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3.4.23.45: memapsin 1

This is an abbreviated version!
For detailed information about memapsin 1, go to the full flat file.

Word Map on EC 3.4.23.45

Reaction

broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein =

Synonyms

aspartic protease BACE2, BACE 2, BACE-1 homologue, BACE-2, BACE2, beta site APP cleaving enzyme, beta-amyloid precursor protein cleavage enzyme 2, beta-secretase, beta-secretase 2, beta-site Alzheimer's amyloid precurser protein cleaving enzyme 2, beta-site amyloid precursor protein cleaving enzyme 2, beta-site amyloid precursor protein-cleaving enzyme 2, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 2, beta-site APP-cleaving enzyme 2, down region aspartic protease, DRAP, memapsin-1, memapsin1, membrane aspartic protease of the pepsin family, More, protease ASP1, theta-secretase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.45 memapsin 1

Substrates Products

Substrates Products on EC 3.4.23.45 - memapsin 1

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(MCA)Glu-Val-Lys-Met-Asp-Ala-Glu-Phe-Lys(DNP) + H2O
(MCA)Glu-Val-Lys-Met + Asp-Ala-Glu-Phe-Lys(DNP)
show the reaction diagram
-
synthetic peptide substrate based on the beta-secretase cleavage site of wild-type APP
-
-
?
amyloid precursor protein + H2O
?
show the reaction diagram
the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation
-
-
?
amyloid precursor protein + H2O
fragments of amyloid precursor protein
show the reaction diagram
amyloid-alpha pecursor protein + H2O
?
show the reaction diagram
-
-
-
-
?
amyloid-beta precursor protein + H2O
?
show the reaction diagram
beta-amyloid precursor protein APP + H2O
beta-amyloid protein + beta-amyloid precursor protein pre-peptide
show the reaction diagram
collectrin + H2O
?
show the reaction diagram
-
-
-
?
delta and notch-like epidermal growth factor-related receptor + H2O
?
show the reaction diagram
-
-
-
?
DELTA322-IL-1R2 + H2O
fragments of DELTA322-IL-1R2
show the reaction diagram
-
truncated protein cotransfected with the enzyme in HEK 293
cleavage in the same manner as for the full length protein with cleavage between Phe329 and Gln330
-
?
fibroblast growth factor receptor 1 + H2O
?
show the reaction diagram
-
-
-
?
gamma-secretase cleavage site of notch + H2O
?
show the reaction diagram
-
NCH-gamma
-
-
?
IL-1R2 + H2O
?
show the reaction diagram
-
synthetic peptide from Val322 to Ser341
-
-
?
IL-1R2 + H2O
fragments of IL-1R2
show the reaction diagram
insulin B chain + H2O
?
show the reaction diagram
-
only pro-BACE2-T1
-
-
?
kinetensin + H2O
?
show the reaction diagram
-
-
-
-
?
Mastoparan + H2O
?
show the reaction diagram
-
-
-
-
?
neuropetide + H2O
?
show the reaction diagram
-
Met-Lys-Arg-Ser-Arg-Gly-Pro-Ser-Pro-Arg-Arg
-
-
?
pigment cell-specific melanocyte protein + H2O
?
show the reaction diagram
-
BACE2 processes pigment cell-specific melanocyte protein to generate functional amyloids. BACE2 cleaves the integral membrane form of pigment cell-specific melanocyte protein within the juxtamembrane domain, releasing the luminal domain into endosomal precursors for the formation of amyloid fibrils and downstream melanosome morphogenesis
-
?
plexin domain containing 2 + H2O
?
show the reaction diagram
-
-
-
?
preproenkephalin fragment 128-140 + H2O
?
show the reaction diagram
-
-
-
-
?
preproenkephalin fragment 129-138 + H2O
?
show the reaction diagram
-
ENK-1
-
-
?
rhodamine-EVNLDAEFK-quencher + H2O
?
show the reaction diagram
-
FRET-substrate
-
-
?
Swedish amyloid-beta pecursor protein + H2O
?
show the reaction diagram
Tmem27 + H2O
?
show the reaction diagram
-
proliferative plasma membrane protein
BACE2 inactivates Tmem27 by cleavage to release a 25000 Da N-terminal part and a 22000 Da C-terminal fragment
-
?
vascular cell adhesion molecule 1 + H2O
?
show the reaction diagram
proinflammatory tumor necrosis factor induces a drastic increase in enzyme-mediated shedding of vascular cell adhesion molecule 1 in cerebrospinal fluid
-
-
?
additional information
?
-