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Literature summary for 3.1.1.7 extracted from

  • Alpan, A.S.; Parlar, S.; Carlino, L.; Tarikogullari, A.H.; Alptuezuen, V.; Guenes, H.S.
    Synthesis, biological activity and molecular modeling studies on 1H-benzimidazole derivatives as acetylcholinesterase inhibitors (2013), Bioorg. Med. Chem., 21, 4928-4937.
    View publication on PubMed
Search for more literature for 3.1.1.7

Inhibitors

Inhibitors Comment Organism Structure
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
 Electrophorus electricus
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
 Homo sapiens
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
 Electrophorus electricus
2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
 Homo sapiens
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
 Electrophorus electricus
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
-
 Homo sapiens
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
 Electrophorus electricus
2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
-
 Homo sapiens
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
 Electrophorus electricus
2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
 Homo sapiens
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
 Electrophorus electricus
2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
-
 Homo sapiens
4-(1H-benzimidazol-2-yl)phenol
-
 Electrophorus electricus
4-(1H-benzimidazol-2-yl)phenol
-
 Homo sapiens
4-(5-chloro-1H-benzimidazol-2-yl)phenol
-
 Electrophorus electricus
4-(5-chloro-1H-benzimidazol-2-yl)phenol
-
 Homo sapiens
4-(5-methyl-1H-benzimidazol-2-yl)phenol
-
 Electrophorus electricus
4-(5-methyl-1H-benzimidazol-2-yl)phenol
-
 Homo sapiens
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
 Electrophorus electricus
4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
 Homo sapiens
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
 Electrophorus electricus
4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
 Homo sapiens
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
 Electrophorus electricus
4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
-
 Homo sapiens
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Electrophorus electricus
5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Homo sapiens
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Electrophorus electricus
5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Homo sapiens
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Electrophorus electricus
5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Homo sapiens
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Electrophorus electricus
5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
-
 Homo sapiens
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
 Electrophorus electricus
N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
 Homo sapiens
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
 Electrophorus electricus
N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
-
 Homo sapiens
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
 Electrophorus electricus
N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
 Homo sapiens
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
 Electrophorus electricus
N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
-
 Homo sapiens
tacrine
-
 Electrophorus electricus
tacrine
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetylcholine + H2O Homo sapiens
-
 choline + acetate
-
 ?
acetylcholine + H2O Electrophorus electricus
-
 choline + acetate
-
 ?

Organism

Organism UniProt Comment Textmining
Electrophorus electricus
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetylcholine + H2O
-
 Homo sapiens choline + acetate
-
 ?
acetylcholine + H2O
-
 Electrophorus electricus choline + acetate
-
 ?
acetylthiocholine + H2O
-
 Homo sapiens thiocholine + acetate
-
 ?
acetylthiocholine + H2O
-
 Electrophorus electricus thiocholine + acetate
-
 ?

Synonyms

Synonyms Comment Organism
AChE
-
 Homo sapiens
AChE
-
 Electrophorus electricus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00013
-
 at pH 8.0 and 20°C Homo sapiens 5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.00039
-
 at pH 8.0 and 20°C Homo sapiens 5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.0004
-
 at pH 8.0 and 20°C Homo sapiens 5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.00052
-
 at pH 8.0 and 20°C Homo sapiens tacrine
0.00058
-
 at pH 8.0 and 20°C Electrophorus electricus N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
0.00061
-
 at pH 8.0 and 20°C Electrophorus electricus 5(6)-chloro-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.00075
-
 at pH 8.0 and 20°C Electrophorus electricus tacrine
0.00084
-
 at pH 8.0 and 20°C Electrophorus electricus 5(6)-methyl-2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.00103
-
 at pH 8.0 and 20°C Homo sapiens 2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
0.00108
-
 at pH 8.0 and 20°C Electrophorus electricus 2-[4-[2-(piperidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
0.00119
-
 at pH 8.0 and 20°C Electrophorus electricus N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
0.00134
-
 at pH 8.0 and 20°C Electrophorus electricus 5(6)-methyl-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.0014
-
 at pH 8.0 and 20°C Homo sapiens 5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.00213
-
 at pH 8.0 and 20°C Homo sapiens 2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
0.00234
-
 at pH 8.0 and 20°C Electrophorus electricus N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
0.00268
-
 at pH 8.0 and 20°C Electrophorus electricus 2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
0.00305
-
 at pH 8.0 and 20°C Electrophorus electricus 2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]-imidazole
0.00324
-
 at pH 8.0 and 20°C Electrophorus electricus 5(6)-chloro-2-[4-[2-(pyrrolidin-1-yl)ethoxy]phenyl]-1H-benzo[d]imidazole
0.0035
-
 at pH 8.0 and 20°C Electrophorus electricus 2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
0.00368
-
 at pH 8.0 and 20°C Homo sapiens N-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
0.00506
-
 at pH 8.0 and 20°C Electrophorus electricus N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
0.00802
-
 at pH 8.0 and 20°C Homo sapiens 2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
0.00875
-
 at pH 8.0 and 20°C Homo sapiens 2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
0.00973
-
 at pH 8.0 and 20°C Homo sapiens 4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.01068
-
 at pH 8.0 and 20°C Homo sapiens 2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
0.01105
-
 at pH 8.0 and 20°C Electrophorus electricus 4-[2-[4-(5(6)-chloro-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.01234
-
 at pH 8.0 and 20°C Homo sapiens N,N-dimethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
0.01292
-
 at pH 8.0 and 20°C Homo sapiens 4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.01312
-
 at pH 8.0 and 20°C Electrophorus electricus 2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-dimethylethanamine
0.01459
-
 at pH 8.0 and 20°C Electrophorus electricus 4-(5-chloro-1H-benzimidazol-2-yl)phenol
0.01564
-
 at pH 8.0 and 20°C Electrophorus electricus 2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
0.01593
-
 at pH 8.0 and 20°C Electrophorus electricus 4-(5-methyl-1H-benzimidazol-2-yl)phenol
0.01733
-
 at pH 8.0 and 20°C Electrophorus electricus 4-(1H-benzimidazol-2-yl)phenol
0.01879
-
 at pH 8.0 and 20°C Electrophorus electricus 4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.02342
-
 at pH 8.0 and 20°C Homo sapiens N-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]-N-isopropylpropan-2-amine
0.05098
-
 at pH 8.0 and 20°C Homo sapiens N,N-diethyl-2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethanamine
0.1
-
 IC50 above 0.1 mM, at pH 8.0 and 20°C Homo sapiens 2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]-N,N-diethylethanamine
0.1
-
 IC50 above 0.1 mM, at pH 8.0 and 20°C Homo sapiens 4-[2-[4-(1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.1
-
 IC50 above 0.1 mM, at pH 8.0 and 20°C Electrophorus electricus 4-[2-[4-(5(6)-methyl-1H-benzo[d]imidazol-2-yl)phenoxy]ethyl]morpholine
0.1
-
 IC50 above 0.1 mM, at pH 8.0 and 20°C Homo sapiens 4-(1H-benzimidazol-2-yl)phenol
0.1
-
 IC50 above 0.1 mM, at pH 8.0 and 20°C Homo sapiens 4-(5-methyl-1H-benzimidazol-2-yl)phenol
0.1
-
 IC50 above 0.1 mM, at pH 8.0 and 20°C Homo sapiens 4-(5-chloro-1H-benzimidazol-2-yl)phenol