Reference on EC 2.7.11.22 - cyclin-dependent kinase and Organism(s) Homo sapiens and UniProt Accession P06493
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
topREF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Johnson, L.N.; Noble, M.E.M.; Owen, D.J.
Active and inactive protein kinases: structural basis for regulation
Cell
85
149-158
1996
Homo sapiens
Hanks, S.K.
Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family
Proc. Natl. Acad. Sci. USA
84
388-392
1987
Homo sapiens (P11802)
Montini, E.; Andolfi, G.; Caruso, A.; Buchner, G.; Walpole, S.M.; Mariani, M.; Consalez, G.; Trump, D.; Ballabio, A.; Franco, B.
Identification and characterization of a novel serine-threonine kinase gene from the Xp22 region
Genomics
51
427-433
1998
Homo sapiens (O76039)
Ohta, T.; Okamoto, K.; Isohashi, F.; Shibata, K.; Fukuda, M.; Yamaguchi, S.; Xiong, Y.
T-loop deletion of CDC2 from breast cancer tissues eliminates binding to cyclin B1 and cyclin-dependent kinase inhibitor p21
Cancer Res.
58
1095-1098
1998
Homo sapiens (P06493), Homo sapiens
Draetta, G.; Beach, D.
Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement
Cell
54
17-26
1988
Homo sapiens (P06493)
Lee, M.G.; Nurse, P.
Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2
Nature
327
31-35
1987
Homo sapiens (P06493)
Soufir, N.; Avril, M.F.; Chompret, A.; Demenais, F.; Bombled, J.; Spatz, A.; Stoppa-Lyonnet, D.; Benard, J.; Bressac-de Paillerets, B.
Prevalence of p16 and CDK4 germline mutations in 48 melanoma-prone families in France. The French Familial Melanoma Study Group
Hum. Mol. Genet.
7
209-216
1998
Homo sapiens (P11802)
Elkahloun, A.G.; Krizman, D.B.; Wang, Z.; Hofmann, T.A.; Roe, B.; Meltzer, P.S.
Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers
Genomics
42
295-301
1997
Homo sapiens (P11802)
Zuo, L.; Weger, J.; Yang, Q.; Goldstein, A.M.; Tucker, M.A.; Walker, G.J.; Hayward, N.; Dracopoli, N.C.
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
Nat. Genet.
12
97-99
1996
Homo sapiens (P11802)
Wolfel, T.; Hauer, M.; Schneider, J.; Serrano, M.; Wolfel, C.; Klehmann-Hieb, E.; De Plaen, E.; Hankeln, T.; Meyer zum Buschenfelde, K.H.; Beach, D.
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma
Science
269
1281-1284
1995
Homo sapiens (P11802), Homo sapiens
Khatib, Z.A.; Matsushime, H.; Valentine, M.; Shapiro, D.N.; Sherr, C.J.; Look, A.T.
Coamplification of the CDK4 gene with MDM2 and GLI in human sarcomas
Cancer Res.
53
5535-5541
1993
Homo sapiens (P11802), Homo sapiens
Matsushime, H.; Jinno, A.; Takagi, N.; Shibuya, M.
A novel mammalian protein kinase gene (mak) is highly expressed in testicular germ cells at and after meiosis
Mol. Cell. Biol.
10
2261-2268
1990
Rattus norvegicus (P20793), Homo sapiens (P20794)
Eipers, P.G.; Lahti, J.M.; Kidd, V.J.
Structure and expression of the human p58clk-1 protein kinase chromosomal gene
Genomics
13
613-621
1992
Homo sapiens (P21127), Homo sapiens
Bunnell, B.A.; Heath, L.S.; Adams, D.E.; Lahti, J.M.; Kidd, V.J.
Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle
Proc. Natl. Acad. Sci. USA
87
7467-7471
1990
Homo sapiens (P21127), Homo sapiens
Gray, N.S.; Wodicka, L.; Thunnissen, A.M.; Norman, T.C.; Kwon, S.; Espinoza, F.H.; Morgan, D.O.; Barnes, G.; LeClerc, S.; Meijer, L.; Kim, S.H.; Lockhart, D.J.; Schultz, P.G.
Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors
Science
281
533-538
1998
Homo sapiens (P24941), Homo sapiens
Lawrie, A.M.; Noble, M.E.; Tunnah, P.; Brown, N.R.; Johnson, L.N.; Endicott, J.A.
Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2
Nat. Struct. Biol.
4
796-801
1997
Homo sapiens (P24941)
Schulze-Gahmen, U.; De Bondt, H.L.; Kim, S.H.
High-resolution crystal structures of human cyclin-dependent kinase 2 with and without ATP: bound waters and natural ligand as guides for inhibitor design
J. Med. Chem.
39
4540-4546
1996
Homo sapiens (P24941), Homo sapiens
Russo, A.A.; Jeffrey, P.D.; Pavletich, N.P.
Structural basis of cyclin-dependent kinase activation by phosphorylation
Nat. Struct. Biol.
3
696-700
1996
Homo sapiens (P24941)
Russo, A.A.; Jeffrey, P.D.; Patten, A.K.; Massague, J.; Pavletich, N.P.
Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex
Nature
382
325-331
1996
Homo sapiens (P24941), Homo sapiens
De Azevedo, W.F., Jr.; Mueller-Dieckmann, H.J.; Schulze-Gahmen, U.; Worland, P.J.; Sausville, E.; Kim, S.H.
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase
Proc. Natl. Acad. Sci. USA
93
2735-2740
1996
Homo sapiens (P24941)
Bourne, Y.; Watson, M.H.; Hickey, M.J.; Holmes, W.; Rocque, W.; Reed, S.I.; Tainer, J.A.
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1
Cell
84
863-874
1996
Homo sapiens (P24941), Homo sapiens
Jeffrey, P.D.; Russo, A.A.; Polyak, K.; Gibbs, E.; Hurwitz, J.; Massague, J.; Pavletich, N.P.
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
Nature
376
313-320
1995
Homo sapiens (P24941), Homo sapiens
De Bondt, H.L.; Rosenblatt, J.; Jancarik, J.; Jones, H.D.; Morgan, D.O.; Kim, S.H.
Crystal structure of cyclin-dependent kinase 2
Nature
363
595-602
1993
Homo sapiens (P24941), Homo sapiens
Gu, Y.; Rosenblatt, J.; Morgan, D.O.
Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
EMBO J.
11
3995-4005
1992
Homo sapiens (P24941), Homo sapiens
Tsai, L.H.; Harlow, E.; Meyerson, M.
Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase
Nature
353
174-177
1991
Homo sapiens (P24941), Homo sapiens
Ninomiya-Tsuji, J.; Nomoto, S.; Yasuda, H.; Reed, S.I.; Matsumoto, K.
Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation
Proc. Natl. Acad. Sci. USA
88
9006-9010
1991
Homo sapiens (P24941), Homo sapiens
Elledge, S.J.; Spottswood, M.R.
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1
EMBO J.
10
2653-2659
1991
Homo sapiens (P24941), Homo sapiens
Tassan, J.P.; Jaquenoud, M.; Leopold, P.; Schultz, S.J.; Nigg, E.A.
Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C
Proc. Natl. Acad. Sci. USA
92
8871-8875
1995
Homo sapiens (P49336), Homo sapiens
Tirode, F.; Busso, D.; Coin, F.; Egly, J.M.
Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7
Mol. Cell
3
87-95
1999
Homo sapiens (P50613)
Akoulitchev, S.; Reinberg, D.
The molecular mechanism of mitotic inhibition of TFIIH is mediated by phosphorylation of CDK7
Genes Dev.
12
3541-3550
1998
Homo sapiens (P50613)
Wu, L.; Yee, A.; Liu, L.; Carbonaro-Hall, D.; Venkatesan, N.; Tolo, V.T.; Hall, F.L.
Molecular cloning of the human CAK1 gene encoding a cyclin-dependent kinase-activating kinase
Oncogene
9
2089-2096
1994
Homo sapiens (P50613)
Tassan, J.P.; Schultz, S.J.; Bartek, J.; Nigg, E.A.
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase)
J. Cell. Biol.
127
467-478
1994
Homo sapiens (P50613), Homo sapiens
Levedakou, E.N.; He, M.; Baptist, E.W.; Craven, R.J.; Cance, W.G.; Welcsh, P.L.; Simmons, A.; Naylor, S.L.; Leach, R.J.; Lewis, T.B.; et al.
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern
Oncogene
9
1977-1988
1994
Homo sapiens (P50613), Homo sapiens
Fisher, R.P.; Morgan, D.O.
A novel cyclin associates with MO15/CDK7 to form the CDK-activating kinase
Cell
78
713-724
1994
Homo sapiens (P50613)
Darbon, J.M.; Devault, A.; Taviaux, S.; Fesquet, D.; Martinez, A.M.; Galas, S.; Cavadore, J.C.; Doree, M.; Blanchard, J.M.
Cloning, expression and subcellular localization of the human homolog of p40MO15 catalytic subunit of cdk-activating kinase
Oncogene
9
3127-3138
1994
Homo sapiens (P50613), Homo sapiens
Liu, H.; Rice, A.P.
Genomic organization and characterization of promoter function of the human CDK9 gene
Gene
252
51-59
2000
Homo sapiens (P50750)
Fu, T.J.; Peng, J.; Lee, G.; Price, D.H.; Flores, O.
Cyclin K functions as a CDK9 regulatory subunit and participates in RNA polymerase II transcription
J. Biol. Chem.
274
34527-34530
1999
Homo sapiens (P50750)
Best, J.L.; Presky, D.H.; Swerlick, R.A.; Burns, D.K.; Chu, W.
Cloning of a full-length cDNA sequence encoding a cdc2-related protein kinase from human endothelial cells
Biochem. Biophys. Res. Commun.
208
562-568
1995
Homo sapiens (P50750), Homo sapiens
Grana, X.; De Luca, A.; Sang, N.; Fu, Y.; Claudio, P.P.; Rosenblatt, J.; Morgan, D.O.; Giordano, A.
PITALRE, a nuclear CDC2-related protein kinase that phosphorylates the retinoblastoma protein in vitro
Proc. Natl. Acad. Sci. USA
91
3834-3838
1994
Homo sapiens (P50750), Homo sapiens
Meyerson, M.; Enders, G.H.; Wu, C.L.; Su, L.K.; Gorka, C.; Nelson, C.; Harlow, E.; Tsai, L.H.
