6.1.1.21: histidine-tRNA ligase
This is an abbreviated version!
For detailed information about histidine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.21
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6.1.1.21
-
synthetases
-
aminoacylation
-
aminoacyl-trna
-
autoantibody
-
histidylation
-
myositis
-
anti-jo-1
-
polymyositis
-
anticodon
-
dermatomyositis
-
aarss
-
perrault
-
hiss
-
histidinol
-
anti-synthetase
-
guanylyltransferase
-
hsd17b4
-
myositis-specific
-
c10orf2
-
thrrs
-
threonyl-trna
-
trna-like
-
acid-starved
-
seryl-trna
-
analysis
-
medicine
- 6.1.1.21
- synthetases
- aminoacylation
- aminoacyl-trna
- autoantibody
-
histidylation
- myositis
-
anti-jo-1
- polymyositis
-
anticodon
- dermatomyositis
-
aarss
-
perrault
- hiss
- histidinol
-
anti-synthetase
-
guanylyltransferase
- hsd17b4
-
myositis-specific
- c10orf2
- thrrs
- threonyl-trna
-
trna-like
-
acid-starved
- seryl-trna
- analysis
- medicine
Reaction
Synonyms
antihistidyl-tRNA synthetase, class II histidyl-tRNA synthetase, HARS, HARS1, HARS2, HisRS, HisRS-1, HisRS-2, Histidine translase, Histidine--tRNA ligase, Histidine--tRNA ligase homolog, histidine-tRNA ligase, histidine-tRNA ligase homolog, histidyl tRNA synthetase, Histidyl-transfer ribonucleate synthetase, histidyl-transfer RNA synthetase, Histidyl-tRNA synthetase, HRS, HTS1, Jo-1, Jo-1 antigen, mitochondrial histidyl tRNA synthetase, Synthetase, histidyl-transfer ribonucleate
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Reference on EC 6.1.1.21 - histidine-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Walker, E.J.; Treacy, G.B.; Jeffrey, P.D.
Molecular weights of mitochondrial and cytoplasmic aminoacyl-tRNA synthetases of beef liver and their complexes
Biochemistry
22
1934-1941
1983
Bos taurus
Airas, R.K.
Differences in the magnesium dependences of the class I and class II aminoacyl-tRNA synthetases from Escherichia coli
Eur. J. Biochem.
240
223-231
1996
Escherichia coli
Arnez, J.G.; Augustine, J.G.; Francklyn, C.S.
The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase
Proc. Natl. Acad. Sci. USA
8
7144-7149
1997
Escherichia coli
Menguito, C.A.; Papaconstantinou, J.; Weigel, P.H.
The histidyl-tRNA synthetase from Streptococcus equisimilis: overexpression in Escherichia coli. Purification and characterization
Prep. Biochem.
23
499-472
1993
Streptococcus dysgalactiae subsp. equisimilis
-
Francklyn, C.; Harris, D.; Moras, D.
Crystallization of histidyl-tRNA synthetase from Escherichia coli
J. Mol. Biol.
241
275-277
1994
Escherichia coli, Escherichia coli overproducing
Yaremchuk, A.D.; Cusack, S.; Aberg, A.; Gudzera, O.; Kryklivyi, I.; Tukalo, M.
Crystallization of Thermus thermophilus histidyl-tRNA synthetase and its complex with tRNAHis
Proteins Struct. Funct. Genet.
22
426-428
1995
Thermus thermophilus
Ruhlmann, A.; Cramer, F.; Englisch, U.
Isolation and analysis of mutated histidyl-tRNA synthetases from Escherichia coli
Biochem. Biophys. Res. Commun.
237
192-201
1997
Escherichia coli
Augustine, J.; Francklyn, C.
Design of an active fragment of a class II aminoacyl-tRNA synthetase and its significance for synthetase evolution
Biochemistry
36
3473-3482
1997
Escherichia coli
Aberg, A.; Yaremchuk, A.; Tukalo, M.; Rasmussen, B.; Cusack, S.
Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase
Biochemistry
36
3084-3094
1997
Thermus thermophilus
Menguito, C.A.; Keherly, M.J.; Tang, C.Y.; Papaconstantinou, J.; Weigel, P.H.
Molecular cloning, sequence, structural analysis and expression of the histidyl-tRNA synthetase gene from Streptococcus equisimilis
Nucleic Acids Res.
21
615-620
1993
Streptococcus dysgalactiae subsp. equisimilis
Rudinger, J.; Felden, B.; Florentz, C.; Giege, R.
