Information on EC 2.3.2.2 - gamma-glutamyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria

EC NUMBER
COMMENTARY
2.3.2.2
-
RECOMMENDED NAME
GeneOntology No.
gamma-glutamyltransferase
REACTION TYPE
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
aminoacyl group transfer
-
-
-
-
PATHWAY
KEGG Link
MetaCyc Link
Arachidonic acid metabolism
-
Cyanoamino acid metabolism
-
gamma-glutamyl cycle
-
Glutathione metabolism
-
hypoglycin biosynthesis
-
leukotriene biosynthesis
-
Metabolic pathways
-
Taurine and hypotaurine metabolism
-
SYSTEMATIC NAME
IUBMB Comments
(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4].
SYNONYMS
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
alpha-glutamyl transpeptidase
-
-
-
-
At1g69820
Q9CAR5
-
At4g29210
Q9M0G0
-
At4g39640
O65652
-
At4g39650
Q680I5
-
gamma-glutamyl peptidyltransferase
-
-
-
-
gamma-glutamyl transferase
-, Q680I5, Q8VYW6, Q9M0G0
-
gamma-glutamyl transpeptidase
-
-
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
Q65KZ6
-
gamma-glutamyl transpeptidase
Bacillus licheniformis ATCC 14580
Q65KZ6
-
-
gamma-glutamyl transpeptidase
Bacillus licheniformis ER-15
-
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
Helicobacter pylori NCTC 11637
-
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
P19440
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
-
-
gamma-glutamyl transpeptidase
O14194
-
gamma-glutamyl transpeptidase 4
Q9M0G0
-
gamma-glutamyltranspeptidase
P54422
-
gamma-glutamyltranspeptidase
Bacillus subtilis 168
P54422
-
-
gamma-glutamyltranspeptidase
-
-
gamma-glutamyltranspeptidase
-
-
gamma-glutamyltranspeptidase
-
-
-
gamma-glutamyltranspeptidase
P07314
-
gamma-GPT
-
-
-
-
gamma-GT
-
-
-
-
gamma-GT
-
-
gamma-GTase
-
-
gamma-GTP
-
-
-
-
gammaGT
-
-
GGT
Bacillus licheniformis ATCC 14580
Q65KZ6
-
-
GGT
Bacillus licheniformis ER-15
-
-
-
GGT
P54422
-
GGT
Bacillus subtilis 168
-, P54422
-
-
GGT
Helicobacter pylori 51, Helicobacter pylori NCTC 11637
-
-
-
GGT
P19440
-
GGT1
Q8VYW6
isoform
GGT1
P19440
-
GGT1
P19440
isoform
GGT2
Q680I5
isoform
GGT3
Q9M0G0
-
GGT3
Q9M0G0
isoform
GGT4
-
isoform
GGT5
-
isoform
GGT5
P36269
-
GGTII protein
O14194
-
GGTLA1
P36269
formerly
glutamyl transpeptidase
-
-
-
-
glutamyltransferase, gamma-
-
-
-
-
L-gamma-glutamyl transpeptidase
-
-
-
-
L-gamma-glutamyltransferase
-
-
-
-
L-glutamyltransferase
-
-
-
-
CAS REGISTRY NUMBER
COMMENTARY
9046-27-9
-
ORGANISM
COMMENTARY
LITERATURE
SEQUENCE CODE
SEQUENCE DB
SOURCE
ecotype Columbia
-
-
Manually annotated by BRENDA team
isoform GGT1; ecotype Columbia
UniProt
Manually annotated by BRENDA team
isoform GGT2; ecotype Columbia
SwissProt
Manually annotated by BRENDA team
isoform GGT3; ecotype Columbia
SwissProt
Manually annotated by BRENDA team
strain MA-27-IM
-
-
Manually annotated by BRENDA team
Aspergillus oryzae MA-27-IM
strain MA-27-IM
-
-
Manually annotated by BRENDA team
ATCC 27811
SwissProt
Manually annotated by BRENDA team
Bacillus licheniformis ATCC 14580
-
SwissProt
Manually annotated by BRENDA team
Bacillus licheniformis ER-15
-
-
-
Manually annotated by BRENDA team
strain A8 originating from Lake Bogoria
-
-
Manually annotated by BRENDA team
Bacillus pumilus A8
strain A8 originating from Lake Bogoria
-
-
Manually annotated by BRENDA team
strain KUN-17
-
-
Manually annotated by BRENDA team
Bacillus sp. KUN-17
strain KUN-17
-
-
Manually annotated by BRENDA team
natto strain NR-1
-
-
Manually annotated by BRENDA team
strain NX-2
-
-
Manually annotated by BRENDA team
