxy-2-(4-(2-(piperidin-1-yl)ethyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00024
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)acetyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00000373
5,6-dimethoxy-2-(4-(2-(pyrrolidin-1-yl)ethyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.0000173
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propanoyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00064
5,6-dimethoxy-2-(4-(3-(piperidin-1-yl)propyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.00000416
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propanoyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000209
5,6-dimethoxy-2-(4-(3-(pyrrolidin-1-yl)propyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000529
5,6-dimethoxy-2-(4-(4-(piperidin-1-yl)butanoyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000062
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butanoyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000415
5,6-dimethoxy-2-(4-(4-(pyrrolidin-1-yl)butyl)phenoxy)-indan-1-one
Rattus norvegicus
-
pH 7.4, 37°C
0.000004
5,6-dimethoxy-2-([1-[2-(1,2,3,4-tetrahydroacridin-9-ylamino)ethyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
Homo sapiens
-
-
0.00000088
5,6-dimethoxy-2-([1-[3-(1,2,3,4-tetrahydroacridin-9-ylamino)propyl]piperidin-4-yl]methyl)-2,3-dihydro-1H-inden-1-one
Homo sapiens
-
-
0.00005
5-(4-chlorophenyl)-N-[10-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]decyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
Homo sapiens
-
-
0.00000192
5-(4-chlorophenyl)-N-[6-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]hexyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
Homo sapiens
-
-
0.0000183
5-(4-chlorophenyl)-N-[7-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]heptyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
Homo sapiens
-
-
0.0000073
5-(4-chlorophenyl)-N-[8-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]octyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
Homo sapiens
-
-
0.0000249 - 0.000093
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
0.000015
5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
Tetronarce californica
-
0.035
5-hydroxy-huperzine A
Electrophorus electricus
-
-
-
0.000527
5-[(1-benzylpiperidin-4-yl)methoxy]-1-methylpyrrolo[1,2-a]thieno[2,3-e]pyrazine
Tetronarce californica
-
0.000423
5-[(1-benzylpiperidin-4-yl)methoxy]pyrrolo[1,2-a]thieno[3,2-e]pyrazine
Tetronarce californica
-
0.000029
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(methylcarbamoyl)quinolinium
Homo sapiens
-
-
0.00086
5-[(dimethylcarbamoyl)oxy]-1-methyl-3-(morpholin-4-ylcarbonyl)quinolinium
Homo sapiens
-
-
0.000007
5-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
Homo sapiens
-
-
0.00011
5-[(dimethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
Homo sapiens
-
-
0.01
5-[(E)-(dimethylhydrazinylidene)methyl]-1-(4-methoxy-3-nitrobenzyl)-1H-imidazole
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.006
5-[(ethylcarbamoyl)oxy]-3-(methoxycarbonyl)-1-methylquinolinium
Homo sapiens
-
-
0.000183
5-[4-(4-benzylpiperazin-1-yl)butyl]-7-phenyl-1,5-dihydro-4H-furo[2,3-b]pyrrolo[2,3-d]pyridin-4-one
Tetronarce californica
-
0.00000131
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.00000316
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0000109
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0000026
6-chloro-N-(2-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]ethyl)-1,2,3,4-tetrahydroacridin-9-amine
Homo sapiens
-
-
0.00000106
6-chloro-N-(3-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]propyl)-1,2,3,4-tetrahydroacridin-9-amine
Homo sapiens
-
-
0.0000083
6-chlorotacrine
Homo sapiens
-
-
0.0167
6-formyl umbelliferone
Electrophorus electricus
pH 8.0, 22°C
0.00000076
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.00000063
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.000006
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.000004
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.00232
6-[7-(benzylmethylamino)heptyloxy]-2,3-dimethoxyxanthen-9-one
Homo sapiens
-
pH 8.0, 37°C
0.74
6beta,8alpha-diacetoxy-9beta-furoyloxy-1alpha-hydroxy-beta-agarofuran
Bos taurus
-
pH 7.6, 22°C
0.0184
7,8-dihydro-[1,3]dioxolo[4,5-g]isoquinoline
Rattus norvegicus
-
pH and temperature not specified in the publication
0.049
7-bromo-6-methyl-7H,9H-pyrano[3,4,5-ij]isoquinolin-9-one
Electrophorus electricus
-
-
0.0018
7-deoxy-trans-dihydronarciclasine
Homo sapiens
-
-
0.00000051
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.00000072
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one
Homo sapiens
-
pH 8.0, 37°C
0.0000027
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0000056
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one
Homo sapiens
-
pH 8.0, 37°C
0.0105
7-O-galloyl-D-sedoheptulose
Tetronarce californica
pH and temperature not specified in the publication
0.0005
7-[(dimethylcarbamoyl)oxy]-3-(ethoxycarbonyl)-1-methylquinolinium
Homo sapiens
-
-
0.0023
8-demethoxy-10-O-methylhostasine
Homo sapiens
-
-
0.01913
8-formyl umbelliferone
Electrophorus electricus
pH 8.0, 22°C
0.01
9-(3-bromo-5-ethoxy-4-hydroxyphenyl)-3,3,6,6-tetramethyl-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001557 - 0.001895
9-amino-1,2,3,4-tetrahydroacridin-1-ol
0.000342 - 0.000387
9-aminoacridine
0.00123
9-O-[2-(9H-carbazole-4-yloxy)ethyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000375
9-O-[2-(benzotriazole-1-yloxy)ethyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000224
9-O-[2-(phenylol-1-yloxy)ethyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000052
9-O-[2-(phenylol-1-yloxy)hexyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.00112
9-O-[3-(9H-carbazole-4-yloxy)propyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000359
9-O-[3-(benzotriazole-1-yloxy)propyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000123
9-O-[3-(phenylol-1-yloxy)propyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000856
9-O-[4-(9H-carbazole-4-yloxy)butyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000224
9-O-[4-(benzotriazole-1-yloxy)butyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000097
9-O-[4-(phenylol-1-yloxy)butyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.00168
9-O-[5-(9H-carbazole-4-yloxy)butyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.00028
9-O-[5-(benzotriazole-1-yloxy)pentyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000398
9-O-[5-(phenylol-1-yloxy)pentyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.0021
9-O-[6-(9H-carbazole-4-yloxy)butyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.000515
9-O-[6-(benzotriazole-1-yloxy)hexyl] berberine bromide
Electrophorus electricus
-
pH 8.0, 37°C
0.1412
acephate
Crassostrea hongkongensis
-
in 80 mM sodium phosphate (pH 7.4), at 37°C
1.625
acrifoline
Electrophorus electricus
-
-
0.000006 - 0.000023
AH233683
0.000086 - 0.01047
Aldicarb
0.002666 - 0.03
aldicarb-sulfone
0.00079
amberboin
Homo sapiens
pH and temperature not specified in the publication
0.000769 - 0.01183
aminocarb
0.191
anhydrolycodoline
Electrophorus electricus
-
-
0.86
annotine
