Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-PAM | i.e. 2-[hydroxyiminomethyl]-1-methyl-pyridinium chloride, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
2-PAM | i.e. 2-[hydroxyiminomethyl]-1-methyl-pyridinium chloride, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
HI-6 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
HI-6 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]methoxy]methyl]-2-[(hydroxyimino)methyl]-pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
HLo-7 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]-methoxy]methyl]-2,4-bis-[(hydroxylimino)methyl] pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
HLo-7 | i.e. 1-[[[4-(aminocarbonyl)pyridinio]-methoxy]methyl]-2,4-bis-[(hydroxylimino)methyl] pyridinium dimethanesulfonate, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
ICD-585 | i.e. 1-(2-hydroxyiminomethyl-1-pyridinium)-1'-(4-carboxy-aminopyridinium)-trimethylene hydrochloride, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
ICD-585 | i.e. 1-(2-hydroxyiminomethyl-1-pyridinium)-1'-(4-carboxy-aminopyridinium)-trimethylene hydrochloride, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
MMB4 | i.e. 1,1'-trimethylene bis(4-hydroxyimino methyl) pyridinium dichloride, an oxime that reactivates nerve-agent-inhibited AChE | Cavia porcellus | |
MMB4 | i.e. 1,1'-trimethylene bis(4-hydroxyimino methyl) pyridinium dichloride, an oxime that reactivates nerve-agent-inhibited AChE | Homo sapiens | |
additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, overview | Cavia porcellus | |
additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
stable expression in CHO cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclosarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
cyclosarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, determination of the aging rate constants of nerve agent-inhibited AChE, overview | Cavia porcellus | |
additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, is the most important step in the treatment of nerve agent poisoning, e.g. by G and V type nerve agents, reactivation kinetics, determination of the aging rate constants of nerve agent-inhibited AChE, overview | Homo sapiens | |
O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
O-ethyl S-2-N,N-diisopropylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
O-isobutyl S-2-N,N-diethylaminoethyl methylphosphonothiolate | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
sarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
sarin | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
soman | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
soman | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens | |
Tabun | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Cavia porcellus | |
Tabun | reactivation of sarin-inhibited acetylcholinesterase by oximes, 2-PAM, MMB4, HI-6, HLo-7, and ICD-585, overview | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | anchored to erythrocyte membranes | Cavia porcellus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cavia porcellus | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | ? | - |
? | |
additional information | Homo sapiens | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
- |
- |
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme released from erythrocyte membranes anchor by phosphatidylinositol-specific phospholipase C, followed by affinity chromatography on a procainamide resin, and anion exchange chromatography | Cavia porcellus |
recombinant enzyme from stably expressing CHO cells by affinity chromatography on a procainamide resin, to homogeneity | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Cavia porcellus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Cavia porcellus |
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | - |
Cavia porcellus | thiocholine + acetate | - |
? | |
acetylthiocholine + H2O | - |
Homo sapiens | thiocholine + acetate | - |
? | |
additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | Cavia porcellus | ? | - |
? | |
additional information | the reactivation of nerve agent-inhibited acetylcholinesterase by oxime is the most important step in the treatment of nerve agent poisoning, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Cavia porcellus |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Cavia porcellus |
AChE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Cavia porcellus |
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Cavia porcellus |
8 | - |
assay at | Homo sapiens |