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Literature summary for 3.4.23.45 extracted from

  • Sun, X.; He, G.; Song, W.
    BACE2, as a novel APP theta-secretase, is not responsible for the pathogenesis of Alzheimers disease in Down syndrome (2006), FASEB J., 20, 1369-1376.
    View publication on PubMed

Application

Application Comment Organism
drug development therapeutic interventions that potentiate BACE2 may prevent Alzheimer’s disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
coexpressed with the Swedish mutant of APP in 20E2 cells, expressed as GFP-fusion protein using lentivirus Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens able to cleave the beta-site but preferential cleavage of amyloid precursor protein (APP) downstream of the alpha-site of A-beta (after Phe19, theta-site), not involved in the Alzheimer’s disease pathogenesis in Down syndrome patients, able to reduce A-beta formation when expressed in primary neurons expressing the Swedish mutant of APP fragments of amyloid precursor protein
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
patients with Down syndrome, slightly increased mRNA levels but protein level is identical to normal individuals
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glycoprotein two potential glycosylation sites at Asn 170 at 366 Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein preferential cleavage of amyloid precursor protein downstream of the alpha-site of A-beta (after Phe19, theta-site), resulting N-terminal sequence of product is FAEDVGSN Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain very low mRNA level Homo sapiens
-
colon
-
Homo sapiens
-
kidney
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-
prostate
-
Homo sapiens
-
stomach
-
Homo sapiens
-
trachea
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O able to cleave the beta-site but preferential cleavage of amyloid precursor protein (APP) downstream of the alpha-site of A-beta (after Phe19, theta-site), not involved in the Alzheimer’s disease pathogenesis in Down syndrome patients, able to reduce A-beta formation when expressed in primary neurons expressing the Swedish mutant of APP Homo sapiens fragments of amyloid precursor protein
-
?
amyloid precursor protein + H2O cleavage after Phe19 Homo sapiens fragments of amyloid precursor protein resulting N-terminal sequence is FAEDVGSN ?

Synonyms

Synonyms Comment Organism
BACE2 homologue to BACE1 Homo sapiens
theta-secretase preferential cleavage of the amyloid precursor protein downstream of the alpha-site of A-beta Homo sapiens