6.1.1.21: histidine-tRNA ligase

This is an abbreviated version!
For detailed information about histidine-tRNA ligase, go to the full flat file.

Reaction

Synonyms

antihistidyl-tRNA synthetase, class II histidyl-tRNA synthetase, HARS, HARS1, HARS2, HisRS, HisRS-1, HisRS-2, Histidine translase, Histidine--tRNA ligase, Histidine--tRNA ligase homolog, histidine-tRNA ligase, histidine-tRNA ligase homolog, histidyl tRNA synthetase, Histidyl-transfer ribonucleate synthetase, histidyl-transfer RNA synthetase, Histidyl-tRNA synthetase, HRS, HTS1, Jo-1, Jo-1 antigen, mitochondrial histidyl tRNA synthetase, Synthetase, histidyl-transfer ribonucleate

ECTree

     6 Ligases

         6.1 Forming carbon-oxygen bonds

             6.1.1 Ligases forming aminoacyl-tRNA and related compounds

                6.1.1.21 histidine-tRNA ligase

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Results	in table
2	Activating Compound
49530	AA Sequence
4	Application
1	CAS Registry Number
22	Cloned(Commentary)
36	Cofactor
13	Crystallization (Commentary)
260	Disease/ Diagnostics
1	Expression
14	General Information
12	General Stability
7	IC50 Value
39	Inhibitors
14	kcat/KM [mM/s]
78	KM Value [mM]
22	Localization
19	Metals/Ions
41	Molecular Weight [Da]
63	Natural Substrates/ Products (Substrates)
111	Organism
1	Oxidation Stability
4	Pathway
86	PDB ID
12	pH Optimum
2	pH Range
1	Posttranslational Modification
57	Protein Variants
26	Purification (Commentary)
12	Reaction
62	Reaction Type
101	Reference
1	Renatured (Commentary)
29	Source Tissue
9	Specific Activity [micromol/min/mg]
5	Storage Stability
134	Substrates and Products (Substrate)
36	Subunits
346	Synonyms
1	Systematic Name
9	Temperature Optimum [°C]
1	Temperature Range [°C]
2	Temperature Stability [°C]
61	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 6.1.1.21 - histidine-tRNA ligase

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

2

(6-bromopyridin-2-yl)methanol

Trypanosoma cruzi

Q4DA54

IC50 above 2.0 mM, at pH 7.5 and 25°C

743941

2

2-aminoquinolin-8-ol

Trypanosoma cruzi

Q4DA54

IC50 above 2.0 mM, at pH 7.5 and 25°C

743941

0.8

2-bromo-N-(quinolin-3-yl)acetamide

Trypanosoma cruzi

Q4DA54

at pH 7.5 and 25°C

743941

1.65

N-(5-hydroxynaphthalen-2-yl)prop-2-enamide

Trypanosoma cruzi

Q4DA54

at pH 7.5 and 25°C

743941

2

N-(quinolin-3-yl)acetamide

Trypanosoma cruzi

Q4DA54

IC50 above 2.0 mM, at pH 7.5 and 25°C

743941

0.85

N-(quinolin-3-yl)prop-2-enamide

Trypanosoma cruzi

Q4DA54

at pH 7.5 and 25°C

743941

2

quinolin-3-amine

Trypanosoma cruzi

Q4DA54

IC50 above 2.0 mM, at pH 7.5 and 25°C

743941