Electrophorus electricus
-
-
0.404
annotine N-oxide
Electrophorus electricus
-
-
2
annotinine
Electrophorus electricus
-
above
0.1
As3+
Cichla ocellaris
-
at pH 7.4 and 25°C
0.00387
assoanine
Homo sapiens
-
-
0.000001 - 0.004559
azamethiphos
0.000067 - 0.000736
bendiocarb
0.932
benzoylphosphoramidic dichloride
Homo sapiens
-
pH 7.4, 37°C
0.00014 - 0.00918
Berberine
0.000000228
bisnorcymserine
Electrophorus electricus
-
-
0.000029 - 0.001928
bromchlophos
0.00000267 - 1.99
BW284c51
0.000162 - 0.000977
carbanolate
0.00000479 - 1.2
Carbaryl
0.000022 - 2.57
carbofuran
0.0046
carinatumin A
Electrophorus electricus
-
-
0.007
carinatumin B
Electrophorus electricus
-
-
0.063
carvacrol
Electrophorus electricus
-
pH 7.8, 37°C
0.000068 - 0.01574
chlorfenvinphos
0.0076
chlorpyrifos
Colossoma macropomum
-
in 0.5 mM Tris-HCl buffer, pH 7.4, at 22°C
0.000153 - 0.000612
chlorpyrifos oxon
0.028
conarrhimin
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.004
conessimin
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.021
conessine
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.023
conimin
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.0000064
coroxon
Stomoxys calcitrans
in potassium phosphate buffer (100 mM, pH 7.5), at 25°C
0.000006 - 0.00143
coumaphos-oxon
0.00497
coumarin 106
Electrophorus electricus
-
-
0.000009 - 0.006978
Crotoxyphos
0.00467
cryptotanshinone
Homo sapiens
pH and temperature not specified in the publication
0.00347
decursidin
Electrophorus electricus
pH 8.0, 22°C
0.000745 - 0.03
demeton-S-methyl
0.000016 - 0.353
dichlorvos
0.002421 - 0.03
dicrotophos
0.00089
dihydrotanshinone
Homo sapiens
pH and temperature not specified in the publication
0.00012 - 0.00441
diisopropylfluorophosphate
0.012 - 0.01435
dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
0.07535
dimethyl [(9R)-9-phenyl-6-oxa-7-azaspiro[3.5]non-7-en-8-yl]propanedioate
Homo sapiens
-
pH and temperature not specified in the publication
0.04676
dimethyl [2-acetyl-4-(4-chlorophenyl)-6,6-dimethyl-5,6-dihydro-2H-1,2-oxazin-3-yl]propanedioate
Homo sapiens
-
pH and temperature not specified in the publication
0.000207 - 0.02601
dioxacarb
0.19
disodium calenduladiol disulfate
Homo sapiens
-
-
0.000016
donecopride
Homo sapiens
pH 8.0, 25°C
0.0000064 - 0.089
donepezil
0.0000116
donepizil
Homo sapiens
-
-
0.00522 - 0.16
edrophonium
0.009
epinorgalantamine
Homo sapiens
-
-
0.0049 - 0.009
Ethidium bromide
Rattus norvegicus
-
pH 7.5, 25°C
0.001285 - 0.03
ethiofencarb
0.00217 - 0.13
ethopropazine
0.00006
ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
Tetronarce californica
-
1
ethyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
Homo sapiens
-
above
1
ethyl 7-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
Homo sapiens
-
above
0.000177 - 0.03
famphur-O
0.00014 - 0.007341
fenobucarb
0.0000005 - 0.001521
fospirate
0.00107 - 0.00276
galantamine
0.00025 - 0.1
galanthamine
0.07
giganteone A
Electrophorus electricus
-
above
0.07
giganteone C
Electrophorus electricus
-
above
1.72
gnidioidine
Electrophorus electricus
-
-
0.000464 - 0.03
heptenophos
0.000006 - 0.000014
heptylene-bis-tacrine
0.0016
hookerianamide-F
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.00004 - 0.0014
huperzine A
0.00079
huperzine B
Electrophorus electricus
-
-
0.0097
infractopicrin
Homo sapiens
-
-
0.3
isoconessimine
Electrophorus electricus
-
IC50 above 0.3 mM, in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.05
isocorydine
Rattus norvegicus
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
0.000312 - 0.008646
isoprocarb
0.00093
Jatrorrhizine
Electrophorus electricus
-
-
0.00052
lipidiol
Homo sapiens
pH and temperature not specified in the publication
0.00033
loganin
Tetronarce californica
pH and temperature not specified in the publication
2
lycodoline
Electrophorus electricus
-
above
0.6
lycofoline
Electrophorus electricus
-
-
0.025
lycoparin C
Bos taurus
-
-
0.0167
lycoposerramine
Electrophorus electricus
-
-
2
lycoposerramine M
Electrophorus electricus
-
above
0.07
maingayone B
Electrophorus electricus
-
above
0.07
maingayone C
Electrophorus electricus
-
above
0.011
malabaricone A
Electrophorus electricus
-
-
0.0094
malabaricone B
Electrophorus electricus
-
-
0.0117
malabaricone C
Electrophorus electricus
-
-
0.000237 - 0.004212
methiocarb
0.006
methyl (2R,5R)-5-[(benzyloxy)methyl]-2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
Electrophorus electricus
-
pH 7.5, 25°C
0.035
methyl (2S,5R)-5-[(benzyloxy)methyl]-2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
Electrophorus electricus
-
pH 7.5, 25°C
0.005
methyl 1-methoxy-5-methyl-1,2,3,6-tetrahydrophosphinine-4-carboxylate 1-oxide
Electrophorus electricus
-
pH 7.5, 25°C
0.007
methyl 2-methoxy-7-methyl-2,3,4,5-tetrahydro-1,2-oxaphosphepine-6-carboxylate 2-oxide
Electrophorus electricus
-
pH 7.5, 25°C
1
methyl 5-[(dimethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
Homo sapiens
-
above
1
methyl 5-[(ethylcarbamoyl)oxy]-1-methyl-1,4-dihydroquinoline-3-carboxylate
Homo sapiens
-
above
0.03512
methyl [(10R)-10-phenyl-7-oxa-8-azaspiro[4.5]dec-8-en-9-yl]acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.0063
methyl [(1S,4S,4'R)-4'-phenyl-4'H-spiro[bicyclo[2.1.1]hexane-5,5'-[1,2]oxazin]-3'-yl]acetate
Homo sapiens
-
pH and temperature not specified in the publication
0.000023 - 0.002946
metrifonate
0.000113 - 0.004501
mevinphos
0.000131 - 0.006511
mexacarbate
0.006814 - 0.03
Monocrotophos
0.00395
morroniside
Tetronarce californica
pH and temperature not specified in the publication
0.01
N'-[(1E)-1-(4-hydroxyphenyl)ethylidene]-2-(2-nitrophenoxy)acetohydrazide
Homo sapiens
-
IC50 above 0.01 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00127 - 0.0106
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
0.00155 - 0.00693
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
0.00234 - 0.05098
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
40.9
N,N-dimethyl phosphoramidic acid bis-(4-chlorophenyl) ester
Homo sapiens
-
-
35.4
N,N-dimethyl phosphoramidic acid bis-(4-methylphenyl) ester
Homo sapiens
-
-
31.3
N,N-dimethyl phosphoramidic acid bis-phenyl ester
Homo sapiens
-
-
0.00506 - 0.01234
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
0.0104
N-(1,3-thiazol-5-ylcarbamothioyl)butanamide
Homo sapiens
pH 7.7, 37°C
0.00016
N-(14-methylallyl)norgalanthamine
Tetronarce californica
-
-
0.0000508
N-(2,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001686
N-(2,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000494
N-(2,5-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000483
N-(2,6-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001739
N-(2-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000653
N-(2-cyanophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000987
N-(2-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001039
N-(2-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.00000513
N-(2-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]ethyl)-1,2,3,4-tetrahydroacridin-9-amine
Homo sapiens
-
-
0.0000499
N-(3,4-difluorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001739
N-(3,4-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001684
