6.1.1.21: histidine-tRNA ligase
This is an abbreviated version!
For detailed information about histidine-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.21
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6.1.1.21
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synthetases
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aminoacylation
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aminoacyl-trna
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autoantibody
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histidylation
-
myositis
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anti-jo-1
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polymyositis
-
anticodon
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dermatomyositis
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aarss
-
perrault
-
hiss
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histidinol
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anti-synthetase
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guanylyltransferase
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hsd17b4
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myositis-specific
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c10orf2
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thrrs
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threonyl-trna
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trna-like
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acid-starved
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seryl-trna
-
analysis
-
medicine
- 6.1.1.21
- synthetases
- aminoacylation
- aminoacyl-trna
- autoantibody
-
histidylation
- myositis
-
anti-jo-1
- polymyositis
-
anticodon
- dermatomyositis
-
aarss
-
perrault
- hiss
- histidinol
-
anti-synthetase
-
guanylyltransferase
- hsd17b4
-
myositis-specific
- c10orf2
- thrrs
- threonyl-trna
-
trna-like
-
acid-starved
- seryl-trna
- analysis
- medicine
Reaction
Synonyms
antihistidyl-tRNA synthetase, class II histidyl-tRNA synthetase, HARS, HARS1, HARS2, HisRS, HisRS-1, HisRS-2, Histidine translase, Histidine--tRNA ligase, Histidine--tRNA ligase homolog, histidine-tRNA ligase, histidine-tRNA ligase homolog, histidyl tRNA synthetase, Histidyl-transfer ribonucleate synthetase, histidyl-transfer RNA synthetase, Histidyl-tRNA synthetase, HRS, HTS1, Jo-1, Jo-1 antigen, mitochondrial histidyl tRNA synthetase, Synthetase, histidyl-transfer ribonucleate
ECTree
6.1.1.21 histidine-tRNA ligaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 6.1.1.21 - histidine-tRNA ligase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidinyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidinyl-tRNAHis
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strong association of autoantibodies, specificity recognizing the enzyme's granzyme B binding site of the lung enzyme, to HisRS with interstitial lung disease in patients with myositis
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidinyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
the enzyme is involved in several regulatory mechanisms of the cell metabolism
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
phylogenetic and evolutionary development
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
the enzyme is involved in several regulatory mechanisms of the cell metabolism
-
ir
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
Trypanosoma brucei CL Brener
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
?
ATP + L-histidine + tRNAHis
AMP + diphosphate + L-histidyl-tRNAHis
-
-
-
-
?
additional information
?
-
-
Caulobacter crescentus HisRS shows very low activity with Escherichia coli tRNAHis
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-
?
additional information
?
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the enzyme can act as an important antigen in autoimmune diseases such as rheumatic arthritis or myositis
-
?
additional information
?
-
-
the enzyme can act as an important antigen in autoimmune diseases such as rheumatic arthritis or myositis
-
?
additional information
?
-
-
determination of enzyme-induced chemotactic activity of human cells, e.g. leukocytes and primary neutrophils, to the enzyme
-
?
additional information
?
-
-
1. plays an important role in the regulation of protein degradation as well as in protein biosynthesis. 2. involvement of tRNAHis and possibly histidyl-tRNA synthetase in a nonlysosomal ubiquitin-dependent and ATP-dependent protein degradation pathway. 3. involvement in autoimmune diseases
-
-
?
additional information
?
-
the enzyme can act as an important antigen in autoimmune diseases such as rheumatic arthritis or myositis
-
?
additional information
?
-
-
the enzyme can act as an important antigen in autoimmune diseases such as rheumatic arthritis or myositis
-
?
