Reference on EC 6.1.1.2 - tryptophan-tRNA ligase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jakubowski, H.; Pawelkiewicz, J.
The plant aminoacyl-tRNA synthetases. Purification and characterization of valyl-tRNA, tryptophanyl-tRNA and seryl-tRNA synthetases from yellow lupin seeds
Eur. J. Biochem.
52
301-310
1975
Lupinus luteus
Goldgur, Y.; Safro, M.
Aminoacyl-tRNA synthetases from Haloarcula marismortui: an evidence for a multienzyme complex in a procaryotic system
Biochem. Mol. Biol. Int.
32
1075-1083
1994
Haloarcula marismortui
Kisselev, L.L.
Mammalian tryptophanyl-tRNA synthetases
Biochimie
75
1027-1039
1993
Bos taurus, Oryctolagus cuniculus, Ovis aries, Homo sapiens, Mammalia, Mus musculus, Primates, Rattus norvegicus, Rodentia, Ruminantia
Chow, K.C.; Xue, H.; Shi, W.; Wong, J.T.F.
Mutational identification of an essential tryptophan in tryptophanyl-tRNA synthetase of Bacillus subtilis
J. Biol. Chem.
267
9146-9149
1992
Bacillus subtilis
Merkulova, T.; Kovaleva, G.; Kisselev, L.
P1,P3-bis(5'-adenosyl)triphosphate (Ap3A) as a substrate and product of mammalian tryptophanyl-tRNA synthetase
FEBS Lett.
350
287-290
1994
Bos taurus
Ala, P.; Xue, H.; Leung, L.; Xue, Y.Q.; Wong, J.T.F.; Yang, D.S.C.
Crystallization of Bacillus subtilis tryptophanyl-tRNA synthetase
J. Mol. Biol.
230
1089-1090
1993
Bacillus subtilis
Hogue, C.W.V.; Doublie, S.; Xue, H.; Wong, J.T.; Carter, C.W.; Szabo, A.G.
A concerted tryptophanyl-adenylate-dependent conformational change in Bacillus subtilis tryptophanyl-tRNA synthetase revealed by the fluorescence of Trp92
J. Mol. Biol.
260
446-466
1996
Bacillus subtilis
Carter Jr., C.W.; Doublie, S.; Coleman, D.E.
Quantitative analysis of crystal growth. Tryptophanyl-tRNA synthetase crystal polymorphism and its relationship to catalysis
J. Mol. Biol.
238
346-365
1994
Geobacillus stearothermophilus
Lemaire,G.; Gros, C.; Epely, S.; Kaminski, M.; Labouesse, B.
Multiple forms of tryptophanyl-tRNA synthetase from beef pancreas
Eur. J. Biochem.
51
237-252
1975
Bos taurus
Favorova, O.O.; Kochkina, L.L.; Meldrajs, J.A.; Kisselev, L.L.; Zinoviev, V.V.; Knorre, D.G.; Lavrik, O.I.; Malygin, E.G.; Nevinski, G.A.
Kinetic parameters of tryptophan:tRNA ligase catalyzed ATP-[32P] pyrophosphate exchange as an approach to estimation of the order of substrate binding
FEBS Lett.
56
322-326
1975
Bos taurus
Werner, R.G.; Thorpe, L.F.; Reuter, W.; Nierhaus, K.H.
Indolmycin inhibits prokaryotic tryptophanyl-tRNA ligase
Eur. J. Biochem.
68
1-3
1976
Escherichia coli, Rattus norvegicus
Winter, G.P.; Hartley, B.S.; McLachlan, A.D.; Lee, M.; Muench, K.H.
Sequence homologies between the tryptophanyl tRNA synthetases of Bacillus stearothermophilus and Escherichia coli
FEBS Lett.
82
348-350
1977
Geobacillus stearothermophilus, Escherichia coli
Kisselev, L.L.; Favorova, O.O.; Kovaleva, G.K.