N-(3,5-dimethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001682
N-(3-chlorophenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001024
N-(3-ethylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001156
N-(3-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.00000216
N-(3-[4-[(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methyl]piperidin-1-yl]propyl)-1,2,3,4-tetrahydroacridin-9-amine
Homo sapiens
-
-
0.0001039
N-(4-methoxyphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001023
N-(4-methylphenyl)-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.00111
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethyl-carbamoyl-3-hydroxy-1-phenylbut-2-yl)-5-[methyl-(methylsulfonyl)amino]-N'-[(R)-1-phenylethyl]isophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00168
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-3-hydroxy-1-phenylbut-2-yl)-N',N'-dipropyl-5-nitroisophthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00139
N-([2S,3(R,S)]-2-[4-(1-benzylpiperidin-4-yl)]ethylcarbamoyl-3-hydroxy-1-phenylbut-2-yl)-N'-[(R)-1-(4-fluorophenyl)ethyl]-5-[methyl(methylsulfonyl)amino]iso phthalamide
Homo sapiens
-
pH 8.0, 37°C
0.00018
N-allylnorgalanthamine
Tetronarce californica
-
-
1.567 - 2.34
N-benzoyl N',N'-(tert-butybenzyl) phosphoramidic chloride
2.986 - 4.64
N-benzoyl N',N'-(tert-butybenzyl) thiophosphoramidic chloride
0.0000991
N-cyclopentyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0001014
N-ethyl-4,4-difluoro-8-(propan-2-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indole-2-carboxamide
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.216
N-trans-caffeoyltyramine
Tetronarce californica
pH 7.8, 25°C
0.158
N-[(2,3-dichlorophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0589
N-[(2,4,6-trimethylphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0427
N-[(2,4-dichlorophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0403
N-[(2,6-dichloro-4-fluorophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0966
N-[(2-methoxyphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0264
N-[(3-nitrophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0491
N-[(4-methoxyphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0425
N-[(4-methylphenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.0297
N-[(4-nitrophenyl)carbamothioyl]butanamide
Homo sapiens
pH 7.7, 37°C
0.00119 - 0.02342
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
0.00058 - 0.00368
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
2.89
N-[di(morpholin-4-yl)phosphoryl]-4-methylbenzamide
Homo sapiens
-
pH 7.4, 37°C
0.62
N-[di(morpholin-4-yl)phosphoryl]benzamide
Homo sapiens
-
pH 7.4, 37°C
0.000005 - 0.61
neostigmine
0.00015 - 0.00059
neostigmine bromide
4.326
neostigmine methylsulfate
Ovis aries
-
-
0.00143
norsanguinine
Homo sapiens
-
-
0.00096
O-acetyllycorine
Electrophorus electricus
-
-
0.00000727
O-isopropyl methylphosphonofluoridate
Cavia porcellus
-
pH 7.4, 37°C
0.0000029
O-pinacolyl methylphosphonofluoridate
Cavia porcellus
-
pH 7.4, 37°C
0.001156 - 0.03969
omethoate
0.0425
oxoxylopine
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000651 - 0.031
oxydemeton methyl
0.00026 - 0.0104
palmatine
1.246
paracetamol/caffeine
Ovis aries
-
-
1.646
paracetamol/propifenazone/caffeine
Ovis aries
-
-
0.000016 - 0.836
paraoxon
0.0000071 - 0.00002777
paraoxon-ethyl
7.75
Pb2+
Parachromis managuensis
-
pH 8.0, 25°C
0.000022
phenserine
Electrophorus electricus
-
-
0.00294 - 0.00305
Phenylmethylsulfonylfluoride
0.000757 - 0.03
Phosphamidon
0.000004 - 0.00645
physostigmine
0.00226 - 0.03
pirimicarb
0.00347 - 0.00356
procainamide
0.000967 - 0.01509
profenofos
0.14
promalabaricone B
Electrophorus electricus
-
above
0.14
promalabaricone C
Electrophorus electricus
-
above
0.00004 - 0.000733
promecarb
0.001132 - 0.001776
propidium iodide
0.000012 - 0.185
propoxur
0.000904 - 0.003122
pyridostigmine
0.165
R-DEPP
Electrophorus electricus
pH 8.0, 25°C
0.0207
remerine
Rattus norvegicus
-
pH and temperature not specified in the publication
0.00381
rivastigmine
Rattus norvegicus
-
pH 7.4, 37°C
0.145
S-DEPP
Electrophorus electricus
pH 8.0, 25°C
0.00000338
S-[2-(diisopropylamino)ethyl]-O-ethylmethylphosphonothioate
Cavia porcellus
-
pH 7.4, 37°C
0.0001
sanguinine
Homo sapiens
-
-
0.0015
sarcovagenine-C
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.0022
sarcovagine-D
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.000775
serpentine
Electrophorus electricus
-
-
0.0000053
sodium 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate
Tetronarce californica
-
0.038
stepharotudine
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000119 - 0.03
tetrachlorvinphos
0.0037
tetraethyl diphosphate
Colossoma macropomum
-
in 0.5 mM Tris-HCl buffer, pH 7.4, at 22°C
0.000004 - 0.004811
tetraethylpyrophosphate
0.0413
tetrahydropalmatine
Rattus norvegicus
-
pH and temperature not specified in the publication
0.3184
tetraisopropyl diphosphoramide
Arapaima gigas
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.05
thalifoline
Rattus norvegicus
-
IC50 above 0.05 mM, pH and temperature not specified in the publication
0.00093 - 0.00159
thiodicarb
0.000093 - 0.00831
thioflavin T
0.54
thyme essential oil
Electrophorus electricus
-
pH 7.8, 37°C
-
0.04
thymohydroquinone
Electrophorus electricus
-
pH 7.8, 37°C
0.74
Thymol
Electrophorus electricus
-
pH 7.8, 37°C
0.14
thymoquinone
Electrophorus electricus
-
pH 7.8, 37°C
0.135
trans-anethole
Electrophorus electricus
-
-
0.233
Trigonelline
Bos taurus
-
-
0.1055
umbelliferone
Electrophorus electricus
pH 8.0, 22°C
0.00035
ungeremine
Homo sapiens
-
-
0.0000003 - 0.0003
xanthostigmine
0.054
[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone
Homo sapiens
-
pH 8.0, 37°C
additional information
additional information
-
0.00183
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)amino]-N-[(R)-1-phenylethyl]isophthalamide
Homo sapiens
-
pH 8.0, 37°C, in vitro AChE inhibition
0.0987
(1S,2R)-N-(1-benzyl-2-hydroxy-3-(S)-[2-(1-benzylpiperidin-4-yl)ethylamino]-propyl)-5-[methyl(methylsulfonyl)amino]-N-[(R)-1-phenylethyl]isophthalamide
Homo sapiens
-
in vivo in amyloid precursor protein-transfected HEK293 cells
0.0065
(R)-(+)-fenoxon sulfoxide
Electrophorus electricus
-
pH 7.5, 25°C, recombinant enzyme
0.0069
(R)-(+)-fenoxon sulfoxide
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
1
(R)-(+)-fenthion sulfoxide
Homo sapiens
-
above, pH 7.5, 25°C, recombinant enzyme
1
(R)-(+)-fenthion sulfoxide
Electrophorus electricus
-
above, pH 7.5, 25°C, recombinant enzyme
0.0087
(rac) fenoxon sulfoxide
Electrophorus electricus
-
pH 7.5, 25°C, recombinant enzyme
0.023
(rac) fenoxon sulfoxide
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
1
(rac) fenthion sulfoxide
Homo sapiens
-
above, pH 7.5, 25°C, recombinant enzyme
1
(rac) fenthion sulfoxide
Electrophorus electricus
-
above, pH 7.5, 25°C, recombinant enzyme
1
(S)-(+)-fenthion sulfoxide
Homo sapiens
-
above, pH 7.5, 25°C, recombinant enzyme
1
(S)-(+)-fenthion sulfoxide
Electrophorus electricus
-
above, pH 7.5, 25°C, recombinant enzyme
0.111
(S)-(-)-fenoxon sulfoxide
Electrophorus electricus
