Literature summary for 6.1.1.2 extracted from

Brown, M.J.; Carter, P.S.; Fenwick, A.S.; Fosberry, A.P.; Hamprecht, D.W.; Hibbs, M.J.; Jarvest, R.L.; Mensah, L.; Milner, P.H.; O'Hanlon, P.J.; Pope, A.J.; Richardson, C.M.; West, A.; Witty, D.R.
The antimicrobial natural product chuangxinmycin and some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase (2002), Bioorg. Med. Chem. Lett., 12, 3171-3174.

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Application

Application	Comment	Organism
medicine	enzyme is the target for antibacterial activity of chuangximycin and chuangximycin lactone	Staphylococcus aureus

Inhibitors

Inhibitors	Comment	Organism	Structure
chuangximycin aldehyde	strong inhibition	Staphylococcus aureus
chuangximycin lactone	-	Staphylococcus aureus
chuangximycin nitrile	-	Staphylococcus aureus
chuangxinmycin	CAS: 63339-68-4, natural product, first isolated from Actinoplanes tsinanensis, potent and selective inhibition of the aminoacylation	Staphylococcus aureus
indolmycin	-	Staphylococcus aureus
additional information	no inhibition by chuangximycin methyl ester, hydroxamic acid, amide, hydroxymethyl or tetrazole analogue	Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + L-tryptophan + tRNATrp	Staphylococcus aureus	activity and fidelity are essential for viability	AMP + diphosphate + L-tryptophan-tRNATrp	-	?

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	-	purified enzyme	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + L-tryptophan + tRNATrp	-	Staphylococcus aureus	AMP + diphosphate + L-tryptophan-tRNATrp	-	?
ATP + L-tryptophan + tRNATrp	activity and fidelity are essential for viability	Staphylococcus aureus	AMP + diphosphate + L-tryptophan-tRNATrp	-	?

Synonyms

Synonyms	Comment	Organism
tryptophanyl tRNA synthase	-	Staphylococcus aureus

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Staphylococcus aureus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Staphylococcus aureus

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Release 2023.1 (January 2023)