Information on EC 2.3.2.2 - gamma-glutamyltransferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
2.3.2.2
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RECOMMENDED NAME
GeneOntology No.
gamma-glutamyltransferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aminoacyl group transfer
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PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Cyanoamino acid metabolism
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gamma-glutamyl cycle
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glutathione metabolism
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Glutathione metabolism
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hypoglycin biosynthesis
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leukotriene biosynthesis
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Taurine and hypotaurine metabolism
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SYSTEMATIC NAME
IUBMB Comments
(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase
The mammlian enzyme is part of the cell antioxidant defense mechanism. It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels. The protein also has EC 3.4.19.13 (glutathione hydrolase) activity [3-4]. The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide. The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions [3-4].
CAS REGISTRY NUMBER
COMMENTARY hide
9046-27-9
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain MA-27-IM
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Manually annotated by BRENDA team
strain MA-27-IM
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain A8 originating from Lake Bogoria
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Manually annotated by BRENDA team
strain A8 originating from Lake Bogoria
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Manually annotated by BRENDA team
strain KUN-17
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Manually annotated by BRENDA team
Bacillus sp. KUN-17
strain KUN-17
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Manually annotated by BRENDA team
NAFM5
Uniprot
Manually annotated by BRENDA team
strain NX-2
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain 81116
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Manually annotated by BRENDA team
strain 81116
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain K12
UniProt
Manually annotated by BRENDA team
strain Novablue
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Manually annotated by BRENDA team
strain NCTC 11637 and strainNCTC 4
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
shiitake mushroom
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Manually annotated by BRENDA team
Kemp's ridley sea-turtle
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
3 isoforms I, II and III
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Manually annotated by BRENDA team
Oncornavirus
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Manually annotated by BRENDA team
Oryctolagus cuniculus Fauve de Bourgogne
male, Fauve de Bourgogne strain
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Manually annotated by BRENDA team
strain IFO 4622
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Manually annotated by BRENDA team
strain IFO 4622
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
enzyme displays both glutathione hydrolase, EC 3.4.19.13, and gamma-glutamyl transpeptidase activity
UniProt
Manually annotated by BRENDA team
enzyme displays both glutathione hydrolase, EC 3.4.19.13, and gamma-glutamyl transpeptidase activity
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Wistar
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Manually annotated by BRENDA team
strain 1278b
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Manually annotated by BRENDA team
GGTII
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
2isoforms I and II
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Manually annotated by BRENDA team
strain ATCC 35405
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(5-L-glutamyl)-peptide + acceptor + H+
peptide + 5-L-glutamyl amino acid
show the reaction diagram
(5-L-glutamyl)-peptide + an amino acid
peptide + 5-L-Glu-Xaa
show the reaction diagram
5-D-glutamyl-4-nitroanilide + acceptor
4-nitroaniline + 5-D-glutamyl-acceptor
show the reaction diagram
5-D/L-glutamyl-phenylhydrazine + acceptor
phenylhydrazine + 5-L-glutamyl-acceptor
show the reaction diagram
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product is cytotoxic
ir
5-L-glutamine + 5-L-glutamine
5-poly-glutamic acid + glutamate
show the reaction diagram
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?
5-L-glutamyglycylglycine + acceptor
glycylglycine + 5-L-glutamyl-acceptor
show the reaction diagram
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?
5-L-glutamyl 3-carboxy-4-nitroanilide + glucana
5-amino-2-nitrobenzoic acid + N-(3-carboxy-4-nitrophenyl)-L-glutaminyl-L-glutamic acid
show the reaction diagram
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ir
5-L-glutamyl 3-carboxy-4-nitronailide + glycylglycine
5-amino-2-nitrobenzoic acid + 5-L-glutamylglycylglycine
show the reaction diagram
5-L-glutamyl 4-nitroanilide + Gly-Gly
4-nitroaniline + 5-L-glutamyl-Gly-Gly
show the reaction diagram
in the standard GGT assay with gamma-glutamyl p-nitroanilide as substrate, GGT1 accounts for 80% to 99% of the activity in all tissues except seeds where GGT2 is 50% of the activity
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?
