Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, overview | Homo sapiens | |
additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
L-tryptophan | product inhibition at physiologic concentrations | Homo sapiens | |
L-tryptophan | product inhibition at physiologic concentrations | Mus musculus | |
tryptamine | a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview | Homo sapiens | |
tryptamine | a metabolic tryptophan analog that acts as a potent competitive inhibitor of TrpRS, overview | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mus musculus | |
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | Mus musculus | - |
AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | Homo sapiens | - |
AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | Mus musculus BALB/c | - |
AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
additional information | Homo sapiens | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | ? | - |
? | |
additional information | Mus musculus | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | ? | - |
? | |
additional information | Mus musculus BALB/c | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
Balb/c mice | - |
Mus musculus BALB/c | - |
Balb/c mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
neuron | - |
Mus musculus | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + L-tryptophan + tRNATrp | - |
Mus musculus | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | - |
Homo sapiens | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
ATP + L-tryptophan + tRNATrp | - |
Mus musculus BALB/c | AMP + diphosphate + L-tryptophanyl-tRNATrp | - |
? | |
additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in human cell models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | Homo sapiens | ? | - |
? | |
additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | Mus musculus | ? | - |
? | |
additional information | tryptamine induces tryptophanyl-tRNA synthetase-mediated neurodegeneration with neurofibrillary tangles in mouse models, the dietary supplementation with tryptophan as a tryptamine competitor may not counteract the deleterious influence of tryptamine, overview | Mus musculus BALB/c | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | TrpRS N-terminal peptide self-assembles in double-helical fibrils in vitro | Mus musculus |
More | TrpRS N-terminal peptide self-assembles in double-helical fibrils in vitro | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
TrpRS | - |
Mus musculus |
TrpRS | - |
Homo sapiens |
Tryptophanyl-tRNA synthetase | - |
Mus musculus |
Tryptophanyl-tRNA synthetase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Mus musculus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Mus musculus |
7.5 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus | |
ATP | - |
Homo sapiens |