Tryptophanyl-tRNA synthetase from beef pancreas
Methods Enzymol.
54
234-257
1979
Bos taurus
-
Drocourt, J.L.; Thang, D.C.; Buckingham, R.H.; Thang M.N.
Blue dextran Sepharose chromatography of the tryptophanyl-tRNA synthetase of E. coli. A potential application for the purification of the enzyme
Nucleic Acids Res.
6
2919-2928
1979
Escherichia coli
Kisselev, L.L.; Favorova, O.O.; Nurbekov, M.K.; Dmitriyenko, S.G.; Engelhardt, W.A.
Bovine tryptophanyl-tRNA synthetase. A zinc metalloenzyme
Eur. J. Biochem.
120
511-517
1981
Bos taurus
Carter, C.W.; Green, D.C.
Use of chromatofocusing in the purification of tryptophanyl-tRNA synthetase from Bacillus stearothermophilus
Anal. Biochem.
124
327-332
1982
Geobacillus stearothermophilus
Coleman, D.E.; Carter, C.W.
Crystals of Bacillus stearothermophilus tryptophanyl-tRNA synthetase containing enzymatically formed acyl transfer product. Tryptophanyl-ATP, an active site marker for the 3' CCA terminus of tryptophanyl-tRNATrp
Biochemistry
23
381-385
1984
Geobacillus stearothermophilus
Andrews, D.; Trezeguet, V.; Merle, M.; Graves, P.V.; Muench, K.H.; Labouesse, B.
Tryptophanamide formation by Escherichia coli tryptophanyl-tRNA synthetase
Eur. J. Biochem.
146
201-209
1985
Escherichia coli
Merle, M.L.; Trezeguet, V.; Graves, P.; Andrews, D.; Muench, K.H.; Labouesse, B.
Tryptophanyl adenylate formation by tryptophanyl-tRNA synthetase from Escherichia coli
Biochemistry
25
1115-1123
1986
Escherichia coli
Sallafranque, M.; Garret, M.; Benedetto, J.P.; Fournier, M.; Labouesse, B.; Bonnet, J.
Tryptophanyl-tRNA synthetase is a major soluble protein species in bovine pancreas
Biochim. Biophys. Acta
882
192-199
1986
Bos taurus
Fournier, M.; Plantard, C.; Labouesse, B.; Labouesse, J.
Binding stoichiometry of tRNATrp and tryptophanyl-tRNA synthetase from bovine pancreas under pH conditions of maximum activity. Analysis by ultracentrifugation, fluorescence quenching and chemical modification
Biochim. Biophys. Acta
916
350-357
1987
Bos taurus
Jia, J.; Xu, F.; Chen, X.; Chen, L.; Jin, Y.; Wang, D.T.
Two essential regions for tRNA recognition in Bacillus subtilis tryptophanyl-tRNA synthetase
Biochem. J.
365
749-756
2002
Bacillus subtilis
Ewalt, K.L.; Schimmel, P.
Activation of angiogenic signaling pathways by two human tRNA synthetases
Biochemistry
41
13344-13349
2002
Homo sapiens
Xu, F.; Jiang, G.; Li, W.; He, X.; Jin, Y.; Wang, D.
Three G.C base pairs required for the efficient aminoacylation of tRNATrp by tryptophanyl-tRNA synthetase from Bacillus subtilis
Biochemistry
41
8087-8092
2002
Bacillus subtilis
Brown, M.J.; Carter, P.S.; Fenwick, A.S.; Fosberry, A.P.; Hamprecht, D.W.; Hibbs, M.J.; Jarvest, R.L.; Mensah, L.; Milner, P.H.; O'Hanlon, P.J.; Pope, A.J.; Richardson, C.M.; West, A.; Witty, D.R.
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase
Bioorg. Med. Chem. Lett.
12
3171-3174
2002
Staphylococcus aureus
Paley, E.L.