5-L-glutamyl-2-naphthylamide + glycylglycine
5-L-glutamyl-glycylglycine + 2-naphthylamine
show the reaction diagram
5-L-glutamyl-3-carboxy-4-nitroanilide + 5-L-glutamyl-3-carboxy-4-nitroanilide
5-L-glutamyl-5-L-glutamyl-3-carboxy-4-nitroanilide + 3-carboxy-4-nitroaniline
show the reaction diagram
5-L-glutamyl-3-carboxy-4-nitroanilide + glycylglycine
5-L-glutamyl-glycylglycine + 3-carboxy-4-nitroaniline
show the reaction diagram
5-L-glutamyl-4-methoxy-2-naphthylamide + glycylglycine
5-L-glutamyl-glycylglycine + 4-methoxy-2-naphthylamine
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide +
4-nitroaniline + 5-L-glutamyl-Gly-Gly-Ala
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + (S)-2-aminobutyrate
4-nitroaniline + N-[(1S)-1-carboxypropyl]-L-glutamine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + 1-amino-cyclopropane-1-carboxylic acid
4-nitroaniline + 5-L-glutamyl-1-amino-cyclopropane-1-carboxylic acid
show the reaction diagram
5-L-glutamyl-4-nitroanilide + 5-L-glutamyl-4-nitroanilide
5-L-glutamyl-5-L-glutamyl-4-nitroanilide + 4-nitroaniline
show the reaction diagram
5-L-glutamyl-4-nitroanilide + acceptor
4-nitroaniline + 5-L-glutamyl-acceptor
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + Ala-Ala-Ala
4-nitroaniline + 5-L-glutamyl-Ala-Ala-Ala
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Arg
4-nitroaniline + 5-L-glutamyl-Arg
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Asn
4-nitroaniline + 5-L-glutamyl-Asn
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Asp
4-nitroaniline + 5-L-glutamyl-Asp
show the reaction diagram
5-L-glutamyl-4-nitroanilide + citrulline
4-nitroaniline + 5-L-glutamyl-citrulline
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Cys
4-nitroaniline + 5-L-glutamyl-Cys
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Cys-Gly
4-nitroaniline + 5-L-glutamyl-Cys-Gly
show the reaction diagram
5-L-glutamyl-4-nitroanilide + DL-Phe
4-nitroaniline + 5-L-glutamyl-DL-Phe
show the reaction diagram
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39.9% of the activity with Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + ethylamine
N-ethyl-L-glutamine + 4-nitroaniline
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + ethylamine
theanine + 4-nitroaniline
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Glu
4-nitroaniline + 5-L-glutamyl-Glu
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Gly
4-nitroaniline + 5-L-glutamyl-Gly
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Gly-Gly
4-nitroaniline + 5-L-glutamyl-Gly-Gly
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Gly-Gly-Ala
4-nitroaniline + 5-L-glutamyl-Gly-Gly-Ala
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Gly-Gly-Gly
4-nitroaniline + 5-L-glutamyl-Gly-Gly-Gly
show the reaction diagram
5-L-glutamyl-4-nitroanilide + glycine
4-nitroaniline + 5-L-glutamyl-glycine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + glycyl-glycine
4-nitroaniline + 5-L-glutamyl-glycyl-glycine
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + glycyl-L-proline
4-nitroaniline + 5-L-glutamyl-glycyl-L-proline
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + glycylglycine
4-nitroaniline + 5-L-glutamylglycylglycine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + glycylglycine
5-L-glutamyl-glycylglycine + 4-nitroaniline
show the reaction diagram
5-L-glutamyl-4-nitroanilide + H2O
4-nitroaniline + Glu
show the reaction diagram
5-L-glutamyl-4-nitroanilide + H2O
4-nitroaniline + L-glutamate
show the reaction diagram
5-L-glutamyl-4-nitroanilide + H2O
L-glutamate + 4-nitroanilide
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + H2O
L-glutamate + 4-nitroaniline
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + H2O
p-nitroaniline + Glu
show the reaction diagram
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in wild-type enzyme the transpeptidation activity is 2.38times higher than the hydrolysis activity
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?