A family of human cdc2-related protein kinases
EMBO J.
11
2909-2917
1992
Homo sapiens (Q00526), Homo sapiens (Q00532), Homo sapiens (Q00534), Homo sapiens (Q00535), Homo sapiens (Q00536), Homo sapiens (Q00537), Homo sapiens (Q07002), Homo sapiens
Russo, A.A.; Tong, L.; Lee, J.O.; Jeffrey, P.D.; Pavletich, N.P.
Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a
Nature
395
237-243
1998
Homo sapiens (Q00534)
Crawford, J.; Ianzano, L.; Savino, M.; Whitmore, S.; Cleton-Jansen, A.M.; Settasatian, C.; d'apolito, M.; Seshadri, R.; Pronk, J.C.; Auerbach, A.D.; Verlander, P.C.; Mathew, C.G.; Tipping, A.J.; Doggett, N.A.; Zelante, L.; Callen, D.F.; Savoia, A.
The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer
Genomics
56
90-97
1999
Homo sapiens (Q15131)
Grana, X.; Claudio, P.P.; De Luca, A.; Sang, N.; Giordano, A.
PISSLRE, a human novel CDC2-related protein kinase
Oncogene
9
2097-2103
1994
Homo sapiens (Q15131), Homo sapiens
Brambilla, R.; Draetta, G.
Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases
Oncogene
9
3037-3041
1994
Homo sapiens (Q15131), Homo sapiens
Hadano, S.; Hand, C.K.; Osuga, H.; Yanagisawa, Y.; Otomo, A.; Devon, R.S.; Miyamoto, N.; Showguchi-Miyata, J.; Okada, Y.; Singaraja, R.; Figlewicz, D.A.; Kwiatkowski, T.; Hosler, B.A.; Sagie, T.; Skaug, J.; Nasir, J.; Brown, R.H., Jr.; Scherer, S.W.; Rouleau, G.A.; Hayden, M.R.; Ikeda, J.E.
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
Nat. Genet.
29
166-173
2001
Homo sapiens (Q96Q40)
Nagase, T.; Ishikawa, K.; Suyama, M.; Kikuno, R.; Hirosawa, M.; Miyajima, N.; Tanaka, A.; Kotani, H.; Nomura, N.; Ohara, O.
Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
DNA Res.
5
355-364
1998
Homo sapiens (Q9NYV4)
Bain, J.; McLauchlan, H.; Elliott, M.; Cohen, P.
The specificities of protein kinase inhibitors: an update
Biochem. J.
371
199-204
2003
Homo sapiens
Hamdane, M.; Sambo, A.V.; Delobel, P.; Begard, S.; Violleau, A.; Delacourte, A.; Bertrand, P.; Benavides, J.; Buee, L.
Mitotic-like tau phosphorylation by p25-Cdk5 kinase complex
J. Biol. Chem.
278
34026-34034
2003
Homo sapiens
Lambourne, S.L.; Sellers, L.A.; Bush, T.G.; Choudhury, S.K.; Emson, P.C.; Suh, Y.H.; Wilkinson, L.S.
Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities
Mol. Cell. Biol.
25
278-293
2005
Homo sapiens, Mus musculus
Bukczynska, P.; Klingler-Hoffmann, M.; Mitchelhill, K.I.; Lam, M.H.C.; Ciccomancini, M.; Tonks, N.K.; Sarcevic, B.; Kemp, B.E.; Tiganis, T.
The T-cell protein tyrosine phosphatase is phosphorylated on Ser-304 by cyclin-dependent protein kinases in mitosis
Biochem. J.
380
939-949
2004
Homo sapiens
Li, J.; Joo, S.H.; Tsai, M.D.
An NF-kappaB-specific inhibitor, IkappaBalpha, binds to and inhibits cyclin-dependent kinase 4
Biochemistry
42
13476-13483
2003
Homo sapiens
Li, J.; Melvin, W.S.; Tsai, M.D.; Muscarella, P.
The nuclear protein p34SEI-1 regulates the kinase activity of cyclin-dependent kinase 4 in a concentration-dependent manner
Biochemistry
43
4394-4399
2004
Homo sapiens
Sachs, N.A.; Vaillancourt, R.R.
Cyclin-dependent kinase 11p110 activity in the absence of CK2
Biochim. Biophys. Acta
1624
98-108
2003
Homo sapiens (P21127)
Kesavapany, S.; Li, B.S.; Amin, N.; Zheng, Y.L.; Grant, P.; Pant, H.C.
Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide
Biochim. Biophys. Acta
1697
143-153
2004
Danio rerio, Saccharomyces cerevisiae, Caenorhabditis elegans, Canis lupus familiaris, Drosophila melanogaster, Homo sapiens, Doryteuthis pealeii, Mus musculus, Rattus norvegicus, Sus scrofa
Andres, V.
Control of vascular cell proliferation and migration by cyclin-dependent kinase signalling: new perspectives and therapeutic potential
Cardiovasc. Res.
63
11-21
2004
Homo sapiens, Mus musculus, Rattus norvegicus
Furet, P.
