Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | the juxtamembrane helix of amyloid precursor protein is crucial to inhibit the beta-secretase activity of the enzyme | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | Mus musculus | the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q9JL18 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain cortex | - |
Mus musculus | - |
cerebral cortical neuron | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
amyloid precursor protein + H2O | the enzyme cleaves amyloid precursor protein within the Abeta domain, particularly at the zeta-site (Phe20) to produce fragment C80 and prevents Abeta generation | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
BACE2 | - |
Mus musculus |
beta-site APP cleaving enzyme 2 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | enzyme-mediated beta-cleavage of amyloid precursor protein is a mechanism underlying Alzheimer's disease pathogenesis | Mus musculus |