5-L-glutamyl-4-nitroanilide + His
4-nitroaniline + 5-L-glutamyl-His
show the reaction diagram
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82.9% of the activity with Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + Ile
4-nitroaniline + 5-L-glutamyl-Ile
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Ala
4-nitroaniline + 5-L-glutamyl-L-Ala
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-alanine
4-nitroaniline + 5-L-glutamyl-L-alanine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-alanylglycine
4-nitroaniline + 5-L-glutamyl-L-alanylglycine
show the reaction diagram
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?
5-L-glutamyl-4-nitroanilide + L-Arg
4-nitroaniline + 5-L-glutamyl-L-Arg
show the reaction diagram
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21.4% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + L-arginine
4-nitroaniline + 5-L-glutamyl-L-arginine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Asn
4-nitroaniline + 5-L-glutamyl-L-Asn
show the reaction diagram
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24.5% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + L-Asp
4-nitroaniline + 5-L-glutamyl-L-Asp
show the reaction diagram
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20.4% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + L-asparagine
4-nitroaniline + 5-L-glutamyl-L-asparagine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-aspartate
4-nitroaniline + 5-L-glutamyl-L-aspartate
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Cys
4-nitroaniline + 5-L-glutamyl-L-Cys
show the reaction diagram
-
11.1% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + L-cysteine
4-nitroaniline + 5-L-glutamyl-L-cysteine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-cysteinylglycine
4-nitroaniline + glutathione
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-cystine
4-nitroaniline + 5-L-glutamyl-L-cystine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Gln
4-nitroaniline + 5-L-glutamyl-L-Gln
show the reaction diagram
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5.4% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + L-Glu
4-nitroaniline + 5-L-glutamyl-L-Glu
show the reaction diagram
-
8.1% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + L-glutamate
4-nitroaniline + 5-L-glutamyl-L-glutamate
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-glutamine
4-nitroaniline + 5-L-glutamyl-L-glutamine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-His
4-nitroaniline + 5-L-glutamyl-L-His
show the reaction diagram
-
35.7% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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?
5-L-glutamyl-4-nitroanilide + L-histidine
4-nitroaniline + 5-L-glutamyl-L-histidine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-hydroxyproline
4-nitroaniline + 5-L-glutamyl-L-hydroxyproline
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Ile
4-nitroaniline + 5-L-glutamyl-L-Ile
show the reaction diagram
-
19.5% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + L-isoleucine
4-nitroaniline + 5-L-glutamyl-L-isoleucine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Leu
4-nitroaniline + 5-L-glutamyl-L-Leu
show the reaction diagram
-
21.1% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + L-leucine
4-nitroaniline + 5-L-glutamyl-L-leucine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-leucyl-L-alanine
4-nitroaniline + 5-L-glutamyl-L-leucyl-L-alanine
show the reaction diagram
-
-
-
-
?
5-L-glutamyl-4-nitroanilide + L-Lys
4-nitroaniline + 5-L-glutamyl-L-Lys
show the reaction diagram
-
11.2% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + L-lysine
4-nitroaniline + 5-L-glutamyl-L-lysine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Met
4-nitroaniline + 5-L-glutamyl-L-Met
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-methioninamide
4-nitroaniline + 5-L-glutamyl-L-methioninamide
show the reaction diagram
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-
-
-
?
5-L-glutamyl-4-nitroanilide + L-methionine
4-nitroaniline + 5-L-glutamyl-L-methionine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-methionyl(2,2,2-trifluoroethylamide)
4-nitroaniline + 5-L-glutamyl-L-methionyl(2,2,2-trifluoroethylamide)
show the reaction diagram
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-
-
?
5-L-glutamyl-4-nitroanilide + L-methionyl(2-fluoroethylamide)
4-nitroaniline + 5-L-glutamyl-L-methionyl(2-fluoroethylamide)
show the reaction diagram
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-
-
-
?
5-L-glutamyl-4-nitroanilide + L-methionyl(3,3,3-trifluoropropylamide)
4-nitroaniline + 5-L-glutamyl-L-methionyl(3,3,3-trifluoropropylamide)
show the reaction diagram
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-
-
-
?
5-L-glutamyl-4-nitroanilide + L-methionylethylamide
4-nitroaniline + 5-L-glutamyl-L-methionylethylamide
show the reaction diagram
-
-
-
-
?
5-L-glutamyl-4-nitroanilide + L-methionylpropylamide
4-nitroaniline + 5-L-glutamyl-L-methionylpropylamide
show the reaction diagram
-
-
-
-
?