Tryptamine-mediated stabilization of tryptophanyl-tRNA synthetase in human cervical carcinoma cell line
Cancer Lett.
137
1-7
1999
Homo sapiens
Zuniga, R.; Salazar, J.; Canales, M.; Orellana, O.
A dispensable peptide from Acidithiobacillus ferrooxidans tryptophanyl-tRNA synthetase affects tRNA binding
FEBS Lett.
532
387-390
2002
Acidithiobacillus ferrooxidans, Escherichia coli
Jorgensen, R.; Sogaard, T.M.; Rossing, A.B.; Martensen, P.M.; Justesen, J.
Identification and characterization of human mitochondrial tryptophanyl-tRNA synthetase
J. Biol. Chem.
275
16820-16826
2000
Homo sapiens (Q9UGM6), Homo sapiens
Yu, Y.; Liu, Y.; Shen, N.; Xu, X.; Xu, F.; Jia, J.; Jin, Y.; Arnold, E.; Ding, J.
Crystal structure of human tryptophanyl-tRNA synthetase catalytic fragment: insights into substrate recognition, tRNA binding, and angiogenesis activity
J. Biol. Chem.
279
8378-8388
2004
Homo sapiens (P23381), Homo sapiens
Retailleau, P.; Huang, X.; Yin, Y.; Hu, M.; Weinreb, V.; Vachette, P.; Vonrhein, C.; Bricogne, G.; Roversi, P.; Ilyin, V.; Carter, C.W., Jr.
Interconversion of ATP binding and conformational free energies by tryptophanyl-tRNA synthetase: structures of ATP bound to open and closed, pre-transition-state conformations
J. Mol. Biol.
325
39-63
2003
Geobacillus stearothermophilus (P00953)
Ivanova, Y.L.; Cherni, N.E.; Narovlyanskii, A.N.; Amchenkova, A.M.; Turpaev, K.T.; Popenko, V.I.
Distribution of tryptophanyl-tRNA synthetase in interferon-treated human monocytes
Mol. Biol.
32
736-742
1998
Homo sapiens
-
Seshaiah, P.; Andrew, D.J.
WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland
Mol. Biol. Cell
10
1595-1608
1999
Drosophila melanogaster (Q9U4Y0), Drosophila melanogaster (Q9U4Y1)
Liu, J.; Shue, E.; Ewalt, K.L.; Schimmel, P.
A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase
Nucleic Acids Res.
32
719-727
2004
Homo sapiens
Yang, X.L.; Otero, F.J.; Skene, R.J.; McRee, D.E.; Schimmel, P.; de Pouplana, L.R.
Crystal structures that suggest late development of genetic code components for differentiating aromatic side chains
Proc. Natl. Acad. Sci. USA
100
15376-15380
2003
Homo sapiens (P23381), Homo sapiens
Xu, F.; Jia, J.; Jin, Y.; Wang, D.T.
High-level expression and single-step purification of human tryptophanyl-tRNA synthetase
Protein Expr. Purif.
23
296-300
2001
Homo sapiens
Wakasugi, K.; Nakano, T.; Morishima, I.
Oxidative stress-responsive intracellular regulation specific for the angiostatic form of human tryptophanyl-tRNA synthetase
Biochemistry
44
225-232
2005
Homo sapiens
Boasso, A.; Herbeuval, J.P.; Hardy, A.W.; Winkler, C.; Shearer, G.M.
Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells
Blood
105
1574-1581
2005
Homo sapiens
Jia, J.; Chen, X.L.; Guo, L.T.; Yu, Y.D.; Ding, J.P.; Jin, Y.X.
Residues Lys-149 and Glu-153 switch the aminoacylation of tRNA(Trp) in Bacillus subtilis
J. Biol. Chem.
279
41960-41965
2004
Bacillus subtilis
Tzima, E.; Reader, J.S.; Irani-Tehrani, M.; Ewalt, K.L.; Schwartz, M.A.; Schimmel, P.
VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function
J. Biol. Chem.
280
2405-2408
2005
Homo sapiens
Buddha, M.R.; Crane, B.R.
Structures of tryptophanyl-tRNA synthetase II from Deinococcus radiodurans bound to ATP and tryptophan. Insight into subunit cooperativity and domain motions linked to catalysis
J. Biol. Chem.
280
31965-31973
2005
Deinococcus radiodurans (Q9RVD6), Deinococcus radiodurans
Kise, Y.; Lee, S.W.; Park, S.G.; Fukai, S.; Sengoku, T.; Ishii, R.; Yokoyama, S.; Kim, S.; Nureki, O.
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
Nat. Struct. Mol. Biol.
11
149-156
2004
Homo sapiens (P23381), Homo sapiens
Buddha, M.R.; Keery, K.M.; Crane, B.R.
An unusual tryptophanyl tRNA synthetase interacts with nitric oxide synthase in Deinococcus radiodurans
Proc. Natl. Acad. Sci. USA
101
15881-15886
2004
Deinococcus radiodurans
Zhang, Z.; Alfonta, L.; Tian, F.; Bursulaya, B.; Uryu, S.; King, D.S.; Schultz, P.G.
Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells
Proc. Natl. Acad. Sci. USA
101
8882-8887
2004
Bacillus subtilis
Yang, X.L.; Schimmel, P.; Ewalt, K.L.
Relationship of two human tRNA synthetases used in cell signaling
Trends Biochem. Sci.
29
250-256
2004
Homo sapiens (P23381), Homo sapiens
Wakasugi, K.
Human tryptophanyl-tRNA synthetase binds with heme to enhance its aminoacylation activity
Biochemistry
46
11291-11298
2007
Homo sapiens (P23381), Homo sapiens
Yang, X.L.; Otero, F.J.; Ewalt, K.L.; Liu, J.; Swairjo, M.A.; Koehrer, C.; RajBhandary, U.L.; Skene, R.J.; McRee, D.E.; Schimmel, P.
Two conformations of a crystalline human tRNA synthetase-tRNA complex: implications for protein synthesis
EMBO J.
25
2919-2929
2006
Homo sapiens (P23381), Homo sapiens
Wu, Y.; Yu, K.; Xu, B.; Chen, L.; Chen, X.; Mao, J.; Danchin, A.; Shen, X.; Qu, D.; Jiang, H.
Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase
J. Antimicrob. Chemother.
60
502-509
2007
Staphylococcus epidermidis (Q8CT69), Staphylococcus epidermidis
Kapustina, M.; Carter, C.W.
Computational studies of tryptophanyl-tRNA synthetase: activation of ATP by induced-fit
J. Mol. Biol.
362
1159-1180
2006
Geobacillus stearothermophilus (P00953), Geobacillus stearothermophilus
Pham, Y.; Li, L.; Kim, A.; Erdogan, O.; Weinreb, V.; Butterfoss, G.L.; Kuhlman, B.; Carter, C.W.
A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases
Mol. Cell
25
851-862
2007
Geobacillus stearothermophilus
Paley, E.L.; Denisova, G.; Sokolova, O.; Posternak, N.; Wang, X.; Brownell, A.L.
Tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell and mouse models
Neuromolecular Med.
9
55-82
2007
Homo sapiens, Mus musculus, Mus musculus BALB/c
Shen, N.; Guo, L.; Yang, B.; Jin, Y.; Ding, J.
Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity
Nucleic Acids Res.
34
3246-3258
2006
Homo sapiens (P23381), Homo sapiens
Guo, L.T.; Chen, X.L.; Zhao, B.T.; Shi, Y.; Li, W.; Xue, H.; Jin, Y.X.
Human tryptophanyl-tRNA synthetase is switched to a tRNA-dependent mode for tryptophan activation by mutations at V85 and I311
Nucleic Acids Res.