Strategy for RNA recognition by yeast histidyl-tRNA synthetase
Bioorg. Med. Chem.
5
1001-1009
1997
Saccharomyces cerevisiae
Vazquez-Abad, D.; Carson, J.H.; Rothfield, N.
Localization of histidyl-tRNA synthetase (Jo-1) in human laryngeal epithelial carcinoma cell line HEp-2 cells)
Cell Tissue Res.
286
487-491
1996
Homo sapiens
Arnez, J.G.; Harris, D.C.; Mitschler, A.; Rees, B.; Francklyn, C.S.; Moras, D.
Crystal structure of histidyl-tRNA synthetase from Escherichia coli complexed with histidyl-adenylate
EMBO J.
14
4143-4155
1995
Escherichia coli
De Lorenzo, F.; di Natale, P.; Schechter, A.N.
Chemical and physical studies on the structure of the histidyl transfer ribonucleic acid synthetase from Salmonella typhimurium
J. Biol. Chem.
249
908-913
1974
Salmonella enterica subsp. enterica serovar Typhimurium
De Lorenzo, F.; Ames, B.N.
Histidine regulation in Salmonella typhimurium. VII. Purification and general properties of the histidyl transfer ribonucleic acid synthetase
J. Biol. Chem.
245
1710-1716
1970
Salmonella enterica subsp. enterica serovar Typhimurium
Kalousek, F.; Konigsberg, W.H.
Purification and characterization of histidyl transfer ribonucleic acid synthetase of Escherichia coli
Biochemistry
13
999-1006
1974
Escherichia coli
Boguslawski, G.; Vodkin, M.H.; Finkelstein, D.B.; Fink, G.R.
Histidyl-tRNAs and histidyl-tRNA synthetases in wild type and cytoplasmic petite mutants of Saccharomyces cerevisiae
Biochemistry
13
4659-4667
1974
Saccharomyces cerevisiae
Lepore, G.C.; di Natale, P.; Guarini, L.; de Lorenzo, F.
Histidyl-tRNA synthetase from Salmonella typhimurium: specificity in the binding of histidine analogues
Eur. J. Biochem.
56
369-374
1975
Salmonella enterica subsp. enterica serovar Typhimurium
Di Natale, P.; Schechter, A.N.; Lepore, G.C.; de Lorenzo, F.
Histidyl transfer ribonucleic acid synthetase from Salmonella typhimurium. Interaction with substrate and ATP analogues
Eur. J. Biochem.
62
293-298
1976
Salmonella enterica subsp. enterica serovar Typhimurium
Kane, S.M.; Vugrincic, C.; Finbloom, D.S.; Smith, D.W.E.
Purification and some properties of the histidyl-tRNA synthetase from cytosol of rabbit reticulocytes
Biochemistry
17
1509-1514
1978
Oryctolagus cuniculus
Chen, C.C.; Somberg, E.W.
Purification and characterization of histidyl-transfer RNA synthetase from Neurospora crassa
Biochim. Biophys. Acta
613
514-525
1980
Neurospora crassa
Eisenbeis, S.J.; Parker, J.
Strains of Escherichia coli carrying the structural gene for histidyl-tRNA synthetase on a high copy-number plasmid
Mol. Gen. Genet.
183
115-122
1981
Escherichia coli
Yang, D.C.H.; Dang, C.V.; Arnett, F.C.
Rat liver histidyl-tRNA synthetase. Purification and inhibition by the myositis-specific anti-Jo-1 autoantibody
Biochem. Biophys. Res. Commun.
120
15-21
1984
Homo sapiens, Rattus norvegicus
Gerken, S.C.; Andrulis, I.L.; Arfin, S.M.
Histidyl-tRNA synthetase of Chinese hamster ovary cells contains phosphoserine
Biochim. Biophys. Acta
869
215-217
1986
Cricetulus griseus
Walker, E.J.; Jeffrey, P.D.
Purification of bovine liver histidyl-tRNA synthetase, the Jo-1 antigen of polymyositis
Biol. Chem. Hoppe-Seyler
368
531-537
1987
Bos taurus
Tsui, F.W.L.; Siminovitch, L.
Isolation, structure and expression of mammalian genes for histidyl-tRNA synthetase
Nucleic Acids Res.
15
3349-3367
1987
Homo sapiens
Fahoum, S.K.; Yang, D.C.H.
Purification of mammalian histidyl-tRNA synthetase and its interaction with myositis-specific anti-Jo-1 antibodies
Biochemistry
26
5871-5877
1987
Rattus norvegicus
Biswas, T.; Miller, F.W.; Plotz, P.H.