5-L-glutamyl-4-nitroanilide + L-Phe
4-nitroaniline + 5-L-glutamyl-L-Phe
show the reaction diagram
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38.4% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + L-phenylalanine
4-nitroaniline + 5-L-glutamyl-L-phenylalanine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Pro
4-nitroaniline + 5-L-glutamyl-L-Pro
show the reaction diagram
-
12.8% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + L-proline
4-nitroaniline + 5-L-glutamyl-L-proline
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Ser
4-nitroaniline + 5-L-glutamyl-L-Ser
show the reaction diagram
-
12.5% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-4-nitroanilide + L-serine
4-nitroaniline + 5-L-glutamyl-L-serine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Thr
4-nitroaniline + 5-L-glutamyl-L-Thr
show the reaction diagram
-
34% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + L-threonine
4-nitroaniline + 5-L-glutamyl-L-threonine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-Trp
4-nitroaniline + 5-L-glutamyl-L-Trp
show the reaction diagram
-
30.9% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-4-nitroanilide + L-tryptophan
4-nitroaniline + 5-L-glutamyl-L-tryptophan
show the reaction diagram
5-L-glutamyl-4-nitroanilide + L-tyrosine
4-nitroaniline + 5-L-glutamyl-L-tyrosine
show the reaction diagram
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24.1% of the activity with Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + L-Val
4-nitroaniline + 5-L-glutamyl-L-Val
show the reaction diagram
-
30.5% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-4-nitroanilide + L-valine
4-nitroaniline + 5-L-glutamyl-L-valine
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Leu
4-nitroaniline + 5-L-glutamyl-Leu
show the reaction diagram
-
21.3% of the activity with Gly-Gly
-
-
?
5-L-glutamyl-4-nitroanilide + Lys
4-nitroaniline + 5-L-glutamyl-Lys
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Met
4-nitroaniline + 5-L-glutamyl-Met
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Pro
4-nitroaniline + 5-L-glutamyl-Pro
show the reaction diagram
-
13.8% of the activity with Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + S-alkylcysteine sulfoxide
4-nitroaniline + 5-L-glutamyl-S-alkylcysteine sulfoxide
show the reaction diagram
-
best substrates
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-
?
5-L-glutamyl-4-nitroanilide + Ser
4-nitroaniline + 5-L-glutamyl-Ser
show the reaction diagram
-
12.8% of the activity with Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + taurine
4-nitroaniline + 5-L-glutamyl-taurine
show the reaction diagram
-
68.8% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
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-
?
5-L-glutamyl-4-nitroanilide + Thr
4-nitroaniline + 5-L-glutamyl-Thr
show the reaction diagram
5-L-glutamyl-4-nitroanilide + Tyr
4-nitroaniline + 5-L-glutamyl-Tyr
show the reaction diagram
-
34.0% of the activity with Gly-Gly
-
-
?
5-L-glutamyl-4-nitroanilide + Val
4-nitroaniline + 5-L-glutamyl-Val
show the reaction diagram
-
30.2% of the activity with Gly-Gly
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-
?
5-L-glutamyl-7-amido-4-methylcoumarin + acceptor
7-amino-4-methylcoumarin + 5-L-glutamyl-acceptor
show the reaction diagram
5-L-glutamyl-7-amido-4-methylcoumarin + glycylglycine
7-amino-4-methylcoumarin + 5-L-glutamyl-glycylglycine
show the reaction diagram
5-L-glutamyl-cis-3-amino-L-proline + acceptor
5-L-glutamyl-acceptor + cis-3-amino-L-proline
show the reaction diagram
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-
-
?
5-L-glutamyl-L-alanine + 5-L-glutamyl-L-alanine
L-glutamine + 5-L-glutamyl-L-glutamyl-L-alanine
show the reaction diagram
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shows also hydrolase activity with this substrate
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?
5-L-glutamyl-L-His + Gly-Gly
L-His + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
106% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-L-leucine + glycylglycine
L-Leu + 5-L-glutamyl-glycylglycine
show the reaction diagram
-
-
-
?
5-L-glutamyl-L-lysine + acceptor
L-lysine + 5-L-glutamyl-acceptor
show the reaction diagram
-
shows also hydrolase activity with this substrate
-
?