X-ray crystallographic studies of CDK2, a basis for cyclin-dependent kinase inhibitor design in anti-cancer drug research
Curr. Med. Chem. Anticancer Agents
3
15-23
2003
Homo sapiens
Zong, H.; Li, Z.; Liu, L.; Hong, Y.; Yun, X.; Jiang, J.; Chi, Y.; Wang, H.; Shen, X.; Hu, Y.; Niu, Z.; Gu, J.
Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity
FEBS Lett.
579
3579-3588
2005
Homo sapiens
D'Angiolella, V.; Mari, C.; Nocera, D.; Rametti, L.; Grieco, D.
The spindle checkpoint requires cyclin-dependent kinase activity
Genes Dev.
17
2520-2525
2003
Homo sapiens, Xenopus laevis
Harwell, R.M.; Mull, B.B.; Porter, D.C.; Keyomarsi, K.
Activation of cyclin-dependent kinase 2 by full length and low molecular weight forms of cyclin E in breast cancer cells
J. Biol. Chem.
279
12695-12705
2004
Homo sapiens
Vax, V.V.; Bibi, R.; Diaz-Cano, S.; Gueorguiev, M.; Kola, B.; Borboli, N.; Bressac-de Paillerets, B.; Walker, G.J.; Dedov, II; Grossman, A.B.; Korbonits, M.
Activating point mutations in cyclin-dependent kinase 4 are not seen in sporadic pituitary adenomas, insulinomas or Leydig cell tumours
J. Endocrinol.
178
301-310
2003
Homo sapiens
Woodard, C.L.; Li, Z.; Kathcart, A.K.; Terrell, J.; Gerena, L.; Lopez-Sanchez, M.; Kyle, D.E.; Bhattacharjee, A.K.; Nichols, D.A.; Ellis, W.; Prigge, S.T.; Geyer, J.A.; Waters, N.C.
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinases
J. Med. Chem.
46
3877-3882
2003
Homo sapiens, Plasmodium falciparum
VanderWel, S.N.; Harvey, P.J.; McNamara, D.J.; Repine, J.T.; Keller, P.R.; Quin, J.3rd.; Booth, R.J.; Elliott, W.L.; Dobrusin, E.M.; Fry, D.W.; Toogood, P.L.
Pyrido[2,3-d]pyrimidin-7-ones as specific inhibitors of cyclin-dependent kinase 4
J. Med. Chem.
48
2371-2387
2005
Homo sapiens
Brana, M.F.; Cacho, M.; Garcia, M.L.; Mayoral, E.P.; Lopez, B.; de Pascual-Teresa, B.; Ramos, A.; Acero, N.; Llinares, F.; Munoz-Mingarro, D.; Lozach, O.; Meijer, L.
Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases
J. Med. Chem.
48
6843-6854
2005
Marthasterias glacialis, Homo sapiens (P24941)
Lu, H.; Chang, D.J.; Baratte, B.; Meijer, L.; Schulze-Gahmen, U.
Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin
J. Med. Chem.
48
737-743
2005
Homo sapiens
Van Dross, R.; Yao, S.; Asad, S.; Westlake, G.; Mays, D.J.; Barquero, L.; Duell, S.; Pietenpol, J.A.; Browning, P.J.
Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells
J. Natl. Cancer Inst.
97
656-666
2005
Homo sapiens
Davido, D.J.; Von Zagorski, W.F.; Maul, G.G.; Schaffer, P.A.
The differential requirement for cyclin-dependent kinase activities distinguishes two functions of herpes simplex virus type 1 ICP0
J. Virol.
77
12603-12616
2003
Homo sapiens
Sanchez, V.; McElroy, A.K.; Spector, D.H.
Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus
J. Virol.
77
13214-13224
2003
Homo sapiens
Sanchez, V.; McElroy, A.K.; Yen, J.; Tamrakar, S.; Clark, C.L.; Schwartz, R.A.; Spector, D.H.
Cyclin-dependent kinase activity is required at early times for accurate processing and accumulation of the human cytomegalovirus UL122-123 and UL37 immediate-early transcripts and at later times for virus production
J. Virol.
78
11219-11232
2004
Homo sapiens
Narayanan, R.; Adigun, A.A.; Edwards, D.P.; Weigel, N.L.
Cyclin-dependent kinase activity is required for progesterone receptor function: novel role for cyclin A/Cdk2 as a progesterone receptor coactivator
Mol. Cell. Biol.
25
264-277
2005
Homo sapiens
Hisanaga, S.; Saito, T.
The regulation of cyclin-dependent kinase 5 activity through the metabolism of p35 or p39 Cdk5 activator
Neurosignals
12
221-229
2003
Homo sapiens, Mus musculus, Rattus norvegicus
Gompel, M.; Soulie, C.; Ceballos-Picot, I.; Meijer, L.
Expression and activity of cyclin-dependent kinases and glycogen synthase kinase-3 during NT2 neuronal differentiation
Neurosignals
13
134-143
2004
Homo sapiens
Watanabe, N.; Arai, H.; Iwasaki, J.i.; Shiina, M.; Ogata, K.; Hunter, T.; Osada, H.
Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic wee1 via multiple pathways
Proc. Natl. Acad. Sci. USA
102
11663-11668
2005
Homo sapiens
Lim, J.T.; Mansukhani, M.; Weinstein, I.B.
Cyclin-dependent kinase 6 associates with the androgen receptor and enhances its transcriptional activity in prostate cancer cells
Proc. Natl. Acad. Sci. USA
102
5156-5161
2005
Homo sapiens
Bartova, I.; Otyepka, M.; Kriz, Z.; Koca, J.
The mechanism of inhibition of the cyclin-dependent kinase-2 as revealed by the molecular dynamics study on the complex CDK2 with the peptide substrate HHASPRK
Protein Sci.
14
445-451
2005
Homo sapiens
Choi, J.S.; Shin, S.; Jin, Y.H.; Yim, H.; Koo, K.T.; Chun, K.H.; Oh, Y.T.; Lee, W.H.; Lee, S.K.
Cyclin-dependent protein kinase 2 activity is required for mitochondrial translocation of Bax and disruption of mitochondrial transmembrane potential during etoposide-induced apoptosis
Apoptosis
12
1229-1241
2007
Homo sapiens
Li, T.; Hawkes, C.; Qureshi, H.Y.; Kar, S.; Paudel, H.K.
Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta
Biochemistry
45
3134-3145
2006
Bos taurus, Homo sapiens, Rattus norvegicus
Gu, J.; Bourne, P.E.
Identifying allosteric fluctuation transitions between different protein conformational states as applied to cyclin dependent kinase 2
BMC Bioinformatics
8
45
2007
Homo sapiens
Yang, H.S.; Hinds, P.W.
Phosphorylation of ezrin by cyclin-dependent kinase 5 induces the release of Rho GDP dissociation inhibitor to inhibit Rac1 activity in senescent cells
Cancer Res.
66
2708-2715
2006
Homo sapiens
den Hollander, P.; Kumar, R.
Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells
Cancer Res.
66
5941-5949
2006
Homo sapiens
Strock, C.J.; Park, J.I.; Nakakura, E.K.; Bova, G.S.; Isaacs, J.T.; Ball, D.W.; Nelkin, B.D.
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells
Cancer Res.
66
7509-7515
2006
Homo sapiens
Bayart, E.; Dutertre, S.; Jaulin, C.; Guo, R.B.; Xi, X.G.; Amor-Gueret, M.
The Bloom syndrome helicase is a substrate of the mitotic Cdc2 kinase
Cell Cycle
5
1681-1686
2006
Homo sapiens
Sengupta, A.; Novak, M.; Grundke-Iqbal, I.; Iqbal, K.
Regulation of phosphorylation of tau by cyclin-dependent kinase 5 and glycogen synthase kinase-3 at substrate level
FEBS Lett.
580
5925-5933
2006
Homo sapiens
Enders, G.H.; Maude, S.L.
Traffic safety for the cell: influence of cyclin-dependent kinase activity on genomic stability
Gene
371
1-6
2006
Saccharomyces cerevisiae, Homo sapiens
Avraham, E.; Rott, R.; Liani, E.; Szargel, R.; Engelender, S.
Phosphorylation of Parkin by the cyclin-dependent kinase 5 at the linker region modulates its ubiquitin-ligase activity and aggregation
J. Biol. Chem.
282
12842-12850
2007
Homo sapiens, Rattus norvegicus, Rattus norvegicus (Q03114)
Sanchez, V.; Spector, D.H.
Cyclin-dependent kinase activity is required for efficient expression and posttranslational modification of human cytomegalovirus proteins and for production of extracellular particles
J. Virol.
80
5886-5896
2006
Homo sapiens
Yamasaki, F.; Zhang, D.; Bartholomeusz, C.; Sudo, T.; Hortobagyi, G.N.; Kurisu, K.; Ueno, N.T.
Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity
Mol. Cancer Ther.
6
2168-2177
2007
Homo sapiens, Homo sapiens (P24941)
Larochelle, S.; Merrick, K.A.; Terret, M.E.; Wohlbold, L.; Barboza, N.M.; Zhang, C.; Shokat, K.M.; Jallepalli, P.V.; Fisher, R.P.
Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells
Mol. Cell
25
839-850
2007
Homo sapiens
Shu, F.; Lv, S.; Qin, Y.; Ma, X.; Wang, X.; Peng, X.; Luo, Y.; Xu, B.E.; Sun, X.; Wu, J.
Functional characterization of human PFTK1 as a cyclin-dependent kinase
Proc. Natl. Acad. Sci. USA
104
9248-9253
2007
Homo sapiens
Moore, N.L.; Narayanan, R.; Weigel, N.L.
Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity
Steroids
72
202-209
2007
Homo sapiens, Rattus norvegicus
Liu, M.; Choi, S.; Cuny, G.D.; Ding, K.; Dobson, B.C.; Glicksman, M.A.; Auerbach, K.; Stein, R.L.
Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors
Biochemistry
47
8367-8377
2008
Homo sapiens
Chen, S.; Chen, L.; Le, N.T.; Zhao, C.; Sidduri, A.; Lou, J.P.; Michoud, C.; Portland, L.; Jackson, N.; Liu, J.J.; Konzelmann, F.; Chi, F.; Tovar, C.; Xiang, Q.; Chen, Y.; Wen, Y.; Vassilev, L.T.
