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6.1.1.2: tryptophan-tRNA ligase

This is an abbreviated version!
For detailed information about tryptophan-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.2

Reaction

ATP
+
L-tryptophan
 +
tRNATrp
=
AMP
 +
diphosphate
 +
L-tryptophyl-tRNATrp

Synonyms

(Mt)TrpRS, BsTRpRS, drTrpRS II, EcTrpRS, hTrpRS, hWRS, IFP53, mini tryptophanyl-tRNA synthetase, mini-TrpRS, More, Synthetase, tryptophanyl-transfer ribonucleate, T2-TrpRS, Trp-RS, TrpRS, TrpRS II, TrpRS Urzyme, TrpRS1, TrpRS2, Tryptophan translase, Tryptophan--tRNA ligase, Tryptophanyl ribonucleic synthetase, tryptophanyl tRNA synthase, tryptophanyl tRNA synthetase, Tryptophanyl-transfer ribonucleate synthetase, Tryptophanyl-transfer ribonucleic acid synthetase, Tryptophanyl-transfer ribonucleic synthetase, Tryptophanyl-transfer RNA synthetase, Tryptophanyl-tRNA synthase, Tryptophanyl-tRNA synthetase, tryptophanyl-tRNA synthetase II, tryptophanyl-tRNA synthetase1, tryptophanyl-tRNA synthetase2, trytophanyl-tRNA synthetase, tyrosyl tRNA synthetase, WARS, WARS2, WRS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.2 tryptophan-tRNA ligase

Turnover Number

Turnover Number on EC 6.1.1.2 - tryptophan-tRNA ligase

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TURNOVER NUMBER [1/s]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
5.7
ammonia
-
-
0.53
Archeoglobus fulgidus tRNATrp(A73, wild-type)
pH 7.0, 65°C
-
0.11
Archeoglobus fulgidus tRNATrp(A73C)
pH 7.0, 65°C
-
0.07
Archeoglobus fulgidus tRNATrp(A73G)
pH 7.0, 65°C
-
0.09
Archeoglobus fulgidus tRNATrp(A73U)
pH 7.0, 65°C
-
1.1 - 419
ATP
0.14
Bacillus subtilis tRNATrp(A73, wild-type)
pH 7.0, 65°C
-
0.06
Bacillus subtilis tRNATrp(A73C)
pH 7.0, 65°C
-
0.04
Bacillus subtilis tRNATrp(A73G)
pH 7.0, 65°C
-
0.05
Bacillus subtilis tRNATrp(A73U)
pH 7.0, 65°C
-
0.03
bovine tRNATrp(G73, wild-type)
pH 7.0, 65°C
-
0.08
bovine tRNATrp(G73A)
pH 7.0, 65°C
-
0.06
bovine tRNATrp(G73C)
pH 7.0, 65°C
-
0.04
bovine tRNATrp(G73U)
pH 7.0, 65°C
-
0.59 - 24.5
L-tryptophan
0.16
tRNAArg
-
pH 7.5, 60°C
0.0009 - 16
tRNATrp
11
tRNATrp(A36C)
-
substrate mutant, pH 7.5, 60°C
-
4.4
tRNATrp(A36G)
-
substrate mutant, pH 7.5, 60°C
-
21
tRNATrp(A36U)
-
substrate mutant, pH 7.5, 60°C
-
0.27
tRNATrp(A36U, A73G)
-
substrate mutant, pH 7.5, 60°C
-
5.5
tRNATrp(A73C)
-
substrate mutant, pH 7.5, 60°C
-
0.62
tRNATrp(A73G)
-
substrate mutant, pH 7.5, 60°C
-
6.1
tRNATrp(A73U)
-
substrate mutant, pH 7.5, 60°C
-
0.17
tRNATrp(C34A)
-
substrate mutant, pH 7.5, 60°C
-
0.13
tRNATrp(C34G)
-
substrate mutant, pH 7.5, 60°C
-
0.11
tRNATrp(C34U)
-
substrate mutant, pH 7.5, 60°C
-
0.15
tRNATrp(C35A)
-
substrate mutant, pH 7.5, 60°C
-
0.079
tRNATrp(C35G)
-
substrate mutant, pH 7.5, 60°C
-
0.47
tRNATrp(C35U)
-
substrate mutant, pH 7.5, 60°C
-
2.3
tRNATrp(G1A-C72U)
-
substrate mutant, pH 7.5, 60°C
-
0.34
tRNATrp(G1C-G72G)
-
substrate mutant, pH 7.5, 60°C
-
0.46
tRNATrp(G1U-C72A)
-
substrate mutant, pH 7.5, 60°C
-
19
tRNATrp(G2A-C71U)
-
substrate mutant, pH 7.5, 60°C
-
1.7
tRNATrp(G2C-G71G)
-
substrate mutant, pH 7.5, 60°C
-
7.2
tRNATrp(G2U-C71A)
-
substrate mutant, pH 7.5, 60°C
-
3.2
tRNATrp(HOG1)
-
substrate mutant, pH 7.5, 60°C
-
4.5
tRNATrp(pppG1)
-
substrate mutant, pH 7.5, 60°C
-
2 - 419
Trp