6.1.1.2: tryptophan-tRNA ligase
This is an abbreviated version!
For detailed information about tryptophan-tRNA ligase, go to the full flat file.
Word Map on EC 6.1.1.2
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6.1.1.2
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synthetases
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aminoacyl-trna
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aminoacylation
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pancreas
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beef
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anticodon
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stearothermophilus
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tyrrs
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tyrosyl-trna
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indoleamine
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angiostatic
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kmsks
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ido
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tryptamine
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tryptophan-dependent
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aarss
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ap4a
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glutaminyl-trna
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hisrs
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anticodon-binding
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glnrs
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medicine
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synthesis
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biotechnology
- 6.1.1.2
- synthetases
- aminoacyl-trna
- aminoacylation
- pancreas
- beef
-
anticodon
- stearothermophilus
- tyrrs
- tyrosyl-trna
- indoleamine
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angiostatic
-
kmsks
-
ido
- tryptamine
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tryptophan-dependent
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aarss
- ap4a
- glutaminyl-trna
- hisrs
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anticodon-binding
- glnrs
- medicine
- synthesis
- biotechnology
Reaction
Synonyms
(Mt)TrpRS, BsTRpRS, drTrpRS II, EcTrpRS, hTrpRS, hWRS, IFP53, mini tryptophanyl-tRNA synthetase, mini-TrpRS, More, Synthetase, tryptophanyl-transfer ribonucleate, T2-TrpRS, Trp-RS, TrpRS, TrpRS II, TrpRS Urzyme, TrpRS1, TrpRS2, Tryptophan translase, Tryptophan--tRNA ligase, Tryptophanyl ribonucleic synthetase, tryptophanyl tRNA synthase, tryptophanyl tRNA synthetase, Tryptophanyl-transfer ribonucleate synthetase, Tryptophanyl-transfer ribonucleic acid synthetase, Tryptophanyl-transfer ribonucleic synthetase, Tryptophanyl-transfer RNA synthetase, Tryptophanyl-tRNA synthase, Tryptophanyl-tRNA synthetase, tryptophanyl-tRNA synthetase II, tryptophanyl-tRNA synthetase1, tryptophanyl-tRNA synthetase2, trytophanyl-tRNA synthetase, tyrosyl tRNA synthetase, WARS, WARS2, WRS
ECTree
6.1.1.2 tryptophan-tRNA ligaseAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 6.1.1.2 - tryptophan-tRNA ligase
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INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
2-[5-[(6-(ethoxycarbonyl)-5-(4-fluorophenyl)-3-oxo-7-phenyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-2(3H)-ylidene)methyl]-2-furyl]benzoic acid
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3-[(4-[[4-oxo-2-(phenylimino)-1,3-thiazolidin-5-ylidene]methyl]phenoxy) methyl]benzoic acid
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3-[[([[2-(4-chlorophenyl)-4-quinolinyl]carbonyl]amino)carbothioyl]amino]benzoic acid
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Adenosine-5'-chloromethylphosphonate
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ATP-diphosphate exchange, reversible, incompetitive
succinylacetone
a heme biosynthesis inhibitor, inhibit cellular TrpRS activity in IFN-gamma-activated cells without affecting TrpRS protein expression
chuangxinmycin
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CAS: 63339-68-4, natural product, first isolated from Actinoplanes tsinanensis, potent and selective inhibition of the aminoacylation
indolmycin
competitive inhibitor, produced by Streptomyces griseus, causes selective, mechanism-based inhibition of the bacterial enzyme, which preferentially binds indolmycin about 1500fold more tightly than its tryptophan substrate, binding structure analysis overview. Long range coupling to residues within an allosteric region called the D1 switch of BsTrpRS positions the Mg2+ ion in a manner that allows it to assist in transition state stabilization. The Mg2+ ion in the inhibited complex forms significantly closer contacts with non-bridging oxygen atoms from each phosphate group of ATP and three water molecules than occur in the (presumably catalytically competent) pre-transition state (preTS) crystal structures. This altered coordination stabilizes a ground state Mg2+-ATP-configuration, accounting for the high affinity inhibition of BsTrpRS by indolmycin
tryptamine
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competitive, inhibition of the enzyme leads to inhibition of protein biosynthesis, tryptamine stabilizes the enzyme
tryptamine
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a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview
tryptamine
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a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview
additional information
indolmycin and ATP form a ternary complex with BsTrpRS
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additional information
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indolmycin and ATP form a ternary complex with BsTrpRS
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additional information
the full-length-WRS-induced TNF-alpha and MIP-1alpha production is significantly inhibited when TLR4, MD2, and TLR2 (to lesser degree) are suppressed
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additional information
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the full-length-WRS-induced TNF-alpha and MIP-1alpha production is significantly inhibited when TLR4, MD2, and TLR2 (to lesser degree) are suppressed
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additional information
the full-length-WRS-induced TNF-alpha and MIP-1alpha production is significantly inhibited when TLR4, MD2, and TLR2 (to lesser degree) are suppressed
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additional information
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the full-length-WRS-induced TNF-alpha and MIP-1alpha production is significantly inhibited when TLR4, MD2, and TLR2 (to lesser degree) are suppressed
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additional information
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no inhibition by chuangximycin methyl ester, hydroxamic acid, amide, hydroxymethyl or tetrazole analogue
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additional information
screening for SeWRS inhibitors, binding site mapping and virtual screening, modeling, overview, MIC values, and cytotoxic activities of inhibitors, overview
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additional information
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screening for SeWRS inhibitors, binding site mapping and virtual screening, modeling, overview, MIC values, and cytotoxic activities of inhibitors, overview
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additional information
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indolmycin, a potential antibacterial drug, completely inhibits bacterial tryptophanyl-tRNA synthetases, identifying indolmycin resistance genes leads to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase
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additional information
indolmycin, a potential antibacterial drug, completely inhibits bacterial tryptophanyl-tRNA synthetases, identifying indolmycin resistance genes leads to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase
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