-
pH 7.5, 25°C, recombinant enzyme
0.23
(S)-(-)-fenoxon sulfoxide
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.00005
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
Gambusia yucatana
-
head enzyme, pH 7.4, temperature not specified in the publication
0.00006
1,5-bis-(4-allyldimethyl-ammoniumphenyl)-pentan-3-one dibromide
Gambusia yucatana
-
muscle enzyme, pH 7.4, temperature not specified in the publication
0.0002606
1-(1-benzyl-7-chloro-4-methoxy-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.0002606
1-(1-benzyl-7-chloro-4-methoxy-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Homo sapiens
pH 8.0, 25°C
0.000133
1-(1-benzylindol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.000133
1-(1-benzylindol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Homo sapiens
pH 8.0, 25°C
0.0000288
1-(7-chloro-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.0000288
1-(7-chloro-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Homo sapiens
pH 8.0, 25°C
0.0000844
1-(7-chloro-4-methoxy-1-methyl-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.0000844
1-(7-chloro-4-methoxy-1-methyl-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Homo sapiens
pH 8.0, 25°C
0.0000914
1-(7-chloro-4-methoxy-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.0000914
1-(7-chloro-4-methoxy-1H-indol-5-yl)-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Homo sapiens
pH 8.0, 25°C
0.000559
1-[1-(benzenesulfonyl)-7-chloro-4-methoxy-indol-5-yl]-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.000559
1-[1-(benzenesulfonyl)-7-chloro-4-methoxy-indol-5-yl]-3-[1-(cyclohexylmethyl)-4-piperidyl]propan-1-one
Homo sapiens
pH 8.0, 25°C
0.00335
2,2-dichlorovinyl dimethyl phosphate
Blattella germanica
-
recombinant enzyme AChE2, pH not specified in the publication, 30°C
0.0861
2,2-dichlorovinyl dimethyl phosphate
Blattella germanica
-
recombinant enzyme AChE1, pH not specified in the publication, 30°C
0.01564
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.1
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
Homo sapiens
-
IC50 above 0.1 mM, at pH 8.0 and 20°C
0.01068
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
Homo sapiens
-
at pH 8.0 and 20°C
0.01312
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.0035
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.00875
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
Homo sapiens
-
at pH 8.0 and 20°C
0.00268
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.00802
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
Homo sapiens
-
at pH 8.0 and 20°C
0.00103
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
Homo sapiens
-
at pH 8.0 and 20°C
0.00108
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
Electrophorus electricus
-
at pH 8.0 and 20°C
0.00213
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
Homo sapiens
-
at pH 8.0 and 20°C
0.00305
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
Electrophorus electricus
-
at pH 8.0 and 20°C
0.0000133
3-(1-benzyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.0000133
3-(1-benzyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
Homo sapiens
pH 8.0, 25°C
0.0000204
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-1H-indol-5-yl)propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.0000204
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-1H-indol-5-yl)propan-1-one
Homo sapiens
pH 8.0, 25°C
0.000275
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-2-trimethylsilyl-1H-indol-5-yl)propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.000275
3-(1-benzyl-4-piperidyl)-1-(7-chloro-4-methoxy-2-trimethylsilyl-1H-indol-5-yl)propan-1-one
Homo sapiens
pH 8.0, 25°C
0.000716
3-(1-butyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.000716
3-(1-butyl-4-piperidyl)-1-(1H-indol-5-yl)propan-1-one
Homo sapiens
pH 8.0, 25°C
0.000051
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.000051
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
Homo sapiens
pH 8.0, 25°C
0.00004
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(4-methoxy-1Hindol-5-yl)propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.00004
3-[1-(cyclohexylmethyl)-4-piperidyl]-1-(4-methoxy-1Hindol-5-yl)propan-1-one
Homo sapiens
pH 8.0, 25°C
0.000094
3-[1-(cyclopentylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
Tetronarce californica
pH 8.0, 25°C
0.000094
3-[1-(cyclopentylmethyl)-4-piperidyl]-1-(1H-indol-5-yl)propan-1-one
Homo sapiens
pH 8.0, 25°C
0.01733
4-(1H-benzimidazol-2-yl)phenol
Electrophorus electricus
-
at pH 8.0 and 20°C
0.1
4-(1H-benzimidazol-2-yl)phenol
Homo sapiens
-
IC50 above 0.1 mM, at pH 8.0 and 20°C
0.01459
4-(5-chloro-1H-benzimidazol-2-yl)phenol
Electrophorus electricus
-
at pH 8.0 and 20°C
0.1
4-(5-chloro-1H-benzimidazol-2-yl)phenol
Homo sapiens
-
IC50 above 0.1 mM, at pH 8.0 and 20°C
0.01593
4-(5-methyl-1H-benzimidazol-2-yl)phenol
Electrophorus electricus
-
at pH 8.0 and 20°C
0.1
4-(5-methyl-1H-benzimidazol-2-yl)phenol
Homo sapiens
-
IC50 above 0.1 mM, at pH 8.0 and 20°C
0.01879
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.1
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
Homo sapiens
-
IC50 above 0.1 mM, at pH 8.0 and 20°C
0.00973
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
Homo sapiens
-
at pH 8.0 and 20°C
0.01105
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.01292
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
Homo sapiens
-
at pH 8.0 and 20°C
0.1
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
Electrophorus electricus
-
IC50 above 0.1 mM, at pH 8.0 and 20°C
0.00013
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Homo sapiens
-
at pH 8.0 and 20°C
0.00061
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Electrophorus electricus
-
at pH 8.0 and 20°C
0.0014
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Homo sapiens
-
at pH 8.0 and 20°C
0.00324
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Electrophorus electricus
-
at pH 8.0 and 20°C
0.00039
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Homo sapiens
-
at pH 8.0 and 20°C
0.00084
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Electrophorus electricus
-
at pH 8.0 and 20°C
0.0004
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Homo sapiens
-
at pH 8.0 and 20°C
0.00134
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
Electrophorus electricus
-
at pH 8.0 and 20°C
0.0000249
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
Homo sapiens
-
-
0.000093
5-(4-chlorophenyl)-N-[9-[(6-chloro-1,2,3,4-tetrahydroacridin-9-yl)amino]nonyl]-3,4-dihydro-2H-pyrano[3,2-c]quinoline-9-carboxamide
Tetronarce californica
-
0.001557
9-amino-1,2,3,4-tetrahydroacridin-1-ol
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001895
9-amino-1,2,3,4-tetrahydroacridin-1-ol
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000342
9-aminoacridine
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000387
9-aminoacridine
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
1.23
acetamiprid
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEBI
1.64
acetamiprid
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEAII
0.000006