35
5934-5943
2007
Homo sapiens (P23381), Homo sapiens
Charriere, F.; Helgadottir, S.; Horn, E.K.; Soell, D.; Schneider, A.
Dual targeting of a single tRNA(Trp) requires two different tryptophanyl-tRNA synthetases in Trypanosoma brucei
Proc. Natl. Acad. Sci. USA
103
6847-6852
2006
Trypanosoma brucei
Azim, M.K.; Budisa, N.
Docking of tryptophanyl [corrected tryptophan] analogs to trytophanyl-tRNA synthetase: implications for non-canonical amino acid incorporations
Biol. Chem.
389
1173-1182
2008
Escherichia coli
Weinreb, V.; Carter, C.W.
Mg2+-free Bacillus stearothermophilus tryptophanyl-tRNA synthetase retains a major fraction of the overall rate enhancement for tryptophan activation
J. Am. Chem. Soc.
130
1488-1494
2008
Geobacillus stearothermophilus
Shen, N.; Zhou, M.; Yang, B.; Yu, Y.; Dong, X.; Ding, J.
Catalytic mechanism of the tryptophan activation reaction revealed by crystal structures of human tryptophanyl-tRNA synthetase in different enzymatic states
Nucleic Acids Res.
36
1288-1299
2008
Homo sapiens (P23381), Homo sapiens
Rajendran, N.; Rajnarayanan, R.V.; Demuth, D.R.
Molecular phylogenetic analysis of tryptophanyl-tRNA synthetase of Actinobacillus actinomycetemcomitans
Z. Naturforsch. C
63
418-428
2008
Aggregatibacter actinomycetemcomitans (Q3YBV1), Aggregatibacter actinomycetemcomitans
Vecchione, J.J.; Sello, J.K.
A novel tryptophanyl-tRNA synthetase gene confers high-level resistance to indolmycin
Antimicrob. Agents Chemother.
53
3972-3980
2009
Streptomyces coelicolor, Streptomyces griseus (B1VQY7)
Wakasugi, K.
An exposed cysteine residue of human angiostatic mini tryptophanyl-tRNA synthetase
Biochemistry
49
3156-3160
2010
Homo sapiens (P23381), Homo sapiens
Ghanipour, A.; Jirstroem, K.; Ponten, F.; Glimelius, B.; Pahlman, L.; Birgisson, H.
The prognostic significance of tryptophanyl-tRNA synthetase in colorectal cancer
Cancer Epidemiol. Biomarkers Prev.
18
2949-2956
2009
Homo sapiens
Wakasugi, K.
Species-specific differences in the regulation of the aminoacylation activity of mammalian tryptophanyl-tRNA synthetases
FEBS Lett.
584
229-232
2010
Bos taurus, Homo sapiens (P23381), Homo sapiens, Mus musculus
Vecchione, J.J.; Sello, J.K.
Characterization of an inducible, antibiotic-resistant aminoacyl-tRNA synthetase gene in Streptomyces coelicolor
J. Bacteriol.
190
6253-6257
2008
Streptomyces coelicolor (Q8CJX0), Streptomyces coelicolor (Q9KZA7)
Tsuchiya, W.; Hasegawa, T.
Molecular recognition of tryptophan tRNA by tryptophanyl-tRNA synthetase from Aeropyrum pernix K1
J. Biochem.
145
635-641
2009
Aeropyrum pernix K1
Hansia, P.; Ghosh, A.; Vishveshwara, S.
Ligand dependent intra and inter subunit communication in human tryptophanyl tRNA synthetase as deduced from the dynamics of structure networks
Mol. Biosyst.
5
1860-1872
2009
Homo sapiens (P23381), Homo sapiens
Hjelm, B.; Fernandez, C.D.; Loefblom, J.; Stahl, S.; Johannesson, H.; Rockberg, J.; Uhlen, M.
