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Literature summary for 3.4.23.45 extracted from

  • Castorina, A.; Tiralongo, A.; Giunta, S.; Carnazza, M.L.; Scapagnini, G.; DAgata, V.
    Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of ss-amyloid toxicity (2010), Cell Biol. Toxicol., 26, 367-377.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amyloid precursor protein + H2O Homo sapiens
-
 fragments of amyloid precursor protein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9Y5Z0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amyloid precursor protein + H2O
-
 Homo sapiens fragments of amyloid precursor protein
-
 ?

Synonyms

Synonyms Comment Organism
BACE-2
-
 Homo sapiens
beta-secretase
-
 Homo sapiens
beta-site amyloid precursor protein-cleaving enzyme 2
-
 Homo sapiens
beta-site APP-cleaving enzyme 2
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens BACE2 mRNA levels are downregulated at 6, 12, and 24 h exposure to 0.01 mM AlCl3 and 0.002 mM amyloid beta peptide down
Homo sapiens neither treatment with 0.002 mM of the Abeta(25-35) fragment nor with 0.01 mM AlCl3 alone influences BACE2 gene mRNA after 24 h additional information
Homo sapiens BACE2 mRNA levels are significantly increased after 1 and 3 h exposure to 0.01 mM AlCl3 and 0.002 mM amyloid beta peptide up

General Information

General Information Comment Organism
metabolism the key step in the generation of Abeta is cleavage of APP by beta-secretase Homo sapiens