Literature summary for 6.1.1.21 extracted from

Chardonnet, S.; Decottignies, P.; Amar, L.; Le Caer, J.P.; Davis, S.; Laroche, S.; Le Marechal, P.
New mortalin and histidyl tRNA synthetase isoforms point out a pitfall in proteomic analysis of Egr1 genetically modified mice (2007), Proteomics, 7, 289-298.

Cloned(Commentary)

Cloned (Comment)	Organism
DNA and amino acid sequence determination and analysis of HisRS gene variants, HisRS genes, which map closely to the Egr1 locus, have conserved the 129/Sv haplotype despite numerous back-crossing of the null mice progeny with C57Bl/6J animals, genetic analysis of isozymes of HisRS encoded by the 129/Sv haplotype, allelic difference for mortalin and HisRS between 129/Sv and C57Bl/6J strains, overview	Mus musculus

Cloned (Comment)

Organism

DNA and amino acid sequence determination and analysis of HisRS gene variants, HisRS genes, which map closely to the Egr1 locus, have conserved the 129/Sv haplotype despite numerous back-crossing of the null mice progeny with C57Bl/6J animals, genetic analysis of isozymes of HisRS encoded by the 129/Sv haplotype, allelic difference for mortalin and HisRS between 129/Sv and C57Bl/6J strains, overview

Mus musculus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of Egr1 null or defect mutants affects HisRS genes, Egr1, Zif268, is an immediate early gene encoding an inducible transcription factor involved in synaptic plasticity and several forms of memory in rodents, allelic differences between mouse strains can introduce variations in differential proteomic analyses of genetically modified organisms	Mus musculus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-histidine + tRNAHis	Mus musculus	-	AMP + diphosphate + L-histidinyl-tRNAHis	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	Egr1 genetically modified mice, several isozymes through allelic difference of HisRS between 129/Sv and C57Bl/6J strains	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-histidine + tRNAHis	-	Mus musculus	AMP + diphosphate + L-histidinyl-tRNAHis	-	?

Synonyms

Synonyms	Comment	Organism
HisRS	-	Mus musculus
histidyl-transfer RNA synthetase	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Mus musculus