Application | Comment | Organism |
---|---|---|
drug development | therapeutic interventions that potentiate BACE2 may prevent Alzheimers disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
coexpressed with the Swedish mutant of APP in 20E2 cells, expressed as GFP-fusion protein using lentivirus | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane protein | Homo sapiens | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Homo sapiens | able to cleave the beta-site but preferential cleavage of amyloid precursor protein (APP) downstream of the alpha-site of A-beta (after Phe19, theta-site), not involved in the Alzheimers disease pathogenesis in Down syndrome patients, able to reduce A-beta formation when expressed in primary neurons expressing the Swedish mutant of APP | fragments of amyloid precursor protein | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with Down syndrome, slightly increased mRNA levels but protein level is identical to normal individuals | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | two potential glycosylation sites at Asn 170 at 366 | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein | preferential cleavage of amyloid precursor protein downstream of the alpha-site of A-beta (after Phe19, theta-site), resulting N-terminal sequence of product is FAEDVGSN | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | very low mRNA level | Homo sapiens | - |
colon | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
prostate | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
trachea | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | able to cleave the beta-site but preferential cleavage of amyloid precursor protein (APP) downstream of the alpha-site of A-beta (after Phe19, theta-site), not involved in the Alzheimers disease pathogenesis in Down syndrome patients, able to reduce A-beta formation when expressed in primary neurons expressing the Swedish mutant of APP | Homo sapiens | fragments of amyloid precursor protein | - |
? | |
amyloid precursor protein + H2O | cleavage after Phe19 | Homo sapiens | fragments of amyloid precursor protein | resulting N-terminal sequence is FAEDVGSN | ? |
Synonyms | Comment | Organism |
---|---|---|
BACE2 | homologue to BACE1 | Homo sapiens |
theta-secretase | preferential cleavage of the amyloid precursor protein downstream of the alpha-site of A-beta | Homo sapiens |