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Literature summary for 6.1.1.21 extracted from

  • Felden, B.; Giege, R.
    Resected RNA pseudoknots and their recognition by histidyl-tRNA synthetase (1998), Proc. Natl. Acad. Sci. USA, 95, 10431-10436.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.1.1.21

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + L-histidine + tRNAHis Saccharomyces cerevisiae
-
 AMP + diphosphate + L-histidyl-tRNAHis
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + L-histidine + tRNAHis = AMP + diphosphate + L-histidyl-tRNAHis N73 is a discriminator base involved in histidylation activity, substrate recognition mechanism Saccharomyces cerevisiae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + L-histidine + minimalist RNA structures in a resected pseudoknot fold specifically recognized substrate, derived from tyrosine-accepting tRNA-like domain of brome mosaic virus RNA Saccharomyces cerevisiae AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
ATP + L-histidine + tRNAHis
-
 Saccharomyces cerevisiae AMP + diphosphate + L-histidyl-tRNAHis
-
 ?
ATP + L-histidine + tyrosine-accepting tRNA-like domain of brome mosaic virus RNA specifically recognized substrate Saccharomyces cerevisiae AMP + diphosphate + L-histidyl-tyrosine-accepting tRNA-like domain of brome mosaic virus RNA
-
 ?
additional information substrate specificty, overview Saccharomyces cerevisiae ?
-
 ?

Synonyms

Synonyms Comment Organism
HisRS
-
 Saccharomyces cerevisiae
Histidine translase
-
 Saccharomyces cerevisiae
histidine-tRNA ligase
-
 Saccharomyces cerevisiae
histidine-tRNA ligase homolog
-
 Saccharomyces cerevisiae
Histidyl-transfer ribonucleate synthetase
-
 Saccharomyces cerevisiae
Histidyl-tRNA synthetase
-
 Saccharomyces cerevisiae
Jo-1
-
 Saccharomyces cerevisiae
Jo-1 antigen
-
 Saccharomyces cerevisiae
Synthetase, histidyl-transfer ribonucleate
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
15
-
-
 Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.1
-
 assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Saccharomyces cerevisiae