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ATP + L-tryptophan + tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
additional information
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ATP + L-tryptophan + tRNATrp
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ATP + L-tryptophan + tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
enzyme is required for embryonic survival, and is essential for viability of the fly
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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enzyme contributes to biological processes involving cell signaling such as angiogenesis regulation
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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full-length and mini enzyme isoforms, enzyme expression is regulated by a dual system of interferon gamma and interferon regulatory factor 1 via 2 specific tandem promoters leading to alternative splicing
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophan-tRNATrp
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activity and fidelity are essential for viability
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
involvement of heme in regulation of TrpRS aminoacylation activity
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
the enzyme is essential for translation
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophanyl-tRNATrp
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both TrpRS1 and TrpRS2 are essential for growth and required for cytosolic and mitochondrial tryptophanyl-tRNA formation, respectively, the edited anticodon and the mitochondria-specific thiolation of U33 in the imported tRNATrp act as antideterminants for the cytosolic TrpRS1, the mitochondrion of Trypanosoma brucei does not encode any tRNAs, this deficiency is compensated for by the import of a small fraction of nearly all of its cytosolic tRNAs from the host
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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ATP + L-tryptophan + tRNATrp
AMP + diphosphate + L-tryptophyl-tRNATrp
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additional information
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additional information
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possibly involved in function other than tRNA aminoacylation
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additional information
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enzyme might by implicated in regulation of P1,P3-bis(5'-adenosyl)triphosphate/P1,P4-bis(5'-adenosyl)tetraphosphate ratio in the cell
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additional information
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tryptophanyl tRNA synthetase II interacts with nitric oxide synthetase and increases activity of nitric oxide synthetase
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additional information
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an ancestral tryptophanyl-tRNA synthetase precursor achieves high catalytic rate enhancement without ordered ground-state tertiary structures
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additional information
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mini isozyme specifically shows anti-proliferative and anti-angiogenic activity
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additional information
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the catalytic fragment exhibits potent angiostatic activity
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additional information
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the catalytic fragment exhibits potent angiostatic activity
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additional information
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the enzymes C-terminal domain, an EMAP II-like protein, inhibits angiogenesis signaling pathways and the development of blood vessels
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additional information
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interferon-gamma-inducible enzyme. Exposure to soluble cytotoxic T lymphocyte antigen-4 induces increased expression of tryptophanyl-tRNA synthetase in unseparated peripheral blood mononuclear cells, as well as in monocyte-derived mature dentritic cells. CD4+ cells and CD8+ cells isolated from peripheral blood mononuclear cells treated with soluble cytotoxic T lymphocyte antigen-4 show increased tryptophanyl-tRNA synthetase compared with untreated cells. Possibility that tryptophanyl-tRNA synthetase may be involved in an important mechanism regulating immune response
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additional information
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the vascular endothelial-cadherin-dependent pathway is proposed to link T2-TrpRS to inhibition of new blood vessel formation
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additional information
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tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview
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additional information
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binding of vascular endothelial (VE)-cadherin, the NH2-terminal Trp2 and Trp4 residues of VE-cadherin are docked into the Trp- and adenosine-binding pockets of human TrpRS
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additional information
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binding of vascular endothelial (VE)-cadherin, the NH2-terminal Trp2 and Trp4 residues of VE-cadherin are docked into the Trp- and adenosine-binding pockets of human TrpRS
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additional information
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tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview
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additional information
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tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview
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additional information
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probably the enzyme fulfills some unknown function(s) important for digestion
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