Stimulation and partial stabilization of human histidyl-tRNA synthetase by hemoglobin
FEBS Lett.
229
203-205
1988
Homo sapiens
Castronuovo Lepore, G.; Geraci, G.; Abrescia, P.; de Lorenzo, F.
Histidyl-transfer-ribonucleic-acid synthetase from Salmonella typhimurium. Studies of the sulfhydryl groups
Eur. J. Biochem.
65
171-176
1976
Salmonella enterica subsp. enterica serovar Typhimurium
O'Hanlon, T.P.; Miller, F.W.
Genomic organization, transcriptional mapping, and evolutionary implications of the human bi-directional histidyl-tRNA synthetase locus (HARS/HARSL)
Biochem. Biophys. Res. Commun.
294
609-614
2002
Homo sapiens (P12081), Homo sapiens (P49590), Homo sapiens
Qiu, X.; Janson, C.A.; Blackburn, M.N.; Chhohan, I.K.; Hibbs, M.; Abdel-Meguid, S.S.
Cooperative structural dynamics and a novel fidelity mechanism in histidyl-tRNA synthetases
Biochemistry
38
12296-12304
1999
Staphylococcus aureus (P60911), Staphylococcus aureus
Connolly, S.A.; Rosen, A.E.; Musier-Forsyth, K.; Francklyn, C.S.
G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase
Biochemistry
43
962-969
2004
Escherichia coli
Freist, W.; Verhey, J.F.; Ruhlmann, A.; Gauss, D.H.; Arnez, J.G.
Histidyl-tRNA synthetase
Biol. Chem.
380
623-646
1999
Archaeoglobus fulgidus (O28631), Salmonella enterica subsp. enterica serovar Typhimurium (O52765), Mesocricetus auratus (P07178), Saccharomyces cerevisiae (P07263), Homo sapiens (P12081), Homo sapiens (P49590), Streptococcus dysgalactiae subsp. equisimilis (P30053), Caenorhabditis elegans (P34183), Haemophilus influenzae (P43823), Mycobacterium leprae (P46696), Mycoplasma genitalium (P47281), Porphyra purpurea (P51348), Thermus thermophilus (P56194), Thermus thermophilus, Helicobacter pylori (P56455), Escherichia coli (P60906), Escherichia coli, Takifugu rubripes (P70076), Mycoplasma pneumoniae (P75069), Oryza sativa (P93422), Mycobacterium tuberculosis (P9WFV5), Synechococcus sp. (Q55267), Synechocystis sp. (Q55653), Methanocaldococcus jannaschii (Q58406), Mus musculus (Q61035), Mycobacterium tuberculosis H37Rv (P9WFV5)
Akashi, K.; Grandjean, O.; Small, I.
Potential dual targeting of an Arabidopsis archaebacterial-like histidyl-tRNA synthetase to mitochondria and chloroplasts
FEBS Lett.
431
39-44
1998
Arabidopsis thaliana (O82413), Arabidopsis thaliana
Howard, O.M.; Dong, H.F.; Yang, D.; Raben, N.; Nagaraju, K.; Rosen, A.; Casciola-Rosen, L.; Hartlein, M.; Kron, M.; Yiadom, K.; Dwivedi, S.; Plotz, P.H.; Oppenheim, J.J.
Histidyl-tRNA synthetase and asparaginyl-tRNA synthetase, autoantigens in myositis, activate chemokine receptors on T lymphocytes and immature dendritic cells
J. Exp. Med.
196
781-791
2002
Homo sapiens
Felden, B.; Giege, R.
Resected RNA pseudoknots and their recognition by histidyl-tRNA synthetase
Proc. Natl. Acad. Sci. USA
95
10431-10436
1998
Saccharomyces cerevisiae
Guth, E.; Connolly, S.H.; Bovee, M.; Francklyn, C.S.
A substrate-assisted concerted mechanism for aminoacylation by a class II aminoacyl-tRNA synthetase
Biochemistry
44
3785-3794
2005
Escherichia coli (P60906), Escherichia coli
Rosen, A.E.; Musier-Forsyth, K.
Recognition of G-1:C73 atomic groups by Escherichia coli histidyl-tRNA synthetase
J. Am. Chem. Soc.
126
64-65
2004
Escherichia coli
Kamei, H.