Bacillus subtilis 168
-
UniProt
Manually annotated by BRENDA team
Bacillus subtilis 168
168
-
-
Manually annotated by BRENDA team
Bacillus subtilis NAFM5
NAFM5
Uniprot
Manually annotated by BRENDA team
Bacillus subtilis NX-2
strain NX-2
-
-
Manually annotated by BRENDA team
Holstein breed
-
-
Manually annotated by BRENDA team
strain 81116
-
-
Manually annotated by BRENDA team
Campylobacter jejuni 81116
strain 81116
-
-
Manually annotated by BRENDA team
2 isozymes A and B; K-12, strain MG1655
-
-
Manually annotated by BRENDA team
K-12, strain MG1655
-
-
Manually annotated by BRENDA team
strain K-1
-
-
Manually annotated by BRENDA team
strain K12
UniProt
Manually annotated by BRENDA team
strain Novablue
-
-
Manually annotated by BRENDA team
Escherichia coli K12
strain K12
UniProt
Manually annotated by BRENDA team
Escherichia coli Novablue
strain Novablue
-
-
Manually annotated by BRENDA team
strain NCTC 11637 and strainNCTC 4
-
-
Manually annotated by BRENDA team
Helicobacter pylori NCTC 11637
strain NCTC 11637 and strainNCTC 4
-
-
Manually annotated by BRENDA team
6 isoforms in hepatic cellular carcinoma
-
-
Manually annotated by BRENDA team
cohort study on construction workers
-
-
Manually annotated by BRENDA team
isoform GGT1
GenBank
Manually annotated by BRENDA team
patients with coronary artery disease
-
-
Manually annotated by BRENDA team
precursor
GenBank
Manually annotated by BRENDA team
precursor
SwissProt
Manually annotated by BRENDA team
shiitake mushroom
-
-
Manually annotated by BRENDA team
Kemp's ridley sea-turtle
-
-
Manually annotated by BRENDA team
3 isoforms I, II and III
-
-
Manually annotated by BRENDA team
Swiss albino and RIII strain, both infected with mammary tumour virus, uninfected: C57BL strain
-
-
Manually annotated by BRENDA team
Oncornavirus
-
-
-
Manually annotated by BRENDA team
male, Fauve de Bourgogne strain
-
-
Manually annotated by BRENDA team
Oryctolagus cuniculus Fauve de Bourgogne
male, Fauve de Bourgogne strain
-
-
Manually annotated by BRENDA team
strain IFO 4622
-
-
Manually annotated by BRENDA team
Penicillium roqueforti IFO 4622
strain IFO 4622
-
-
Manually annotated by BRENDA team
male, Donryu
-
-
Manually annotated by BRENDA team
male, Sprague-Dawley
-
-
Manually annotated by BRENDA team
multiparous rats
-
-
Manually annotated by BRENDA team
Sprague-Dawley rats, female
UniProt
Manually annotated by BRENDA team
streptozotocin-induced diabetic, female and male
-
-
Manually annotated by BRENDA team
Wistar, female
-
-
Manually annotated by BRENDA team
Rattus norvegicus Wistar
Wistar
-
-
Manually annotated by BRENDA team
strain 1278b
-
-
Manually annotated by BRENDA team
wild-type and enzyme-deficient strain, nitrogen starvation-induced
-
-
Manually annotated by BRENDA team
Saccharomyces cerevisiae 1278b
strain 1278b
-
-
Manually annotated by BRENDA team
2isoforms I and II
-
-
Manually annotated by BRENDA team
strain ATCC 35405
-
-
Manually annotated by BRENDA team
pI VALUE
pI VALUE MAXIMUM
ORGANISM
UNIPROT ACCESSION NO.
COMMENTARY
LITERATURE
4.8
-
-
chromatofocusing
PDB
SCOP
CATH
ORGANISM
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Bacillus subtilis (strain 168)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Escherichia coli (strain K12)
Helicobacter pylori (strain ATCC 700392 / 26695)
Helicobacter pylori (strain ATCC 700392 / 26695)
Helicobacter pylori (strain ATCC 700392 / 26695)
Helicobacter pylori (strain ATCC 700392 / 26695)