5-L-glutamyl-L-Met + Gly-Gly
L-Met + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
114% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-L-Phe + Gly-Gly
L-Phe + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
103% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-L-Trp + Gly-Gly
L-Trp + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
127% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-L-Tyr + Gly-Gly
L-Tyr + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
94.7% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamyl-L-Val + Gly-Gly
L-Val + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
113% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
5-L-glutamylaniline + 5-L-glutamylaniline
aniline + 5-L-glutamyl-5-L-glutamylaniline
show the reaction diagram
-
-
-
ir
5-L-glutamylaniline + H2O
aniline + L-glutamic acid
show the reaction diagram
-
-
-
ir
5-L-glutamylaniline + S-methyl-L-cysteine
aniline + 5-L-glutamyl-S-methyl-L-cysteine
show the reaction diagram
-
-
-
ir
7-(N-gamma-glutamylamino)-4-methylcoumarin + H2O
7-amino-4-methylcoumarin + ?
show the reaction diagram
D-Gln + Ala
D-Glu-Ala + NH3
show the reaction diagram
-
6.2% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + Cys
D-Glu-Cys + NH3
show the reaction diagram
-
19.3% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + ethylamine
?
show the reaction diagram
1.3% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
D-Gln + Glu
D-Glu-Glu + NH3
show the reaction diagram
-
8.1% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + Gly
D-Glu-Gly + NH3
show the reaction diagram
-
20.1% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + Gly-Gly
Glu-Gly-Gly + NH3
show the reaction diagram
-
-
-
-
?
D-Gln + His
D-Glu-His + NH3
show the reaction diagram
-
116% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + L-Val
D-Glu-Val + NH3
show the reaction diagram
-
8.1% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + Met
D-Glu-Met + NH3
show the reaction diagram
-
352% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + Phe
D-Glu-Phe + NH3
show the reaction diagram
-
144% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + taurine
D-Glu-taurine + NH3
show the reaction diagram
-
422% of the activity with D-Gln and Gly-Gly
-
-
?
D-Gln + Trp
D-Glu-Trp + NH3
show the reaction diagram
-
558% of the activity with D-Gln and Gly-Gly
-
-
?
diclofenac-S-acyl-glutathione + Gly
diclofenac-S-acyl-cysteinylglycine + ?
show the reaction diagram
-
-
-
-
?
gamma-Glu-Cys + Gly-Gly
Cys + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
-
-
-
?
gamma-Glu-L-Tyr + ethylamine
?
show the reaction diagram
5.2% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
gamma-Glu-Leu + ethylamine
?
show the reaction diagram
3.4% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
gamma-glutamyl-D,L-phenylthioglycylglycine + acceptor
gamma-glutamyl-acceptor + alpha-phenylthioglycyl-glycine
show the reaction diagram
-
-
-
-
?
gamma-L-glutamyl-4-nitroanilide + Gly-Gly
4-nitroaniline + gamma-L-glutamyl-Gly-Gly
show the reaction diagram
Gln + H2O
Glu + NH3
show the reaction diagram
glutamic acid gamma methyl ester + ethylamine
theanine + ethanol
show the reaction diagram
-
-
-
-
ir
glutathione + 1-aminocyclopropane-1-carboxylic acid
L-cysteinylglycine + 5-L-glutamyl-1-aminocyclopropane-1-carboxylic acid
show the reaction diagram
-
isoforms I and II
-
?
glutathione + acceptor
cysteinylglycine + 5-L-glutamyl-acceptor
show the reaction diagram
glutathione + amino acid
L-cysteinylglycine + 5-L-glutamyl-amino acid
show the reaction diagram
-
Ggt1 initiates enzymatic breakdown of GSH by cleavage of the gamma-glutamyl bond and release of cysteinylglycine. Second, the thiol group of the released dipeptide reduces ferric to ferrous iron. A combination of kinetic properties of both reactions results in efficient iron reduction over a broad pH range
-
-
?
glutathione + an amino acid
L-cysteinylglycine + 5-L-glutamyl-amino acid
show the reaction diagram
glutathione + an amino acid
L-cysteinylglycine + a 5-L-glutamyl-amino acid
show the reaction diagram
glutathione + daunomycin
L-cysteinylglycine + 5-L-glutamyl-daunomycin
show the reaction diagram
-
detoxification of daunomycin by transpeptidation
-
ir
glutathione + glutathione
L-cysteinylglycine + 5-glutamyl-glutathione
show the reaction diagram
glutathione + Gly-Gly
L-cysteinylglycine + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
-
-
-
?