Intracellular localization of histidyl-tRNA synthetase/Jo-1 antigen in T24 cells and some other cells
J. Autoimmun.
22
201-210
2004
Homo sapiens
Levine, S.M.; Raben, N.; Xie, D.; Askin, F.B.; Tuder, R.; Mullins, M.; Rosen, A.; Casciola-Rosen, L.A.
Novel conformation of histidyl-transfer RNA synthetase in the lung: the target tissue in Jo-1 autoantibody-associated myositis
Arthritis Rheum.
56
2729-2739
2007
Homo sapiens
Chardonnet, S.; Decottignies, P.; Amar, L.; Le Caer, J.P.; Davis, S.; Laroche, S.; Le Marechal, P.
New mortalin and histidyl tRNA synthetase isoforms point out a pitfall in proteomic analysis of Egr1 genetically modified mice
Proteomics
7
289-298
2007
Mus musculus
Rosen, A.E.; Brooks, B.S.; Guth, E.; Francklyn, C.S.; Musier-Forsyth, K.
Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs
RNA
12
1315-1322
2006
Saccharomyces cerevisiae, Escherichia coli
Wegner, N.; Wait, R.; Venables, P.J.
Evolutionarily conserved antigens in autoimmune disease: Implications for an infective aetiology
Int. J. Biochem. Cell Biol.
41
390-397
2008
Homo sapiens
Polosa, R.; Di Mauro, C.; Spampinato, B.; Castelli, L.; DAmico, G.; Edwards, C.J.; Russo, C.
A patient with antihistidyl-tRNA synthetase positive polymyositis presenting as acute respiratory distress syndrome
J. Clin. Rheumatol.
14
219-221
2008
Homo sapiens
Ardell, D.H.; Andersson, S.G.
TFAM detects co-evolution of tRNA identity rules with lateral transfer of histidyl-tRNA synthetase
Nucleic Acids Res.
34
893-904
2006
Ruegeria pomeroyi (Q5LVN3), Ruegeria pomeroyi
Guth, E.; Farris, M.; Bovee, M.; Francklyn, C.S.
Asymmetric amino acid activation by class II histidyl-tRNA synthetase from Escherichia coli
J. Biol. Chem.
284
20753-20762
2009
Escherichia coli (P60906), Escherichia coli
Merritt, E.A.; Arakaki, T.L.; Gillespie, J.R.; Larson, E.T.; Kelley, A.; Mueller, N.; Napuli, A.J.; Kim, J.; Zhang, L.; Verlinde, C.L.; Fan, E.; Zucker, F.; Buckner, F.S.; van Voorhis, W.C.; Hol, W.G.
Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs
J. Mol. Biol.
397
481-494
2010
Trypanosoma brucei (Q4DA54), Trypanosoma brucei, Trypanosoma cruzi (Q4DA54), Trypanosoma cruzi
Banik, S.D.; Nandi, N.
Aminoacylation reaction in the histidyl-tRNA synthetase: fidelity mechanism of the activation step
J. Phys. Chem. B
114
2301-2311
2010
Escherichia coli (P60906), Escherichia coli
Casciola-Rosen, L.
Histidyl-transfer RNA synthetase: A key participant in idiopathic inflammatory myopathies
Arthritis Rheum.
63
331-333
2011
Homo sapiens, Mus musculus
Banik, S.D.; Nandi, N.
Influence of the conserved active site residues of histidyl tRNA synthetase on the mechanism of aminoacylation reaction
Biophys. Chem.
158
61-72
2011
Escherichia coli, Thermus thermophilus, Staphylococcus aureus
Li, L.; Weinreb, V.; Francklyn, C.; Carter, C.W.
Histidyl-tRNA synthetase urzymes: class I and II aminoacyl tRNA synthetase urzymes have comparable catalytic activities for cognate amino acid activation
J. Biol. Chem.
286
10387-10395
2011
Escherichia coli
Yuan, J.; Gogakos, T.; Babina, A.M.; Soell, D.; Randau, L.
Change of tRNA identity leads to a divergent orthogonal histidyl-tRNA synthetase/tRNAHis pair
Nucleic Acids Res.
39
2286-2293
2011
Caulobacter vibrioides
Su, D.; Lieberman, A.; Lang, B.F.; Simonovic, M.; Soell, D.; Ling, J.
An unusual tRNAThr derived from tRNAHis reassigns in yeast mitochondria the CUN codons to threonine
Nucleic Acids Res.
39
4866-4874
2011
Saccharomyces cerevisiae
Pierce, S.B.; Chisholm, K.M.; Lynch, E.D.; Lee, M.K.; Walsh, T.; Opitz, J.M.; Li, W.; Klevit, R.E.; King, M.C.
Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome
Proc. Natl. Acad. Sci. USA
108
6543-6548
2011
Caenorhabditis elegans, Homo sapiens
van Dooren, S.H.; Raijmakers, R.; Pluk, H.; Lokate, A.M.; Koemans, T.S.; Spanjers, R.E.; Heck, A.J.; Boelens, W.C.; van Venrooij, W.J.; Pruijn, G.J.
Oxidative stress-induced modifications of histidyl-tRNA synthetase affect its tRNA aminoacylation activity but not its immunoreactivity
Biochem. Cell Biol.
89
545-553
2011
Homo sapiens
Fernandez, I.; Harlow, L.; Zang, Y.; Liu-Bryan, R.; Ridgway, W.M.; Clemens, P.R.; Ascherman, D.P.
Functional redundancy of MyD88-dependent signaling pathways in a murine model of histidyl-transfer RNA synthetase-induced myositis
J. Immunol.
191
1865-1872
2013
Homo sapiens
Nagatoyo, Y.; Iwaki, J.; Suzuki, S.; Kuno, A.; Hasegawa, T.
Molecular recognition of histidine tRNA by histidyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1
Nucleic Acids Symp. Ser.
2005
307-308
2005
Aeropyrum pernix (Q9YEB2), Aeropyrum pernix DSM 11879 (Q9YEB2)
Koh, C.Y.; Siddaramaiah, L.K.; Ranade, R.M.; Nguyen, J.; Jian, T.; Zhang, Z.; Gillespie, J.R.; Buckner, F.S.; Verlinde, C.L.; Fan, E.; Hol, W.G.
A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens
Acta Crystallogr. Sect. D
71
1684-1698
2015
Trypanosoma cruzi (Q4DA54), Trypanosoma cruzi
Abbott, J.A.; Guth, E.; Kim, C.; Regan, C.; Siu, V.M.; Rupar, C.A.; Demeler, B.; Francklyn, C.S.; Robey-Bond, S.M.
The Usher Syndrome Type IIIB histidyl-tRNA synthetase mutation confers temperature sensitivity
Biochemistry
56
3619-3631
2017
Homo sapiens
Englert, M.; Vargas-Rodriguez, O.; Reynolds, N.M.; Wang, Y.S.; Soell, D.; Umehara, T.
A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase tRNAHis pair
Biochim. Biophys. Acta
1861
3009-3015
2017
Caulobacter vibrioides
Koh, C.Y.; Wetzel, A.B.; de van der Schueren, W.J.; Hol, W.G.
Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases
Biochimie
106
111-120
2014
Homo sapiens (P12081), Homo sapiens, Trypanosoma brucei (Q4DA54), Trypanosoma brucei, Trypanosoma brucei CL Brener (Q4DA54)
Lee, Y.H.; Chang, C.P.; Cheng, Y.J.; Kuo, Y.Y.; Lin, Y.S.; Wang, C.C.
Evolutionary gain of highly divergent tRNA specificities by two isoforms of human histidyl-tRNA synthetase
Cell. Mol. Life Sci.
74
2663-2677
2017
Bacillus subtilis, Saccharomyces cerevisiae, Homo sapiens
Abbott, J.A.; Meyer-Schuman, R.; Lupo, V.; Feely, S.; Mademan, I.; Oprescu, S.N.; Griffin, L.B.; Alberti, M.A.; Casasnovas, C.; Aharoni, S.; Basel-Vanagaite, L.; Zuechner, S.; De Jonghe, P.; Baets, J.; Shy, M.E.; Espinos, C.; Demeler, B.; Antonellis, A.; Francklyn, C.
Substrate interaction defects in histidyl-tRNA synthetase linked to dominant axonal peripheral neuropathy
Hum. Mutat.
39
415-432
2018
Homo sapiens
Zhou, J.J.; Wang, F.; Xu, Z.; Lo, W.S.; Lau, C.F.; Chiang, K.P.; Nangle, L.A.; Ashlock, M.A.; Mendlein, J.D.; Yang, X.L.; Zhang, M.; Schimmel, P.
Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis
J. Biol. Chem.
289
19269-19275
2014
Homo sapiens
Dutta, S.; Kundu, S.; Saha, A.; Nandi, N.
Dynamics of the active site loops in catalyzing aminoacylation reaction in seryl and histidyl tRNA synthetases
J. Biomol. Struct. Dyn.
36
878-892
2018
Thermus thermophilus
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