AH233683
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000023
AH233683
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000086
Aldicarb
Bactrocera dorsalis
-
enzyme from larva, at pH 7.4 and 37°C
0.00022
Aldicarb
Diopatra neapolitana
-
inhibition of acetylcholine esterase activity, pH 8.0, 25°C
0.000292
Aldicarb
Bactrocera dorsalis
-
enzyme from pupa, at pH 7.4 and 37°C
0.000338
Aldicarb
Liposcelis entomophila
-
enzyme from Sichuan Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0004217
Aldicarb
Bactrocera dorsalis
-
enzyme from adult, at pH 7.4 and 37°C
0.000432
Aldicarb
Liposcelis entomophila
-
enzyme from Chongqing Municipality population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.000503
Aldicarb
Liposcelis entomophila
-
enzyme from Hubei Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.001685
Aldicarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.01047
Aldicarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.002666
aldicarb-sulfone
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
aldicarb-sulfone
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
aldicarb-sulfoxide
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
aldicarb-sulfoxide
Lucilia cuprina
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000769
aminocarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.01183
aminocarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000001
azamethiphos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.004559
azamethiphos
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000067
bendiocarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000736
bendiocarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00014
Berberine
Electrophorus electricus
pH 8.0, 22°C
0.000374
Berberine
Electrophorus electricus
-
pH 8.0, 37°C
0.00045
Berberine
Tetronarce californica
pH and temperature not specified in the publication
0.00058
Berberine
Electrophorus electricus
-
-
0.00918
Berberine
Electrophorus electricus
pH 8.0, 22°C
0.000029
bromchlophos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001928
bromchlophos
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
butocarboxim
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
butocarboxim
Lucilia cuprina
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
butoxycarboxim
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
butoxycarboxim
Lucilia cuprina
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00000267
BW284c51
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.00000433
BW284c51
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
0.000011
BW284c51
Liposcelis entomophila
-
enzyme from Sichuan Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.00001906
BW284c51
Bactrocera dorsalis
-
enzyme from larva, at pH 7.4 and 37°C
0.00002
BW284c51
Liposcelis entomophila
-
enzyme from Chongqing Municipality population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0000368
BW284c51
Pardosa pseudoannulata
pH 8.0, temperature not specified in the publication
0.0000428
BW284c51
Bactrocera dorsalis
-
enzyme from pupa, at pH 7.4 and 37°C
0.000049
BW284c51
Liposcelis entomophila
-
enzyme from Hubei Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0000512
BW284c51
Pardosa pseudoannulata
pH 7.0, temperature not specified in the publication
0.00007052
BW284c51
Bactrocera dorsalis
-
enzyme from adult, at pH 7.4 and 37°C
0.000075
BW284c51
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000106
BW284c51
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000368
BW284c51
Blattella germanica
-
recombinant enzyme AChE2, pH not specified in the publication, 30°C
0.000441
BW284c51
Blattella germanica
-
recombinant enzyme AChE1, pH not specified in the publication, 30°C
0.000471
BW284c51
Pardosa pseudoannulata
pH 7.0, temperature not specified in the publication
0.001
BW284c51
Sitobion avenae
-
purified enzyme, at pH 7.5 and 30°C
0.00166
BW284c51
Schizaphis graminum
-
pH and temperature not specified in the publication
0.00196
BW284c51
Hoplosternum littorale
-
pH 8.0, 30°C
0.00254
BW284c51
Pardosa pseudoannulata
pH 7.0, temperature not specified in the publication
0.00257
BW284c51
Rhopalosiphum padi
-
purified enzyme, at pH 7.5 and 30°C
0.003
BW284c51
Heterorhabditis bacteriophora
-
pH 7.5, 37°C, isozyme AChE1A
0.00396
BW284c51
Rachycentron canadum
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00412
BW284c51
Oreochromis niloticus
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00574
BW284c51
Gammarus pulex
-
pH 7.8, 25°C, versus acetylcholine iodide
0.00682
BW284c51
Cyprinus carpio
pH 7.6, 40°C, recombinant enzyme
0.00722
BW284c51
Cyprinus carpio
pH 7.6, 40°C, native enzyme
0.00752
BW284c51
Colossoma macropomum
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00773
BW284c51
Gammarus pulex
-
pH 7.8, 25°C, versus propionylcholine iodide
0.02
BW284c51
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine
0.032
BW284c51
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine
0.3184
BW284c51
Arapaima gigas
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.52
BW284c51
Heterorhabditis bacteriophora
-
isozyme isozyme AChEA, pH 8.5, 35°C
0.63
BW284c51
Heterorhabditis bacteriophora
-
isozyme isozyme AChEB, pH 8.5, 35°C
0.87
BW284c51
Parachromis managuensis
-
pH 8.0, 25°C
1.99
BW284c51
Anopheles gambiae
-
-
0.000162
carbanolate
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000977
carbanolate
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00000479
Carbaryl
Eisenia andrei
-
pH 7.4, 25°C, versus propionylthiocholine
0.00000575
Carbaryl
Eisenia andrei
-
pH 7.4, 25°C, versus acetylthiocholine
0.000009
Carbaryl
Ctenocephalides felis
isoform AChE2, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C
0.000038
Carbaryl
Ctenocephalides felis
isoform AChE1, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C
0.000182
Carbaryl
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000343
Carbaryl
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.00094
Carbaryl
Schizaphis graminum
-
pH and temperature not specified in the publication
0.00493
Carbaryl
Diopatra neapolitana
-
inhibition of acetylcholine esterase activity, pH 8.0, 25°C
0.008185
Carbaryl
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0135
Carbaryl
Blattella germanica
-
recombinant enzyme AChE2, pH not specified in the publication, 30°C
0.0338
Carbaryl
Colossoma macropomum
-
in 0.5 mM Tris-HCl buffer, pH 7.4, at 22°C
0.36
Carbaryl
Blattella germanica
-
recombinant enzyme AChE1, pH not specified in the publication, 30°C
0.725
Carbaryl
Anopheles gambiae
-
-
1.2
Carbaryl
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
0.000022
carbofuran
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000247
carbofuran
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00056
carbofuran
Diopatra neapolitana
-
inhibition of acetylcholine esterase activity, pH 8.0, 25°C
0.000902
carbofuran
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.00092
carbofuran
Colossoma macropomum
-
in 0.5 mM Tris-HCl buffer, pH 7.4, at 22°C
0.0169
carbofuran
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
1.4
carbofuran
