Application | Comment | Organism |
---|---|---|
medicine | as producers of nearly half of the 10000 known antibiotics, Streptomyces bacteria have been particularly important in drug discovery and are a major source of drug resistance genes | Streptomyces coelicolor |
medicine | as producers of nearly half of the 10000 known antibiotics, Streptomyces bacteria have been particularly important in drug discovery and are a major source of drug resistance genes | Streptomyces griseus |
Cloned (Comment) | Organism |
---|---|
the vectors pMS81, pIJ10257, and pBluescript KS+ are used | Streptomyces coelicolor |
Protein Variants | Comment | Organism |
---|---|---|
TrpRS2(H48N) | ORF mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2(H48Q) | ORF mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2(L9F) | ORF mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2(L9F/H48Q) | ORF mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2(L9F/Q13K) | ORF mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2(Q13K) | ORF mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2[C(-17)A/H48Q] | locus mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2[C(-17)A/L9F] | locus mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2[C(-17)A] | locus mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2[G(-13)T/H48Q] | locus mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2[G(-13)T/L9F] | locus mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
TrpRS2[G(-13)T] | locus mutant, constructed for analysing the indolmycin resistance | Streptomyces coelicolor |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | indolmycin, a potential antibacterial drug, completely inhibits bacterial tryptophanyl-tRNA synthetases, identifying indolmycin resistance genes leads to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase | Streptomyces coelicolor | |
additional information | indolmycin, a potential antibacterial drug, completely inhibits bacterial tryptophanyl-tRNA synthetases, identifying indolmycin resistance genes leads to the discovery of a gene encoding an indolmycin-resistant isoform of tryptophanyl-tRNA synthetase | Streptomyces griseus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | Streptomyces coelicolor | - |
AMP + diphosphate + L-tryptophyl-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | Streptomyces griseus | - |
AMP + diphosphate + L-tryptophyl-tRNATrp | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Streptomyces coelicolor | - |
- |
- |
Streptomyces griseus | B1VQY7 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | - |
Streptomyces coelicolor | AMP + diphosphate + L-tryptophyl-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | - |
Streptomyces griseus | AMP + diphosphate + L-tryptophyl-tRNATrp | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TrpRS2 | - |
Streptomyces coelicolor |
TrpRS2 | - |
Streptomyces griseus |
Tryptophanyl-tRNA synthetase | - |
Streptomyces coelicolor |
Tryptophanyl-tRNA synthetase | - |
Streptomyces griseus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Streptomyces coelicolor | |
ATP | - |
Streptomyces griseus |