Exploring epitopes of antibodies toward the human tryptophanyl-tRNA synthetase
N. Biotechnol.
27
129-137
2010
Homo sapiens (P23381), Homo sapiens
Zhou, Q.; Kapoor, M.; Guo, M.; Belani, R.; Xu, X.; Kiosses, W.B.; Hanan, M.; Park, C.; Armour, E.; Do, M.H.; Nangle, L.A.; Schimmel, P.; Yang, X.L.
Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality
Nat. Struct. Mol. Biol.
17
57-61
2010
Homo sapiens (P23381), Homo sapiens
Dong, X.; Zhou, M.; Zhong, C.; Yang, B.; Shen, N.; Ding, J.
Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase
Nucleic Acids Res.
38
1401-1412
2010
Pyrococcus horikoshii (O59584), Pyrococcus horikoshii
Bhattacharyya, M.; Ghosh, A.; Hansia, P.; Vishveshwara, S.
Allostery and conformational free energy changes in human tryptophanyl-tRNA synthetase from essential dynamics and structure networks
Proteins
78
506-517
2010
Homo sapiens (P23381), Homo sapiens
Vecchione, J.J.; Sello, J.K.
Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation
J. Bacteriol.
192
3565-3573
2010
Streptomyces coelicolor, Streptomyces avermitilis (Q82HU1), Streptomyces avermitilis, Streptomyces coelicolor M600, Streptomyces avermitilis ATCC 31267 (Q82HU1)
Arakaki, T.L.; Carter, M.; Napuli, A.J.; Verlinde, C.L.; Fan, E.; Zucker, F.; Buckner, F.S.; Van Voorhis, W.C.; Hol, W.G.; Merritt, E.A.
The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs
J. Struct. Biol.
171
238-243
2010
Giardia intestinalis
Merritt, E.A.; Arakaki, T.L.; Gillespie, R.; Napuli, A.J.; Kim, J.E.; Buckner, F.S.; Van Voorhis, W.C.; Verlinde, C.L.; Fan, E.; Zucker, F.; Hol, W.G.
Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase
Mol. Biochem. Parasitol.
177
20-28
2011
Cryptosporidium parvum (Q5CYP8), Cryptosporidium parvum, Entamoeba histolytica (C4LU94), Entamoeba histolytica (C4LUB5), Entamoeba histolytica (C4M7U9), Entamoeba histolytica, Trypanosoma brucei (Q580R7), Trypanosoma brucei
Zhou, M.; Dong, X.; Shen, N.; Zhong, C.; Ding, J.
Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design
Nucleic Acids Res.
38
3399-3413
2010
Saccharomyces cerevisiae
Hughes, R.A.; Ellington, A.D.
Rational design of an orthogonal tryptophanyl nonsense suppressor tRNA
Nucleic Acids Res.
38
6813-6830
2010
Escherichia coli, Escherichia coli CSH108
Guo, Q.; Gong, Q.; Tong, K.L.; Vestergaard, B.; Costa, A.; Desgres, J.; Wong, M.; Grosjean, H.; Zhu, G.; Wong, J.T.; Xue, H.
Recognition by tryptophanyl-tRNA synthetases of discriminator base on tRNATrp from three biological domains
J. Biol. Chem.
277
14343-14349
2002
Archaeoglobus fulgidus (O28579), Archaeoglobus fulgidus
Weinreb, V.; Li, L.; Chandrasekaran, S.N.; Koehl, P.; Delarue, M.; Carter, C.W.
Enhanced amino acid selection in fully evolved tryptophanyl-tRNA synthetase, relative to its urzyme, requires domain motion sensed by the D1 switch, a remote dynamic packing motif
J. Biol. Chem.
289
4367-4376
2014
Geobacillus stearothermophilus (P00953), Geobacillus stearothermophilus
Koh, C.Y.; Kim, J.E.; Napoli, A.J.; Verlinde, C.L.; Fan, E.; Buckner, F.S.; Van Voorhis, W.C.; Hol, W.G.
Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design
Mol. Biochem. Parasitol.
189
26-32
2013
Plasmodium falciparum
Tsuchiya W, Umehara T, Kuno A, Hasegawa T.
Determination of tryptophan tRNA recognition sites for tryptophanyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1
Nucleic Acids Symp. Ser.
2004
185-186
2004
Aeropyrum pernix (Q9Y924), Aeropyrum pernix, Aeropyrum pernix DSM 11879 (Q9Y924)
Khan, S.; Garg, A.; Sharma, A.; Camacho, N.; Picchioni, D.; Saint-Leger, A.; Ribas de Pouplana, L.; Yogavel, M.; Sharma, A.
An appended domain results in an unusual architecture for malaria parasite tryptophanyl-tRNA synthetase
PLoS ONE
8
e66224
2013
Plasmodium falciparum (Q8IDW3), Plasmodium falciparum
Miyanokoshi, M.; Tanaka, T.; Tamai, M.; Tagawa, Y.; Wakasugi, K.
Expression of the rodent-specific alternative splice variant of tryptophanyl-tRNA synthetase in murine tissues and cells
Sci. Rep.
3
3477
2013
Mus musculus (P32921), Mus musculus
Sapienza, P.J.; Li, L.; Williams, T.; Lee, A.L.; Carter, C.W.
An ancestral tryptophanyl-tRNA synthetase precursor achieves high catalytic rate enhancement without ordered ground-state tertiary structures
ACS Chem. Biol.
11
1661-1668
2016
Geobacillus stearothermophilus
Al-Gubory, K.H.; Arianmanesh, M.; Garrel, C.; Fowler, P.A.
The conceptus regulates tryptophanyl-tRNA synthetase and superoxide dismutase 2 in the sheep caruncular endometrium during early pregnancy
Int. J. Biochem. Cell Biol.
60
112-118
2015
Ovis aries (W5NVE5), Ovis aries
Williams, T.L.; Yin, Y.W.; Carter, C.W.
Selective inhibition of bacterial tryptophanyl-tRNA synthetases by indolmycin is mechanism-based
J. Biol. Chem.
291
255-265
2016
Geobacillus stearothermophilus (P00953), Geobacillus stearothermophilus
Ahn, Y.H.; Park, S.; Choi, J.J.; Park, B.K.; Rhee, K.H.; Kang, E.; Ahn, S.; Lee, C.H.; Lee, J.S.; Inn, K.S.; Cho, M.L.; Park, S.H.; Park, K.; Park, H.J.; Lee, J.H.; Park, J.W.; Kwon, N.H.; Shim, H.; Han, B.W.; Kim, P.; Lee, J.Y.; Jeon, Y.; Huh, J.W.; Jin, M.; Kim, S.
Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection
Nat. Microbiol.
2
16191
2016
Homo sapiens (P23381), Homo sapiens, Mus musculus (P32921), Mus musculus, Mus musculus C57BL/6 (P32921)
Dong, X.; Zhou, M.; Zhong, C.; Yang, B.; Shen, N.; Ding, J.
Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase
Nucleic Acids Res.
38
1401-1412
2009
Pyrococcus horikoshii (O59584), Pyrococcus horikoshii
Lee, C.W.; Chang, K.P.; Chen, Y.Y.; Liang, Y.; Hsueh, C.; Yu, J.S.; Chang, Y.S.; Yu, C.J.
Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness
Oncotarget
6
21979-21992
2015
Homo sapiens
Nakamoto, T.; Miyanokoshi, M.; Tanaka, T.; Wakasugi, K.
Identification of a residue crucial for the angiostatic activity of human mini tryptophanyl-tRNA synthetase by focusing on its molecular evolution
Sci. Rep.
6
24750
2016
Bos taurus (P17248), Bos taurus, Homo sapiens (P23381), Homo sapiens, Danio rerio (Q6PBS3), Danio rerio, Arabidopsis thaliana (Q9SR15)
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