Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone | - |
Homo sapiens | |
(3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone | - |
Homo sapiens | |
(3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone | - |
Homo sapiens | |
(3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone | - |
Homo sapiens | |
(3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone | - |
Homo sapiens | |
(3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone | - |
Homo sapiens | |
(3,4-dimethoxyphenyl)-{4-[(ethylpropylamino)methyl]phenyl}methanone | - |
Homo sapiens | |
(4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone | - |
Homo sapiens | |
(4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone | - |
Homo sapiens | |
(4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone | - |
Homo sapiens | |
(4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone | - |
Homo sapiens | |
(4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone | - |
Homo sapiens | |
(4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone | - |
Homo sapiens | |
(4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone | - |
Homo sapiens | |
(4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone | - |
Homo sapiens | |
donepezil | - |
Homo sapiens | |
additional information | design, synthesis, and evaluation of benzophenone derivatives as novel acetylcholinesterase inhibitors, structure-based drug design, overview | Homo sapiens | |
[4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine iodide + H2O | detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB | Homo sapiens | acetate + thiocholine iodide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00002 | - |
- |
Homo sapiens | donepezil | |
0.00046 | - |
pH 8.0, 37°C | Homo sapiens | (4-[(benzylmethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone | |
0.0006 | - |
pH 8.0, 37°C | Homo sapiens | (4-[(benzylethylamino)methyl]phenyl)-(3,4-dimethoxyphenyl)methanone | |
0.0014 | - |
pH 8.0, 37°C | Homo sapiens | (4-([benzyl-(2-hydroxyethyl)amino]methyl)phenyl)-(3,4-dimethoxyphenyl)methanone | |
0.0016 | - |
pH 8.0, 37°C | Homo sapiens | (4-[(benzylmethylamino)methyl]phenyl)-(3-fluoro-4-methoxyphenyl)methanone | |
0.0017 | - |
pH 8.0, 37°C | Homo sapiens | (3,4-dimethoxyphenyl)-(4-([methyl-(3-methylbenzyl)amino]methyl)phenyl)methanone | |
0.0018 | - |
pH 8.0, 37°C | Homo sapiens | (4-[(benzylmethylamino)methyl]phenyl)-(4-methoxyphenyl)methanone | |
0.0021 | - |
pH 8.0, 37°C | Homo sapiens | (4-[3-(benzylmethylamino)propenyl]phenyl)-(3,4-dimethoxyphenyl)methanone | |
0.0024 | - |
pH 8.0, 37°C | Homo sapiens | (3,4-dimethoxyphenyl)-(4-([(2-dimethylaminoethyl)-methylamino]methyl)phenyl)-methanone | |
0.0037 | - |
pH 8.0, 37°C | Homo sapiens | (3,4-dimethoxyphenyl)-(4-([(2-methoxybenzyl)methylamino]methyl)phenyl)-methanone | |
0.0043 | - |
pH 8.0, 37°C | Homo sapiens | (3,4-dimethoxyphenyl)-(4-([methyl-(3-nitrobenzyl)amino]methyl)phenyl)methanone | |
0.0086 | - |
pH 8.0, 37°C | Homo sapiens | (4-([benzyl-(2-dimethylaminoethyl)amino]methyl)-phenyl)-(3,4-dimethoxyphenyl)methanone | |
0.0196 | - |
pH 8.0, 37°C | Homo sapiens | (4-[(benzylmethylamino)methyl]phenyl)naphthalen-2-yl-methanone | |
0.0272 | - |
pH 8.0, 37°C | Homo sapiens | (3,4-dimethoxyphenyl)-(4-[(methylprop-2-ynylamino)-methyl]phenyl)methanone | |
0.0368 | - |
pH 8.0, 37°C | Homo sapiens | (3,4-dimethoxyphenyl)-(4-[(ethylpropylamino)methyl]phenyl)methanone | |
0.054 | - |
pH 8.0, 37°C | Homo sapiens | [4-(3,4-dihydro-1H-isoquinolin-2-ylmethyl)phenyl]-(3,4-dimethoxyphenyl)methanone | |
0.345 | - |
pH 8.0, 37°C | Homo sapiens | (3,4-dimethoxyphenyl)-(4-morpholin-4-ylmethylphenyl)methanone |