Crystallization (Comment) | Organism |
---|---|
complex with rivastigmine or (-)-S-3-[1-(dimethylamino)ethyl]phenol, hanging drop vapor diffusion method | Tetronarce californica |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(-)-S-3-[1-(dimethylamino)ethyl]phenol | competitive reversible inhibitor | Tetronarce californica | |
rivastigmine | trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneous at a slow rate | Drosophila melanogaster | |
rivastigmine | trade name: Exelon, carbamylates the enzyme, enzyme reactivates spontaneously at a slow rate | Homo sapiens | |
rivastigmine | trade name: Exelon, carbamylates the enzyme, 10% spontaneous reactivation after 48 h | Tetronarce californica | |
SDZ 212-712 | optical isomer of rivastigmine | Drosophila melanogaster |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
- |
- |
Homo sapiens | - |
- |
- |
Tetronarce californica | P04058 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | - |
Drosophila melanogaster | thiocholine + acetate | - |
? | |
acetylthiocholine + H2O | - |
Homo sapiens | thiocholine + acetate | - |
? | |
acetylthiocholine + H2O | - |
Tetronarce californica | thiocholine + acetate | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0005 | - |
(-)-S-3-[1-(dimethylamino)ethyl]phenol | pH 7.5, 25°C | Tetronarce californica |