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Literature summary for 3.1.1.7 extracted from
- Kinetics of inhibition of acetylcholinesterase in the presence of acetonitrile (2009), FEBS J., 276, 2292-2307.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-benzyl-2-(propan-2-ylamino)-1,2,5,6,7,8-hexahydro-4H-pyrido[4',3':4,5]thieno[2,3-d][1,3]thiazin-4-one | the substance acts as a hyperbolic mixed-type inhibitor | Electrophorus electricus |  |
| acetonitrile | a competitive pseudo-inhibition is observed for 6% acetonitrile | Electrophorus electricus | |
| gallamine | inhibition by gallamine follows the steric blockade hypothesis, i.e. only substrate association to as well as substrate-product dissociation from the active site were reduced in the presence of the inhibitor | Electrophorus electricus | |
| additional information | interaction of acetylcholinesterase with acetonitrile and tacrine or gallamine results in a 7-10fold increase in the KI values, whereas the principal mode of inhibition is not affected by the organic solvent | Electrophorus electricus | |
| tacrine | a mixed-type inhibitor with a strong noncompetitive component, completely blocks deacylation of the acyl-enzyme | Electrophorus electricus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Electrophorus electricus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| commercial preparation | - |
Electrophorus electricus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetylthiocholine + H2O | - |
Electrophorus electricus | acetate + thiocholine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AChE | - |
Electrophorus electricus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | nonlinear Michaelis-Menten inhibition kinetics, detailed overview | Electrophorus electricus | |
| 0.00059 | - |
7-benzyl-2-(propan-2-ylamino)-1,2,5,6,7,8-hexahydro-4H-pyrido[4',3':4,5]thieno[2,3-d][1,3]thiazin-4-one | in presence of acetonitrile at 6% v/v | Electrophorus electricus | |
| 2500 | - |
acetonitrile | - |
Electrophorus electricus | |
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