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEBI
2.57
carbofuran
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEAII
3.656
Cd2+
Parachromis managuensis
-
pH 8.0, 25°C
6.14
Cd2+
Cichla ocellaris
-
at pH 7.4 and 25°C
0.000068
chlorfenvinphos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.01574
chlorfenvinphos
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000153
chlorpyrifos oxon
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.000612
chlorpyrifos oxon
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
0.000006
coumaphos-oxon
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00143
coumaphos-oxon
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000009
Crotoxyphos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.006978
Crotoxyphos
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.773
Cu2+
Parachromis managuensis
-
pH 8.0, 25°C
2.1
Cu2+
Cichla ocellaris
-
at pH 7.4 and 25°C
0.000745
demeton-S-methyl
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
demeton-S-methyl
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000016
dichlorvos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00004
dichlorvos
Colossoma macropomum
-
in 0.5 mM Tris-HCl buffer, pH 7.4, at 22°C
0.03
dichlorvos
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0503
dichlorvos
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.353
dichlorvos
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
0.002421
dicrotophos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
dicrotophos
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00012
diisopropylfluorophosphate
Electrophorus electricus
-
pH 7.5, 25°C
0.00439
diisopropylfluorophosphate
Cyprinus carpio
pH 7.6, 40°C, recombinant enzyme
0.00441
diisopropylfluorophosphate
Cyprinus carpio
pH 7.6, 40°C, native enzyme
0.012
dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
Homo sapiens
-
pH and temperature not specified in the publication
0.01435
dimethyl (2-acetyl-6,6-dimethyl-4-phenyl-5,6-dihydro-2H-1,2-oxazin-3-yl)propanedioate
Homo sapiens
-
pH and temperature not specified in the publication
0.000207
dioxacarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.02601
dioxacarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0000064
donepezil
Homo sapiens
-
pH 7.3
0.0000067
donepezil
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.000014
donepezil
Electrophorus electricus
-
at pH 8.0 and 25°C
0.000019
donepezil
Rattus norvegicus
-
pH 7.4, 37°C
0.00002
donepezil
Homo sapiens
-
-
0.0000268
donepezil
Rattus norvegicus
-
pH 7.4, 37°C
0.00005
donepezil
Homo sapiens
-
-
0.00006
donepezil
Homo sapiens
pH 8.0, 25°C
0.069
donepezil
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine
0.089
donepezil
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine
0.00522
edrophonium
Cyprinus carpio
pH 7.6, 40°C, recombinant enzyme
0.0066
edrophonium
Cyprinus carpio
pH 7.6, 40°C, native enzyme
0.031
edrophonium
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine
0.16
edrophonium
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine
0.00000042
eserine
Bactrocera dorsalis
-
enzyme from larva, at pH 7.4 and 37°C
0.00000158
eserine
Bactrocera dorsalis
-
enzyme from pupa, at pH 7.4 and 37°C
0.00000256
eserine
Bactrocera dorsalis
-
enzyme from adult, at pH 7.4 and 37°C
0.000005
eserine
Stomoxys calcitrans
in potassium phosphate buffer (100 mM, pH 7.5), at 25°C
0.000012
eserine
Eisenia andrei
-
pH 7.4, 25°C, versus propionylthiocholine
0.0000144
eserine
Eisenia andrei
-
pH 7.4, 25°C, versus acetylthiocholine
0.0000652
eserine
Pardosa pseudoannulata
pH 8.0, temperature not specified in the publication
0.0001167
eserine
Pardosa pseudoannulata
pH 7.0, temperature not specified in the publication
0.0002
eserine
Hoplosternum littorale
-
pH 8.0, 30°C
0.00022
eserine
Gambusia yucatana
-
head enzyme, pH 7.4, temperature not specified in the publication
0.000298
eserine
Blattella germanica
-
recombinant enzyme AChE2, pH not specified in the publication, 30°C
0.00031
eserine
Arapaima gigas
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00033
eserine
Gambusia yucatana
-
muscle enzyme, pH 7.4, temperature not specified in the publication
0.000371
eserine
Colossoma macropomum
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00049
eserine
Rachycentron canadum
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00054
eserine
Diopatra neapolitana
-
inhibition of acetylthiocholine esterase activity, pH 8.0, 25°C
0.00076
eserine
Oreochromis niloticus
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00109
eserine
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.001163
eserine
Pardosa pseudoannulata
pH 7.0, temperature not specified in the publication
0.00164
eserine
Sitobion avenae
-
purified enzyme, at pH 7.5 and 30°C
0.00186
eserine
Pardosa pseudoannulata
pH 7.0, temperature not specified in the publication
0.00189
eserine
Rhopalosiphum padi
-
purified enzyme, at pH 7.5 and 30°C
0.00201
eserine
Blattella germanica
-
recombinant enzyme AChE1, pH not specified in the publication, 30°C
0.0035
eserine
Heterorhabditis bacteriophora
-
pH 7.5, 37°C, isozyme AChE1A
0.0173
eserine
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
0.083
eserine
Anopheles gambiae
-
-
0.17
eserine
Parachromis managuensis
-
pH 8.0, 25°C
1
eserine
Heterorhabditis bacteriophora
-
isozyme isozyme AChEA, pH 8.5, 35°C
1.3
eserine
Heterorhabditis bacteriophora
-
isozyme isozyme AChEB, pH 8.5, 35°C
0.001285
ethiofencarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
ethiofencarb
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00217
ethopropazine
Cyprinus carpio
pH 7.6, 40°C, recombinant enzyme
0.00335
ethopropazine
Cyprinus carpio
pH 7.6, 40°C, native enzyme
0.0659
ethopropazine
Anopheles gambiae
-
-
0.093
ethopropazine
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine
0.102
ethopropazine
Schizaphis graminum
-
pH and temperature not specified in the publication
0.13
ethopropazine
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine
0.000177
famphur-O
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
famphur-O
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00014
fenobucarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.007341
fenobucarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0097
fenoxon
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.021
fenoxon
Electrophorus electricus
-
pH 7.5, 25°C, recombinant enzyme
0.0807
fenthion
Homo sapiens
-
pH 7.5, 25°C, recombinant enzyme
0.114
fenthion
Electrophorus electricus
-
pH 7.5, 25°C, recombinant enzyme
0.0000005
fospirate
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001521
fospirate
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00107
galantamine
Homo sapiens
-
-
0.00276
galantamine
Tetronarce californica
pH 7.8, 25°C
0.00025
galanthamine
Electrophorus electricus
-
pH 7.8, 37°C
0.000291
galanthamine
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000623
galanthamine
Electrophorus electricus
-
pH 8.0, 37°C
0.001165
galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.00127
galanthamine
Bos taurus
-
-
0.0018
galanthamine
Electrophorus electricus
-
pH 8.0, 37°C
0.00182
galanthamine