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors
Bioorg. Med. Chem. Lett.
17
2134-2138
2007
Homo sapiens (P06493), Homo sapiens
Lee, J.; Choi, H.; Kim, K.H.; Jeong, S.; Park, J.W.; Baek, C.S.; Lee, S.H.
Synthesis and biological evaluation of 3,5-diaminoindazoles as cyclin-dependent kinase inhibitors
Bioorg. Med. Chem. Lett.
18
2292-2295
2008
Homo sapiens, Homo sapiens (P06493), Homo sapiens (P24941)
Finlay, M.R.; Acton, D.G.; Andrews, D.M.; Barker, A.J.; Dennis, M.; Fisher, E.; Graham, M.A.; Green, C.P.; Heaton, D.W.; Karoutchi, G.; Loddick, S.A.; Morgentin, R.; Roberts, A.; Tucker, J.A.; Weir, H.M.
Imidazole piperazines: SAR and development of a potent class of cyclin-dependent kinase inhibitors with a novel binding mode
Bioorg. Med. Chem. Lett.
18
4442-4446
2008
Homo sapiens (P24941)
Anderson, M.; Andrews, D.M.; Barker, A.J.; Brassington, C.A.; Breed, J.; Byth, K.F.; Culshaw, J.D.; Finlay, M.R.; Fisher, E.; McMiken, H.H.; Green, C.P.; Heaton, D.W.; Nash, I.A.; Newcombe, N.J.; Oakes, S.E.; Pauptit, R.A.; Roberts, A.; Stanway, J.J.; Thomas, A.P.; Tucker, J.A.; Walker, M.; Weir, H.M.
Imidazoles: SAR and development of a potent class of cyclin-dependent kinase inhibitors
Bioorg. Med. Chem. Lett.
18
5487-5492
2008
Homo sapiens (P11802), Homo sapiens (P24941)
De Vivo, M.; Cavalli, A.; Carloni, P.; Recanatini, M.
Computational study of the phosphoryl transfer catalyzed by a cyclin-dependent kinase
Chemistry
13
8437-8444
2007
Homo sapiens
North, B.J.; Verdin, E.
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
J. Biol. Chem.
282
19546-19555
2007
Homo sapiens (P06493), Homo sapiens
Paoletti, P.; Vila, I.; Rife, M.; Lizcano, J.M.; Alberch, J.; Gines, S.
Dopaminergic and glutamatergic signaling crosstalk in Huntingtons disease neurodegeneration: the role of p25/cyclin-dependent kinase 5
J. Neurosci.
28
10090-10101
2008
Mus musculus, Homo sapiens (Q00535), Homo sapiens
Sanchez, V.; Mahr, J.A.; Orazio, N.I.; Spector, D.H.
Nuclear export of the human cytomegalovirus tegument protein pp65 requires cyclin-dependent kinase activity and the Crm1 exporter
J. Virol.
81
11730-11736
2007
Homo sapiens
Sabo, A.; Lusic, M.; Cereseto, A.; Giacca, M.
Acetylation of conserved lysines in the catalytic core of cyclin-dependent kinase 9 inhibits kinase activity and regulates transcription
Mol. Cell. Biol.
28
2201-2212
2008
Homo sapiens (P50750)
Lewis, A.E.; Rusten, M.; Hoivik, E.A.; Vikse, E.L.; Hansson, M.L.; Wallberg, A.E.; Bakke, M.
Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7
Mol. Endocrinol.
22
91-104
2008
Homo sapiens (P50613), Mus musculus (Q03147)
Costoya, J.A.; Hobbs, R.M.; Pandolfi, P.P.
Cyclin-dependent kinase antagonizes promyelocytic leukemia zinc-finger through phosphorylation
Oncogene
27
3789-3796
2008
Homo sapiens (P06493), Homo sapiens (P24941), Homo sapiens
Marchetti, F.; Sayle, K.L.; Bentley, J.; Clegg, W.; Curtin, N.J.; Endicott, J.A.; Golding, B.T.; Griffin, R.J.; Haggerty, K.; Harrington, R.W.; Mesguiche, V.; Newell, D.R.; Noble, M.E.; Parsons, R.J.; Pratt, D.J.; Wang, L.Z.; Hardcastle, I.R.
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2
Org. Biomol. Chem.
5
1577-1585
2007
Homo sapiens
Bartova, I.; Koca, J.; Otyepka, M.
Functional flexibility of human cyclin-dependent kinase-2 and its evolutionary conservation
Protein Sci.
17
22-33
2008
Homo sapiens (P24941), Homo sapiens
Chen, H.; Van Duyne, R.; Zhang, N.; Kashanchi, F.; Zeng, C.
A novel binding pocket of cyclin-dependent kinase 2
Proteins
74
122-132
2008
Homo sapiens (P24941)
Wang, S.; Fischer, P.M.
Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology
Trends Pharmacol. Sci.
29
302-313
2008
Homo sapiens (P50750)
Chen, R.; Wierda, W.G.; Chubb, S.; Hawtin, R.E.; Fox, J.A.; Keating, M.J.; Gandhi, V.; Plunkett, W.
