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Literature summary for 6.1.1.2 extracted from

  • Vecchione, J.J.; Sello, J.K.
    Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation (2010), J. Bacteriol., 192, 3565-3573.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene trpRS1 orthologue SAV4725, DNA and amino acid sequence determination and analysis, mapping of the SAV4725 transcription start site, overview. The full-length transcript is detected only in Streptomyces avermitilis cultures that are treated with indolmycin, 5'-RACE analysis reveals that the SAV4725 transcript has a leader that is 156 nucleotides in length and highly homologous to the trpRS1 leader of Streptomyces coelicolor Streptomyces avermitilis
gene trpRS1, DNA and amino acid sequence determination and analysis, the auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene trpRS1 in Streptomyces coelicolor is regulated by a ribosome-mediated attenuator in the 5' leader of its mRNA region, overview. This regulatory element controls gene transcription in response to the physiological effects of indolmycin and chuangxinmycin, two antibiotic enzyme inhibitors. The trpRS1 locus is a widely distributed and self-regulating antibiotic resistance cassette. Cloning of several orthologues of trpRS1 Streptomyces coelicolor

Protein Variants

Protein Variants Comment Organism
H48N naturally occuring mutation of TrpRS2 Streptomyces coelicolor
H48Q naturally occuring mutation of TrpRS2 Streptomyces coelicolor
additional information targeted deletions and missense point mutations within the trpRS1 leader deregulate transcription Streptomyces coelicolor
additional information targeted deletions and missense point mutations within the trpRS1 leader deregulate transcription Streptomyces avermitilis

Inhibitors

Inhibitors Comment Organism Structure
chuangxinmycin
-
Streptomyces coelicolor
indolmycin
-
Streptomyces coelicolor

Organism

Organism UniProt Comment Textmining
Streptomyces avermitilis Q82HU1
-
-
Streptomyces avermitilis ATCC 31267 Q82HU1
-
-
Streptomyces coelicolor
-
gene trpRS1, an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene
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Streptomyces coelicolor M600
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gene trpRS1, an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene
-

Synonyms

Synonyms Comment Organism
TrpRS1
-
Streptomyces coelicolor
TrpRS1
-
Streptomyces avermitilis
TrpRS2
-
Streptomyces coelicolor
Tryptophanyl-tRNA synthetase
-
Streptomyces coelicolor
Tryptophanyl-tRNA synthetase
-
Streptomyces avermitilis

General Information

General Information Comment Organism
physiological function the auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene trpRS1 in Streptomyces coelicolor is regulated by a ribosome-mediated attenuator in the 5' leader of its mRNA region, overview. This regulatory element controls gene transcription in response to the physiological effects of indolmycin and chuangxinmycin, two antibiotic enzyme inhibitors. Tryptophanyl-tRNA synthetase activity is inversely correlated with antitermination of trpRS1 transcription Streptomyces coelicolor