Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-naphthyl phenothiazine carbamate | - |
Homo sapiens | |
2-(1-piperidinyl)ethyl phenothiazine carbamate | - |
Homo sapiens | |
2-(1-pyrrolidinyl)ethyl phenothiazine carbamate | - |
Homo sapiens | |
2-(4-morpholino)ethyl phenothiazine carbamate | - |
Homo sapiens | |
2-(N,N-diethylamino)ethyl phenothiazine carbamate | - |
Homo sapiens | |
2-(N,N-dimethylamino)ethyl phenothiazine carbamate | - |
Homo sapiens | |
2-chlorophenyl phenothiazine carbamate | - |
Homo sapiens | |
2-methoxyphenyl phenothiazine carbamate | - |
Homo sapiens | |
2-methylphenyl phenothiazine carbamate | - |
Homo sapiens | |
2-naphthyl phenothiazine carbamate | - |
Homo sapiens | |
2-t-butylphenyl phenothiazine carbamate | - |
Homo sapiens | |
3-(N,N-diethylamino)propyl phenothiazine carbamate | - |
Homo sapiens | |
3-(N,N-dimethylamino) phenyl phenothiazine carbamate | binding by residues F329 and Y332, structure, overview | Homo sapiens | |
3-chlorophenyl phenothiazine carbamate | - |
Homo sapiens | |
3-methoxyphenyl phenothiazine carbamate | - |
Homo sapiens | |
3-methylphenyl phenothiazine carbamate | - |
Homo sapiens | |
4-biphenyl phenothiazine carbamate | - |
Homo sapiens | |
4-chlorophenyl phenothiazine carbamate | - |
Homo sapiens | |
4-methoxyphenyl phenothiazine carbamate | - |
Homo sapiens | |
4-methylphenyl phenothiazine carbamate | - |
Homo sapiens | |
4-t-butylphenyl phenothiazine carbamate | - |
Homo sapiens | |
butyl carbamate | - |
Homo sapiens | |
cyclopentyl phenothiazine carbamate | - |
Homo sapiens | |
donepezil | - |
Homo sapiens | |
ethyl carbamate | - |
Homo sapiens | |
galanthamine | - |
Homo sapiens | |
additional information | inhibitor molecular mechanics calculations, general mechanism of pseudoirreversible cholinesterase inhibition by carbamates. Enzyme deactivation is initiated by nucleophilic attack of the catalytic triad serine oxygen on the carbonyl group of the carbamate, structure-activity relationships, overview | Homo sapiens | |
phenyl phenothiazine carbamate | - |
Homo sapiens | |
propyl phenothiazine carbamate | - |
Homo sapiens | |
rivastigmine | - |
Homo sapiens | |
t-butyl phenothiazine carbamate | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetylthiocholine + H2O | detection using 5,5'-dithiobis(2-nitrobenzoic acid) | Homo sapiens | acetate + thiocholine | - |
? | |
additional information | acetylcholinesterase is a serine hydrolase that catalyze the hydrolysis of acetylcholine, thus regulating cholinergic neurotransmission | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
acetylcholinesterase | - |
Homo sapiens |
AChE | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | molecular mechanics calculations and inhibition kinetics, overview | Homo sapiens |