Tetronarce californica
-
-
0.00239
galanthamine
Electrophorus electricus
-
-
0.002908
galanthamine
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00301
galanthamine
Rattus norvegicus
-
pH 7.4, 37°C
0.0087
galanthamine
Homo sapiens
-
-
0.1
galanthamine
Bos taurus
-
pH 7.6, 22°C
0.000464
heptenophos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
heptenophos
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000006
heptylene-bis-tacrine
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000014
heptylene-bis-tacrine
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.013
Hg2+
Parachromis managuensis
-
pH 8.0, 25°C
0.22
Hg2+
Cichla ocellaris
-
at pH 7.4 and 25°C
0.00004
huperzine A
Homo sapiens
-
pH 7.4, 37°C
0.000053
huperzine A
Rattus norvegicus
-
pH 7.4, 37°C
0.00006
huperzine A
Electrophorus electricus
-
in 0.1 M sodium phosphate buffer, pH 8.0, at 37°C
0.0008
huperzine A
Electrophorus electricus
-
-
0.0014
huperzine A
Electrophorus electricus
-
pH 8.0, 37°C
0.00483
iso-ompa
Hoplosternum littorale
-
pH 8.0, 30°C
0.0217
iso-ompa
Pardosa pseudoannulata
pH 7.0, temperature not specified in the publication
0.2
iso-ompa
Parachromis managuensis
-
pH 8.0, 25°C
0.000312
isoprocarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.008646
isoprocarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000061
malaoxon
Schizaphis graminum
-
pH and temperature not specified in the publication
0.00326
malaoxon
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.00919
malaoxon
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
3.28
malaoxon
Anopheles gambiae
-
-
0.087
malathion
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEBI
0.11
malathion
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEAII
0.000237
methiocarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.004212
methiocarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00031
methomyl
Diopatra neapolitana
-
inhibition of acetylcholine esterase activity, pH 8.0, 25°C
0.00141
methomyl
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00288
methomyl
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00556
methomyl
Rhopalosiphum padi
-
purified enzyme, at pH 7.5 and 30°C
0.00723
methomyl
Sitobion avenae
-
purified enzyme, at pH 7.5 and 30°C
18
methomyl
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEBI
23
methomyl
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEAII
0.000023
metrifonate
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.002946
metrifonate
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000113
mevinphos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.004501
mevinphos
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000131
mexacarbate
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.006511
mexacarbate
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.006814
Monocrotophos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
Monocrotophos
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00127
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
Tribolium confusum
-
pH 7.4, 22°C
0.00516 - 0.00585
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
Cimex lectularius
-
pH 7.4, 22°C
0.00563
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
Vespula maculifrons
-
pH 7.4, 22°C
0.00611 - 0.00886
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
Blattella germanica
-
different stages of males, 5th instar larvae and adults, pH 7.4, 22°C, overview
0.00649
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
Harmonia axyridis
-
pH 7.4, 22°C
0.00827
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
Periplaneta americana
-
adult male, pH 7.4, 22°C
0.0106
N,N,N-trimethyl-17-(methylsulfonylthio)heptadecan-1-aminium bromide
Periplaneta americana
-
male 7th instar larva, pH 7.4, 22°C
0.00155
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
Tribolium confusum
-
pH 7.4, 22°C
0.00693
N,N,N-trimethyl-18-(methylsulfonylthio)octadecan-1-aminium bromide
Blattella germanica
-
male 5th instar larva, pH 7.4, 22°C
0.00234
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.05098
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
Homo sapiens
-
at pH 8.0 and 20°C
0.00506
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.01234
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
Homo sapiens
-
at pH 8.0 and 20°C
1.567
N-benzoyl N',N'-(tert-butybenzyl) phosphoramidic chloride
Homo sapiens
-
pH 7.4, 25°C, purified enzyme
2.34
N-benzoyl N',N'-(tert-butybenzyl) phosphoramidic chloride
Homo sapiens
-
pH 7.4, 25°C, crude enzyme
2.986
N-benzoyl N',N'-(tert-butybenzyl) thiophosphoramidic chloride
Homo sapiens
-
pH 7.4, 25°C, purified enzyme
4.64
N-benzoyl N',N'-(tert-butybenzyl) thiophosphoramidic chloride
Homo sapiens
-
pH 7.4, 25°C, crude enzyme
0.00119
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.02342
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
Homo sapiens
-
at pH 8.0 and 20°C
0.00058
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.00368
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
Homo sapiens
-
at pH 8.0 and 20°C
0.000005
neostigmine
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0000462
neostigmine
Rattus norvegicus
-
pH 7.4, temperature not specified in the publication
0.0000503
neostigmine
Homo sapiens
-
pH 7.3
0.000177
neostigmine
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00034
neostigmine
Hoplosternum littorale
-
pH 8.0, 30°C
0.0024
neostigmine
Homo sapiens
-
pH and temperature not specified in the publication
0.0222
neostigmine
Homo sapiens
pH 7.7, 37°C
0.61
neostigmine
Parachromis managuensis
-
pH 8.0, 25°C
0.00015
neostigmine bromide
Colossoma macropomum
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00016
neostigmine bromide
Oreochromis niloticus
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00017
neostigmine bromide
Rachycentron canadum
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.00059
neostigmine bromide
Arapaima gigas
-
in 0.5 M Tris-HCl buffer, pH 8.0, temperature not specified in the publication
0.001156
omethoate
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.01724
omethoate
Liposcelis entomophila
-
enzyme from Hubei Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.02492
omethoate
Liposcelis entomophila
-
enzyme from Sichuan Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.03
omethoate
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03969
omethoate
Liposcelis entomophila
-
enzyme from Chongqing Municipality population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.16
oxamyl
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEBI
0.21
oxamyl
Heterorhabditis bacteriophora
-
pH 8.5, 37°C, isozyme AChEAII
0.000651
oxydemeton methyl
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.031
oxydemeton methyl
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00026
palmatine
Electrophorus electricus
-
-
0.0104
palmatine
Rattus norvegicus
-
pH and temperature not specified in the publication
0.000016
paraoxon
Schizaphis graminum
-
pH and temperature not specified in the publication
0.00004
paraoxon
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000195
paraoxon