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia
Blood
113
4637-4645
2009
Homo sapiens
Leitch, A.E.; Haslett, C.; Rossi, A.G.
Cyclin-dependent kinase inhibitor drugs as potential novel anti-inflammatory and pro-resolution agents
Br. J. Pharmacol.
158
1004-1016
2009
Homo sapiens
Ali, S.; Heathcote, D.A.; Kroll, S.H.; Jogalekar, A.S.; Scheiper, B.; Patel, H.; Brackow, J.; Siwicka, A.; Fuchter, M.J.; Periyasamy, M.; Tolhurst, R.S.; Kanneganti, S.K.; Snyder, J.P.; Liotta, D.C.; Aboagye, E.O.; Barrett, A.G.; Coombes, R.C.
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity
Cancer Res.
69
6208-6215
2009
Homo sapiens
Uchiyama, H.; Sowa, Y.; Wakada, M.; Yogosawa, M.; Nakanishi, R.; Horinaka, M.; Shimazaki, C.; Taniwaki, M.; Sakai, T.
Cyclin-dependent kinase inhibitor SU9516 enhances sensitivity to methotrexate in human T-cell leukemia Jurkat cells
Cancer Sci.
101
728-734
2010
Homo sapiens
Bonvini, P.; Zorzi, E.; Mussolin, L.; Monaco, G.; Pigazzi, M.; Basso, G.; Rosolen, A.
The effect of the cyclin-dependent kinase inhibitor flavopiridol on anaplastic large cell lymphoma cells and relationship with NPM-ALK kinase expression and activity
Haematologica
94
944-955
2009
Homo sapiens
Kim, H.S.; Lee, W.J.; Lee, S.W.; Chae, H.W.; Kim, D.H.; Oh, Y.
Insulin-like growth factor binding protein-3 induces G1 cell cycle arrest with inhibition of cyclin-dependent kinase 2 and 4 in MCF-7 human breast cancer Ccells
Horm. Metab. Res.
42
165-172
2009
Homo sapiens
Mohapatra, S.; Chu, B.; Zhao, X.; Djeu, J.; Cheng, J.Q.; Pledger, W.J.
Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors
Int. J. Biochem. Cell Biol.
41
595-602
2009
Homo sapiens
Moss, S.C.; Lightell, D.J.; Marx, S.O.; Marks, A.R.; Woods, T.C.
Rapamycin regulates endothelial cell migration through regulation of the cyclin-dependent kinase inhibitor, p27Kip1
J. Biol. Chem.
285
11991-11997
2010
Homo sapiens
Tan, V.B.; Zhang, B.; Lim, K.M.; Tay, T.E.
Explaining the inhibition of cyclin-dependent kinase 5 by peptides derived from p25 with molecular dynamics simulations and MM-PBSA
J. Mol. Model.
16
1-8
2010
Homo sapiens
Malmstroem, J.; Viklund, J.; Slivo, C.; Costa, A.; Maudet, M.; Sandelin, C.; Hiller, G.; Olsson, L.L.; Aagaard, A.; Geschwindner, S.; Xue, Y.; Vasaenge, M.
Synthesis and structure-activity relationship of 4-(1,3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors
Bioorg. Med. Chem. Lett.
22
5919-5923
2012
Homo sapiens (Q00535)
Aggarwal, P.; Vaites, L.P.; Kim, J.K.; Mellert, H.; Gurung, B.; Nakagawa, H.; Herlyn, M.; Hua, X.; Rustgi, A.K.; McMahon, S.B.; Diehl, J.A.
Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase
Cancer Cell
18
329-340
2010
Homo sapiens, Mus musculus
Leitch, A.E.; Lucas, C.D.; Marwick, J.A.; Duffin, R.; Haslett, C.; Rossi, A.G.
Cyclin-dependent kinases 7 and 9 specifically regulate neutrophil transcription and their inhibition drives apoptosis to promote resolution of inflammation
Cell Death Differ.
19
1950-1961
2012
Homo sapiens
Flores, O.; Wang, Z.; Knudsen, K.E.; Burnstein, K.L.
Nuclear targeting of cyclin-dependent kinase 2 reveals essential roles of cyclin-dependent kinase 2 localization and cyclin E in vitamin D-mediated growth inhibition
Endocrinology
151
896-908
2010
Homo sapiens
Ngompaza-Diarra, J.; Bettayeb, K.; Gresh, N.; Meijer, L.; Oumata, N.
Synthesis and biological evaluation of selective and potent cyclin-dependent kinase inhibitors
Eur. J. Med. Chem.
56
210-216
2012
Asteroidea, Homo sapiens
Moshe, Y.; Bar-On, O.; Ganoth, D.; Hershko, A.
Regulation of the action of early mitotic inhibitor 1 on the anaphase-promoting complex/cyclosome by cyclin-dependent kinases
J. Biol. Chem.
286
16647-16657
2011
Homo sapiens
Cuomo, M.E.; Platt, G.M.; Pearl, L.H.; Mittnacht, S.
