3.4.23.45: memapsin 1
This is an abbreviated version!
For detailed information about memapsin 1, go to the full flat file.
Reaction
broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-/-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein
=
Synonyms
aspartic protease BACE2, BACE 2, BACE-1 homologue, BACE-2, BACE2, beta site APP cleaving enzyme, beta-amyloid precursor protein cleavage enzyme 2, beta-secretase, beta-secretase 2, beta-site Alzheimer's amyloid precurser protein cleaving enzyme 2, beta-site amyloid precursor protein cleaving enzyme 2, beta-site amyloid precursor protein-cleaving enzyme 2, beta-site APP cleaving enzyme, beta-site APP cleaving enzyme 2, beta-site APP-cleaving enzyme 2, down region aspartic protease, DRAP, memapsin-1, memapsin1, membrane aspartic protease of the pepsin family, More, protease ASP1, theta-secretase
ECTree
Organism
Organism on EC 3.4.23.45 - memapsin 1
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
-
UniProt
brenda
C57/B16
-
-
brenda
-
638894, 638895, 638896, 638897, 638901, 668810, 669871, 669915, 669916, 687544, 697442 -
-
brenda
-
SwissProt
brenda
-
-
-
brenda
-
SwissProt
brenda
3 different forms: A,B and C
-
-
brenda
enzyme level is decreased in Alzheimers disease patients
-
-
brenda
form A
SwissProt
brenda
form B
SwissProt
brenda
form C
SwissProt
brenda
healthy and trisomy 21 patients
-
-
brenda
healthy and trisomy 21 patients
SwissProt
brenda
patients with Alzheimers disease, BACE1 and BACE2 levels are found to be decreased in Alzheimers disease patients
-
-
brenda
patients with Down syndrome and control individuals, protein levels between the groups do not differ significantly
-
-
brenda
patients with Down syndrome, slightly increased mRNA levels but protein level is identical to normal individuals
-
-
brenda
patients with myopathies
-
-
brenda
precursor protein
SwissProt
brenda
-
-
-
brenda
-
UniProt
brenda
C57/B16
-
-
brenda
-
-
-
brenda
Sprague Dawley
-
-
brenda