Stomoxys calcitrans
in potassium phosphate buffer (100 mM, pH 7.5), at 25°C
0.000217
paraoxon
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00101
paraoxon
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.00133
paraoxon
Blattella germanica
-
recombinant enzyme AChE1, pH not specified in the publication, 30°C
0.004
paraoxon
Electrophorus electricus
-
pH 8.0, 37°C
0.00447
paraoxon
Blattella germanica
-
recombinant enzyme AChE2, pH not specified in the publication, 30°C
0.0458
paraoxon
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
0.836
paraoxon
Anopheles gambiae
-
-
0.0000071
paraoxon-ethyl
Bactrocera dorsalis
-
enzyme from larva, at pH 7.4 and 37°C
0.00001782
paraoxon-ethyl
Bactrocera dorsalis
-
enzyme from pupa, at pH 7.4 and 37°C
0.00002777
paraoxon-ethyl
Bactrocera dorsalis
-
enzyme from adult, at pH 7.4 and 37°C
0.00294
Phenylmethylsulfonylfluoride
Cyprinus carpio
pH 7.6, 40°C, recombinant enzyme
0.00305
Phenylmethylsulfonylfluoride
Cyprinus carpio
pH 7.6, 40°C, native enzyme
0.000757
Phosphamidon
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
Phosphamidon
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000004
physostigmine
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000028
physostigmine
Electrophorus electricus
-
-
0.000061
physostigmine
Homo sapiens
-
pH 7.4, 37°C
0.00007
physostigmine
Electrophorus electricus
-
-
0.000234
physostigmine
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00084
physostigmine
Electrophorus electricus
-
-
0.0026
physostigmine
Homo sapiens
-
-
0.00645
physostigmine
Electrophorus electricus
-
-
0.00226
pirimicarb
Rhopalosiphum padi
-
purified enzyme, at pH 7.5 and 30°C
0.00351
pirimicarb
Sitobion avenae
-
purified enzyme, at pH 7.5 and 30°C
0.003596
pirimicarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
pirimicarb
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00347
procainamide
Cyprinus carpio
pH 7.6, 40°C, native enzyme
0.00356
procainamide
Cyprinus carpio
pH 7.6, 40°C, recombinant enzyme
0.000967
profenofos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.01509
profenofos
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00004
promecarb
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000733
promecarb
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
propidium
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine
0.3
propidium
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine
0.001132
propidium iodide
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.001776
propidium iodide
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000012
propoxur
Ctenocephalides felis
isoform AChE2, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C
0.00002304
propoxur
Bactrocera dorsalis
-
enzyme from larva, at pH 7.4 and 37°C
0.000024
propoxur
Ctenocephalides felis
isoform AChE1, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C
0.0000481
propoxur
Bactrocera dorsalis
-
enzyme from pupa, at pH 7.4 and 37°C
0.0000658
propoxur
Bactrocera dorsalis
-
enzyme from adult, at pH 7.4 and 37°C
0.000068
propoxur
Liposcelis entomophila
-
enzyme from Sichuan Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.000077
propoxur
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000078
propoxur
Liposcelis entomophila
-
enzyme from Chongqing Municipality population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.000085
propoxur
Liposcelis entomophila
-
enzyme from Hubei Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.003562
propoxur
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00755
propoxur
Blattella germanica
-
recombinant enzyme AChE1, pH not specified in the publication, 30°C
0.00799
propoxur
Blattella germanica
-
recombinant enzyme AChE2, pH not specified in the publication, 30°C
0.0533
propoxur
Apis mellifera
-
isoform AChE2, at 30°C, pH not specified in the publication
0.185
propoxur
Apis mellifera
-
isoform AChE1, at 30°C, pH not specified in the publication
0.000904
pyridostigmine
Homo sapiens
-
pH 7.4, 37°C
0.002702
pyridostigmine
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.003122
pyridostigmine
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0002
serine
Schizaphis graminum
-
pH and temperature not specified in the publication
0.000823
serine
Liposcelis entomophila
-
enzyme from Sichuan Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.001225
serine
Liposcelis entomophila
-
enzyme from Chongqing Municipality population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.001263
serine
Liposcelis entomophila
-
enzyme from Hubei Province population, crude extract, in 0.1 M phosphate buffer (pH 7.0), at 37°C
0.0000118
tacrine
Homo sapiens
-
pH 7.3
0.0001
tacrine
Electrophorus electricus
pH 8.0, 37°C
0.000126
tacrine
Ctenocephalides felis
isoform AChE1, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C
0.000135
tacrine
Mus musculus
-
pH 7.4, 25°C
0.00017
tacrine
Rattus norvegicus
-
pH and temperature not specified in the publication
0.0002044
tacrine
Homo sapiens
pH 8.0, 37°C
0.000205
tacrine
Homo sapiens
-
-
0.000227
tacrine
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000295
tacrine
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00052
tacrine
Homo sapiens
-
at pH 8.0 and 20°C
0.00071
tacrine
Homo sapiens
-
-
0.00075
tacrine
Electrophorus electricus
-
at pH 8.0 and 20°C
0.00208
tacrine
Ctenocephalides felis
isoform AChE2, in 10 mM Na2HPO4/NaH2PO4, pH 7.4, pH, at 22°C
0.062
tacrine
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 0.1 mM substrate acetylcholine
0.1
tacrine
Electrophorus electricus
-
-
0.115
tacrine
Electrophorus electricus
-
-
0.14
tacrine
Dugesia japonica
-
pH 7.4, 22°C, crude enzyme, with 1 mM substrate acetylcholine
0.000119
tetrachlorvinphos
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.03
tetrachlorvinphos
Homo sapiens
-
IC50 above 0.03 mM, at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.000004
tetraethylpyrophosphate
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.004811
tetraethylpyrophosphate
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00093
thiodicarb
Rhopalosiphum padi
-
purified enzyme, at pH 7.5 and 30°C
0.00159
thiodicarb
Sitobion avenae
-
purified enzyme, at pH 7.5 and 30°C
0.000093
thioflavin T
Lucilia cuprina
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.00831
thioflavin T
Homo sapiens
-
at 22°C in 10 mM Na2HPO4/NaH2PO4, pH 7.4
0.0000003
xanthostigmine
Homo sapiens
-
-
0.0003
xanthostigmine
Homo sapiens
-
-
0.1165
Zn2+
Parachromis managuensis
-
pH 8.0, 25°C
2.57
Zn2+
Cichla ocellaris
-
at pH 7.4 and 25°C
12.969
Zn2+
Parachromis managuensis
-
pH 8.0, 25°C
additional information
additional information
Homo sapiens
-
-
-
additional information
additional information
Electrophorus electricus
-
-
-
additional information
additional information
Electrophorus electricus
-
IC50s: for 1,8-cineole 0.015 mg/ml, for alpha-pinene 0.022 mg/ml, for eugenol 0.48 mg/ml, for alpha-terpineol 1.3 mg/ml, for terpinen-4-ol 3.2 mg/ml, at 37°C, pH not specified in the publication
-
additional information
physostigmine
Electrophorus electricus
-
0.0028 mg/ml
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