glutathione + H2O
cysteinylglycine + glutamate
show the reaction diagram
glutathione + H2O
L-cysteinylglycine + glutamate
show the reaction diagram
-
-
-
?
glutathione + L-cysteinylglycine
L-cysteinylglycine + glutathione
show the reaction diagram
glutathione + leukotriene D
cysteinylglycine + leukotriene C
show the reaction diagram
glutathione sulfonic acid + glycylglycine
?
show the reaction diagram
-
-
-
?
glutathionesulfonic acid + glycylglycine
?
show the reaction diagram
-
-
-
?
GS-bimane + Gly-Gly
?
show the reaction diagram
-
GS-bimane is the conjugate of GSH and monobromobimane
-
-
?
GSH + ethylamine
?
show the reaction diagram
56.7% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
GSH + Gly-Gly
?
show the reaction diagram
GSH + glycylglycine
L-Cys-Gly + 5-L-glutamyl-glycylglycine
show the reaction diagram
-
-
-
?
GSSG + ethylamine
?
show the reaction diagram
10.6% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
GSSG + Gly-Gly
?
show the reaction diagram
-
-
-
-
?
GSSG + glycylglycine
L-Cys-Gly + 5-L-glutamyl-glycylglycine
show the reaction diagram
-
-
-
?
hypoglycin A + GSH
hypoglycin B + cysteinylglycine
show the reaction diagram
-
-
-
-
?
L-alpha-methyl-5-glutamyl-L-alpha-aminobutyrate + acceptor
L-alpha-methyl-5-glutamyl acceptor + L-2-aminobutyrate
show the reaction diagram
L-gamma-glutamyl-3-carboxy-4-nitroanilide + H2O
3-carboxy-4-nitroaniline + L-glutamate
show the reaction diagram
assay at pH 8
-
-
?
L-Gln + ethylamine
?
show the reaction diagram
18.8% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
L-Gln + Gly-Gly
NH3 + 5-L-glutamyl-Gly-Gly
show the reaction diagram
-
78.1% of the transpeptidase activity with 5-L-glutamyl-4-nitroanilide and Gly-Gly
-
-
?
L-Glu-4-nitroanilide + glutathione
4-nitroaniline + 5-L-glutamyl-glutathione
show the reaction diagram
L-Glu-gamma-3-carboxy-4-hydroxy-anilide + ethylamine
?
show the reaction diagram
3.9% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
L-Glu-gamma-monohydroxamate + ethylamine
?
show the reaction diagram
0.5% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
L-Glu-gamma-monomethyl ester + ethylamine
?
show the reaction diagram
L-glutamic acid 5-(3-carboxy-4-nitroanilide) + ?
?
show the reaction diagram
-
-
-
-
?
lentinic acid + amino acid
desglutamyl lentinic acid + 5-L-glutamylamino acid
show the reaction diagram
leukotriene C4 + acceptor
leukotriene D4 + glutamyl-acceptor
show the reaction diagram
leukotriene C4 + glycylglycine
leukotriene D4 + 5-L-glutamyl-glycylglycine
show the reaction diagram
-
-
-
?
poly(gamma-glutamic acid) + H2O
D-Glu + L-Glu
show the reaction diagram
S-(4-nitro-benzyl)glutathione + glycylglycine
?
show the reaction diagram
-
-
-
?
S-methyl-glutathione + ethylamine
?
show the reaction diagram
1.8% of the activity with 5-L-glutamyl-4-nitroanilide
-
-
?
S-methylglutathione + acceptor
S-methyl-L-cysteinylglycine + 5-L-glutamyl-acceptor
show the reaction diagram
-
shows also hydrolase activity with this substrate
-
?
S-methylglutathione + glycylglycine
?
show the reaction diagram
-
-
-
?
S-nitroso-glutathione + glycyl-glycine
S-nitroso-cysteinylglycine + gamma-L-glutamyl-glycyl-glycine
show the reaction diagram
-
-
-
-
?
additional information
?
-