Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3-dimethoxy-6-methyl-9H-xanthen-9-one | - |
Homo sapiens | |
2-(3-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
2-(4-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
3-(3-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
3-(4-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one | - |
Homo sapiens | |
3-methoxy-6-methyl-9H-xanthen-9-one | - |
Homo sapiens | |
3-methyl-2-(4-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one | - |
Homo sapiens | |
7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one | - |
Homo sapiens | |
AP2238 | - |
Homo sapiens | |
donepezil | - |
Homo sapiens | |
additional information | inhibitor structure-activity relationships, simulation of pseudo-irreversible AChE covalent inhibitors, overview | Homo sapiens | |
N-methyl-N-(3-carbamoyloxyphenyl)methyl-amino inhibitor | - |
Homo sapiens | |
phenylcoumarin | - |
Homo sapiens | |
xanthostigmine | three-dimensional model of the quaternary complex between AChE and xanthostigmine | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant serum enzyme | Homo sapiens | - |
serum | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
S-acetylthiocholine iodide + H2O | detection with 5,5'-dithio-bis-2-nitrobenzoic acid, i.e. DTNB | Homo sapiens | acetate + thiocholine iodide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AChE | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000003 | - |
- |
Homo sapiens | xanthostigmine | |
0.00000032 | - |
pH 8.0, 37°C | Homo sapiens | 3-([7-[methyl(3-[[(methylamino)oxy]carbonyl]benzyl)amino]heptyl]oxy)-9H-xanthen-9-one | |
0.00000051 | - |
pH 8.0, 37°C | Homo sapiens | 7-methoxy-2-(3-methylphenyl)-4H-chromen-4-one | |
0.00000052 | - |
pH 8.0, 37°C | Homo sapiens | 2-(3-methylphenyl)-4H-chromen-4-one | |
0.00000063 | - |
pH 8.0, 37°C | Homo sapiens | 6-methoxy-2-(4-methylphenyl)-4H-chromen-4-one | |
0.00000072 | - |
pH 8.0, 37°C | Homo sapiens | 7-methoxy-2-(4-methylphenyl)-4H-chromen-4-one | |
0.00000073 | - |
pH 8.0, 37°C | Homo sapiens | 2-(4-methylphenyl)-4H-chromen-4-one | |
0.00000076 | - |
pH 8.0, 37°C | Homo sapiens | 6-methoxy-2-(3-methylphenyl)-4H-chromen-4-one | |
0.00000085 | - |
pH 8.0, 37°C | Homo sapiens | 3-methoxy-6-methyl-9H-xanthen-9-one | |
0.0000012 | - |
pH 8.0, 37°C | Homo sapiens | 3-(4-methylphenyl)-2H-chromen-2-one | |
0.00000131 | - |
pH 8.0, 37°C | Homo sapiens | 6,7-dimethoxy-2-(3-methylphenyl)-4H-chromen-4-one | |
0.00000156 | - |
pH 8.0, 37°C | Homo sapiens | 2,3-dimethoxy-6-methyl-9H-xanthen-9-one | |
0.00000176 | - |
pH 8.0, 37°C | Homo sapiens | 3-methyl-2-(4-methylphenyl)-4H-chromen-4-one | |
0.0000027 | - |
pH 8.0, 37°C | Homo sapiens | 7-methoxy-3-(3-methylphenyl)-2H-chromen-2-one | |
0.00000316 | - |
pH 8.0, 37°C | Homo sapiens | 6,7-dimethoxy-3-(3-methylphenyl)-2H-chromen-2-one | |
0.0000036 | - |
pH 8.0, 37°C | Homo sapiens | 3-(3-methylphenyl)-2H-chromen-2-one | |
0.000004 | - |
pH 8.0, 37°C | Homo sapiens | 6-methoxy-3-(4-methylphenyl)-2H-chromen-2-one | |
0.0000056 | - |
pH 8.0, 37°C | Homo sapiens | 7-methoxy-3-(4-methylphenyl)-2H-chromen-2-one | |
0.000006 | - |
pH 8.0, 37°C | Homo sapiens | 6-methoxy-3-(3-methylphenyl)-2H-chromen-2-one | |
0.0000109 | - |
pH 8.0, 37°C | Homo sapiens | 6,7-dimethoxy-3-(4-methylphenyl)-2H-chromen-2-one |