3.4.23.45: memapsin 1
This is an abbreviated version!
For detailed information about memapsin 1, go to the full flat file.
Word Map on EC 3.4.23.45
Reaction
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =
Synonyms
aspartic protease BACE2, BACE 2, BACE-1 homologue, BACE-2, BACE2, beta site APP cleaving enzyme, beta-amyloid precursor protein cleavage enzyme 2, beta-secretase, beta-secretase 2, beta-site Alzheimer's amyloid precurser protein cleaving enzyme 2, beta-site amyloid precursor protein cleaving enzyme 2, beta-site amyloid precursor protein-cleaving enzyme 2, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 2, beta-site APP-cleaving enzyme 2, down region aspartic protease, DRAP, memapsin-1, memapsin1, membrane aspartic protease of the pepsin family, More, protease ASP1, theta-secretase
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3.4.23.45 memapsin 1Advanced search results
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Natural Substrates Products on EC 3.4.23.45 - memapsin 1
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
amyloid precursor protein + H2O
?
the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation
-
-
?
beta-amyloid precursor protein APP + H2O
beta-amyloid protein + beta-amyloid precursor protein pre-peptide
delta and notch-like epidermal growth factor-related receptor + H2O
?
-
-
-
?
IL-1R2 + H2O
fragments of IL-1R2
-
cleavage produces fragments which are almost identical to those produced by alpha-sectretase, enzyme might act in an alternative alpha-sectretase like cleavage
cleavage between Phe329 and Gln330
-
?
pigment cell-specific melanocyte protein + H2O
?
-
BACE2 processes pigment cell-specific melanocyte protein to generate functional amyloids. BACE2 cleaves the integral membrane form of pigment cell-specific melanocyte protein within the juxtamembrane domain, releasing the luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis
-
?
vascular cell adhesion molecule 1 + H2O
?
proinflammatory tumor necrosis factor induces a drastic increase in enzyme-mediated shedding of vascular cell adhesion molecule 1 in cerebrospinal fluid
-
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
-
-
-
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
-
-
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
-
able to cleave the beta-site but preferential cleavage of amyloid precursor protein (APP) downstream of the alpha-site of A-beta (after Phe19, theta-site), not involved in the Alzheimers disease pathogenesis in Down syndrome patients, able to reduce A-beta formation when expressed in primary neurons expressing the Swedish mutant of APP
-
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
-
can cleave the amyloid precursor protein (APP) at the N terminal Asp-1 position of A-beta, preferential cleavage within the A-beta region at Phe19 or Phe20, enzyme function is not consistent with a requirement and function of BACE1 as a beta-secretase in the brain, may act antagonistically to BACE1
soluble ectodomain (sAPPb),and a membrane-bound APP C-terminal fragment of 99 amino acids
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
-
cleavage at the beta site of amyloid precursor protein but preferably between Phe690 and Phe691 or Phe691 and Ala692
-
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
-
cleavage at the beta-site but more effectively at a different site within A-beta, non-amyloidogenic function suggested
-
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
-
-
-
-
?
amyloid-beta precursor protein + H2O
?
-
-
-
-
?
beta-amyloid precursor protein APP + H2O
beta-amyloid protein + beta-amyloid precursor protein pre-peptide
-
-
-
-
?
beta-amyloid precursor protein APP + H2O
beta-amyloid protein + beta-amyloid precursor protein pre-peptide
-
-
-
?
beta-amyloid precursor protein APP + H2O
beta-amyloid protein + beta-amyloid precursor protein pre-peptide
-
cleavage at KLVF-/-FAED and at LVFF-/-AEDV, and with low activity at EVKM-/-DAEF
-
-
?
additional information
?
-
-
BACE2 cleaves at the beta site and more efficiently at a different site within amyloid-beta precursor protein
-
-
?
additional information
?
-
-
the enzyme is involved in Alzheimer's disease
-
-
?
additional information
?
-
-
the enzyme might be involved in Alzheimer's disease
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-
?
additional information
?
-
the enzyme might be involved in Alzheimer's disease
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-
?
additional information
?
-
-
the enzyme might be involved in Alzheimer's disease
-
-
?
additional information
?
-
-
the enzyme might be involved in early onset of dementia in patients with Down syndrome, and is highly expressed in breast cancers, the enzyme may also be involved in muscle functions
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-
?
