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Literature summary for 3.4.23.45 extracted from
- Protein expression of BACE1, BACE2 and APP in Down syndrome brains (2007), Amino Acids, 35, 339-343.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | Homo sapiens | cleavage at the beta-site but more effectively at a different site within A-beta, non-amyloidogenic function suggested | fragments of amyloid precursor protein | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
patients with Down syndrome and control individuals, protein levels between the groups do not differ significantly | - |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein | cleavage at the beta-site but more effectively at a different site within A-beta | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | postmortem samples of fetal brain at 18-19 weeks of gestational age and of frontal cortex of adult brains | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amyloid precursor protein + H2O | cleavage at the beta-site but more effectively at a different site within A-beta, non-amyloidogenic function suggested | Homo sapiens | fragments of amyloid precursor protein | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| BACE2 | - |
Homo sapiens |
| DRAP | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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