6.1.1.2: tryptophan-tRNA ligase This is an abbreviated version! For detailed information about tryptophan-tRNA ligase, go to the full flat file .
Reaction
ATP +
L-tryptophan +
tRNATrp =
AMP +
diphosphate +
L-tryptophyl-tRNATrp
Synonyms (Mt)TrpRS, BsTRpRS, drTrpRS II, EcTrpRS, hTrpRS, hWRS, IFP53, mini tryptophanyl-tRNA synthetase, mini-TrpRS, More, Synthetase, tryptophanyl-transfer ribonucleate, T2-TrpRS, Trp-RS, TrpRS, TrpRS II, TrpRS Urzyme, TrpRS1, TrpRS2, Tryptophan translase, Tryptophan--tRNA ligase, Tryptophanyl ribonucleic synthetase, tryptophanyl tRNA synthase, tryptophanyl tRNA synthetase, Tryptophanyl-transfer ribonucleate synthetase, Tryptophanyl-transfer ribonucleic acid synthetase, Tryptophanyl-transfer ribonucleic synthetase, Tryptophanyl-transfer RNA synthetase, Tryptophanyl-tRNA synthase, Tryptophanyl-tRNA synthetase, tryptophanyl-tRNA synthetase II, tryptophanyl-tRNA synthetase1, tryptophanyl-tRNA synthetase2, trytophanyl-tRNA synthetase, tyrosyl tRNA synthetase, WARS, WARS2, WRS
ECTree
Organism
Organism on EC 6.1.1.2 - tryptophan-tRNA ligase
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gene trpS
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contains a single TrpRS gene
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single copy gene
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Balb/c mice
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gene trpS
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purified enzyme
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strain ATCC 12228; strains ATCC 12228 and ATCC 35984
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gene trpRS1, an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene
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mutant enzymes Trp92 to Phe, Trp92 to Gln and Trp92 to Ala
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overexpressed in Escherichia coli
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purified homogenic recombinant wild-type enzyme
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3 different forms: TRS108, TRS82 and TRS85
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TrpRS homologue 1; the Entamoeba histolytica genome contains three sequences that appear to be TrpRS homologues
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TrpRS homologue 2; the Entamoeba histolytica genome contains three sequences that appear to be TrpRS homologues
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TrpRS homologue 3; the Entamoeba histolytica genome contains three sequences that appear to be TrpRS homologues
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gene trpS
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purified native and selenomethionyl enzyme
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2 enzyme isoforms by alternative splicing in vivo, i.e. full-length and mini enzyme
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gene trpS
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mitochondrial specific isozyme containing a mitochondrial localization signal sequence
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recombinant purified native and selenomethionyl-enzyme
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Balb/c mice
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gene trpRS1, an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene
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isozymes TrpRS1 and TrpRS2 encoded by two distinct genes
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the Trypanosoma brucei genome contains separate cytosolic and mitochondrial isoforms of TrpRS that are both required and have diverged in their respective tRNA recognition domains
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