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6.1.1.2: tryptophan-tRNA ligase

This is an abbreviated version!
For detailed information about tryptophan-tRNA ligase, go to the full flat file.

Word Map on EC 6.1.1.2

Reaction

ATP
+
L-tryptophan
 +
tRNATrp
=
AMP
 +
diphosphate
 +
L-tryptophyl-tRNATrp

Synonyms

(Mt)TrpRS, BsTRpRS, drTrpRS II, EcTrpRS, hTrpRS, hWRS, IFP53, mini tryptophanyl-tRNA synthetase, mini-TrpRS, More, Synthetase, tryptophanyl-transfer ribonucleate, T2-TrpRS, Trp-RS, TrpRS, TrpRS II, TrpRS Urzyme, TrpRS1, TrpRS2, Tryptophan translase, Tryptophan--tRNA ligase, Tryptophanyl ribonucleic synthetase, tryptophanyl tRNA synthase, tryptophanyl tRNA synthetase, Tryptophanyl-transfer ribonucleate synthetase, Tryptophanyl-transfer ribonucleic acid synthetase, Tryptophanyl-transfer ribonucleic synthetase, Tryptophanyl-transfer RNA synthetase, Tryptophanyl-tRNA synthase, Tryptophanyl-tRNA synthetase, tryptophanyl-tRNA synthetase II, tryptophanyl-tRNA synthetase1, tryptophanyl-tRNA synthetase2, trytophanyl-tRNA synthetase, tyrosyl tRNA synthetase, WARS, WARS2, WRS

ECTree

     6 Ligases
         6.1 Forming carbon-oxygen bonds
             6.1.1 Ligases forming aminoacyl-tRNA and related compounds
                6.1.1.2 tryptophan-tRNA ligase

KM Value

KM Value on EC 6.1.1.2 - tryptophan-tRNA ligase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00006
Archeoglobus fulgidus tRNATrp(A73, wild-type)
pH 7.0, 65°C
-
0.00005
Archeoglobus fulgidus tRNATrp(A73C)
pH 7.0, 65°C
-
0.00006
Archeoglobus fulgidus tRNATrp(A73G)
pH 7.0, 65°C
-
0.00005
Archeoglobus fulgidus tRNATrp(A73U)
pH 7.0, 65°C
-
0.03 - 2
ATP
0.00009
Bacillus subtilis tRNATrp(A73, wild-type)
pH 7.0, 65°C
-
0.00012
Bacillus subtilis tRNATrp(A73C)
pH 7.0, 65°C
-
0.0001
Bacillus subtilis tRNATrp(A73G)
pH 7.0, 65°C
-
0.00012
Bacillus subtilis tRNATrp(A73U)
pH 7.0, 65°C
-
0.00018
bovine tRNATrp(G73, wild-type)
pH 7.0, 65°C
-
0.00021
bovine tRNATrp(G73A)
pH 7.0, 65°C
-
0.00022
bovine tRNATrp(G73C)
pH 7.0, 65°C
-
0.00017
bovine tRNATrp(G73U)
pH 7.0, 65°C
-
0.00073 - 0.027
L-tryptophan
1
P1,P3-bis(5'-adenosyl)triphosphate
0.0021
tRNAArg
-
pH 7.5, 60°C
0.00012 - 0.0248
tRNATrp
0.0059
tRNATrp(A36C)
-
substrate mutant, pH 7.5, 60°C
-
0.0053
tRNATrp(A36G)
-
substrate mutant, pH 7.5, 60°C
-
0.0058
tRNATrp(A36U)
-
substrate mutant, pH 7.5, 60°C
-
0.0098
tRNATrp(A36U, A73G)
-
substrate mutant, pH 7.5, 60°C
-
0.0017
tRNATrp(A73C)
-
substrate mutant, pH 7.5, 60°C
-
0.0058
tRNATrp(A73G)
-
substrate mutant, pH 7.5, 60°C
-
0.0051
tRNATrp(A73U)
-
substrate mutant, pH 7.5, 60°C
-
0.06
tRNATrp(C34A)
-
substrate mutant, pH 7.5, 60°C
-
0.038
tRNATrp(C34G)
-
substrate mutant, pH 7.5, 60°C
-
0.048
tRNATrp(C34U)
-
substrate mutant, pH 7.5, 60°C
-
0.014
tRNATrp(C35A)
-
substrate mutant, pH 7.5, 60°C
-
0.038
tRNATrp(C35G)
-
substrate mutant, pH 7.5, 60°C
-
0.021
tRNATrp(C35U)
-
substrate mutant, pH 7.5, 60°C
-
0.025
tRNATrp(G1A-C72U)
-
substrate mutant, pH 7.5, 60°C
-
0.0055
tRNATrp(G1C-G72G)
-
substrate mutant, pH 7.5, 60°C
-
0.021
tRNATrp(G1U-C72A)
-
substrate mutant, pH 7.5, 60°C
-
0.015
tRNATrp(G2A-C71U)
-
substrate mutant, pH 7.5, 60°C
-
0.0019
tRNATrp(G2C-G71G)
-
substrate mutant, pH 7.5, 60°C
-
0.0058
tRNATrp(G2U-C71A)
-
substrate mutant, pH 7.5, 60°C
-
0.006
tRNATrp(HOG1)
-
substrate mutant, pH 7.5, 60°C
-
0.012
tRNATrp(pppG1)
-
substrate mutant, pH 7.5, 60°C
-
0.00045 - 0.128
Trp
additional information
additional information
-