Cyclin-cyclin-dependent kinase regulatory response is linked to substrate recognition
J. Biol. Chem.
286
9713-9725
2011
Homo sapiens, Human gammaherpesvirus 8
Traquandi, G.; Ciomei, M.; Ballinari, D.; Casale, E.; Colombo, N.; Croci, V.; Fiorentini, F.; Isacchi, A.; Longo, A.; Mercurio, C.; Panzeri, A.; Pastori, W.; Pevarello, P.; Volpi, D.; Roussel, P.; Vulpetti, A.; Brasca, M.G.
Identification of potent pyrazolo[4,3-h]quinazoline-3-carboxamides as multi-cyclin-dependent kinase inhibitors
J. Med. Chem.
53
2171-2187
2010
Homo sapiens
Hisanaga, S.; Endo, R.
Regulation and role of cyclin-dependent kinase activity in neuronal survival and death
J. Neurochem.
115
1309-1321
2010
Homo sapiens, Mus musculus
Rovnak, J.; Brewster, C.D.; Quackenbush, S.L.
Retroviral cyclin enhances cyclin-dependent kinase-8 activity
J. Virol.
86
5742-5751
2012
Homo sapiens
Hizli, A.A.; Chi, Y.; Swanger, J.; Carter, J.H.; Liao, Y.; Welcker, M.; Ryazanov, A.G.; Clurman, B.E.
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A-cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase
Mol. Cell. Biol.
33
596-604
2013
Homo sapiens
Wang, H.; Xu, Y.; Fang, Z.; Chen, S.; Balk, S.P.; Yuan, X.
Doxycycline regulated induction of AKT in murine prostate drives proliferation independently of p27 cyclin dependent kinase inhibitor downregulation
PLoS ONE
7
e41330
2012
Homo sapiens
Liberal, V.; Martinsson-Ahlzen, H.S.; Liberal, J.; Spruck, C.H.; Widschwendter, M.; McGowan, C.H.; Reed, S.I.
Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression overrides the DNA damage response barrier triggered by activated oncoproteins
Proc. Natl. Acad. Sci. USA
109
2754-2759
2012
Homo sapiens
Chen, N.; Yang, H.; Niu, J.; Liu, S.
Determination of kinetic parameters and structure-activity relationships of ginsenosides as inhibitors of cyclin-dependent kinase 5/p25 using ultra-pressure liquid chromatography with triple quadrupole tandem mass spectrometry
Rapid Commun. Mass Spectrom.
27
985-992
2013
Homo sapiens
Albert, T.K.; Rigault, C.; Eickhoff, J.; Baumgart, K.; Antrecht, C.; Klebl, B.; Mittler, G.; Meisterernst, M.
Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor
Br. J. Pharmacol.
171
55-68
2014
Homo sapiens
Vymetalova, L.; Havlicek, L.; Sturc, A.; Skraskova, Z.; Jorda, R.; Pospisil, T.; Strnad, M.; Krystof, V.
5-Substituted 3-isopropyl-7-[4-(2-pyridyl)benzyl]amino-1(2)H-pyrazolo[4,3-d]pyrimidines with anti-proliferative activity as potent and selective inhibitors of cyclin-dependent kinases
Eur. J. Med. Chem.
110
291-301
2016
Homo sapiens
Fujino, A.; Fukushima, K.; Kubota, T.; Kosugi, T.; Takimoto-Kamimura, M.
Crystal structure of human cyclin-dependent kinase-2 complex with MK2 inhibitor TEI-I01800: insight into the selectivity
J. Synchrotron Radiat.
20
905-909
2013
Homo sapiens
Liang, K.; Gao, X.; Gilmore, J.M.; Florens, L.; Washburn, M.P.; Smith, E.; Shilatifard, A.
Characterization of human cyclin-dependent kinase 12 (CDK12) and CDK13 complexes in C-terminal domain phosphorylation, gene transcription, and RNA processing
Mol. Cell. Biol.
35
928-938
2015
Homo sapiens (Q14004), Homo sapiens (Q9NYV4), Homo sapiens
Petrone, A.; Adamo, M.E.; Cheng, C.; Kettenbach, A.N.
Identification of candidate cyclin-dependent kinase 1 (Cdk1) substrates in mitosis by quantitative phosphoproteomics
Mol. Cell. Proteomics
15
2448-2461
2016
Homo sapiens
Talapati, S.; Nataraj, V.; Pothuganti, M.; Gore, S.; Ramachandra, M.; Antony, T.; More, S.; Krishnamurthy, N.
Structure of cyclin-dependent kinase 2 (CDK2) in complex with the specific and potent inhibitor CVT-313
Acta Crystallogr. Sect. F
76
350-356
2020
Homo sapiens (P24941), Homo sapiens
Beaujois, R.; Ottoni, E.; Zhang, X.; Gagnon, C.; HSine, S.; Mollet, S.; Viranaicken, W.; DesGroseillers, L.
The M-phase specific hyperphosphorylation of Staufen2 involved the cyclin-dependent kinase CDK1
BMC Cell Biol.
18
25
2017
Homo sapiens (P06493)
Naseh, G.; Mohammadifard, M.; Mohammadifard, M.
Upregulation of cyclin-dependent kinase 7 and matrix metalloproteinase-14 expression contribute to metastatic properties of gastric cancer
IUBMB Life
2020
799-805
2016
Homo sapiens (P50613)
